Discover the Most-Read Biological Chemistry Articles of November 2019 - ACS Axial | ACS Publications
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Discover the Most-Read Biological Chemistry Articles of November 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in November 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of November’s most-read articles.


ACS Applied Bio Materials
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Doxorubicin–Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo/Chemodynamic Therapy in Vitro
DOI: 10.1021/acsabm.9b00879

Cucurbit[7]uril-Anchored Porphyrin-Based Multifunctional Molecular Platform for Photodynamic Antimicrobial and Cancer Therapy
DOI: 10.1021/acsabm.9b00763

Stabilization of Fibronectin by Random Copolymer Brushes Inhibits Macrophage Activation
DOI: 10.1021/acsabm.9b00815

NIR-Triggered Theranostic Bi2S3 Light Transducer for On-Demand NO Release and Synergistic Gas/Photothermal Combination Therapy of Tumors
DOI: 10.1021/acsabm.9b00522

Engineering Human-Scale Artificial Bone Grafts for Treating Critical-Size Bone Defects
DOI: 10.1021/acsabm.9b00756


ACS Biomaterials Science & Engineering

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Interfacial Diffusion Printing: An Efficient Manufacturing Technique for Artificial Tubular Grafts
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsbiomaterials.9b01293

Metal–Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction
DOI: 10.1021/acsbiomaterials.9b01200

Modular Assembly of Biomaterials Using Polyphenols as Building Blocks
DOI: 10.1021/acsbiomaterials.8b01507

Submicron Patterns-on-a-Chip: Fabrication of a Microfluidic Device Incorporating 3D Printed Surface Ornaments
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.9b01155

3,4-Dihydroxyphenylalanine (DOPA)-Containing Silk Fibroin: Its Enzymatic Synthesis and Adhesion Properties
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.8b01309


ACS Catalysis

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Operando Insights into Nanoparticle Transformations during Catalysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscatal.9b01831

Recent Insights into the Oxygen-Reduction Electrocatalysis of Fe/N/C Materials
DOI: 10.1021/acscatal.9b02583

Copper Single Atoms Anchored in Porous Nitrogen-Doped Carbon as Efficient pH-Universal Catalysts for the Nitrogen Reduction Reaction
DOI: 10.1021/acscatal.9b02944

Site-Selective C–H Acylation of Pyridinium Derivatives by Photoredox Catalysis
DOI: 10.1021/acscatal.9b03367

Recent Advances and Prospective in Ruthenium-Based Materials for Electrochemical Water Splitting
DOI: 10.1021/acscatal.9b02457


ACS Chemical Biology

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Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications
DOI: 10.1021/acschembio.8b01083

Chemical Modulation of Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics
DOI: 10.1021/acschembio.9b00347

DPP9’s Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation
This article is part of the Proteolytic Regulation of Cellular Physiology special issue.
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00462

Chemical Tools and Biochemical Assays for SUMO Specific Proteases (SENPs)
This article is part of the Proteolytic Regulation of Cellular Physiology special issue.
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00402

Selective and Rapid Cell-Permeable Inhibitor of Human Caspase-3
DOI: 10.1021/acschembio.9b00564


ACS Chemical Neuroscience

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In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer’s Disease
DOI: 10.1021/acschemneuro.9b00331

NeuroChat with Professor David Olson
DOI: 10.1021/acschemneuro.9b00513

Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer
DOI: 10.1021/acschemneuro.9b00438

NeuroChat with Professor Corey R. Hopkins
DOI: 10.1021/acschemneuro.9b00526

Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acschemneuro.9b00390


ACS Infectious Diseases

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Ureadepsipeptides as ClpP Activators
DOI: 10.1021/acsinfecdis.9b00245

Antagonistic Interaction of Staphylococcus aureus and Staphylococcus epidermidis with Rhizopus arrhizus Mediated by Phenol Soluble Modulins and Organic Acids
DOI: 10.1021/acsinfecdis.9b00205

A Novel Capsid Binding Inhibitor Displays Potent Antiviral Activity against Enterovirus D68
DOI: 10.1021/acsinfecdis.9b00284

Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov–Doebner Reactions
DOI: 10.1021/acsinfecdis.9b00022

Conformational Dynamics of AcrA Govern Multidrug Efflux Pump Assembly
DOI: 10.1021/acsinfecdis.9b00273


ACS Medicinal Chemistry Letters

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DOI: 10.1021/acsmedchemlett.9b00381

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
DOI: 10.1021/acsmedchemlett.9b00141

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis
DOI: 10.1021/acsmedchemlett.9b00377

Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation
DOI: 10.1021/acsmedchemlett.9b00409

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy
DOI: 10.1021/acsmedchemlett.9b00344


ACS Synthetic Biology

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CReasPy-Cloning: A Method for Simultaneous Cloning and Engineering of Megabase-Sized Genomes in Yeast Using the CRISPR-Cas9 System
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00224

Model-Assisted Fine-Tuning of Central Carbon Metabolism in Yeast through dCas9-Based Regulation
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssynbio.9b00258

A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells
DOI: 10.1021/acssynbio.9b00322

Exploring Chemical Biosynthetic Design Space with Transform-MinER
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00105

Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens
DOI: 10.1021/acssynbio.9b00352


Biochemistry

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Rebooting the Epigenome: Erasure of Parental Histone Marks for Establishing the Regulatory Landscape in Zygotes
DOI: 10.1021/acs.biochem.9b00815

Development of an Efficient Enzyme Production and Structure-Based Discovery Platform for BACE1 Inhibitors
DOI: 10.1021/acs.biochem.9b00714

Discovery of Amidotemplated Natural Product Assembly
DOI: 10.1021/acs.biochem.9b00928

Catalytic M Center of Copper Monooxygenases Probed by Rational Design. Effects of Selenomethionine and Histidine Substitution on Structure and Reactivity
DOI: 10.1021/acs.biochem.9b00823

Drivers of α-Sheet Formation in Transthyretin under Amyloidogenic Conditions
DOI: 10.1021/acs.biochem.9b00769


Bioconjugate Chemistry

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Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00588

Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy
DOI: 10.1021/acs.bioconjchem.9b00564

Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates
DOI: 10.1021/acs.bioconjchem.9b00713

Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody–Drug Conjugates
DOI: 10.1021/acs.bioconjchem.9b00609

Fast and Efficient Fc-Specific Photoaffinity Labeling To Produce Antibody–DNA Conjugates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00548


Biomacromolecules

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Interaction Pathways and Structure–Chemical Transformations of Alginate Gels in Physiological Environments
DOI: 10.1021/acs.biomac.9b01052

Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b01341

Antimicrobial Peptide-Conjugated Hierarchical Antifouling Polymer Brushes for Functionalized Catheter Surfaces
DOI: 10.1021/acs.biomac.9b01060

Electrospinning Nanofibers from Chitosan/Hyaluronic Acid Complex Coacervates
DOI: 10.1021/acs.biomac.9b01072

Synthetic 3D PEG-Anisogel Tailored with Fibronectin Fragments Induce Aligned Nerve Extension
DOI: 10.1021/acs.biomac.9b00891


Journal of Agricultural and Food Chemistry

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Reclaiming Phosphate from Waste Solutions with Fe(III)–Polysaccharide Hydrogel Beads for Photo-Controlled-Release Fertilizer
DOI: 10.1021/acs.jafc.9b02860

Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure
DOI: 10.1021/acs.jafc.9b03652

Discovery of Novel Isothiazole, 1,2,3-Thiadiazole, and Thiazole-Based Cinnamamides as Fungicidal Candidates
DOI: 10.1021/acs.jafc.9b03891

Metabolomics for Biomarker Discovery in Fermented Black Garlic and Potential Bioprotective Responses against Cardiovascular Diseases
DOI: 10.1021/acs.jafc.9b04073

Application of a Plant Biostimulant To Improve Maize (Zea mays) Tolerance to Metolachlor
DOI: 10.1021/acs.jafc.9b04949


Journal of Chemical Theory and Computation

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OpenMolcas: From Source Code to Insight
DOI: 10.1021/acs.jctc.9b00532

