Discover the Most-Read Organic/Inorganic Chemistry Articles of June 2019 - ACS Axial
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Discover the Most-Read Organic/Inorganic Chemistry Articles of June 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in July 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of July’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Catalysis
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Heteroarene Phosphinylalkylation via a Catalytic, Polarity-Reversing Radical Cascade
DOI: 10.1021/acscatal.9b01580
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Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes
DOI: 10.1021/acscatal.9b01530
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Surface Reconstructions of Metal Oxides and the Consequences on Catalytic Chemistry
DOI: 10.1021/acscatal.9b01097
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Homogeneous, Heterogeneous, and Biological Catalysts for Electrochemical N2 Reduction toward NH3 under Ambient Conditions
DOI: 10.1021/acscatal.9b00994
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Catalyst-Controlled C–H Functionalization of Adamantanes Using Selective H-Atom Transfer
DOI: 10.1021/acscatal.9b01394

ACS Combinatorial Science
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Early Years of High-Throughput Experimentation and Combinatorial Approaches in Catalysis and Materials Science
DOI: 10.1021/acscombsci.8b00189
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Molecular Imaging of Retinoic Acids in Live Cells Using Single-Chain Bioluminescence Probes
DOI: 10.1021/acscombsci.9b00035
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Spray Pyrolysis as a Combinatorial Method for the Generation of Photocatalyst Libraries
DOI: 10.1021/acscombsci.9b00042
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Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker
DOI: 10.1021/acscombsci.9b00039
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Realization of Spatially Addressable Library by a Novel Combinatorial Approach on Atomic Layer Deposition: A Case Study of Zinc Oxide
DOI: 10.1021/acscombsci.9b00007
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ACS Medicinal Chemistry Letters
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Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsmedchemlett.9b00108
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Securing and Maintaining a Strong Patent Portfolio for Pharmaceuticals
DOI: 10.1021/acsmedchemlett.9b00201
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Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood–Brain Barrier Penetration
DOI: 10.1021/acsmedchemlett.9b00186
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LRRK2 Kinase Inhibitors as Possible Therapy for Parkinson’s Disease and Other Neurodegenerative Disorders
DOI: 10.1021/acsmedchemlett.9b00216
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Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres
DOI: 10.1021/acsmedchemlett.9b00106
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Bioconjugate Chemistry
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Development of Theragnostic Tool Using NIR Fluorescence Probe Targeting Mitochondria in Glioma Cells
DOI: 10.1021/acs.bioconjchem.9b00375
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Artificial Viral Capsid Dressed Up with Human Serum Albumin
DOI: 10.1021/acs.bioconjchem.9b00327
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Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release
DOI: 10.1021/acs.bioconjchem.9b00244
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Protein PEPylation: A New Paradigm of Protein–Polymer Conjugation
DOI: 10.1021/acs.bioconjchem.9b00236
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Porphyrin-Based Nanomedicines for Cancer Treatment
DOI: 10.1021/acs.bioconjchem.9b00231
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Inorganic Chemistry
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Metal Bonding with 3d and 6d Orbitals: An EPR and ENDOR Spectroscopic Investigation of Ti3+–Al and Th3+–Al Heterobimetallic Complexes
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.9b00720
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Highly Active Ruthenium CNC Pincer Photocatalysts for Visible-Light-Driven Carbon Dioxide Reduction
DOI: 10.1021/acs.inorgchem.9b00791
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Room-Temperature Synthesis of Metal–Organic Framework Isomers in the Tetragonal and Kagome Crystal Structure
DOI: 10.1021/acs.inorgchem.8b03202
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Luminescence Enhancement of cis-[Ru(bpy)2(py)2]2+ via Confinement within a Metal–Organic Framework
DOI: 10.1021/acs.inorgchem.9b00396
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Stable M(II)-Radicals and Nickel(III) Complexes of a Bis(phenol) N-Heterocyclic Carbene Chelated to Group 10 Metal Ions
DOI: 10.1021/acs.inorgchem.9b00784
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Journal of Medicinal Chemistry
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The Future Is Now: Artificial Intelligence in Drug Discovery
DOI: 10.1021/acs.jmedchem.9b00805
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CF2H, a Functional Group-Dependent Hydrogen-Bond Donor: Is It a More or Less Lipophilic Bioisostere of OH, SH, and CH3?
DOI: 10.1021/acs.jmedchem.9b00604

