Call for Papers: 9th HUPO Human Proteome Project (HPP) Special Issue - ACS Axial
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Call for Papers: 9th HUPO Human Proteome Project (HPP) Special Issue

The Journal of Proteome Research is preparing to publish its ninth annual special issue dedicated to highlighting the progress made on the HUPO Human Proteome Project (HPP). Since 2013, this series of special issues has documented incredibly important discoveries in the field through more than 250 articles that have collectively received more than 5,000 citations.

The editorial team organizing this year’s addition to the series invites you to submit a manuscript for consideration by June 30, 2021.

HPP Special Issue Editorial Team

Journal of Proteome Research Associate Editor Christopher M. Overall of The University of British Columbia will work on this year’s special issue with a team of guest editors:

  • Young-Ki Paik, Yonsei University
  • Eric Deutsch, Institute for Systems Biology
  • Fernando Corrales, CSIC, Madrid
  • Lydie Lane, Swiss Institute of Bioinformatics
  • Gilbert S. Omenn, University of Michigan
  • Robert Moritz, Institute for Systems Biology

Thematic Priorities

For this special issue, the editorial team will consider research papers encompassing both the Chromosome-Centric Human Proteome Project (C-HPP) and the Biology and Disease Human Proteome Project (B/D-HPP), as well from the HPP Resource Pillars (Antibody, MS, Pathology, and Knowledgebase), and short definitive reports, submitted in the Letters format, on the discovery of a missing protein(s).

Since 2013, this series of special issues has documented incredibly important discoveries in the field through more than 250 articles that have collectively received more than 5,000 citations.

To be considered, the missing protein(s) must meet the HPP Data Interpretation Guidelines Version 3.0 and be cast in the context of the HPP and biological setting in which they were discovered.

The editorial team is particularly interested in receiving manuscripts that relate to one of these themes:

  • Completing the high-resolution draft of the human proteome with new strategies and results leading to confident identifications of neXtProt missing proteins (PE2 – 4) according to the C-HPP Guidelines v 3.0 or recent updates
  • Progress on the protein list of individual chromosomes and groups of chromosomes, annotating known proteins and their isoforms/proteoforms and/or credibly identifying missing proteins (PE2 – 4)
  • Annotating proteins and their isoforms/proteoforms and/or identifying missing proteins found in rare or under explored cells and tissues, and protein lists of human cell types as a step in creating a human cell proteome atlas
  • Produce and use “popular proteins” lists in B/D-HPP and contribute to the identification of missing proteins
  • Proteomic studies of proteoforms produced by proteolytic processing, PTMs, alternative splicing (ASV),
    coding non‐synonymous single nucleotide polymorphisms (cSNPs), or chromosome abnormalities
  • Use of targeted proteomics, especially SRM and MS‐SWATH, to extend chromosome‐based protein findings
  • New bioinformatic tools and approaches for annotating the human proteome
  • Biological mechanistic analyses inspired from proteomics data in diseases or biological processes
  • Biomarker discoveries based on the identification of novel ASVs, PTMs or cSNPs in proteomic studies
  • Studies using the Human Protein Atlas to identify missing proteins

Manuscript Requirements & Submission Deadline

Manuscripts must be submitted electronically through the ACS Paragon Plus Environment online submission system by June 30, 2021, to be considered for inclusion in this ninth special issue on the HUPO HPP.

Manuscripts that don’t meet these requirements will be returned without review:

HPP Special Issue Review and Publication Process

Editorial triage will determine whether manuscripts are appropriate for the HPP Special Issue and meet all of the above requirements. Nonconforming papers will be returned unreviewed. All relevant papers will go through full peer review.

As papers are accepted they will be published online and available in time for HUPO-2021. Due to the publication schedule, only papers accepted by September 31, 2021, will be published in the December 2021 HPP Special Issue. Papers requiring more time for revision or falling outside of the scope of the special issue will be published in regular issues of the journal.

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