Discover the Most-Read Biological Chemistry Articles of June 2019 - ACS Axial | ACS Publications
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Discover the Most-Read Biological Chemistry Articles of June 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in July 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of July’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Applied Bio Materials
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Recent Advances in Synthesis, Optical Properties, and Biomedical Applications of Carbon Dots
DOI: 10.1021/acsabm.9b00112
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Enhanced Antitumor Immunity Using a Tumor Cell Lysate-Encapsulated CO2-Generating Liposomal Carrier System and Photothermal Irradiation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsabm.9b00183
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High Permeability of Polyunsaturated Lipid Bilayers As Applied to Attoliter Enzyme Reactors
DOI: 10.1021/acsabm.9b00165
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Diatom Biogenic Silica as a Felicitous Platform for Biochemical Engineering: Expanding Frontiers
DOI: 10.1021/acsabm.9b00050
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Precise Generation of Selective Surface-Confined Glycoprotein Recognition Sites
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsabm.9b00289
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ACS Biomaterials Science & Engineering
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The Chemistry of Bioinspired Catechol(amine)-Based Coatings
DOI: 10.1021/acsbiomaterials.9b00281
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Dynamic Hydrogels and Polymers as Inks for Three-Dimensional Printing
DOI: 10.1021/acsbiomaterials.9b00047
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Chiral Recognition of Lipid Bilayer Membranes by Supramolecular Assemblies of Peptide Amphiphiles
DOI: 10.1021/acsbiomaterials.9b00553
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Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics
DOI: 10.1021/acsbiomaterials.8b01173
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Fiber Density Modulates Cell Spreading in 3D Interstitial Matrix Mimetics
DOI: 10.1021/acsbiomaterials.9b00141
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ACS Catalysis
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Heteroarene Phosphinylalkylation via a Catalytic, Polarity-Reversing Radical Cascade
DOI: 10.1021/acscatal.9b01580
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Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes
DOI: 10.1021/acscatal.9b01530
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Surface Reconstructions of Metal Oxides and the Consequences on Catalytic Chemistry
DOI: 10.1021/acscatal.9b01097
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Homogeneous, Heterogeneous, and Biological Catalysts for Electrochemical N2 Reduction toward NH3 under Ambient Conditions
DOI: 10.1021/acscatal.9b00994
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Catalyst-Controlled C–H Functionalization of Adamantanes Using Selective H-Atom Transfer
DOI: 10.1021/acscatal.9b01394
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ACS Chemical Biology
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A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure
DOI: 10.1021/acschembio.9b00002
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Site-Selective Synthetic Acylation of a Target Protein in Living Cells Promoted by a Chemical Catalyst/Donor System
DOI: 10.1021/acschembio.9b00102
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Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00223
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Chemistry of Photosensitive Fluorophores for Single-Molecule Localization Microscopy
DOI: 10.1021/acschembio.9b00197
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Bifunctional Cytochrome P450 Enzymes Involved in Camptothecin Biosynthesis
DOI: 10.1021/acschembio.8b01124
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ACS Chemical Neuroscience
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Identification of a New α-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening
DOI: 10.1021/acschemneuro.9b00092
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HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.9b00105
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NeuroChat with Professor W. Michael Caudle
DOI: 10.1021/acschemneuro.9b00237
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Fluorescence Chemicals To Detect Insoluble and Soluble Amyloid-β Aggregates
DOI: 10.1021/acschemneuro.9b00199
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Prolines Affect the Nucleation Phase of Amyloid Fibrillation Reaction; Mutational Analysis of Human Stefin B
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.8b00621
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ACS Infectious Diseases
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Quantifying the Interactions between Biomolecules: Guidelines for Assay Design and Data Analysis
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.9b00012
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Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.9b00048
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LRRK2 in Infection: Friend or Foe?
