This Virtual Special Issue will showcase the latest disruptive advances in the realm of molecular diagnostics, with a particular focus on developing decentralized diagnostic solutions. Submit your manuscript by January 31, 2025.

A blue background with a dna and a blood sample.

Effective diagnostics play a pivotal role not only in disease detection, as witnessed during the recent COVID-19 pandemic, and therapy monitoring but also in fields such as water quality assessment, agriculture, environmental health, and many others, thereby contributing to the sustainability of our planet.

A new Virtual Special Issue from ACS Synthetic Biology will focus on this topic, showcasing the latest disruptive advances in the realm of molecular diagnostics. We are particularly interested in exploring novel design principles for sensors and reporters, harnessing molecular machineries, and utilizing biomaterials to develop decentralized diagnostic solutions.

Relevant topics include:

  • Design, building, and testing of novel molecular reagents (such as CRISPR/Cas technology) for biosensing applications.
  • Improved genetic circuit design principles for sensitive and specific diagnostics.
  • Multiplexed detection of viruses, or virus variants, as well as other infectious pathogens using synthetic biology.
  • Disruptive technologies for signal amplification to enhance assay sensitivity.
  • Mass-scale production of biorecognition elements, enzymes, and other reagents for on-site diagnostics.
  • Sensing applications for diverse biomarkers and drugs, including nucleic acids (circulating species) and non-nucleic-acid markers such as proteins, antibiotics, and other environmental contaminants.
The deadline for submissions is January 31, 2025.

Organizing Editors

Magdy Mahfouz, Associate Editor, ACS Synthetic Biology
King Abdullah University of Science and Technology, Saudi Arabia

Alexander Green, Guest Editor
Boston University, United States

Cameron Myhrvold, Guest Editor
Princeton University, United States

Can Dincer, Guest Editor
University of Freiburg, Germany

Author Instructions

To learn more about how to submit your manuscript, visit the ACS Synthetic Biology website. When you are ready to submit, please follow the normal procedures for manuscript submission:

  • Log in to the ACS Paragon Plus submission site.
  • Choose ACS Synthetic Biology.
  • Select your manuscript type, and, under "Special Issue Selection," choose "Diagnostics."

All manuscripts will undergo the normal peer review process. For additional submission instructions, please see the ACS Synthetic Biology Author Guidelines.

The deadline for submissions is January 31, 2025.

Open Access

There are diverse open-access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

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