Biochemistry Perspectives are designed to communicate a focused review of the most exciting new developments in a field or area and with an eye toward guiding future research. Explore the Perspectives published in Biochemistry over the past year: Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics Tanya R. […]
Explore the Perspectives published in Biochemistry over the past year:
Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics
Tanya R. McKitrickTanya R. McKitrick, Deniz Eris, Nandini Mondal, Rajindra P. Aryal, Nathanael McCurley, Jamie Heimburg-Molinaro, and Richard D. Cummings
DOI: 10.1021/acs.biochem.9b01015
***
Tafenoquine: A Step toward Malaria Elimination
Kuan-Yi Lu and Emily R. Derbyshire
DOI: 10.1021/acs.biochem.9b01105
***
The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy
Patrick Lomonte, Faouzi Baklouti, and Olivier Binda
DOI: 10.1021/acs.biochem.9b01124
***
mRNA Therapies: New Hope in the Fight against Melanoma
Melissa van Dülmen and Andrea Rentmeister
DOI: 10.1021/acs.biochem.0c00181
***
Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes
Margarita Vázquez-González, Zhixin Zhou, Yonatan Biniuri, Bilha Willner, and Itamar Willner
DOI: 10.1021/acs.biochem.0c00421
***
Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials
Heloise Ribeiro de Barros, Fernando López-Gallego*, and Luis M. Liz-Marzán
DOI: 10.1021/acs.biochem.0c00447
***
Hepatocellular Carcinoma and Statins
Ghazal Alipour Talesh, Véronique Trézéguet*, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00476
***
Specificity Distorted: Chemical Induction of Biological Paracatalysis
Brian P. Callahan, Daniel A. Ciulla, Andrew G. Wagner, Zihan Xu, and Xiaoyu Zhang
DOI: 10.1021/acs.biochem.0c00643
***
Targeting Lipid Metabolism in Liver Cancer
Malak Alannan, Hussein Fayyad-Kazan, Véronique Trézéguet, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00477
***
Illuminating the Path to Target GPCR Structures and Functions
Christian D.-T. Nielsen, Divya Dhasmana, Giuseppe Floresta, Thorsten Wohland, and Agostino Cilibrizzi
DOI: 10.1021/acs.biochem.0c00606
***
The Origin of Lipid Rafts
Steven L. Regen
DOI: 10.1021/acs.biochem.0c00851
***
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
Kingshuk Dutta, Ritam Das, Jewel Medeiros, and S. Thayumanavan
DOI: 10.1021/acs.biochem.0c00860
***
Early Strides in NMR Dynamics Measurements
Jane Dyson
DOI: 10.1021/acs.biochem.1c00141
***
Buffers, Especially the Good Kind
Gary J. Pielak
DOI: 10.1021/acs.biochem.1c00200
***
Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery
John A. Gerlt
DOI: 10.1021/acs.biochem.1c00211
***
Long-Acting Cabotegravir for HIV/AIDS Prophylaxis
Kathleen D. Engelman and Alan N. Engelman
DOI: 10.1021/acs.biochem.1c00157
***
Live and Let Dye
Luke D. Lavis
DOI: 10.1021/acs.biochem.1c00299
***
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?
Michael A. Marletta
DOI: 10.1021/acs.biochem.1c00276
***
Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair
Adela Nano, Joanne Dai, Julie M. Bailis, and Jacqueline K. Barton
DOI: 10.1021/acs.biochem.1c00302
***
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin
Riley B. Peacock and Elizabeth A. Komives
DOI: 10.1021/acs.biochem.1c00277
***
Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case
Jiří Zahradník and Gideon Schreiber
DOI: 10.1021/acs.biochem.1c00356
***
Genetic Code Expansion: A Brief History and Perspective
Mia A. Shandell, Zhongping Tan, and Virginia W. Cornish
DOI: 10.1021/acs.biochem.1c00286
***
Origins of Ca2+ Imaging with Fluorescent Indicators
Xinqi Zhou, Kayla J. Belavek, and Evan W. Miller
DOI: 10.1021/acs.biochem.1c00350
***
Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery
Robert A. Copeland
DOI: 10.1021/acs.biochem.1c00345
***
Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes
Edward I. Solomon, Dory E. DeWeese, and Jeffrey T. Babicz Jr.