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.9b00051
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Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics
DOI: 10.1021/acsinfecdis.9b00019
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Correction to Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease
DOI: 10.1021/acsinfecdis.9b00098
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ACS Medicinal Chemistry Letters
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsmedchemlett.9b00108
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Securing and Maintaining a Strong Patent Portfolio for Pharmaceuticals
DOI: 10.1021/acsmedchemlett.9b00201
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Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood–Brain Barrier Penetration
DOI: 10.1021/acsmedchemlett.9b00186

LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson’s Disease and Other Neurodegenerative Disorders
DOI: 10.1021/acsmedchemlett.9b00216
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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
DOI: 10.1021/acsmedchemlett.9b00106
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ACS Synthetic Biology
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Elucidating the Determinants of Polymerase Specificity by Microfluidic-Based Deep Mutational Scanning
DOI: 10.1021/acssynbio.9b00104
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RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00075
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Fluorescence-Activated Droplet Sorting for Single-Cell Directed Evolution
DOI: 10.1021/acssynbio.9b00103
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Altering the Substrate Specificity of Acetyl-CoA Synthetase by Rational Mutagenesis of the Carboxylate Binding Pocket
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00008
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Lessons from Two Design–Build–Test–Learn Cycles of Dodecanol Production in Escherichia coli Aided by Machine Learning
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00020
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Biochemistry
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Installing Terminal-Alkyne Reactivity into Proteins in Engineered Bacteria
DOI: 10.1021/acs.biochem.9b00392
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IID in 3D: Improved Resolution of Transcription Factor Structure by Cryo-Electron Microscopy
DOI: 10.1021/acs.biochem.9b00102
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Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies
DOI: 10.1021/acs.biochem.8b01218
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Vibrio natriegens: An Alternative Expression System for the High-Yield Production of Isotopically Labeled Proteins
DOI: 10.1021/acs.biochem.9b00403
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Eight-Letter DNA
DOI: 10.1021/acs.biochem.9b00274
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Bioconjugate Chemistry
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Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells
DOI: 10.1021/acs.bioconjchem.9b00375
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Artificial Viral Capsid Dressed Up with Human Serum Albumin
DOI: 10.1021/acs.bioconjchem.9b00327
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Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release
DOI: 10.1021/acs.bioconjchem.9b00244
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Protein PEPylation: A New Paradigm of Protein–Polymer Conjugation
DOI: 10.1021/acs.bioconjchem.9b00236
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Porphyrin-Based Nanomedicines for Cancer Treatment
DOI: 10.1021/acs.bioconjchem.9b00231
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Biomacromolecules
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Switching of Cell Proliferation/Differentiation in Thiol–Maleimide Clickable Microcapsules Triggered by in Situ Conjugation of Biomimetic Peptides
DOI: 10.1021/acs.biomac.9b00333
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Design and Synthesis of Biocompatible, Hemocompatible, and Highly Selective Antimicrobial Cationic Peptidopolysaccharides via Click Chemistry
DOI: 10.1021/acs.biomac.9b00179
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Supramolecular Modification of a Sequence-Controlled Collagen-Mimicking Polymer
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00353
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Glyoxylic Hydrazone Linkage-Based PEG Hydrogels for Covalent Entrapment and Controlled Delivery of Doxorubicin
DOI: 10.1021/acs.biomac.9b00020
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Nano- and Micropatterned Polycaprolactone Cellulose Composite Surfaces with Tunable Protein Adsorption, Fibrin Clot Formation, and Endothelial Cellular Response
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00304
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Journal of Agricultural and Food Chemistry
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Anaerobic Degradation of N-ε-Carboxymethyllysine, a Major Glycation End-Product, by Human Intestinal Bacteria
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b02208
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Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)
DOI: 10.1021/acs.jafc.9b01356
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Toxicity and Metabolic Fate of the Fungicide Carbendazim in the Typical Freshwater Diatom Navicula Species
DOI: 10.1021/acs.jafc.8b06179
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Controlled Release of Agrochemicals Using pH and Redox Dual-Responsive Cellulose Nanogels
DOI: 10.1021/acs.jafc.9b00536
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Low Nitrogen Enhances Nitrogen Use Efficiency by Triggering NO3– Uptake and Its Long-Distance Translocation
DOI: 10.1021/acs.jafc.9b02491
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Journal of Chemical Theory and Computation
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Assessment of DFT Methods for Transition Metals with the TMC151 Compilation of Data Sets and Comparison with Accuracies for Main-Group Chemistry
DOI: 10.1021/acs.jctc.9b00239
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PhysNet: A Neural Network for Predicting Energies, Forces, Dipole Moments, and Partial Charges
DOI: 10.1021/acs.jctc.9b00181
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MiMiC: A Novel Framework for Multiscale Modeling in Computational Chemistry
DOI: 10.1021/acs.jctc.9b00093
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Quantum Package 2.0: An Open-Source Determinant-Driven Suite of Programs
DOI: 10.1021/acs.jctc.9b00176
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Can Density Functional Theory Be Trusted for High-Order Electric Properties? The Case of Hydrogen-Bonded Complexes
DOI: 10.1021/acs.jctc.9b00139
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Journal of Medicinal Chemistry
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The Future Is Now: Artificial Intelligence in Drug Discovery
DOI: 10.1021/acs.jmedchem.9b00805
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CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?
