Discover the Most-Read Biological Chemistry Articles of August 2019 - ACS Axial | ACS Publications

Discover the Most-Read Biological Chemistry Articles of August 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in August 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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ACS Applied Bio Materials

Thermosensitive Hydrogel Interface Switching from Hydrophilic Lubrication to Infection Defense
DOI: 10.1021/acsabm.9b00457

Cytocompatibility of Molecularly Imprinted Polymers for Deodorants: Evaluation on Human Keratinocytes and Axillary-Hosted Bacteria
DOI: 10.1021/acsabm.9b00388

Mussel-Inspired Hydrogel with Potent in Vivo Contact-Active Antimicrobial and Wound Healing Promoting Activities
DOI: 10.1021/acsabm.9b00353

Multifunctional Cancer Phototherapy Using Fluorophore-Functionalized Nanodiamond Supraparticles
DOI: 10.1021/acsabm.9b00603

Self-Assembly of a Catalytically Active Lipopeptide and Its Incorporation into Cubosomes
DOI: 10.1021/acsabm.9b00489

ACS Biomaterials Science & Engineering


Special Issue: Biomaterials for Cell Mechanobiology
DOI: 10.1021/acsbiomaterials.9b01123

Hyaluronic Acid: Incorporating the Bio into the Material
DOI: 10.1021/acsbiomaterials.8b01268

Cancer Mechanobiology: Microenvironmental Sensing and Metastasis
DOI: 10.1021/acsbiomaterials.8b01230

Effects of Geometry on the Mechanics and Alignment of Three-Dimensional Engineered Microtissues
DOI: 10.1021/acsbiomaterials.8b01183

Where No Hand Has Gone Before: Probing Mechanobiology at the Cellular Level
DOI: 10.1021/acsbiomaterials.8b01206

ACS Catalysis


The 2018 Journal Impact Factor for ACS Catalysis
DOI: 10.1021/acscatal.9b03106

A Method for Assessing Catalyst Deactivation: A Case Study on Methanol-to-Hydrocarbons Conversion
DOI: 10.1021/acscatal.9b01106

Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis
DOI: 10.1021/acscatal.9b01785

Electrochemical Reduction of CO2 on Metal-Nitrogen-Doped Carbon Catalysts
DOI: 10.1021/acscatal.9b01405

Identification of FeN4 as an Efficient Active Site for Electrochemical N2 Reduction
DOI: 10.1021/acscatal.9b00959

ACS Chemical Biology


Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase
DOI: 10.1021/acschembio.9b00290

Secondary Forces in Protein Folding
DOI: 10.1021/acschembio.9b00339

Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes
DOI: 10.1021/acschembio.9b00493

Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure
DOI: 10.1021/acschembio.9b00410

Rational Design of Hybrid Natural Products by Utilizing the Promiscuity of an Amide Synthetase
DOI: 10.1021/acschembio.9b00351

ACS Chemical Neuroscience


Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents
DOI: 10.1021/acschemneuro.9b00226

Transglutaminase Activity Determines Nuclear Localization of Serotonin Immunoreactivity in the Early Embryos of Invertebrates and Vertebrates
DOI: 10.1021/acschemneuro.9b00346

Understanding the Role of Systemic Inflammation in Alzheimer’s Disease
DOI: 10.1021/acschemneuro.9b00333

Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function
DOI: 10.1021/acschemneuro.9b00325

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes
DOI: 10.1021/acschemneuro.9b00320

ACS Infectious Diseases


Call for Papers: Antibiotics Special Issue
DOI: 10.1021/acsinfecdis.9b00262

FtsZ as an Antibacterial Target: Status and Guidelines for Progressing This Avenue
DOI: 10.1021/acsinfecdis.9b00055

Synergy between Synthetic Antimicrobial Polymer and Antibiotics: A Promising Platform To Combat Multidrug-Resistant Bacteria
DOI: 10.1021/acsinfecdis.9b00049

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis
DOI: 10.1021/acsinfecdis.9b00112

Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions
DOI: 10.1021/acsinfecdis.9b00093

ACS Medicinal Chemistry Letters


Treatment of Cancer and Alzheimer’s Disease by PROTAC Degradation of EGFR
DOI: 10.1021/acsmedchemlett.9b00283

Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist
DOI: 10.1021/acsmedchemlett.9b00248

PROTACs and Targeted Protein Degradation for Treating ALK-Mediated Cancers
DOI: 10.1021/acsmedchemlett.9b00296

Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis
DOI: 10.1021/acsmedchemlett.9b00205

