2021 in Biochemistry Perspectives - ACS Axial | ACS Publications
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2021 in Biochemistry Perspectives

Biochemistry Perspectives are designed to communicate a focused review of the most exciting new developments in a field or area and with an eye toward guiding future research.

Explore the Perspectives published in Biochemistry over the past year:

Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics
Tanya R. McKitrickTanya R. McKitrick, Deniz Eris, Nandini Mondal, Rajindra P. Aryal, Nathanael McCurley, Jamie Heimburg-Molinaro, and Richard D. Cummings
DOI: 10.1021/acs.biochem.9b01015
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Tafenoquine: A Step toward Malaria Elimination
Kuan-Yi Lu and Emily R. Derbyshire
DOI: 10.1021/acs.biochem.9b01105
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The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy
Patrick Lomonte, Faouzi Baklouti, and Olivier Binda
DOI: 10.1021/acs.biochem.9b01124
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mRNA Therapies: New Hope in the Fight against Melanoma
Melissa van Dülmen and Andrea Rentmeister
DOI: 10.1021/acs.biochem.0c00181
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Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes
Margarita Vázquez-González, Zhixin Zhou, Yonatan Biniuri, Bilha Willner, and Itamar Willner
DOI: 10.1021/acs.biochem.0c00421
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Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials
Heloise Ribeiro de Barros, Fernando López-Gallego*, and Luis M. Liz-Marzán
DOI: 10.1021/acs.biochem.0c00447
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Hepatocellular Carcinoma and Statins
Ghazal Alipour Talesh, Véronique Trézéguet*, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00476
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Specificity Distorted: Chemical Induction of Biological Paracatalysis
Brian P. Callahan, Daniel A. Ciulla, Andrew G. Wagner, Zihan Xu, and Xiaoyu Zhang
DOI: 10.1021/acs.biochem.0c00643
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Targeting Lipid Metabolism in Liver Cancer
Malak Alannan, Hussein Fayyad-Kazan, Véronique Trézéguet, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00477
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Illuminating the Path to Target GPCR Structures and Functions
Christian D.-T. Nielsen, Divya Dhasmana, Giuseppe Floresta, Thorsten Wohland, and Agostino Cilibrizzi
DOI: 10.1021/acs.biochem.0c00606
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The Origin of Lipid Rafts
Steven L. Regen
DOI: 10.1021/acs.biochem.0c00851
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Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
Kingshuk Dutta, Ritam Das, Jewel Medeiros, and S. Thayumanavan
DOI: 10.1021/acs.biochem.0c00860
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Early Strides in NMR Dynamics Measurements
Jane Dyson
DOI: 10.1021/acs.biochem.1c00141
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Buffers, Especially the Good Kind
Gary J. Pielak
DOI: 10.1021/acs.biochem.1c00200
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Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery
John A. Gerlt
DOI: 10.1021/acs.biochem.1c00211
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Long-Acting Cabotegravir for HIV/AIDS Prophylaxis
Kathleen D. Engelman and Alan N. Engelman
DOI: 10.1021/acs.biochem.1c00157
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Live and Let Dye
Luke D. Lavis
DOI: 10.1021/acs.biochem.1c00299
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Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?
Michael A. Marletta
DOI: 10.1021/acs.biochem.1c00276
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Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair
Adela Nano, Joanne Dai, Julie M. Bailis, and Jacqueline K. Barton
DOI: 10.1021/acs.biochem.1c00302
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Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin
Riley B. Peacock and Elizabeth A. Komives
DOI: 10.1021/acs.biochem.1c00277
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Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case
Jiří Zahradník and Gideon Schreiber
DOI: 10.1021/acs.biochem.1c00356
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Genetic Code Expansion: A Brief History and Perspective
Mia A. Shandell, Zhongping Tan, and Virginia W. Cornish
DOI: 10.1021/acs.biochem.1c00286