DOI: 10.1021/acs.jmedchem.9b00604

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Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b00517
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From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1)
DOI: 10.1021/acs.jmedchem.9b00455
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Covalent Inhibitors of Protein–Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues
DOI: 10.1021/acs.jmedchem.9b00561
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Journal of Natural Products
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Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves
DOI: 10.1021/acs.jnatprod.8b01025
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Cyathane Diterpenes from Cultures of the Bird’s Nest Fungus Cyathus hookeri and Their Neurotrophic and Anti-neuroinflammatory Activities
DOI: 10.1021/acs.jnatprod.9b00091
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Isolation of Sesquiterpene–Amino Acid Conjugates, Onopornoids A–D, and a Flavonoid Glucoside from Onopordum alexandrinum
DOI: 10.1021/acs.jnatprod.8b00948
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17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei
DOI: 10.1021/acs.jnatprod.9b00059
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Indole Diterpenoids from an Endophytic Penicillium sp.
DOI: 10.1021/acs.jnatprod.8b00723
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The Journal of Physical Chemistry B
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Finite-Size-Corrected Rotational Diffusion Coefficients of Membrane Proteins and Carbon Nanotubes from Molecular Dynamics Simulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b01656
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Solvation of Na– in the Sodide Solution, LiNa·10MeNH2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b03792
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The Classifying Autoencoder: Gaining Insight into Amyloid Assembly of Peptides and Proteins
DOI: 10.1021/acs.jpcb.9b03415
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On the Miscibility and Immiscibility of Ionic Liquids and Water
DOI: 10.1021/acs.jpcb.9b02187
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Water Structure and Dynamics in the Stern Layer of Micelles: Femtosecond Mid-Infrared Pump-Probe Spectroscopy Study
DOI: 10.1021/acs.jpcb.9b03183
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The Journal of Physical Chemistry Letters
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Insights into Direct Methods for Predictions of Ionization Potential and Electron Affinity in Density Functional Theory
DOI: 10.1021/acs.jpclett.9b01052
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Two-Dimensional Transition Metal MXene-Based Photocatalysts for Solar Fuel Generation
DOI: 10.1021/acs.jpclett.9b00736
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Intramolecular Noncovalent Interactions Facilitate Thermally Activated Delayed Fluorescence (TADF)
DOI: 10.1021/acs.jpclett.9b01220
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Electroabsorption Spectroscopy as a Tool for Probing Charge Transfer and State Mixing in Thermally Activated Delayed Fluorescence Emitters
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b00999
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Two-Photon Absorption-Based Upconverted Circularly Polarized Luminescence Generated in Chiral Perovskite Nanocrystals
DOI: 10.1021/acs.jpclett.9b01224
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Journal of Proteome Research
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Proteomics of Communities: Metaproteomics
DOI: 10.1021/acs.jproteome.9b00276
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DO-MS: Data-Driven Optimization of Mass Spectrometry Methods
DOI: 10.1021/acs.jproteome.9b00039
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Optimized Cross-Linking Mass Spectrometry for in Situ Interaction Proteomics
DOI: 10.1021/acs.jproteome.9b00085
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Advances in Higher Order Multiplexing Techniques in Proteomics
DOI: 10.1021/acs.jproteome.9b00228
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An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.8b00786
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Molecular Pharmaceutics
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Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides
DOI: 10.1021/acs.molpharmaceut.8b01290
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Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency
DOI: 10.1021/acs.molpharmaceut.9b00308
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Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00276
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Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein
DOI: 10.1021/acs.molpharmaceut.9b00078
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Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00159
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