There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
Get free monthly updates on the most-read research in your field.
Read more of October’s most-read articles.
ACS Applied Bio Materials *** Stimulus-Responsive Biopolymeric Surface: Molecular Switches for Oil/Water Separation Aggregate Formation of BODIPY-Tethered Oligonucleotides That Led to Efficient Intracellular Penetration and Gene Regulation Rapid and Reversible Reaction-Based Ratiometric Fluorescent Probe for Imaging of Different Glutathione Levels in Living Cells Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors ACS Biomaterials Science & Engineering *** Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications Exosomes as Carriers for Antitumor Therapy How Functionalized Surfaces Can Inhibit Bacterial Adhesion and Viability Differentiation of Bioengineered Skeletal Muscle within a 3D Printed Perfusion Bioreactor Reduces Atrophic and Inflammatory Gene Expression Biodegradable Microneedle Patch Delivering Antigenic Peptide–Hyaluronate Conjugate for Cancer Immunotherapy ACS Catalysis *** Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis Catalysis of Organic Reactions through Halogen Bonding Nickel/Cobalt-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates Gold-Catalyzed C–H Functionalization with Aryl Germanes A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis ACS Chemical Biology *** Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway Extending the Detection Limit in Fragment Screening of Proteins Using Reverse Micelle Encapsulation Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking ACS Chemical Neuroscience *** NeuroChat with Professor Catherine Abbott Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer’s Disease Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging ACS Infectious Diseases *** Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206 Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits Sugar-Modified Analogs of Auranofin Are Potent Inhibitors of the Gastric Pathogen Helicobacter pylori ACS Medicinal Chemistry Letters *** PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates “AβTau”, Lobby or Religion? PROTAC Degradation of IRAK4 for the Treatment of Cancer Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing ACS Synthetic Biology *** Exploiting Day- and Night-Time Metabolism of Synechocystis sp. PCC 6803 for Fitness-Coupled Fumarate Production around the Clock An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics Mevalonate Pathway Promiscuity Enables Noncanonical Terpene Production HOLMESv2: A CRISPR-Cas12b-Assisted Platform for Nucleic Acid Detection and DNA Methylation Quantitation Modular Thermal Control of Protein Dimerization Biochemistry *** The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways Nuclear Magnetic Resonance Solution Structure and Functional Behavior of the Human Proton Channel Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis Interaction of the Full-Length Heme-Based CO Sensor Protein RcoM-2 with Ligands NosP Modulates Cyclic-di-GMP Signaling in Legionella pneumophila Bioconjugate Chemistry *** Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes Zwitterionic Modification of Nanomaterials for Improved Diagnosis of Cancer Cells Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention Biomacromolecules *** Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles Predicting Protein–Polymer Block Copolymer Self-Assembly from Protein Properties Extracellular Antifreeze Protein Significantly Enhances the Cryopreservation of Cell Monolayers Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide Journal of Agricultural and Food Chemistry *** Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract Melanoidins from Coffee, Cocoa, and Bread Are Able to Scavenge α-Dicarbonyl Compounds under Simulated Physiological Conditions Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of myo-Inositol Phosphate Esters in Various Feed Materials Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors New Acylated Phenolic Glycosides with ROS-Scavenging Activity from Psidium guajava Leaves Journal of Chemical Theory and Computation *** Pitfalls of the Martini Model Self-Consistent Density-Functional Embedding: A Novel Approach for Density-Functional Approximations Insights into Membrane Protein–Lipid Interactions from Free Energy Calculations A Linear-Scaling Method for Noncovalent Interactions: An Efficient Combination of Absolutely Localized Molecular Orbitals and a Local Random Phase Approximation Approach Accuracy of Spin-Component-Scaled CC2 Excitation Energies and Potential Energy Surfaces Journal of Medicinal Chemistry *** Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases Antibiotic Adjuvants: Make Antibiotics Great Again! Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases Journal of Natural Products *** Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114 Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2 Anti-Lymphangiogenic Alkaloids from the Zoanthid Zoanthus vietnamensis Collected in Taiwan Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon Tripterfordins A–O, Dihydro-β-agarofuran Sesquiterpenoids from the Leaves of Tripterygium wilfordii The Journal of Physical Chemistry B *** Proteins: “Boil ’Em, Mash ’Em, Stick ’Em in a Stew” Physical Chemistry of Epigenetics: Single-Molecule Investigations Insights into Proton-Transfer Pathways during Water Oxidation in Photosystem II Electrolytes Change the Interfacial Water Structure but Not the Vibrational Dynamics The Widom Line and the Lennard-Jones Potential The Journal of Physical Chemistry Letters *** The Causes of Degradation of Perovskite Solar Cells Two Dimensions Are Better for Perovskites Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes Journey of Making Cesium Lead Halide Perovskite Nanocrystals: What’s Next Outstanding Challenges of Zero-Dimensional Perovskite Materials Journal of Proteome Research *** Common Repository of FBS Proteins (cRFP) To Be Added to a Search Database for Mass Spectrometric Analysis of Cell Secretome Current Understanding of Human Metaproteome Association and Modulation Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis One Thousand and One Software for Proteomics: Tales of the Toolmakers of Science Extremely Fast and Accurate Open Modification Spectral Library Searching of High-Resolution Mass Spectra Using Feature Hashing and Graphics Processing Units Molecular Pharmaceutics *** Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods Recent Advances in Understanding the Micro- and Nanoscale Phenomena of Amorphous Solid Dispersions Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design
DOI: 10.1021/acsabm.9b00531
DOI: 10.1021/acsabm.9b00631
DOI: 10.1021/acsabm.9b00642
DOI: 10.1021/acsabm.9b00622
DOI: 10.1021/acsabm.9b00501
DOI: 10.1021/acsbiomaterials.9b00464
DOI: 10.1021/acsbiomaterials.9b00417
DOI: 10.1021/acsbiomaterials.9b00849
DOI: 10.1021/acsbiomaterials.9b00975
DOI: 10.1021/acsbiomaterials.9b00961
DOI: 10.1021/acscatal.9b03084
DOI: 10.1021/acscatal.9b02894
DOI: 10.1021/acscatal.9b03352
DOI: 10.1021/acscatal.9b02841
DOI: 10.1021/acscatal.9b03190
DOI: 10.1021/acschembio.9b00525
DOI: 10.1021/acschembio.9b00537
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00560
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00640
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00427
DOI: 10.1021/acschemneuro.9b00511
DOI: 10.1021/acschemneuro.9b00297
DOI: 10.1021/acschemneuro.9b00287
DOI: 10.1021/acschemneuro.9b00430
DOI: 10.1021/acschemneuro.9b00481
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.9b00128
DOI: 10.1021/acsinfecdis.9b00249
DOI: 10.1021/acsinfecdis.9b00217
DOI: 10.1021/acsinfecdis.9b00256
DOI: 10.1021/acsinfecdis.9b00251
DOI: 10.1021/acsmedchemlett.9b00397
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00301
DOI: 10.1021/acsmedchemlett.9b00439
DOI: 10.1021/acsmedchemlett.9b00423
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00310
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00289
DOI: 10.1021/acssynbio.9b00175
DOI: 10.1021/acssynbio.9b00230
DOI: 10.1021/acssynbio.9b00209
DOI: 10.1021/acssynbio.9b00275
DOI: 10.1021/acs.biochem.9b00735
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.biochem.9b00471
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biochem.9b00592
DOI: 10.1021/acs.biochem.9b00623
DOI: 10.1021/acs.biochem.9b00618
DOI: 10.1021/acs.bioconjchem.9b00306
DOI: 10.1021/acs.bioconjchem.9b00639
DOI: 10.1021/acs.bioconjchem.9b00582
DOI: 10.1021/acs.bioconjchem.9b00543
DOI: 10.1021/acs.bioconjchem.9b00587
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00701
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00768
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00951
DOI: 10.1021/acs.biomac.9b01024
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00512
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jafc.9b04435
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03744
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03919
DOI: 10.1021/acs.jafc.9b04009
DOI: 10.1021/acs.jafc.9b04318
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00473
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00063
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00548
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00615
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00676
DOI: 10.1021/acs.jmedchem.9b01234
DOI: 10.1021/acs.jmedchem.9b01612
DOI: 10.1021/acs.jmedchem.8b01781
DOI: 10.1021/acs.jmedchem.9b00444
DOI: 10.1021/acs.jmedchem.9b00533
DOI: 10.1021/acs.jnatprod.8b01056
DOI: 10.1021/acs.jnatprod.9b00212
DOI: 10.1021/acs.jnatprod.9b00451
DOI: 10.1021/acs.jnatprod.9b00522
DOI: 10.1021/acs.jnatprod.9b00089
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b05467
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b06214
DOI: 10.1021/acs.jpcb.9b06244
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b08131
DOI: 10.1021/acs.jpcb.9b05426
DOI: 10.1021/acs.jpclett.9b00613
DOI: 10.1021/acs.jpclett.9b01568
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b02531
DOI: 10.1021/acs.jpclett.9b02412
DOI: 10.1021/acs.jpclett.9b00175
DOI: 10.1021/acs.jproteome.9b00475
DOI: 10.1021/acs.jproteome.9b00301
DOI: 10.1021/acs.jproteome.9b00254
DOI: 10.1021/acs.jproteome.9b00219
DOI: 10.1021/acs.jproteome.9b00291
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00703
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00406
DOI: 10.1021/acs.molpharmaceut.9b00601
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00730
DOI: 10.1021/acs.molpharmaceut.9b00634
Add a Comment