Discover the Most-Read Organic/Inorganic Chemistry Articles of August 2019 - ACS Axial
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Discover the Most-Read Organic/Inorganic Chemistry Articles of August 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in August 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of August’s most-read articles.


ACS Catalysis
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The 2018 Journal Impact Factor for ACS Catalysis
DOI: 10.1021/acscatal.9b03106

A Method for Assessing Catalyst Deactivation: A Case Study on Methanol-to-Hydrocarbons Conversion
DOI: 10.1021/acscatal.9b01106

Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis
DOI: 10.1021/acscatal.9b01785

Electrochemical Reduction of CO2 on Metal-Nitrogen-Doped Carbon Catalysts
DOI: 10.1021/acscatal.9b01405

Identification of FeN4 as an Efficient Active Site for Electrochemical N2 Reduction
DOI: 10.1021/acscatal.9b00959


ACS Combinatorial Science

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On-DNA Decarboxylative Arylation: Merging Photoredox with Nickel Catalysis in Water
DOI: 10.1021/acscombsci.9b00076

High-Affinity α5β1-Integrin-Selective Bicyclic RGD Peptides Identified via Screening of Designed Random Libraries
DOI: 10.1021/acscombsci.9b00081

Multicomponent Synthesis of Diversified Chromeno[3,2-d]oxazoles
DOI: 10.1021/acscombsci.9b00084

Plasmonic Selection of ssDNA Aptamers against Fibroblast Growth Factor Receptor
DOI: 10.1021/acscombsci.9b00059

Encrypted Oligonucleotide Arrays for Molecular Authentication
DOI: 10.1021/acscombsci.9b00088


ACS Medicinal Chemistry Letters

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Treatment of Cancer and Alzheimer’s Disease by PROTAC Degradation of EGFR
DOI: 10.1021/acsmedchemlett.9b00283

Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a logD Lowering Twist
DOI: 10.1021/acsmedchemlett.9b00248

PROTACs and Targeted Protein Degradation for Treating ALK-Mediated Cancers
DOI: 10.1021/acsmedchemlett.9b00296

Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis
DOI: 10.1021/acsmedchemlett.9b00205

In Praise of Remarkably Powerful Centamolecular Therapeutic Agents
DOI: 10.1021/acsmedchemlett.9b00286


Bioconjugate Chemistry

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Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection
DOI: 10.1021/acs.bioconjchem.9b00403

Cell-Penetrating Peptide Enhanced Antigen Presentation for Cancer Immunotherapy
DOI: 10.1021/acs.bioconjchem.9b00245

Site-Specific Incorporation of a Dithiolane Containing Amino Acid into Proteins
DOI: 10.1021/acs.bioconjchem.9b00413

Recent Advances of Molecular Optical Probes in Imaging of β-Galactosidase
DOI: 10.1021/acs.bioconjchem.9b00391

Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis
DOI: 10.1021/acs.bioconjchem.9b00447


Inorganic Chemistry

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What IS Inorganic Chemistry?
DOI: 10.1021/acs.inorgchem.9b02015

Inorganic Young Investigators: A Celebration for Our Rising Stars
DOI: 10.1021/acs.inorgchem.9b02249

Celebrating the Year of the Periodic Table: Emerging Investigators in Inorganic Chemistry
DOI: 10.1021/acs.inorgchem.9b02174

Metal–Oxyl Species and Their Possible Roles in Chemical Oxidations
DOI: 10.1021/acs.inorgchem.8b03459

Observations on the Mechanochemical Insertion of Zinc(II), Copper(II), Magnesium(II), and Select Other Metal(II) Ions into Porphyrins
DOI: 10.1021/acs.inorgchem.9b00052


Journal of Medicinal Chemistry

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3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma
DOI: 10.1021/acs.jmedchem.9b00719

Synthetic Approaches to the New Drugs Approved During 2017
DOI: 10.1021/acs.jmedchem.9b00196

Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway
DOI: 10.1021/acs.jmedchem.9b00348

Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways
DOI: 10.1021/acs.jmedchem.9b00030

Development of Multifunctional Histone Deacetylase 6 Degraders with Potent Antimyeloma Activity
DOI: 10.1021/acs.jmedchem.9b00516


Journal of Natural Products

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Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity
DOI: 10.1021/acs.jnatprod.9b00144

Aphidicolin Chemistry of the Deep-Sea-Derived Fungus Botryotinia fuckeliana MCCC 3A00494
DOI: 10.1021/acs.jnatprod.9b00705

