Virtual Issue: Molecular Imaging

Molecular Imaging is a relatively new biomedical research field that has gained significant traction over the last decade. Using various techniques, molecular imaging allows for the non-invasive identification, visualization, characterization, and quantification of biological processes occurring in living organisms. From live-cell microscopic technologies, such as atomic force microscopy (AFM), to full body clinical imaging technologies, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), molecular imaging has led to improvements in the diagnosis and management of many diseases worldwide.

In this Virtual Issue, we are delighted to present many of the incredible ACS publications from molecular imaging laboratories across the globe, which have been published in ACS Central Science, ACS Chemical Biology, ACS Chemical Neuroscience, ACS Combinatorial Science, ACS Infectious Diseases, ACS Medicinal Chemistry Letters, ACS Nano, Biochemistry, Bioconjugate Chemistry, Journal of Medicinal Chemistry, and Molecular Pharmaceutics. We hope you enjoy reading this unique collection of Research Articles, Reviews, Perspectives, and Viewpoints.  As always, thank you for being a loyal reader of ACS Publications!

ACS Central Science
Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells
ACS Cent. Sci., 2018, 4 (9), pp 1173–1178
DOI: 10.1021/acscentsci.8b00346
In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes
ACS Cent. Sci., 2018, 4 (10), pp 1371–1378
DOI: 10.1021/acscentsci.8b00422
Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes
ACS Cent. Sci., 2017, 3 (4), pp 349–358
DOI: 10.1021/acscentsci.7b00058
General Synthetic Method for Si-Fluoresceins and Si-Rhodamines
ACS Cent. Sci., 2017, 3 (9), pp 975–985
DOI: 10.1021/acscentsci.7b00247
Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer’s Disease in Mice, Observed by in Vivo Two-Photon Imaging
ACS Cent. Sci., 2016, 2 (12), pp 967–975
DOI: 10.1021/acscentsci.6b00309

ACS Chemical Biology
Lessons Learned from Luminous Luciferins and Latent Luciferases
ACS Chem. Biol., 2018, 13 (7), pp 1734–1740
DOI: 10.1021/acschembio.7b00964
Fluorescent Chemosensors as Future Tools for Cancer Biology
ACS Chem. Biol., 2018, 13 (7), pp 1785–1798
DOI: 10.1021/acschembio.8b00014
Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
ACS Chem. Biol., 2018, 13 (7), pp 1810–1823
DOI: 10.1021/acschembio.8b00371
Tuning the Color Palette of Fluorescent Copper Sensors through Systematic Heteroatom Substitution at Rhodol Cores
ACS Chem. Biol., 2018, 13 (7), pp 1844–1852
DOI: 10.1021/acschembio.7b00748
Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe
ACS Chem. Biol., 2018, 13 (7), pp 1853–1861
DOI: 10.1021/acschembio.7b00939

ACS Chemical Neuroscience
Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET
ACS Chem. Neurosci., 2017, 8 (9), pp 1817–1819
DOI: 10.1021/acschemneuro.7b00252
Classics in Neuroimaging: Radioligands for the Vesicular Monoamine Transporter 2
ACS Chem. Neurosci., 2019, 10 (1), pp 25–29
DOI: 10.1021/acschemneuro.8b00429
Classics in Neuroimaging: The Serotonergic 2A Receptor System—from Discovery to Modern Molecular Imaging
ACS Chem. Neurosci., 2018, 9 (6), pp 1226–1229
DOI: 10.1021/acschemneuro.8b00176

ACS Combinatorial Science
Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity
ACS Comb. Sci., 2018, 20 (2), pp 75–81
DOI: 10.1021/acscombsci.7b00155
Fabrication of a New Lineage of Artificial Luciferases from Natural Luciferase Pools
ACS Comb. Sci., 2017, 19 (9), pp 594–599
DOI: 10.1021/acscombsci.7b00081
Assembly of Macrocycle Dye Derivatives into Particles for Fluorescence and Photoacoustic Applications
ACS Comb. Sci., 2017, 19 (6), pp 397–406
DOI: 10.1021/acscombsci.7b00031
Fluorescence Multiplexing with Spectral Imaging and Combinatorics
ACS Comb. Sci., 2018, 20 (11), pp 653–659
DOI: 10.1021/acscombsci.8b00101
A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach
ACS Comb. Sci., 2016, 18 (5), pp 209–219
DOI: 10.1021/acscombsci.5b00175

