Discover the Most-Read Organic/Inorganic Chemistry Articles of September 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in September 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of September’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical
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Dehydration, Dienes, High Octane, and High Pressures: Contributions from Vladimir Nikolaevich Ipatieff, a Father of Catalysis
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (9), pp 8531–8539
DOI: 10.1021/acscatal.8b02310

A Matter of Life(time) and Death
ACS Catal., 2018, 8 (9), pp 8597–8599
DOI: 10.1021/acscatal.8b03199

Viewpoint on the Partial Oxidation of Methane to Methanol Using Cu- and Fe-Exchanged Zeolites
ACS Catal., 2018, 8 (9), pp 8306–8313
DOI: 10.1021/acscatal.8b01180

The Use of Controls for Consistent and Accurate Measurements of Electrocatalytic Ammonia Synthesis from Dinitrogen
ACS Catal., 2018, 8 (9), pp 7820–7827
DOI: 10.1021/acscatal.8b02120

Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)-ones
ACS Catal., 2018, 8 (9), pp 8925–8931
DOI: 10.1021/acscatal.8b02445
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ACS Combinatorial Science

Materials Functionalization with Multicomponent Reactions: State of the Art
ACS Comb. Sci., 2018, 20 (9), pp 499–528
DOI: 10.1021/acscombsci.8b00072

Issue Editorial Masthead
ACS Comb. Sci., 2018, 20 (9),
DOI: 10.1021/cov020i009_1217543

Combinatorial Synthesis and High-Throughput Characterization of Fe–V–O Thin-Film Materials Libraries for Solar Water Splitting
ACS Comb. Sci., 2018, 20 (9), pp 544–553
DOI: 10.1021/acscombsci.8b00030

Polymer-Supported Syntheses of Heterocycles Bearing Oxazine and Thiazine Scaffolds
ACS Comb. Sci., 2018, 20 (9), pp 529–543
DOI: 10.1021/acscombsci.8b00076

Development of Biphasic Formulations for Use in Electrowetting-Based Liquid Lenses with a High Refractive Index Difference
ACS Comb. Sci., 2018, 20 (9), pp 554–566
DOI: 10.1021/acscombsci.8b00042
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ACS Medicinal Chemistry Letters

Precedence and Promise of Covalent Inhibitors of EGFR and KRAS for Patients with Non-Small-Cell Lung Cancer
ACS Med. Chem. Lett., 2018, 9 (9), pp 861–863
DOI: 10.1021/acsmedchemlett.8b00311

VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
ACS Med. Chem. Lett., 2018, 9 (9), pp 917–922
DOI: 10.1021/acsmedchemlett.8b00261

5-HT2C Receptor Agonists for the Treatment of Obesity
ACS Med. Chem. Lett., 2018, 9 (9), pp 864–865
DOI: 10.1021/acsmedchemlett.8b00328

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
ACS Med. Chem. Lett., 2018, 9 (9), pp 941–946
DOI: 10.1021/acsmedchemlett.8b00296

A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth
ACS Med. Chem. Lett., 2018, 9 (9), pp 901–906
DOI: 10.1021/acsmedchemlett.8b00212
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Bioconjugate Chemistry

Protein–Polymer Delivery: Chemistry from the Cold Chain to the Clinic
Bioconjugate Chem., 2018, 29 (9), pp 2867–2883
DOI: 10.1021/acs.bioconjchem.8b00483

Drug “Clicking” on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (9), pp 3154–3160
DOI: 10.1021/acs.bioconjchem.8b00481

Highly Stable and Selective Tetrazines for the Coordination-Assisted Bioorthogonal Ligation with Vinylboronic Acids
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (9), pp 3054–3059
DOI: 10.1021/acs.bioconjchem.8b00439

Water-Soluble Isatoic Anhydrides: A Platform for RNA-SHAPE Analysis and Protein Bioconjugation
Bioconjugate Chem., 2018, 29 (9), pp 3196–3202
DOI: 10.1021/acs.bioconjchem.8b00518

