Discover the Most-Read Biological Chemistry Articles of September 2019 - ACS Axial
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Discover the Most-Read Biological Chemistry Articles of September 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in September 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of September’s most-read articles.


ACS Applied Bio Materials

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Platinum/Graphene Oxide Coated Microfabricated Arrays for Multinucleus Neural Activities Detection in the Rat Models of Parkinson’s Disease Treated by Apomorphine
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsabm.9b00541

In Situ Bioprocessing of Bacterial Cellulose with Graphene: Percolation Network Formation, Kinetic Analysis with Physicochemical and Structural Properties Assessment
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsabm.9b00581

Poly(l-lactic acid) (PLLA) Coatings with Controllable Hierarchical Porous Structures on Magnesium Substrate: An Evaluation of Corrosion Behavior and Cytocompatibility
DOI: 10.1021/acsabm.9b00461

Plasmonic Nanohybrid with High Photothermal Conversion Efficiency for Simultaneously Effective Antibacterial/Anticancer Photothermal Therapy
DOI: 10.1021/acsabm.9b00521

Receptor-Targeting Drug and Drug Carrier for Enhanced Killing Efficacy against Non-Muscle-Invasive Bladder Cancer
DOI: 10.1021/acsabm.9b00403


ACS Biomaterials Science & Engineering

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Electrospun Nanofibers for Drug Delivery and Biosensing
DOI: 10.1021/acsbiomaterials.9b00853

Self-Assembled Protein- and Peptide-Based Nanomaterials
DOI: 10.1021/acsbiomaterials.9b00408

Recent Advances in Engineering of Lipid Drug Conjugates for Cancer Therapy
DOI: 10.1021/acsbiomaterials.9b00689

Nanomedicine Fabricated from A Boron-dipyrromethene (BODIPY)-Embedded Amphiphilic Copolymer for Photothermal-Enhanced Chemotherapy
DOI: 10.1021/acsbiomaterials.9b01145

Breast Cancer Cells Transition from Mesenchymal to Amoeboid Migration in Tunable Three-Dimensional Silk–Collagen Hydrogels
DOI: 10.1021/acsbiomaterials.9b00519


ACS Catalysis

Catalytic Approaches to Monomers for Polymers Based on Renewables
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acscatal.9b01665

Opportunities and Challenges for Catalysis in Carbon Dioxide Utilization
DOI: 10.1021/acscatal.9b02113

CO2 Hydrogenation to Methanol over ZrO2-Containing Catalysts: Insights into ZrO2 Induced Synergy9
DOI: 10.1021/acscatal.9b01943

Iron-Catalyzed Borrowing Hydrogen β-C(sp3)-Methylation of Alcohols
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscatal.9b02461

Oxa- and Azabenzonorbornadienes as Electrophilic Partners under Photoredox/Nickel Dual Catalysis
DOI: 10.1021/acscatal.9b02458


ACS Chemical Biology

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00505

Vancomycin–Arginine Conjugate Inhibits Growth of Carbapenem-Resistant E. coli and Targets Cell-Wall Synthesis
DOI: 10.1021/acschembio.9b00565

CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins
DOI: 10.1021/acschembio.9b00399

Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity
DOI: 10.1021/acschembio.9b00424

Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00367


ACS Chemical Neuroscience

Learnings from Protein Folding Projected onto Amyloid Misfolding
DOI: 10.1021/acschemneuro.9b00445

A Cleaning Crew: The Pursuit of Autophagy in Parkinson’s Disease
DOI: 10.1021/acschemneuro.9b00244

Lanosterol Disrupts the Aggregation of Amyloid-β Peptides
DOI: 10.1021/acschemneuro.9b00285

Multitarget Approach for the Treatment of Alzheimer’s Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles
DOI: 10.1021/acschemneuro.9b00303

Molecular Dynamics Simulations Reveal the Inhibitory Mechanism of Dopamine against Human Islet Amyloid Polypeptide (hIAPP) Aggregation and Its Destabilization Effect on hIAPP Protofibrils
DOI: 10.1021/acschemneuro.9b00393


ACS Infectious Diseases

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Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.9b00179

Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.9b00084

(p)ppGpp and the Stringent Response: An Emerging Threat to Antibiotic Therapy
DOI: 10.1021/acsinfecdis.9b00204