ACS Infectious Diseases
Prediction of Drug Penetration in Tuberculosis Lesions
ACS Infect. Dis., 2016, 2 (8), pp 552–563
DOI: 10.1021/acsinfecdis.6b00051
Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli
ACS Infect. Dis., 2016, 2 (10), pp 688–701
DOI: 10.1021/acsinfecdis.6b00080
Optimized Fluorescence Complementation Platform for Visualizing Salmonella Effector Proteins Reveals Distinctly Different Intracellular Niches in Different Cell Types
ACS Infect. Dis., 2017, 3 (8), pp 575–584
DOI: 10.1021/acsinfecdis.7b00052
Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate
ACS Infect. Dis., 2018, 4 (5), pp 797–805
DOI: 10.1021/acsinfecdis.7b00234
[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism
ACS Infect. Dis., 2018, 4 (7), pp 1067–1072
DOI: 10.1021/acsinfecdis.8b00061

ACS Medicinal Chemistry Letters
18F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor
ACS Med. Chem. Lett., 2017, 8 (4), pp 418–422
DOI: 10.1021/acsmedchemlett.6b00520
Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma
ACS Med. Chem. Lett., 2017, 8 (3), pp 304–309
DOI: 10.1021/acsmedchemlett.6b00467
Radiosynthesis of Carbon-11 Labeled Puromycin as a Potential PET Candidate for Imaging Protein Synthesis in Vivo
ACS Med. Chem. Lett., 2016, 7 (6), pp 647–651
DOI: 10.1021/acsmedchemlett.6b00093
Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging
ACS Med. Chem. Lett., 2016, 7 (3), pp 245–249
DOI: 10.1021/acsmedchemlett.5b00360

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging
ACS Med. Chem. Lett., 2016, 7 (1), pp 62–66
DOI: 10.1021/acsmedchemlett.5b00330

ACS Nano
Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window
ACS Nano, 2018, 12 (10), pp 9654–9659
DOI: 10.1021/acsnano.8b07536
Correlated Materials Characterization via Multimodal Chemical and Functional Imaging
ACS Nano, 2018, 12 (12), pp 11798–11818
DOI: 10.1021/acsnano.8b07292
Mitochondria-Targeted DNA Nanoprobe for Real-Time Imaging and Simultaneous Quantification of Ca2+ and pH in Neurons
ACS Nano, 2018, 12 (12), pp 12357–12368
DOI: 10.1021/acsnano.8b06322
Large Hollow Cavity Luminous Nanoparticles with Near-Infrared Persistent Luminescence and Tunable Sizes for Tumor Afterglow Imaging and Chemo-/Photodynamic Therapies
ACS Nano, 2018, 12 (5), pp 4246–4258
DOI: 10.1021/acsnano.7b07606
Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging
ACS Nano, 2018, 12 (2), pp 1350–1358
DOI: 10.1021/acsnano.7b07716

Chemistry Is Dead. Long Live Chemistry!
Biochemistry, 2017, 56 (39), pp 5165–5170
DOI: 10.1021/acs.biochem.7b00529
Voltage Imaging: Pitfalls and Potential
Biochemistry, 2017, 56 (39), pp 5171–5177
DOI: 10.1021/acs.biochem.7b00490
Bioluminescent Probes for Imaging Biology beyond the Culture Dish
Biochemistry, 2017, 56 (39), pp 5178–5184
DOI: 10.1021/acs.biochem.7b00435
HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution
Biochemistry, 2017, 56 (39), pp 5194–5201
DOI: 10.1021/acs.biochem.7b00545
Illuminating the Cell’s Biochemical Activity Architecture
Biochemistry, 2017, 56 (39), pp 5210–5213
DOI: 10.1021/acs.biochem.7b00561