Long-Acting Human Growth Hormone Analogue by Noncovalent Albumin Binding
Bioconjugate Chem., 2018, 29 (9), pp 3129–3143
DOI: 10.1021/acs.bioconjchem.8b00463
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Inorganic Chemistry

O–O Radical Coupling: From Detailed Mechanistic Understanding to Enhanced Water Oxidation Catalysis
Open access through ACS Editors’ Choice
Inorg. Chem., 2018, 57 (17), pp 10533–10542
DOI: 10.1021/acs.inorgchem.8b00329

Straddling the Rooftop: Finding a Balance between Traditional and Modern Views of Chemistry†
Inorg. Chem., 2018, 57 (18), pp 11299–11305
DOI: 10.1021/acs.inorgchem.8b02237

Electrocatalytic Water Oxidation by an Unsymmetrical Di-Copper Complex
Inorg. Chem., 2018, 57 (17), pp 10481–10484
DOI: 10.1021/acs.inorgchem.8b01173

Cobalt(II)-Mediated Desulfurization of Thiophenes, Sulfides, and Thiols
Inorg. Chem., 2018, 57 (18), pp 11306–11309
DOI: 10.1021/acs.inorgchem.8b01588

Water-Stable Metal–Organic Framework for Effective and Selective Cr2O72– Capture through Single-Crystal to Single-Crystal Anion Exchange
Inorg. Chem., 2018, 57 (18), pp 11746–11752
DOI: 10.1021/acs.inorgchem.8b01879
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Journal of Medicinal Chemistry

What Makes a Great Medicinal Chemist? A Personal Perspective
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (17), pp 7419–7424
DOI: 10.1021/acs.jmedchem.7b01445

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
J. Med. Chem., 2018, 61 (18), pp 8120–8135
DOI: 10.1021/acs.jmedchem.8b01040

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
J. Med. Chem., 2018, 61 (17), pp 7785–7795
DOI: 10.1021/acs.jmedchem.8b00765

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine
J. Med. Chem., 2018, 61 (18), pp 8202–8211
DOI: 10.1021/acs.jmedchem.8b00666

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (18), pp 8226–8240
DOI: 10.1021/acs.jmedchem.8b00690
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Journal of Natural Products

Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review
J. Nat. Prod., 2018, 81 (9), pp 2138–2154
DOI: 10.1021/acs.jnatprod.8b00159

Rare Thioglycosides from the Roots of Wasabia japonica
J. Nat. Prod., 2018, 81 (9), pp 2129–2133
DOI: 10.1021/acs.jnatprod.8b00570

Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin
J. Nat. Prod., 2018, 81 (9), pp 1919–1927
DOI: 10.1021/acs.jnatprod.7b00690

Dinghupeptins A–D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces
J. Nat. Prod., 2018, 81 (9), pp 1928–1936
DOI: 10.1021/acs.jnatprod.7b01009

GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts
J. Nat. Prod., 2018, 81 (9), pp 2018–2025
DOI: 10.1021/acs.jnatprod.8b00314
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The Journal of Organic Chemistry

Straddling the Rooftop: Finding a Balance between Traditional and Modern Views of Chemistry†
J. Org. Chem., 2018, 83 (17), pp 9573–9579
DOI: 10.1021/acs.joc.8b02126

Molecular Motors in Aqueous Environment
Open access through ACS AuthorChoice
J. Org. Chem., 2018, 83 (18), pp 11008–11018
DOI: 10.1021/acs.joc.8b01627

Interplay of Protecting Groups and Side Chain Conformation in Glycopyranosides. Modulation of the Influence of Remote Substituents on Glycosylation?
Open access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (17), pp 10334–10351
DOI: 10.1021/acs.joc.8b01459

Mechanistic Insight into Additions of Allylic Grignard Reagents to Carbonyl Compounds
J. Org. Chem., 2018, 83 (17), pp 10197–10206
DOI: 10.1021/acs.joc.8b01430

Reactions of Arylsulfonate Electrophiles with NMe4F: Mechanistic Insight, Reactivity, and Scope
J. Org. Chem., 2018, 83 (18), pp 11178–11190
DOI: 10.1021/acs.joc.8b01762
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Molecular Pharmaceutics