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Origins of Ca2+ Imaging with Fluorescent Indicators
Xinqi Zhou, Kayla J. Belavek, and Evan W. Miller
DOI: 10.1021/acs.biochem.1c00350
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Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery
Robert A. Copeland
DOI: 10.1021/acs.biochem.1c00345
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Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes
Edward I. Solomon, Dory E. DeWeese, and Jeffrey T. Babicz Jr.
DOI: 10.1021/acs.biochem.1c00370
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Correlated Motions in Structural Biology
Da Xu, Steve P. Meisburger, and Nozomi Ando
DOI: 10.1021/acs.biochem.1c00420
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Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
Zhe Feng, Bowen Jia, and Mingjie Zhang
DOI: 10.1021/acs.biochem.1c00376
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Inducible Protein Degradation to Understand Genome Architecture
Alexi Tallan and Benjamin Z. Stanton
DOI: 10.1021/acs.biochem.1c00306
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Functional Roles of Chelated Magnesium Ions in RNA Folding and Function
Ryota Yamagami, Jacob P. Sieg, and Philip C. Bevilacqua
DOI: 10.1021/acs.biochem.1c00012
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Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics
Robin Lorenz, Jian Wu, Friedrich W. Herberg, Susan S. Taylor, and Richard A. Engh
DOI: 10.1021/acs.biochem.1c00359
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Phase Separation in Cell Polarity
Heyang Wei and Wenyu Wen
DOI: 10.1021/acs.biochem.1c00372
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Global Mapping of Metalloproteomes
Xin Zeng, Yao Cheng, and Chu Wang
DOI: 10.1021/acs.biochem.1c00404
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Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists
Edward L. Stahl and Laura M. Bohn
DOI: 10.1021/acs.biochem.1c00466
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Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Bridget P. Belcher, Carl C. Ward, and Daniel K. Nomura
DOI: 10.1021/acs.biochem.1c00464
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Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway
Katelyn Cassidy and Heng Zhao
DOI: 10.1021/acs.biochem.1c00330
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The Birth of Genomic Enzymology: Discovery of the Mechanistically Diverse Enolase Superfamily
Karen N. Allen and Christian P. Whitman
DOI: 10.1021/acs.biochem.1c00494
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Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport
Janae B. Brown, Mark A. Lee, and Aaron T. Smith
DOI: 10.1021/acs.biochem.1c00586
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The Moderately (D)efficient Enzyme: Catalysis-Related Damage In Vivo and Its Repair
Ulschan Bathe, Bryan J. Leong, Donald R. McCarty, Christopher S. Henry, Paul E. Abraham, Mark A. Wilson, and Andrew D. Hanson
DOI: 10.1021/acs.biochem.1c00613
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Bacterial Responses to Iron Withholding by Calprotectin
Adunoluwa O. Obisesan, Emily M. Zygiel, and Elizabeth M. Nolan
DOI: 10.1021/acs.biochem.1c00572
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Reframing the Protein Folding Problem: Entropy as Organizer
George D. Rose
DOI: 10.1021/acs.biochem.1c00687
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Toward Elucidating the Human Gut Microbiota–Brain Axis: Molecules, Biochemistry, and Implications for Health and Diseases
Yunjia Lai, Radhika Dhingra, Zhenfa Zhang, Louise M. Ball, Mark J. Zylka, and Kun Lu
DOI: 10.1021/acs.biochem.1c00656
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Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products
Marina Toplak and Robin Teufel
DOI: 10.1021/acs.biochem.1c00763
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Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
Xiaohui Zhao, Xinglin Yang, and Howard C. Hang
DOI: 10.1021/acs.biochem.1c00758
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Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
Truc Do and A. James Link
DOI: 10.1021/acs.biochem.1c00714
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Biochemistry Perspectives are usually submitted by invitation, but suggestions to the Biochemistry editors of both topics and authors are welcome. Make a suggestion:
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