Novel Oleanolic and Maslinic Acid Derivatives as a Promising Treatment against Bacterial Biofilm in Nosocomial Infections: An in Vitro and in Vivo Study
DOI: 10.1021/acsinfecdis.9b00125

Candida auris: The Canary in the Mine of Antifungal Drug Resistance
DOI: 10.1021/acsinfecdis.9b00239


ACS Medicinal Chemistry Letters

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PROTAC Degradation of IRAK4 for the Treatment of Neurodegenerative and Cardiovascular Diseases
DOI: 10.1021/acsmedchemlett.9b00385

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C
DOI: 10.1021/acsmedchemlett.9b00258

Call for Papers: Special Issue in Honor of Dr. Maurizio Botta
DOI: 10.1021/acsmedchemlett.9b00392

Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00142

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsmedchemlett.9b00276


ACS Synthetic Biology

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Defensive Function of Transposable Elements in Bacteria
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00218

CRISPRi-Based Downregulation of Transcriptional Feedback Improves Growth and Metabolism of Arginine Overproducing E. coli
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00183

Synthetic Biology Tools for the Fast-Growing Marine Bacterium Vibrio natriegens
DOI: 10.1021/acssynbio.9b00176

Employing 25-Residue Docking Motifs from Modular Polyketide Synthases as Orthogonal Protein Connectors
DOI: 10.1021/acssynbio.9b00047

Reversible Gene Regulation in Mammalian Cells Using Riboswitch-Engineered Vesicular Stomatitis Virus Vector
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00177


Biochemistry

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Unusual Activity of a Chlamydomonas TET/JBP Family Enzyme
DOI: 10.1021/acs.biochem.9b00609

Off-Target Editing by CRISPR-Guided DNA Base Editors
DOI: 10.1021/acs.biochem.9b00573

N-Terminal Acetylation Affects α-Synuclein Fibril Polymorphism
DOI: 10.1021/acs.biochem.9b00629

Protecting Enzymes from Stress-Induced Inactivation
DOI: 10.1021/acs.biochem.9b00675

Protecting Enzymes from Stress-Induced Inactivation
DOI: 10.1021/acs.biochem.9b00675


Bioconjugate Chemistry

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A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide
DOI: 10.1021/acs.bioconjchem.9b00436

Nanoparticle Interactions with the Tumor Microenvironment
DOI: 10.1021/acs.bioconjchem.9b00448

Site-Specific Modification of Proteins through N-Terminal Azide Labeling and a Chelation-Assisted CuAAC Reaction
DOI: 10.1021/acs.bioconjchem.9b00515

Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine
DOI: 10.1021/acs.bioconjchem.9b00456

Efficient Small-Scale Conjugation of DNA to Primary Antibodies for Multiplexed Cellular Targeting
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00490


Biomacromolecules

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Polyhydroxyalkanoates and Other Biopolymers
DOI: 10.1021/acs.biomac.9b01044

Thermoresponsive Protein-Engineered Coiled-Coil Hydrogel for Sustained Small Molecule Release
DOI: 10.1021/acs.biomac.9b00107

Polydiacetylene (PDA) Liposome-Based Immunosensor for the Detection of Exosomes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00641

Ligand-Functionalized Poly(ethylene glycol) Particles for Tumor Targeting and Intracellular Uptake
DOI: 10.1021/acs.biomac.9b00925

Injectable Shape-Holding Collagen Hydrogel for Cell Encapsulation and Delivery Cross-linked Using Thiol-Michael Addition Click Reaction
DOI: 10.1021/acs.biomac.9b00769


Journal of Agricultural and Food Chemistry

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Presence of Acetamide in Milk and Beef from Cattle Consuming AFEX-Treated Crop Residues
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b04030

Isolation and Characterization of Angiotensin Converting Enzyme Inhibitory Peptides from Peach Seed Hydrolysates: In Vivo Assessment of Antihypertensive Activity
DOI: 10.1021/acs.jafc.9b02213

Protein-Based Pickering High Internal Phase Emulsions as Nutraceutical Vehicles of and the Template for Advanced Materials: A Perspective Paper
DOI: 10.1021/acs.jafc.9b03356

Identification and Functional Analysis of a Delta Class Glutathione S-Transferase Gene Associated with Insecticide Detoxification in Bradysia odoriphaga
DOI: 10.1021/acs.jafc.9b02874

Grape Pomace as a Promising Antimicrobial Alternative in Feed: A Critical Review
DOI: 10.1021/acs.jafc.9b02861