New Directions for Drug Delivery in Cancer Therapy
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3601–3602
DOI: 10.1021/acs.molpharmaceut.8b00860

Peptide-Based 68Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2018, 15 (9), pp 3946–3952
DOI: 10.1021/acs.molpharmaceut.8b00399

Drug Delivery in Cancer Therapy, Quo Vadis?
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3603–3616
DOI: 10.1021/acs.molpharmaceut.8b00037

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3625–3633
DOI: 10.1021/acs.molpharmaceut.8b00277

Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility
Mol. Pharmaceutics, 2018, 15 (9), pp 3846–3859
DOI: 10.1021/acs.molpharmaceut.8b00341
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Organic Letters

Straddling the Rooftop: Finding a Balance between Traditional and Modern Views of Chemistry†
Org. Lett., 2018, 20 (17), pp 5075–5081
DOI: 10.1021/acs.orglett.8b02620

Total Syntheses of Aromatic Abietane Diterpenoids Utilizing Advances in the Pummerer Rearrangement
Org. Lett., 2018, 20 (18), pp 5546–5549
DOI: 10.1021/acs.orglett.8b02060

Cp*Co(III)-Catalyzed C–H Acylmethylation of Arenes by Employing Sulfoxonium Ylides as Carbene Precursors
Org. Lett., 2018, 20 (18), pp 5981–5984
DOI: 10.1021/acs.orglett.8b02796

Dual Lewis Acid/Photoredox-Catalyzed Addition of Ketyl Radicals to Vinylogous Carbonates in the Synthesis of 2,6-Dioxabicyclo[3.3.0]octan-3-ones
Org. Lett., 2018, 20 (18), pp 5727–5731
DOI: 10.1021/acs.orglett.8b02442

Visible-Light-Triggered C–C and C–N Bond Formation by C–S Bond Cleavage of Benzylic Thioethers
Org. Lett., 2018, 20 (17), pp 5247–5250
DOI: 10.1021/acs.orglett.8b02196
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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (9), pp 1036–1044
DOI: 10.1021/acs.oprd.8b00283

Using Data Analysis To Evaluate and Compare Chemical Syntheses
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2018, 22 (9), pp 1222–1235
DOI: 10.1021/acs.oprd.8b00199

Development of an SNAr Reaction: A Practical and Scalable Strategy To Sequester and Remove HF
Org. Process Res. Dev., 2018, 22 (9), pp 1086–1091
DOI: 10.1021/acs.oprd.8b00090

The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations
Org. Process Res. Dev., 2018, 22 (9), pp 1143–1166
DOI: 10.1021/acs.oprd.8b00160

Route Optimization and Manufacture of Multihundred Grams of a Ghrelin Receptor Agonist
Org. Process Res. Dev., 2018, 22 (9), pp 1174–1187
DOI: 10.1021/acs.oprd.8b00179
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Organometallics

Second-Order Jahn–Teller (SOJT) Structural Distortions in Multiply Bonded Higher Main Group Compounds
Organometallics, 2018, 37 (18), pp 2929–2936
DOI: 10.1021/acs.organomet.8b00382

When Applying the Mercury Poisoning Test to Palladacycle-Catalyzed Reactions, One Should Not Consider the Common Misconception of Mercury(0) Selectivity
Open access through ACS Editors’ Choice
Organometallics, 2018, 37 (17), pp 2842–2858
DOI: 10.1021/acs.organomet.8b00363

Cobalt(0) and Iron(0) Isocyanides as Catalysts for Alkene Hydrosilylation with Hydrosiloxanes
Open access through ACS Editors’ Choice
Organometallics, 2018, 37 (17), pp 2859–2871
DOI: 10.1021/acs.organomet.8b00389

Straddling the Rooftop: Finding a Balance between Traditional and Modern Views of Chemistry†
Organometallics, 2018, 37 (17), pp 2825–2831
DOI: 10.1021/acs.organomet.8b00592

Probing the Strongest Aromatic Cyclopentadiene Ring by Hyperconjugation
Organometallics, 2018, 37 (18), pp 3219–3224
DOI: 10.1021/acs.organomet.8b00571