Discover the Most-Read Organic/Inorganic Chemistry Articles of September 2019 - ACS Axial
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Discover the Most-Read Organic/Inorganic Chemistry Articles of September 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in September 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of September’s most-read articles.


ACS Catalysis

Catalytic Approaches to Monomers for Polymers Based on Renewables
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acscatal.9b01665

Opportunities and Challenges for Catalysis in Carbon Dioxide Utilization
DOI: 10.1021/acscatal.9b02113

CO2 Hydrogenation to Methanol over ZrO2-Containing Catalysts: Insights into ZrO2 Induced Synergy9
DOI: 10.1021/acscatal.9b01943

Iron-Catalyzed Borrowing Hydrogen β-C(sp3)-Methylation of Alcohols
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscatal.9b02461

Oxa- and Azabenzonorbornadienes as Electrophilic Partners under Photoredox/Nickel Dual Catalysis
DOI: 10.1021/acscatal.9b02458


ACS Combinatorial Science

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One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles
DOI: 10.1021/acscombsci.9b00120

Overview of Analytical-to-Preparative Liquid Chromatography Method Development
DOI: 10.1021/acscombsci.8b00187

Energy–Geometry Dependency of Molecular Structures: A Multistep Machine Learning Approach
DOI: 10.1021/acscombsci.9b00028

Parallel Solution Phase Synthesis and Preliminary Biological Activity of a 5′-Substituted Cytidine Analog Library
DOI: 10.1021/acscombsci.9b00072

A Tyrosinase Inhibitor from a Nitrogen-Enriched Chemically Engineered Extract
DOI: 10.1021/acscombsci.9b00064


ACS Medicinal Chemistry Letters

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PROTAC Degradation of IRAK4 for the Treatment of Neurodegenerative and Cardiovascular Diseases
DOI: 10.1021/acsmedchemlett.9b00385

Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C
DOI: 10.1021/acsmedchemlett.9b00258

Call for Papers: Special Issue in Honor of Dr. Maurizio Botta
DOI: 10.1021/acsmedchemlett.9b00392

Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00142

Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsmedchemlett.9b00276


Bioconjugate Chemistry

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A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide
DOI: 10.1021/acs.bioconjchem.9b00436

Nanoparticle Interactions with the Tumor Microenvironment
DOI: 10.1021/acs.bioconjchem.9b00448

Site-Specific Modification of Proteins through N-Terminal Azide Labeling and a Chelation-Assisted CuAAC Reaction
DOI: 10.1021/acs.bioconjchem.9b00515

Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine
DOI: 10.1021/acs.bioconjchem.9b00456

Efficient Small-Scale Conjugation of DNA to Primary Antibodies for Multiplexed Cellular Targeting
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00490


Inorganic Chemistry

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An Insider’s Tour to the Peer-Review Process at Inorganic Chemistry
DOI: 10.1021/acs.inorgchem.9b02503

Preface for the Forum on Paradigm Shifts in Magnetism: From Molecules to Materials
DOI: 10.1021/acs.inorgchem.9b02488

Catalytic Reduction of Nitriles by Polymethylhydrosiloxane Using a Phenalenyl-Based Iron(III) Complex
DOI: 10.1021/acs.inorgchem.9b01377

The 4-Electron Cleavage of a N═N Double Bond by a Trimetallic TiNi2 Complex
DOI: 10.1021/acs.inorgchem.9b01805

The Thiolate Trans Effect in Heme {FeNO}6 Complexes and Beyond: Insight into the Nature of the Push Effect
DOI: 10.1021/acs.inorgchem.9b00091


Journal of Medicinal Chemistry

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases
DOI: 10.1021/acs.jmedchem.9b00794

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity
DOI: 10.1021/acs.jmedchem.9b00723

Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma
DOI: 10.1021/acs.jmedchem.9b00555

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b00911

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
DOI: 10.1021/acs.jmedchem.9b00687


Journal of Natural Products

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Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
DOI: 10.1021/acs.jnatprod.9b00471

Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of Alangium salviifolium and Their Cytotoxicity
DOI: 10.1021/acs.jnatprod.9b00670

Cytotoxic Limonoids from the Twigs and Leaves of Toona ciliata
DOI: 10.1021/acs.jnatprod.8b00954

Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms
DOI: 10.1021/acs.jnatprod.9b00410

