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Discover the Most-Read Organic/Inorganic Chemistry Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Catalysis

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Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination
ACS Catal., 2019, 9 (2), pp 1558–1563
DOI: 10.1021/acscatal.8b04284

Effective Use of Renewable Electricity for Making Renewable Fuels and Chemicals
ACS Catal., 2019, 9 (2), pp 946–950
DOI: 10.1021/acscatal.8b04143

What Is Measured When Measuring Acidity in Zeolites with Probe Molecules?
Open Access Through ACS AuthorChoice
ACS Catal., 2019, 9 (2), pp 1539–1548
DOI: 10.1021/acscatal.8b04317

Carbonyl–Olefin Metathesis Catalyzed by Molecular Iodine
ACS Catal., 2019, 9 (2), pp 912–919
DOI: 10.1021/acscatal.8b03769

Visible-Light-Mediated Regioselective Chlorosulfonylation of Alkenes and Alkynes: Introducing the Cu(II) Complex [Cu(dap)Cl2] to Photochemical ATRA Reactions
ACS Catal., 2019, 9 (2), pp 1103–1109
DOI: 10.1021/acscatal.8b04188


ACS Combinatorial Science

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Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections
ACS Comb. Sci., 2019, 21 (2), pp 75–82
DOI: 10.1021/acscombsci.8b00116

Mild and Efficient Palladium-Mediated C–N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines
ACS Comb. Sci., 2019, 21 (2), pp 69–74
DOI: 10.1021/acscombsci.8b00142

Advances in the Solid-Phase Synthesis of Pyrimidine Derivatives
ACS Comb. Sci., 2019, 21 (2), pp 35–68
DOI: 10.1021/acscombsci.8b00172

Exploration of Catalytic Nucleic Acids on Porphyrin Metalation and Peroxidase Activity by in Vitro Selection of Aptamers for N-Methyl Mesoporphyrin IX
ACS Comb. Sci., 2019, 21 (2), pp 83–89
DOI: 10.1021/acscombsci.8b00129

FTIR Spectroscopy Suggests a Revised Mode of Action for the Cationic Side-Chain Effect of Ionic Liquids
ACS Comb. Sci., 2019, 21 (2), pp 90–97
DOI: 10.1021/acscombsci.8b00141


ACS Medicinal Chemistry Letters

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Tissue Imaging by Mass Spectrometry: A Practical Guide for the Medicinal Chemist
ACS Med. Chem. Lett., 2019, 10 (2), pp 161–167
DOI: 10.1021/acsmedchemlett.8b00480

Evolution of Small Molecule Kinase Drugs
ACS Med. Chem. Lett., 2019, 10 (2), pp 153–160
DOI: 10.1021/acsmedchemlett.8b00445

Cytosine-Based TET Enzyme Inhibitors
ACS Med. Chem. Lett., 2019, 10 (2), pp 180–185
DOI: 10.1021/acsmedchemlett.8b00474

TRPV1 Modulators for the Treatment of Pain and Inflammation
ACS Med. Chem. Lett., 2019, 10 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.8b00618

Imidazoquinolines as Novel Inhibitors of LRRK2 Kinase Activity
ACS Med. Chem. Lett., 2019, 10 (2), pp 148–149
DOI: 10.1021/acsmedchemlett.8b00654


Bioconjugate Chemistry

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Delivery of Proteins and Nucleic Acids: Achievements and Challenges
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 261–262
DOI: 10.1021/acs.bioconjchem.9b00096

Overcoming Endosomal Entrapment in Drug Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 273–283
DOI: 10.1021/acs.bioconjchem.8b00778

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 263–272
DOI: 10.1021/acs.bioconjchem.8b00732

Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 366–383
DOI: 10.1021/acs.bioconjchem.8b00761

Recent Advances in Anti-cancer Protein/Peptide Delivery
Bioconjugate Chem., 2019, 30 (2), pp 305–324
DOI: 10.1021/acs.bioconjchem.8b00750


