Discover the Most-Read Organic/Inorganic Chemistry Articles of November 2019 - ACS Axial | ACS Publications
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Discover the Most-Read Organic/Inorganic Chemistry Articles of November 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in November 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of November’s most-read articles.


ACS Catalysis

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Operando Insights into Nanoparticle Transformations during Catalysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscatal.9b01831

Recent Insights into the Oxygen-Reduction Electrocatalysis of Fe/N/C Materials
DOI: 10.1021/acscatal.9b02583

Copper Single Atoms Anchored in Porous Nitrogen-Doped Carbon as Efficient pH-Universal Catalysts for the Nitrogen Reduction Reaction
DOI: 10.1021/acscatal.9b02944

Site-Selective C–H Acylation of Pyridinium Derivatives by Photoredox Catalysis
DOI: 10.1021/acscatal.9b03367

Recent Advances and Prospective in Ruthenium-Based Materials for Electrochemical Water Splitting
DOI: 10.1021/acscatal.9b02457


ACS Combinatorial Science

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Calculating Resin Functionalization in Solid-Phase Peptide Synthesis Using a Standardized Method based on Fmoc Determination
DOI: 10.1021/acscombsci.9b00154

Cleaning Matters!
DOI: 10.1021/acscombsci.9b00122

Metric Learning for High-Throughput Combinatorial Data Sets
DOI: 10.1021/acscombsci.9b00086

Profiling Protein Tyrosine Phosphatase Specificity with Self-Assembled Monolayers for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry and Peptide Arrays
DOI: 10.1021/acscombsci.9b00152

Alloyed Thermoelectric PbTe–SnTe Films Formed via Aerosol Deposition
DOI: 10.1021/acscombsci.9b00145


ACS Medicinal Chemistry Letters

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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
DOI: 10.1021/acsmedchemlett.9b00381

Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
DOI: 10.1021/acsmedchemlett.9b00141

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis
DOI: 10.1021/acsmedchemlett.9b00377

Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation
DOI: 10.1021/acsmedchemlett.9b00409

Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy
DOI: 10.1021/acsmedchemlett.9b00344


Bioconjugate Chemistry

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Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00588

Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy
DOI: 10.1021/acs.bioconjchem.9b00564

Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates
DOI: 10.1021/acs.bioconjchem.9b00713

Site-Specific Lysine Arylation as an Alternative Bioconjugation Strategy for Chemically Programmed Antibodies and Antibody–Drug Conjugates
DOI: 10.1021/acs.bioconjchem.9b00609

Fast and Efficient Fc-Specific Photoaffinity Labeling To Produce Antibody–DNA Conjugates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00548


Inorganic Chemistry

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Supramolecular Anchoring of Octahedral Molybdenum Clusters onto Graphene and Their Synergies in Photocatalytic Water Reduction
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.9b02529

Viewpoint: Atomic-Scale Design Protocols toward Energy, Electronic, Catalysis, and Sensing Applications
DOI: 10.1021/acs.inorgchem.9b01785

Terbium Triangle Bridged by a Triazole Nitronyl Nitroxide Radical with Single-Molecule-Magnet Behavior
DOI: 10.1021/acs.inorgchem.9b01647

Electronic Structure of Tetracyanonickelate(II)
DOI: 10.1021/acs.inorgchem.9b02135

Redox Tuning via Ligand-Induced Geometric Distortions at a YMn3O4 Cubane Model of the Biological Oxygen Evolving Complex
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.9b00510


Journal of Medicinal Chemistry

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How Significant Are Unusual Protein–Ligand Interactions? Insights from Database Mining
DOI: 10.1021/acs.jmedchem.9b01545

Overview of Recent Strategic Advances in Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b00359

Halogens in Protein–Ligand Binding Mechanism: A Structural Perspective
DOI: 10.1021/acs.jmedchem.8b01453

The Blood–Brain Barrier (BBB) Score
DOI: 10.1021/acs.jmedchem.9b01220

Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
DOI: 10.1021/acs.jmedchem.9b00846