Bioconjugate Chemistry
Combinatorial Screening of DNA Aptamers for Molecular Imaging of HER2 in Cancer
Bioconjugate Chem., 2017, 28 (4), pp 1068–1075
DOI: 10.1021/acs.bioconjchem.6b00746
Preassembled Fluorescent Multivalent Probes for the Imaging of Anionic Membranes
Bioconjugate Chem., 2017, 28 (4), pp 1093–1101
DOI: 10.1021/acs.bioconjchem.7b00012
Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68
Bioconjugate Chem., 2017, 28 (2), pp 481–495
DOI: 10.1021/acs.bioconjchem.6b00621
Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging
Bioconjugate Chem., 2017, 28 (7), pp 1925–1930
DOI: 10.1021/acs.bioconjchem.7b00245
Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors
Bioconjugate Chem., 2017, 28 (11), pp 2865–2873
DOI: 10.1021/acs.bioconjchem.7b00566

Journal of Medicinal Chemistry
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain+
J. Med. Chem., 2018, 61 (8), pp 3296–3308
DOI: 10.1021/acs.jmedchem.7b01769
A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation
J. Med. Chem., 2017, 60 (12), pp 5222–5227
DOI: 10.1021/acs.jmedchem.7b00432
Lanthanides: Applications in Cancer Diagnosis and Therapy
J. Med. Chem., 2016, 59 (13), pp 6012–6024
DOI: 10.1021/acs.jmedchem.5b01975
Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
J. Med. Chem., 2016, 59 (10), pp 4778–4789
DOI: 10.1021/acs.jmedchem.6b00166
Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
J. Med. Chem., 2016, 59 (4), pp 1357–1369
DOI: 10.1021/acs.jmedchem.5b01537

Journal of Proteome Research
Mass Spectrometry Imaging, Laser Capture Microdissection, and LC-MS/MS of the Same Tissue Section
J. Proteome Res., 2017, 16 (8), pp 2993–3001
DOI: 10.1021/acs.jproteome.7b00284
Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes
J. Proteome Res., 2017, 16 (8), pp 3009–3018
DOI: 10.1021/acs.jproteome.7b00293
A Comparison of Common Mass Spectrometry Approaches for Paleoproteomics
J. Proteome Res., 2018, 17 (3), pp 936–945
DOI: 10.1021/acs.jproteome.7b00703
Interactive Visual Exploration of 3D Mass Spectrometry Imaging Data Using Hierarchical Stochastic Neighbor Embedding Reveals Spatiomolecular Structures at Full Data Resolution
J. Proteome Res., 2018, 17 (3), pp 1054–1064
DOI: 10.1021/acs.jproteome.7b00725
Dynamic Changes in the Protein Localization in the Nuclear Environment in Pancreatic β-Cell after Brief Glucose Stimulation
J. Proteome Res., 2018, 17 (4), pp 1664–1676
DOI: 10.1021/acs.jproteome.7b00930

Molecular Pharmaceutics
Effect of Dye and Conjugation Chemistry on the Biodistribution Profile of Near-Infrared-Labeled Nanobodies as Tracers for Image-Guided Surgery
Mol. Pharmaceutics, 2017, 14 (4), pp 1145–1153
DOI: 10.1021/acs.molpharmaceut.6b01053
Viewing Molecular and Interface Interactions of Curcumin Amorphous Solid Dispersions for Comprehending Dissolution Mechanisms
Mol. Pharmaceutics, 2017, 14 (8), pp 2781–2792
DOI: 10.1021/acs.molpharmaceut.7b00319
Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091
18F-Alanine Derivative Serves as an ASCT2 Marker for Cancer Imaging
Mol. Pharmaceutics, 2018, 15 (3), pp 947–954
DOI: 10.1021/acs.molpharmaceut.7b00884
ImmunoPET Imaging of CTLA-4 Expression in Mouse Models of Non-small Cell Lung Cancer
Mol. Pharmaceutics, 2017, 14 (5), pp 1782–1789
DOI: 10.1021/acs.molpharmaceut.7b00056


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