In Praise of Remarkably Powerful Centamolecular Therapeutic Agents
DOI: 10.1021/acsmedchemlett.9b00286

ACS Synthetic Biology


Communicating Structure and Function in Synthetic Biology Diagrams
DOI: 10.1021/acssynbio.9b00139

Reverse Engineering of an Aspirin-Responsive Transcriptional Regulator in Escherichia coli
DOI: 10.1021/acssynbio.9b00191

Synthetic, Context-Dependent Microbial Consortium of Predator and Prey
DOI: 10.1021/acssynbio.9b00110

Developing a Protein Scaffolding System for Rapid Enzyme Immobilization and Optimization of Enzyme Functions for Biocatalysis
DOI: 10.1021/acssynbio.9b00187

Engineered Production of Hapalindole Alkaloids in the Cyanobacterium Synechococcus sp. UTEX 2973
DOI: 10.1021/acssynbio.9b00229



A Bounty of New Challenging Targets in Oncology for Chemical Discovery
DOI: 10.1021/acs.biochem.9b00570

Enhanced Antibiotic Discovery by PROSPECTing
DOI: 10.1021/acs.biochem.9b00616

Seeing Is Believing: ORCA Allows Visualization of Three-Dimensional Genome Organization at Single-Cell Resolution
DOI: 10.1021/acs.biochem.9b00611

Engineering Spatial Orthogonality into Protein Translation
DOI: 10.1021/acs.biochem.9b00569

Revisiting Trade-offs between Rubisco Kinetic Parameters
DOI: 10.1021/acs.biochem.9b00237

Bioconjugate Chemistry


Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection
DOI: 10.1021/acs.bioconjchem.9b00403

Cell-Penetrating Peptide Enhanced Antigen Presentation for Cancer Immunotherapy
DOI: 10.1021/acs.bioconjchem.9b00245

Site-Specific Incorporation of a Dithiolane Containing Amino Acid into Proteins
DOI: 10.1021/acs.bioconjchem.9b00413

Recent Advances of Molecular Optical Probes in Imaging of β-Galactosidase
DOI: 10.1021/acs.bioconjchem.9b00391

Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis
DOI: 10.1021/acs.bioconjchem.9b00447



Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations
DOI: 10.1021/acs.biomac.9b00104

Synthetically Scalable Poly(ampholyte) Which Dramatically Enhances Cellular Cryopreservation
DOI: 10.1021/acs.biomac.9b00681

Hyaluronic Acid Derivatives for Translational Medicines
DOI: 10.1021/acs.biomac.9b00564

Functionalization of Liposomes with Hydrophilic Polymers Results in Macrophage Uptake Independent of the Protein Corona
DOI: 10.1021/acs.biomac.9b00539

Antimicrobial Peptide-Reduced Gold Nanoclusters with Charge-Reversal Moieties for Bacterial Targeting and Imaging
DOI: 10.1021/acs.biomac.9b00392

Journal of Agricultural and Food Chemistry


Role of Glutamine Synthetase Isogenes and Herbicide Metabolism in the Mechanism of Resistance to Glufosinate in Lolium perenne L. spp. multiflorum Biotypes from Oregon
DOI: 10.1021/acs.jafc.9b01392

Unified Flavor Quantitation: Toward High-Throughput Analysis of Key Food Odorants and Tastants by Means of Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry
DOI: 10.1021/acs.jafc.9b03466

Synthesis, Biological Evaluation and In Silico Computational Studies of 7-Chloro-4-(1H-1,2,3-triazol-1-yl)quinoline Derivatives: Search for New Controlling Agents against Spodoptera frugiperda (Lepidoptera: Noctuidae) Larvae
DOI: 10.1021/acs.jafc.9b01067

Simplified Tracking of a Soy Allergen in Processed Food Using a Monoclonal Antibody-Based Sandwich ELISA Targeting the Soybean 2S Albumin Gly m 8
DOI: 10.1021/acs.jafc.9b02717

Site-Specific Analysis of N-Linked Glycosylation Heterogeneity from Royal Jelly Glycoproteins
DOI: 10.1021/acs.jafc.9b03080

Journal of Chemical Theory and Computation


Bootstrap Embedding for Molecules
DOI: 10.1021/acs.jctc.9b00529

PES-Learn: An Open-Source Software Package for the Automated Generation of Machine Learning Models of Molecular Potential Energy Surfaces
DOI: 10.1021/acs.jctc.9b00312

Calculation of Molecular Vibrational Spectra on a Quantum Annealer
DOI: 10.1021/acs.jctc.9b00402