Natural Hydroxamate-Containing Siderophore Acremonpeptides A–D and an Aluminum Complex of Acremonpeptide D from the Marine-Derived Acremonium persicinum SCSIO 115
DOI: 10.1021/acs.jnatprod.9b00545


The Journal of Organic Chemistry

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Small-Scale Procedure for Acid-Catalyzed Ketal Formation
DOI: 10.1021/acs.joc.9b01541

Palladium-Catalyzed Decarbonylative Suzuki–Miyaura Coupling of Amides To Achieve Biaryls via C–N Bond Cleavage
DOI: 10.1021/acs.joc.9b01103

Organophotoredox-Catalyzed Intermolecular Oxa-[4+2] Cycloaddition Reactions
DOI: 10.1021/acs.joc.9b01156

Enantiospecific Entry to a Common Decalin Intermediate for the Syntheses of Highly Oxygenated Terpenoids
DOI: 10.1021/acs.joc.9b01937

Asymmetric Total Syntheses of Rhynchophylline and Isorhynchophylline
DOI: 10.1021/acs.joc.9b01977


Molecular Pharmaceutics

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Cyclic Cell-Penetrating Peptides as Efficient Intracellular Drug Delivery Tools
DOI: 10.1021/acs.molpharmaceut.9b00633

Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00535

A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation
DOI: 10.1021/acs.molpharmaceut.9b00529

Induction of Mitochondrial Cell Death and Reversal of Anticancer Drug Resistance via Nanocarriers Composed of a Triphenylphosphonium Derivative of Tocopheryl Polyethylene Glycol Succinate
DOI: 10.1021/acs.molpharmaceut.9b00177

Distribution of Small Molecular Weight Drugs into the Porcine Lens: Studies on Imaging Mass Spectrometry, Partition Coefficients, and Implications in Ocular Pharmacokinetics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00585


Organic Letters

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Iridium-Catalyzed Aza-Spirocyclization of Indole-Tethered Amides: An Interrupted Pictet–Spengler Reaction
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.9b02194

Contra-thermodynamic Olefin Isomerization by Chain-Walking Hydrofunctionalization and Formal Retro-hydrofunctionalization
DOI: 10.1021/acs.orglett.9b02695

Synthesis of Ynolates via Double Deprotonation of Nonbrominated Esters
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.9b02069

Visible-Light Photoredox-Catalyzed Decarboxylative Alkylation of Heteroarenes Using Carboxylic Acids with Hydrogen Release
DOI: 10.1021/acs.orglett.9b02539

Transition-Metal-Free Borylation of Alkyl Iodides via a Radical Mechanism
DOI: 10.1021/acs.orglett.9b01951


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00371

Process Research and Impurity Control Strategy for Obeticholic Acid, a Farnesoid X Receptor Agonist
DOI: 10.1021/acs.oprd.9b00252

Generation of Hydrogen Cyanide from the Reaction of Oxyma (Ethyl Cyano(hydroxyimino)acetate) and DIC (Diisopropylcarbodiimide)
DOI: 10.1021/acs.oprd.9b00344

Development and Optimization of Liquid Chromatography Analytical Methods by Using AQbD Principles: Overview and Recent Advances
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.oprd.9b00238

Development of a Robust Synthesis of Dactolisib on a Commercial Manufacturing Scale
DOI: 10.1021/acs.oprd.9b00221


Organometallics

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Organometallic Chemistry within Metal–Organic Frameworks
DOI: 10.1021/acs.organomet.9b00539

Identification of Reactive Intermediates Relevant to Dimethylgermylene Group Transfer Reactions of an Anthracene-Based Precursor
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.9b00410

Bis(dialkylphosphino)ferrocene-Ligated Nickel(II) Precatalysts for Suzuki–Miyaura Reactions of Aryl Carbonates
DOI: 10.1021/acs.organomet.9b00543

Nickel-Catalyzed C(sp2)–H Borylation of Arenes
DOI: 10.1021/acs.organomet.9b00364

Synthesis of Half-Titanocenes Containing Anionic N-Heterocyclic Carbenes That Contain a Weakly Coordinating Borate Moiety, Cp′TiX2(WCA-NHC), and Their Use as Catalysts for Ethylene (Co)polymerization
DOI: 10.1021/acs.organomet.8b00841

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