HFLD: A Nonempirical London Dispersion-Corrected Hartree–Fock Method for the Quantification and Analysis of Noncovalent Interaction Energies of Large Molecular Systems
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00425

String Method for Protein–Protein Binding Free-Energy Calculations
DOI: 10.1021/acs.jctc.9b00499

Less Is More: Coarse-Grained Integrative Modeling of Large Biomolecular Assemblies with HADDOCK
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00310

MemSurfer: A Tool for Robust Computation and Characterization of Curved Membranes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00453


Journal of Medicinal Chemistry

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How Significant Are Unusual Protein–Ligand Interactions? Insights from Database Mining
DOI: 10.1021/acs.jmedchem.9b01545

Overview of Recent Strategic Advances in Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00359

Halogens in Protein–Ligand Binding Mechanism: A Structural Perspective
DOI: 10.1021/acs.jmedchem.8b01453

The Blood–Brain Barrier (BBB) Score
DOI: 10.1021/acs.jmedchem.9b01220

Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
DOI: 10.1021/acs.jmedchem.9b00846


Journal of Natural Products

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Ealamines A–H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jnatprod.9b00755

Terpenoids from the Stems of Fissistigma polyanthoides and Their Anti-Inflammatory Activity
DOI: 10.1021/acs.jnatprod.9b00208

Total Synthesis of Clavatadine B
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.9b00813

Anti-inflammatory and α-Glucosidase Inhibitory Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes of Amomum villosum
DOI: 10.1021/acs.jnatprod.9b00283

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches
DOI: 10.1021/acs.jnatprod.8b00380


The Journal of Physical Chemistry B

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Energy Transport across Interfaces in Biomolecular Systems
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b07086

Halogen Bonding beyond Crystals in Materials Science
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b07035

Solubility of Caffeine in Supercritical CO2: A Molecular Dynamics Simulation Study
DOI: 10.1021/acs.jpcb.9b08351

Hydrogen Abstraction of Ketoprofen in the Excited Triplet State with Indole and Methylindoles
DOI: 10.1021/acs.jpcb.9b06786

Interaction and Dynamics in a Fully Biodegradable Glucose-Containing Naturally Abundant Deep Eutectic Solvent: Temperature-Dependent Time-Resolved Fluorescence Measurements
DOI: 10.1021/acs.jpcb.9b06783


The Journal of Physical Chemistry Letters

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DOI: 10.1021/acsmedchemlett.9b00381

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
DOI: 10.1021/acsmedchemlett.9b00141

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis
DOI: 10.1021/acsmedchemlett.9b00377

Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation
DOI: 10.1021/acsmedchemlett.9b00409

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy
DOI: 10.1021/acsmedchemlett.9b00344


Journal of Proteome Research

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MHCquant: Automated and Reproducible Data Analysis for Immunopeptidomics
DOI: 10.1021/acs.jproteome.9b00313

Proteome Integral Solubility Alteration: A High-Throughput Proteomics Assay for Target Deconvolution
DOI: 10.1021/acs.jproteome.9b00500

Evaluating False Transfer Rates from the Match-between-Runs Algorithm with a Two-Proteome Model
DOI: 10.1021/acs.jproteome.9b00492

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol
DOI: 10.1021/acs.jproteome.9b00481

Vegetative Cell and Spore Proteomes of Clostridioides difficile Show Finite Differences and Reveal Potential Protein Markers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00413


Molecular Pharmaceutics

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A Human Immortalized Cell-Based Blood–Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug−Brain Permeability Studies
DOI: 10.1021/acs.molpharmaceut.9b00519

Brivanib Exhibits Potential for Pharmacokinetic Drug–Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes
DOI: 10.1021/acs.molpharmaceut.9b00361

Molecular Engineering of Adeno-Associated Virus Capsid Improves Its Therapeutic Gene Transfer in Murine Models of Hemophilia and Retinal Degeneration
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00959

Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides
DOI: 10.1021/acs.molpharmaceut.9b00695

Deep Convolutional Generative Adversarial Network (dcGAN) Models for Screening and Design of Small Molecules Targeting Cannabinoid Receptors
DOI: 10.1021/acs.molpharmaceut.9b00500


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