Journal of Chemical Theory and Computation

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Large-Scale Benchmark of Exchange–Correlation Functionals for the Determination of Electronic Band Gaps of Solids
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jctc.9b00322

EnzyDock: Protein–Ligand Docking of Multiple Reactive States along a Reaction Coordinate in Enzymes
DOI: 10.1021/acs.jctc.9b00366

Development of an Advanced Force Field for Water Using Variational Energy Decomposition Analysis
DOI: 10.1021/acs.jctc.9b00478

Fragment Binding Pose Predictions Using Unbiased Simulations and Markov-State Models
DOI: 10.1021/acs.jctc.9b00069

ωB2PLYP and ωB2GPPLYP: The First Two Double-Hybrid Density Functionals with Long-Range Correction Optimized for Excitation Energies
DOI: 10.1021/acs.jctc.9b00013


Journal of Medicinal Chemistry

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
DOI: 10.1021/acs.jmedchem.9b00794

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
DOI: 10.1021/acs.jmedchem.9b00723

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
DOI: 10.1021/acs.jmedchem.9b00555

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b00911

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
DOI: 10.1021/acs.jmedchem.9b00687


Journal of Natural Products

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Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
DOI: 10.1021/acs.jnatprod.9b00471

Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of Alangium salviifolium and Their Cytotoxicity
DOI: 10.1021/acs.jnatprod.9b00670

Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata
DOI: 10.1021/acs.jnatprod.8b00954

Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms
DOI: 10.1021/acs.jnatprod.9b00410

Natural Hydroxamate-Containing Siderophore Acremonpeptides A–D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115
DOI: 10.1021/acs.jnatprod.9b00545


The Journal of Physical Chemistry B

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Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b02280

Vibrational Coupling on Stepwise Hydrogen Bond Formation of Amide I
DOI: 10.1021/acs.jpcb.9b05118

Studying Hemoglobin and a Bare Metal–Porphyrin Complex Immobilized on Functionalized Silicon Surfaces Using Synchrotron X-ray Reflectivity
DOI: 10.1021/acs.jpcb.9b03085

Dynamics of Water Molecules and Ions in Concentrated Lithium Chloride Solutions Probed with Ultrafast 2D IR Spectroscopy
DOI: 10.1021/acs.jpcb.9b06038

Force Field Comparison of GM1 in a DOPC Bilayer Validated with AFM and FRET Experiments
DOI: 10.1021/acs.jpcb.9b05095


The Journal of Physical Chemistry Letters

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Relaxation Dynamics and Genuine Properties of the Solvated Electron in Neutral Water Clusters
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b01802

Band Gap Engineering in Cs2(NaxAg1–x)BiCl6 Double Perovskite Nanocrystals
DOI: 10.1021/acs.jpclett.9b02168

Nuclear Quantum Effects in Hydrophobic Nanoconfinement
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b01835

A Machine Learning Approach for Prediction of Rate Constants
DOI: 10.1021/acs.jpclett.9b01810

Artificial Intelligence Approach To Investigate the Longevity Drug
DOI: 10.1021/acs.jpclett.9b02220


Journal of Proteome Research

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Identification of a Biomarker Panel for Early Detection of Lung Cancer Patients
DOI: 10.1021/acs.jproteome.9b00287

“Differential Visual Proteomics”: Enabling the Proteome-Wide Comparison of Protein Structures of Single-Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00447

Improved Protein Inference from Multiple Protease Bottom-Up Mass Spectrometry Data
DOI: 10.1021/acs.jproteome.9b00330

pClean: An Algorithm To Preprocess High-Resolution Tandem Mass Spectra for Database Searching
DOI: 10.1021/acs.jproteome.9b00141

Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia
DOI: 10.1021/acs.jproteome.9b00160


Molecular Pharmaceutics

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Cyclic Cell-Penetrating Peptides as Efficient Intracellular Drug Delivery Tools
DOI: 10.1021/acs.molpharmaceut.9b00633

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00535

A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation
DOI: 10.1021/acs.molpharmaceut.9b00529

Induction of Mitochondrial Cell Death and Reversal of Anticancer Drug Resistance via Nanocarriers Composed of a Triphenylphosphonium Derivative of Tocopheryl Polyethylene Glycol Succinate
DOI: 10.1021/acs.molpharmaceut.9b00177

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00585

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