Professor David Julius at the University of California, San Francisco and Professor Ardem Patapoutian, at Scripps Research in California won the 2021 Nobel Prize in Physiology or Medicine “for their discoveries of receptors for temperature and touch,” both of which are essential to our ability to navigate, understand, and interact with the world.
The pair will receive equal shares of the $1.1 million prize for their work exploring the molecular basis for our bodies’ ability to sense temperature and pressure. Their work on the ion channels that react to heat, cold, and mechanical force has also opened up research opportunities in a number of clinical areas, including treating pain, cancer, and asthma.
Professor Patapoutian has published the following articles in ACS Publications journals. In recognition of his win, these articles will be made free-to-read for 30 days, starting Oct. 4, 2021.
Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists
J. Med. Chem. 2014, 57, 12, 5129–5140
A FAAH-Regulated Class of N-Acyl Taurines That Activates TRP Ion Channels
Biochemistry 2006, 45, 30, 9007–9015