Inorganic Chemistry

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Actinide Chemistry at the Extreme
Inorg. Chem., 2019, 58 (3), pp 1721–1723
DOI: 10.1021/acs.inorgchem.8b03603

Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters
Inorg. Chem., 2019, 58 (4), pp 2336–2345
DOI: 10.1021/acs.inorgchem.8b02701

Histidine Targeting Heterobimetallic Ruthenium(II)–Gold(I) Complexes
Open Access Through ACS AuthorChoice
Inorg. Chem., 2019, 58 (4), pp 2501–2513
DOI: 10.1021/acs.inorgchem.8b03069

Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications
Inorg. Chem., 2019, 58 (4), pp 2231–2247
DOI: 10.1021/acs.inorgchem.8b02979

Superhydrophobic/Superoleophilic MOF Composites for Oil–Water Separation
Inorg. Chem., 2019, 58 (4), pp 2261–2264
DOI: 10.1021/acs.inorgchem.8b03293


Journal of Medicinal Chemistry

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1781–1792
DOI: 10.1021/acs.jmedchem.8b01725

Retraction of “CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain”
J. Med. Chem., 2019, 62 (3), pp 1699–1699
DOI: 10.1021/acs.jmedchem.8b01388

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
J. Med. Chem., 2019, 62 (3), pp 1626–1642
DOI: 10.1021/acs.jmedchem.8b01884

Cubanes in Medicinal Chemistry
J. Med. Chem., 2019, 62 (3), pp 1078–1095
DOI: 10.1021/acs.jmedchem.8b00888

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1793–1802
DOI: 10.1021/acs.jmedchem.8b01726


Journal of Natural Products

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Bioactive Diterpenoids from the Stems of Euphorbia royleana
J. Nat. Prod., 2019, 82 (2), pp 183–193
DOI: 10.1021/acs.jnatprod.8b00493

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products
J. Nat. Prod., 2019, 82 (2), pp 211–220
DOI: 10.1021/acs.jnatprod.8b00575

Acidiphilamides A–E, Modified Peptides as Autophagy Inhibitors from an Acidophilic Actinobacterium, Streptacidiphilus rugosus
J. Nat. Prod., 2019, 82 (2), pp 341–348
DOI: 10.1021/acs.jnatprod.8b00828

Synthesis and Structure Reassignment of Malylglutamate, a Recently Discovered Earthworm Metabolite
J. Nat. Prod., 2019, 82 (2), pp 417–421
DOI: 10.1021/acs.jnatprod.8b01083

Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects
J. Nat. Prod., 2019, 82 (2), pp 232–238
DOI: 10.1021/acs.jnatprod.8b00590


The Journal of Organic Chemistry

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[6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope
Open Access Through ACS AuthorChoice
J. Org. Chem., 2019, 84 (3), pp 1139–1153
DOI: 10.1021/acs.joc.8b03144

Catalytic One-Step Deoxytrifluoromethylation of Alcohols
J. Org. Chem., 2019, 84 (4), pp 2061–2071
DOI: 10.1021/acs.joc.8b03072

Preparation and Physicochemical Properties of [6]Helicenes Fluorinated at Terminal Rings
J. Org. Chem., 2019, 84 (4), pp 1980–1993
DOI: 10.1021/acs.joc.8b02870

Selective Oxidative Phenol Coupling by Iron Catalysis
J. Org. Chem., 2019, 84 (4), pp 1677–1686
DOI: 10.1021/acs.joc.8b03084

NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids
J. Org. Chem., 2019, 84 (3), pp 1126–1138
DOI: 10.1021/acs.joc.8b02389


Molecular Pharmaceutics

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Transferrin Receptor-Mediated Uptake at the Blood–Brain Barrier Is Not Impaired by Alzheimer’s Disease Neuropathology
Mol. Pharmaceutics, 2019, 16 (2), pp 583–594
DOI: 10.1021/acs.molpharmaceut.8b00870

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics
Mol. Pharmaceutics, 2019, 16 (2), pp 632–647
DOI: 10.1021/acs.molpharmaceut.8b00941

Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake
Mol. Pharmaceutics, 2019, 16 (2), pp 469–479
DOI: 10.1021/acs.molpharmaceut.7b00484

Effect of Polymer Hydrophobicity on the Stability of Amorphous Solid Dispersions and Supersaturated Solutions of a Hydrophobic Pharmaceutical
Mol. Pharmaceutics, 2019, 16 (2), pp 682–688
DOI: 10.1021/acs.molpharmaceut.8b00972

Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (2), pp 701–708
DOI: 10.1021/acs.molpharmaceut.8b00950


Organic Letters

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Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H-Azirines”
Org. Lett., 2019, 21 (3), pp 850–850
DOI: 10.1021/acs.orglett.8b03324

Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones
Org. Lett., 2019, 21 (4), pp 1237–1240
DOI: 10.1021/acs.orglett.9b00361

Palladium-Catalyzed Oxidative Allylation of Sulfoxonium Ylides: Regioselective Synthesis of Conjugated Dienones
Org. Lett., 2019, 21 (4), pp 872–875
DOI: 10.1021/acs.orglett.8b03606

Enantioselective Total Synthesis of (−)-Δ9-Tetrahydrocannabinol via N-Heterocyclic Carbene Catalysis
Org. Lett., 2019, 21 (4), pp 1212–1215
DOI: 10.1021/acs.orglett.9b00198

Enantioselective Synthesis of Nicotine via an Iodine-Mediated Hofmann–Löffler Reaction
Open Access Through ACS Editors’ Choice
Org. Lett., 2019, 21 (3), pp 705–708
DOI: 10.1021/acs.orglett.8b03909


Organic Process Research & Development

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Gender Diversity in Process Chemistry
Org. Process Res. Dev., 2019, 23 (2), pp 109–113
DOI: 10.1021/acs.oprd.8b00378

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2019, 23 (2), pp 114–121
DOI: 10.1021/acs.oprd.9b00036

Development of a Large-Scale Asymmetric Process for tert-Butanesulfinamide
Open Access Through ACS Editors’ Choice
Org. Process Res. Dev., 2019, 23 (2), pp 263–268
DOI: 10.1021/acs.oprd.8b00399

Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications
Org. Process Res. Dev., 2019, 23 (2), pp 122–144
DOI: 10.1021/acs.oprd.8b00319

Automated On-Demand Titration of Organometallic Reagents in Continuous Flow
Org. Process Res. Dev., 2019, 23 (2), pp 278–282
DOI: 10.1021/acs.oprd.8b00434


Organometallics

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How To Make Your Computational Paper Interesting and Have It Published
Organometallics, 2019, 38 (3), pp 603–605
DOI: 10.1021/acs.organomet.8b00942

Neutral Mono(5-aryl-2-iminopyrrolyl)nickel(II) Complexes as Precatalysts for the Synthesis of Highly Branched Ethylene Oligomers: Preparation, Molecular Characterization, and Catalytic Studies
Open Access Through ACS Editors’ Choice
Organometallics, 2019, 38 (3), pp 614–625
DOI: 10.1021/acs.organomet.8b00669

Zinc-Mediated Chain Transfer from Hafnium to Aluminum in the Hafnium-Pyridyl Amido-Catalyzed Polymerization of 1-Octene Revealed by Job Plot Analysis
Open Access Through ACS Editors’ Choice
Organometallics, 2019, 38 (4), pp 926–932
DOI: 10.1021/acs.organomet.8b00900

Tandem Remote Csp3–H Activation/Csp3–Csp3 Cleavage in Unstrained Aliphatic Chains Assisted by Palladium(II)
Organometallics, 2019, 38 (4), pp 973–980
DOI: 10.1021/acs.organomet.8b00920

Two Carbenes versus One in Magnesium Chemistry: Synthesis of Terminal Dihalide, Dialkyl, and Grignard Reagents
Organometallics, 2019, 38 (3), pp 688–696
DOI: 10.1021/acs.organomet.8b00866

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