This Special Issue will showcase cutting-edge advances in the rapidly evolving field of targeted protein degradation. Submit your manuscript by April 30, 2027.
Bioconjugate Chemistry invites submissions to our upcoming Special Issue on “Targeted Protein and Nucleic Acid Degradation: From Molecular Design to Therapeutic Translation,” highlighting advances at the intersection of chemical biology, medicinal chemistry, bioconjugation, and therapeutic development.
Targeted protein and nucleic acid degradation has emerged as a transformative strategy for modulating biological systems and treating disease. Approaches such as PROTACs, molecular glues, lysosome-targeting chimeras (LYTACs), autophagy-targeting chimeras (AUTACs), Ribonuclease-Targeting Chimeras (RIBOTACs), Proximity-Induced Nucleic Acid Degrader (PINAD), and related technologies are redefining how researchers address challenging biological targets. Bioconjugate chemistry is playing an increasingly important role in enabling these modalities through the design of novel conjugation strategies, targeted delivery systems, biomolecular engineering, and mechanistic investigations.
This Special Issue seeks original Research Articles, Communications, Reviews, and Viewpoints that advance our understanding of targeted protein degradation and the technologies that enable it.
Topics include, but are not limited to:
- PROTACs, molecular glues, and induced-proximity therapeutics
- Emerging targeted protein degradation modalities
- Antibody-, peptide-, oligonucleotide-, and protein-based degraders
- RIBOTACs, PINAD, and related technologies
- Bioconjugation approaches for degrader design and delivery
- Novel ligands, linkers, and conjugation chemistries
- AI-guided degrader design
- Imaging and tracking of degradation pathways
- Mechanistic and chemical biology studies of protein degradation
- Translational and therapeutic applications of protein degraders
We look forward to receiving your contributions and highlighting the innovative science that is shaping the future of targeted protein degradation.
Organizing Editors
Daniel J. Blair, Guest Editor
St. Jude Children’s Research Hospital, United States
Mariko Morimoto, Guest Editor
University of Notre Dame, United States
Quanyin Hu, Early Career Board Member, Bioconjugate Chemistry
University of Wisconsin-Madison, United States
Xiaohu Gao, Associate Editor, Bioconjugate Chemistry
University of Washington, United States
Theresa Reineke, Editor-in-Chief, Bioconjugate Chemistry
University of Minnesota, United States
Submission Information
We welcome submissions for this Special Issue through April 30, 2027. For more information on submission requirements, please visit the journal’s Author Guidelines page.
Accepted manuscripts for consideration in this Special Issue will include Research Articles, Communications, Reviews, and Viewpoints. Papers accepted for publication in this Special Issue will be available ASAP (as soon as publishable) online. After all submissions have been published, they will then be compiled online on a dedicated landing page to form the Special Issue. Manuscripts submitted for consideration will undergo the full rigorous peer-review process expected from ACS journals.
Open Access: There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.
How to Submit
- Log in to the ACS Publishing Center.
- Select your manuscript type; upload your manuscript and related files.
- Review the title and abstract fields to ensure any pre-populated information has uploaded correctly.
- Under “Special Issue Selection,” select Targeted Protein and Nucleic Acid Degradation: From Molecular Design to Therapeutic Translation.
- Confirm all other information has uploaded correctly.
- Submit your article.
If you have any general questions regarding submission to this Special Issue, please contact eic@bioconj.acs.org.
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