DOI: 10.1021/acs.biochem.1c00370
***
Correlated Motions in Structural Biology
Da Xu, Steve P. Meisburger, and Nozomi Ando
DOI: 10.1021/acs.biochem.1c00420
***
Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
Zhe Feng, Bowen Jia, and Mingjie Zhang
DOI: 10.1021/acs.biochem.1c00376
***
Inducible Protein Degradation to Understand Genome Architecture
Alexi Tallan and Benjamin Z. Stanton
DOI: 10.1021/acs.biochem.1c00306
***
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function
Ryota Yamagami, Jacob P. Sieg, and Philip C. Bevilacqua
DOI: 10.1021/acs.biochem.1c00012
***
Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics
Robin Lorenz, Jian Wu, Friedrich W. Herberg, Susan S. Taylor, and Richard A. Engh
DOI: 10.1021/acs.biochem.1c00359
***
Phase Separation in Cell Polarity
Heyang Wei and Wenyu Wen
DOI: 10.1021/acs.biochem.1c00372
***
Global Mapping of Metalloproteomes
Xin Zeng, Yao Cheng, and Chu Wang
DOI: 10.1021/acs.biochem.1c00404
***
Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists
Edward L. Stahl and Laura M. Bohn
DOI: 10.1021/acs.biochem.1c00466
***
Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Bridget P. Belcher, Carl C. Ward, and Daniel K. Nomura
DOI: 10.1021/acs.biochem.1c00464
***
Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway
Katelyn Cassidy and Heng Zhao
DOI: 10.1021/acs.biochem.1c00330
***
The Birth of Genomic Enzymology: Discovery of the Mechanistically Diverse Enolase Superfamily
Karen N. Allen and Christian P. Whitman
DOI: 10.1021/acs.biochem.1c00494
***
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport
Janae B. Brown, Mark A. Lee, and Aaron T. Smith
DOI: 10.1021/acs.biochem.1c00586
***
The Moderately (D)efficient Enzyme: Catalysis-Related Damage In Vivo and Its Repair
Ulschan Bathe, Bryan J. Leong, Donald R. McCarty, Christopher S. Henry, Paul E. Abraham, Mark A. Wilson, and Andrew D. Hanson
DOI: 10.1021/acs.biochem.1c00613
***
Bacterial Responses to Iron Withholding by Calprotectin
Adunoluwa O. Obisesan, Emily M. Zygiel, and Elizabeth M. Nolan
DOI: 10.1021/acs.biochem.1c00572
***
Reframing the Protein Folding Problem: Entropy as Organizer
George D. Rose
DOI: 10.1021/acs.biochem.1c00687
***
Toward Elucidating the Human Gut Microbiota–Brain Axis: Molecules, Biochemistry, and Implications for Health and Diseases
Yunjia Lai, Radhika Dhingra, Zhenfa Zhang, Louise M. Ball, Mark J. Zylka, and Kun Lu
DOI: 10.1021/acs.biochem.1c00656
***
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products
Marina Toplak and Robin Teufel
DOI: 10.1021/acs.biochem.1c00763
***
Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
Xiaohui Zhao, Xinglin Yang, and Howard C. Hang
DOI: 10.1021/acs.biochem.1c00758
***
Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
Truc Do and A. James Link
DOI: 10.1021/acs.biochem.1c00714
***
Biochemistry Perspectives are usually submitted by invitation, but suggestions to the Biochemistry editors of both topics and authors are welcome. Make a suggestion:
***