Solving the Trivial Crossing Problem While Preserving the Nodal Symmetry of the Wave Function
DOI: 10.1021/acs.jctc.9b00302

Identifying Physical Causes of Apparent Enhanced Cyclization of Short DNA Molecules with a Coarse-Grained Model
DOI: 10.1021/acs.jctc.9b00112

Journal of Medicinal Chemistry


3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma
DOI: 10.1021/acs.jmedchem.9b00719

Synthetic Approaches to the New Drugs Approved During 2017
DOI: 10.1021/acs.jmedchem.9b00196

Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway
DOI: 10.1021/acs.jmedchem.9b00348

Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways
DOI: 10.1021/acs.jmedchem.9b00030

Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
DOI: 10.1021/acs.jmedchem.9b00516

Journal of Natural Products


Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity
DOI: 10.1021/acs.jnatprod.9b00144

Aphidicolin Chemistry of the Deep-Sea-Derived Fungus Botryotinia fuckeliana MCCC 3A00494
DOI: 10.1021/acs.jnatprod.9b00705

Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea
DOI: 10.1021/acs.jnatprod.8b01078

Brominated Azaphilones from the Sponge-Associated Fungus Penicillium canescens Strain 4.14.6a
DOI: 10.1021/acs.jnatprod.9b00151

HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-Derived Aspergillus versicolor
DOI: 10.1021/acs.jnatprod.9b00183

The Journal of Physical Chemistry B


Two-Dimensional Infrared Spectroscopy and Molecular Dynamics Simulation Studies of Nonaqueous Lithium Ion Battery Electrolytes
DOI: 10.1021/acs.jpcb.9b02026

Role of the Photosystem II as an Environment in the Oxidation Free Energy of the Mn Cluster from S1 to S2
DOI: 10.1021/acs.jpcb.9b03831

Sensing Temperature in Vitro and in Cells Using a BODIPY Molecular Probe
DOI: 10.1021/acs.jpcb.9b04384

Measuring Intrinsic Disorder and Tracking Conformational Transitions Using Rosetta ResidueDisorder
DOI: 10.1021/acs.jpcb.9b04333

Role of Water Hydrogen Bonding on Transport of Small Molecules inside Hydrophobic Channels
DOI: 10.1021/acs.jpcb.9b03060

The Journal of Physical Chemistry Letters


Striking Isotopologue-Dependent Photodissociation Dynamics of Water Molecules: The Signature of an Accidental Resonance
DOI: 10.1021/acs.jpclett.9b01710

Convolutional Neural Network of Atomic Surface Structures To Predict Binding Energies for High-Throughput Screening of Catalysts
DOI: 10.1021/acs.jpclett.9b01428

Role of Halogen Atoms on High-Efficiency Mn2+ Emission in Two-Dimensional Hybrid Perovskites
DOI: 10.1021/acs.jpclett.9b01996

Titration of Aerosol pH through Droplet Coalescence
DOI: 10.1021/acs.jpclett.9b00757

Ligand Shell Structure in Lead Sulfide–Oleic Acid Colloidal Quantum Dots Revealed by Small-Angle Scattering
DOI: 10.1021/acs.jpclett.9b01008

Journal of Proteome Research


Proteomics INTegrator (PINT): An Online Tool To Store, Query, and Visualize Large Proteomics Experiment Results
DOI: 10.1021/acs.jproteome.8b00711

In Depth Quantification of Extracellular Matrix Proteins from Human Pancreas
DOI: 10.1021/acs.jproteome.9b00241

Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple-Knockout Mouse Model
DOI: 10.1021/acs.jproteome.9b00263

Analysis of the Zika and Japanese Encephalitis Virus NS5 Interactomes
DOI: 10.1021/acs.jproteome.9b00318

Prediction of an Upper Limit for the Fraction of Interprotein Cross-Links in Large-Scale In Vivo Cross-Linking Studies
DOI: 10.1021/acs.jproteome.9b00189

Molecular Pharmaceutics


Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations
DOI: 10.1021/acs.molpharmaceut.9b00455

Increasing the Potential of the Auristatin Cancer-Drug Family by Shifting the Conformational Equilibrium
DOI: 10.1021/acs.molpharmaceut.9b00437

Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib
DOI: 10.1021/acs.molpharmaceut.9b00557

Exosomes: Diagnostic Biomarkers and Therapeutic Delivery Vehicles for Cancer
DOI: 10.1021/acs.molpharmaceut.9b00409

Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
DOI: 10.1021/acs.molpharmaceut.9b00418

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