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Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b00517
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From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1)
DOI: 10.1021/acs.jmedchem.9b00455
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Covalent Inhibitors of Protein–Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues
DOI: 10.1021/acs.jmedchem.9b00561

Journal of Natural Products
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Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves
DOI: 10.1021/acs.jnatprod.8b01025
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Cyathane Diterpenes from Cultures of the Bird’s Nest Fungus Cyathus hookeri and Their Neurotrophic and Anti-neuroinflammatory Activities
DOI: 10.1021/acs.jnatprod.9b00091
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Isolation of Sesquiterpene–Amino Acid Conjugates, Onopornoids A–D, and a Flavonoid Glucoside from Onopordum alexandrinum
DOI: 10.1021/acs.jnatprod.8b00948
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17-nor-Cephalotane-Type Diterpenoids from Cephalotaxus fortunei
DOI: 10.1021/acs.jnatprod.9b00059
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Indole Diterpenoids from an Endophytic Penicillium sp.
DOI: 10.1021/acs.jnatprod.8b00723
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The Journal of Organic Chemistry
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Potassium tert-Amylate: A Cautionary Tale
DOI: 10.1021/acs.joc.9b00815
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Iodine-Catalyzed Nazarov Cyclizations
DOI: 10.1021/acs.joc.9b01083
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Unified Enantioselective, Convergent Synthetic Approach toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Synthesis of a Series of Ineleganoloids by Oxidation-State Manipulation of the Carbocyclic Core
DOI: 10.1021/acs.joc.9b00635
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Natural Products Containing the Oxetane and Related Moieties Present Additional Challenges for Structure Elucidation: A DU8+ Computational Case Study
DOI: 10.1021/acs.joc.9b01005
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Structure Validation of Complex Natural Products: Time to Change the Paradigm. What did Synthesis of Alstofolinine A Prove?
DOI: 10.1021/acs.joc.9b00969
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Molecular Pharmaceutics
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Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides
DOI: 10.1021/acs.molpharmaceut.8b01290
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Glucagon-Like Peptide-1 Receptor Agonists and Strategies To Improve Their Efficiency
DOI: 10.1021/acs.molpharmaceut.9b00308
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Solid-State Behavior and Solubilization of Flash Nanoprecipitated Clofazimine Particles during the Dispersion and Digestion of Milk-Based Formulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00276
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Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein
DOI: 10.1021/acs.molpharmaceut.9b00078
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Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00159
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Organic Letters
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Additive-Free Palladium-Catalyzed Decarboxylative Cross-Coupling of Aryl Chlorides
DOI: 10.1021/acs.orglett.9b01620
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Selective, Intermolecular Alkylarylation of Alkenes via Photoredox/Nickel Dual Catalysis
DOI: 10.1021/acs.orglett.9b01658
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Switchable Smiles Rearrangement for Enantioselective O-Aryl Amination
DOI: 10.1021/acs.orglett.9b01848
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Photocatalyzed Metal-Free Alkylheteroarylation of Unactivated Olefins via Direct Acidic C(sp3)–H Bond Activation
DOI: 10.1021/acs.orglett.9b01329
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Indium-Mediated Synthesis of Benzylic Hydroperoxides
DOI: 10.1021/acs.orglett.9b01070
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Organic Process Research & Development
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The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00140
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Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00250
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Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation
DOI: 10.1021/acs.oprd.9b00138
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Green Chemistry Articles of Interest to the Pharmaceutical Industry
DOI: 10.1021/acs.oprd.9b00158
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Development of a Safe Process for Manufacturing of the Potent Anticancer Agent Melflufen Hydrochloride
DOI: 10.1021/acs.oprd.9b00116
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Organometallics
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N-Heterocarbene Palladium Complexes with Dianisole Backbones: Synthesis, Structure, and Catalysis
DOI: 10.1021/acs.organomet.9b00230
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Macrocyclic N-Heterocyclic Carbenes: Synthesis and Catalytic Applications
DOI: 10.1021/acs.organomet.9b00152
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Synthesis of Iron(0) Complexes Bearing Protic NHC Ligands: Synthesis and Catalytic Activity
DOI: 10.1021/acs.organomet.9b00260
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Synthesis and Characteristics of Iridium Complexes Bearing N-Heterocyclic Nitrenium Cationic Ligands
DOI: 10.1021/acs.organomet.9b00220
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C–H and C–N Bond Activation of Tertiary Amines by Cationic Germanium(IV) Corrole
DOI: 10.1021/acs.organomet.9b00237
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