Bioactive Sesquiterpene Lactones Isolated from the Whole Plants of Vernonia cinerea
DOI: 10.1021/acs.jnatprod.8b01078

Brominated Azaphilones from the Sponge-Associated Fungus Penicillium canescens Strain 4.14.6a
DOI: 10.1021/acs.jnatprod.9b00151

HPLC-DAD-Directed Isolation of Linearly Fused Prenylated Indole Alkaloids from a Soil-Derived Aspergillus versicolor
DOI: 10.1021/acs.jnatprod.9b00183


The Journal of Organic Chemistry

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Inverse Electron Demand Diels–Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective
DOI: 10.1021/acs.joc.9b00834

Nickel(II)-Catalyzed [5 + 1] Annulation of 2-Carbonyl-1-propargylindoles with Hydroxylamine To Synthesize Pyrazino[1,2-a]indole-2-oxides in Water
DOI: 10.1021/acs.joc.9b00784

Generation of Aryl Radicals from Aryl Halides: Rongalite-Promoted Transition-Metal-Free Arylation
DOI: 10.1021/acs.joc.9b01113

Perylene Bisimide Dyes with up to Five Independently Introduced Substituents: Controlling the Functionalization Pattern and Photophysical Properties Using Regiospecific Bay Substitution
DOI: 10.1021/acs.joc.9b01131

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway
DOI: 10.1021/acs.joc.9b00942


Molecular Pharmaceutics

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Assessing the Impact of Endogenously Derived Crystalline Drug on the in Vivo Performance of Amorphous Formulations
DOI: 10.1021/acs.molpharmaceut.9b00455

Increasing the Potential of the Auristatin Cancer-Drug Family by Shifting the Conformational Equilibrium
DOI: 10.1021/acs.molpharmaceut.9b00437

Low-Frequency Raman Spectroscopic Study on Compression-Induced Destabilization in Melt-Quenched Amorphous Celecoxib
DOI: 10.1021/acs.molpharmaceut.9b00557

Exosomes: Diagnostic Biomarkers and Therapeutic Delivery Vehicles for Cancer
DOI: 10.1021/acs.molpharmaceut.9b00409

Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
DOI: 10.1021/acs.molpharmaceut.9b00418


Organic Letters

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Organic Synthesis: Where to from Now? A Personal Perspective from Down Under
DOI: 10.1021/acs.orglett.9b02271

Visible Light-Promoted Aliphatic C–H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent
DOI: 10.1021/acs.orglett.9b01635

Arylation of Aldehydes To Directly Form Ketones via Tandem Nickel Catalysis
DOI: 10.1021/acs.orglett.9b01782

COtab: Expedient and Safe Setup for Pd-Catalyzed Carbonylation Chemistry
DOI: 10.1021/acs.orglett.9b01423

Benzaldehyde- and Nickel-Catalyzed Photoredox C(sp3)–H Alkylation/Arylation with Amides and Thioethers
DOI: 10.1021/acs.orglett.9b02226


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00327

The 25th Anniversary of the Buchwald–Hartwig Amination: Development, Applications, and Outlook
DOI: 10.1021/acs.oprd.9b00161

Honoring 25 Years of the Buchwald–Hartwig Amination
DOI: 10.1021/acs.oprd.9b00177

Development and Scale-Up of a Continuous Aerobic Oxidative Chan–Lam Coupling
DOI: 10.1021/acs.oprd.9b00125

Metal-Reductant-Free Electrochemical Nickel-Catalyzed Couplings of Aryl and Alkyl Bromides in Acetonitrile
DOI: 10.1021/acs.oprd.9b00232


Organometallics

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Synthesis and Characterization of (DIPPCCC)Fe Complexes: A Zwitterionic Metalation Method and CO2 Reactivity
DOI: 10.1021/acs.organomet.9b00271

Reactions of Metallacyclopentadiene with Terminal Alkynes: Isolation and Characterization of Metallafulvenallene Complexes
DOI: 10.1021/acs.organomet.9b00371

Sequential Hydrogenation of CO2 to Methanol Using a Pincer Iron Catalyst
DOI: 10.1021/acs.organomet.9b00413

Alkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides
DOI: 10.1021/acs.organomet.9b00421

Synthesis of Molybdenum(VI) Neopentylidene Neopentylidyne Complexes
DOI: 10.1021/acs.organomet.9b00412

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