Journal of Natural Products

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Ealamines A–H, a Series of Naphthylisoquinolines with the Rare 7,8′-Coupling Site, from the Congolese Liana Ancistrocladus ealaensis, Targeting Pancreatic Cancer Cells
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jnatprod.9b00755

Terpenoids from the Stems of Fissistigma polyanthoides and Their Anti-Inflammatory Activity
DOI: 10.1021/acs.jnatprod.9b00208

Total Synthesis of Clavatadine B
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.9b00813

Anti-inflammatory and α-Glucosidase Inhibitory Activities of Labdane and Norlabdane Diterpenoids from the Rhizomes of Amomum villosum
DOI: 10.1021/acs.jnatprod.9b00283

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches
DOI: 10.1021/acs.jnatprod.8b00380


The Journal of Organic Chemistry

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Recent Advances in Titanium Radical Redox Catalysis
DOI: 10.1021/acs.joc.9b02465

Technical Synthesis of 1,5,9-Cyclododecatriene Revisited: Surprising Byproducts from a Venerable Industrial Process
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.9b01633

Asymmetric Total Synthesis of (+)-Winchinine B
DOI: 10.1021/acs.joc.9b02462

Total Synthesis of (−)-Phomoarcherin C
DOI: 10.1021/acs.joc.9b02206

Direct Amidation of Carboxylic Acids with Nitroarenes
DOI: 10.1021/acs.joc.9b02068


Molecular Pharmaceutics

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A Human Immortalized Cell-Based Blood–Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug−Brain Permeability Studies
DOI: 10.1021/acs.molpharmaceut.9b00519

Brivanib Exhibits Potential for Pharmacokinetic Drug–Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes
DOI: 10.1021/acs.molpharmaceut.9b00361

Molecular Engineering of Adeno-Associated Virus Capsid Improves Its Therapeutic Gene Transfer in Murine Models of Hemophilia and Retinal Degeneration
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00959

Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides
DOI: 10.1021/acs.molpharmaceut.9b00695

Deep Convolutional Generative Adversarial Network (dcGAN) Models for Screening and Design of Small Molecules Targeting Cannabinoid Receptors
DOI: 10.1021/acs.molpharmaceut.9b00500


Organic Letters

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Letters from India: A Personal Perspective from the Subcontinent
DOI: 10.1021/acs.orglett.9b03837

Alkaline-Metal-Catalyzed One-Pot Aminobenzylation of Aldehydes with Toluenes
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.9b02737

N-Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3-Alkylindoles with o-Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines
DOI: 10.1021/acs.orglett.9b03011

Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination
DOI: 10.1021/acs.orglett.9b03356

Synthesis of (+)-Tacamonine via Stereoselective Radical Cyclization
DOI: 10.1021/acs.orglett.9b03308


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00465

Green Chemistry Articles of Interest to the Pharmaceutical Industry
DOI: 10.1021/acs.oprd.9b00450

Mutagenic Impurities in 1-Hydroxybenzotriazole (HOBt)
DOI: 10.1021/acs.oprd.9b00376

Scalable, Economical, and Practical Synthesis of 4-(Difluoromethyl)pyridin-2-amine, a Key Intermediate for Lipid Kinase Inhibitors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.oprd.9b00312

A Scalable Process for the Synthesis of 1,2-Dialkyldiselanes and 1-Alkaneselenols
DOI: 10.1021/acs.oprd.9b00380


Organometallics

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An Information-Rich Graphical Representation of Catalytic Cycles
DOI: 10.1021/acs.organomet.9b00563

Masked Radicals: Iron Complexes of Trityl, Benzophenone, and Phenylacetylene
DOI: 10.1021/acs.organomet.9b00534

Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.9b00327

Structure and Dynamics of Iron Pentacarbonyl
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.9b00559

Cooperative CO2 Scission by Anomalous Insertion into a Rh–Si Bond
DOI: 10.1021/acs.organomet.9b00556


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