These 23 ACS journal articles from researchers at St. Jude highlight how chemistry-enabled approaches are shaping discovery across disease biology, drug development, and analytical technologies.
Chemistry is deeply embedded in modern healthcare research. Researchers across oncology, immunology, pharmacology, biomedical engineering, and related disciplines may not always think of themselves as chemists. Still, their work often relies on chemistry insights that shape experimental approaches, bridge scientific disciplines, and enable new discoveries.
This interdisciplinary nature of healthcare research is reflected in the broad range of discoveries published across ACS journals, which span fields within and beyond traditional chemistry disciplines.
In this post, we highlight 23 recent publications by researchers at St. Jude Children’s Research Hospital across a wide range of biomedical research areas. These articles showcase the contribution from the biomedical research community and demonstrate how chemistry-enabled insights continue to advance disease understanding, therapeutic development, diagnostics, and more.
We hope you find this curated collection insightful and inspiring as you pursue your own research.
Oncology & Therapeutic Development
- HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel Scaffolds
- Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs
- Direct-to-Biology Enabled Molecular Glue Discovery
- NanoBRET Tracer Development for Class I Bromodomain Target Engagement in Live Cells
- Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding
- NMR2-Based Drug Discovery Pipeline Presented on the Oncogenic Protein KRAS
Infectious Disease & Vaccine Research
- Pathogen-Specific PET Imaging of Pulmonary Infection Using [18F]Fluoromannitol
- Detecting Bacteria in Their Mammalian Hosts Using Metabolism-Targeted [13C]CO2 Breath Testing
- Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria
- Protonated Phenanthroline Catalyzed Stereoselective Glycosylation: Synthesis and Evaluation of Saponin Adjuvant Lablaboside F and Variants Leading to Simplified Vaccine Adjuvants
- Isoleucine Binding and Regulation of Escherichia coli and Staphylococcus aureus Threonine Dehydratase (IlvA)
Diagnostics, Imaging & Analytical Technologies
- Production of 14 Clinical Carbon-11 Radiopharmaceuticals for Neuroimaging Using a GE FASTLab 2 Cassette-Based Synthesis Module
- Fast Proton NMR Detection of Aqueous Ammonia with Relaxation Agent and Nitrogen Decoupling
- Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass Spectrometry
Chemical Biology & Molecular Mechanisms
- Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation
- Comprehensive and Site-Specific Characterization of Protein N-Glycosylation in AD Samples Reveals Its Potential Roles in Protein Aggregation and Synaptic Dysfunction
- Probing Submillisecond-to-Millisecond Time Scale Conformational Dynamics in High-Molecular-Weight Biomolecules via 15N Clean TROSY-CEST
- Chemical Control of Genes: Synthetic Genome Readers and Gene Regulators
- α-Synuclein Early-Oligomers Regulate Self-Assembly through Nucleation and Liquid–Liquid Phase Separation
Pharmacology & Drug Metabolism
Research Methods & Enabling Technologies
- rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data
- Recent Advances and Applications of NMR Techniques in Plastic Characterizations
- Energy Resolved Mass Spectrometry Data from Surface-Induced Dissociation Improves Prediction of Protein Complex Structure
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