Discover the Most-Read Biological Chemistry Articles of Jan. 2017

What were chemists reading in January of 2017? To find out, we’ve compiled lists of the five most-read biological chemistry articles that appeared in each a chemistry ACS Publications journal in January 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Analytical Chemistry | Applied Chemistry| Materials Science & Engineering | Multidisciplinary Journals| Organic/Inorganic Chemistry | Physical Chemistry |

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Poly(ethylene glycol)-Based Coatings Combining Low-Biofouling and Quorum-Sensing Inhibiting Properties to Reduce Bacterial Colonization
Open Access Through ACS Editors’ ChoiceMost Read Articles
ACS Biomater. Sci. Eng., 2017, 3 (1), pp 78–87
DOI: 10.1021/acsbiomaterials.6b00579

Theranostic Nanoparticles for MRI-Guided Thermochemotherapy: “Tight” Clustering of Magnetic Nanoparticles Boosts Relaxivity and Heat-Generation Power
Open Access Through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (1), pp 95–105
DOI: 10.1021/acsbiomaterials.6b00536

Continued Growth in 2017
ACS Biomater. Sci. Eng., 2017, 3 (1), pp 1–1
DOI: 10.1021/acsbiomaterials.6b00797

Biocompatibility Pathways: Biomaterials-Induced Sterile Inflammation, Mechanotransduction, and Principles of Biocompatibility Control
ACS Biomater. Sci. Eng., 2017, 3 (1), pp 2–35
DOI: 10.1021/acsbiomaterials.6b00607

Membrane Fusion-Mediated Gold Nanoplating of Red Blood Cell: A Bioengineered CT-Contrast Agent
ACS Biomater. Sci. Eng., 2017, 3 (1), pp 36–41
DOI: 10.1021/acsbiomaterials.6b00573

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ACS Catalysis

Catalysis by Supported Single Metal Atoms
ACS Catal., 2017, 7 (1), pp 34–59
DOI: 10.1021/acscatal.6b01534

Predicting a Breakthrough Year for ACS Catalysis
ACS Catal., 2017, 7 (1), pp 919–919
DOI: 10.1021/acscatal.6b03629

Photoelectrocatalytic Water Splitting: Significance of Cocatalysts, Electrolyte, and Interfaces
ACS Catal., 2017, 7 (1), pp 675–688
DOI: 10.1021/acscatal.6b03107

Electrochemical Ammonia Synthesis—The Selectivity Challenge
ACS Catal., 2017, 7 (1), pp 706–709
DOI: 10.1021/acscatal.6b03035

Recent Advances in Transition-Metal-Catalyzed Synthetic Transformations of Organosilicon Reagents
ACS Catal., 2017, 7 (1), pp 631–651
DOI: 10.1021/acscatal.6b02374

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ACS Chemical Biology

Live Cell Imaging of Endogenous mRNA Using RNA-Based Fluorescence “Turn-On” Probe
ACS Chem. Biol., 2017, 12 (1), pp 200–205
DOI: 10.1021/acschembio.6b00586

What Can We Learn from Bioactivity Data? Chemoinformatics Tools and Applications in Chemical Biology Research
ACS Chem. Biol., 2017, 12 (1), pp 23–35
DOI: 10.1021/acschembio.6b00706

Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase
ACS Chem. Biol., 2017, 12 (1), pp 83–91
DOI: 10.1021/acschembio.6b00788

SIRT7 Is an RNA-Activated Protein Lysine Deacylase
ACS Chem. Biol., 2017, 12 (1), pp 300–310
DOI: 10.1021/acschembio.6b00954

Introducing Our Authors
ACS Chem. Biol., 2017, 12 (1), pp 1–5
DOI: 10.1021/acschembio.7b00014

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ACS Chemical Neuroscience

The “Century of Biology” and the Evolving Role of Medicinal Chemists in Neuroscience
ACS Chem. Neurosci., 2017, 8 (1), pp 8–11
DOI: 10.1021/acschemneuro.6b00394

Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies
ACS Chem. Neurosci., 2017, 8 (1), pp 5–7
DOI: 10.1021/acschemneuro.6b00384

Editors’ Favorites of 2016
ACS Chem. Neurosci., 2017, 8 (1), pp 1–3
DOI: 10.1021/acschemneuro.6b00461

Technically Extended MultiParameter Optimization (TEMPO): An Advanced Robust Scoring Scheme To Calculate Central Nervous System Druggability and Monitor Lead Optimization
Open Access Through ACS AuthorChoice
ACS Chem. Neurosci., 2017, 8 (1), pp 147–154
DOI: 10.1021/acschemneuro.6b00273

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation
ACS Chem. Neurosci., 2017, 8 (1), pp 89–99
DOI: 10.1021/acschemneuro.6b00250

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Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Open Access Through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (1), pp 34–44
DOI: 10.1021/acsinfecdis.6b00078

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis
Open Access Through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (1), pp 5–17
DOI: 10.1021/acsinfecdis.6b00102

The Bare Essentials of Antibiotic Target Validation
ACS Infect. Dis., 2017, 3 (1), pp 2–4
DOI: 10.1021/acsinfecdis.6b00185

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump
ACS Infect. Dis., 2017, 3 (1), pp 89–98
DOI: 10.1021/acsinfecdis.6b00167

Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis
ACS Infect. Dis., 2017, 3 (1), pp 18–33
DOI: 10.1021/acsinfecdis.6b00103

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Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More
ACS Med. Chem. Lett., 2017, 8 (1), pp 19–21
DOI: 10.1021/acsmedchemlett.6b00515

Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules
ACS Med. Chem. Lett., 2017, 8 (1), pp 124–127
DOI: 10.1021/acsmedchemlett.6b00451

ACS Medicinal Chemistry Letters: Technology Notes
ACS Med. Chem. Lett., 2017, 8 (1), pp 1–2
DOI: 10.1021/acsmedchemlett.6b00484

Viral Replication Inhibitors May Treat the Dengue Virus Infections
ACS Med. Chem. Lett., 2017, 8 (1), pp 14–16
DOI: 10.1021/acsmedchemlett.6b00513

Potential Treatment of Cognitive Impairment in Schizophrenia by Phosphodiesterase 2 (PDE2) Inhibitors
ACS Med. Chem. Lett., 2017, 8 (1), pp 17–18
DOI: 10.1021/acsmedchemlett.6b00514

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In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis

Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae
ACS Synth. Biol., 2017, 6 (1), pp 159–166
DOI: 10.1021/acssynbio.6b00202

Evolving Orthogonal Suppressor tRNAs To Incorporate Modified Amino Acids
ACS Synth. Biol., 2017, 6 (1), pp 108–119
DOI: 10.1021/acssynbio.6b00145

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (1), pp 3–5
DOI: 10.1021/acssynbio.6b00398

Improving Metabolic Pathway Efficiency by Statistical Model-Based Multivariate Regulatory Metabolic Engineering
ACS Synth. Biol., 2017, 6 (1), pp 148–158
DOI: 10.1021/acssynbio.6b00187

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Biochemistry

It Is Chemistry but Not Your Grandfather’s Chemistry
Biochemistry, 2017, 56 (1), pp 1–2
DOI: 10.1021/acs.biochem.6b01262

The Biology of Free Guanidine As Revealed by Riboswitches
Biochemistry, 2017, 56 (2), pp 345–347
DOI: 10.1021/acs.biochem.6b01269

Structural Roles of Noncoding RNAs in the Heart of Enzymatic Complexes
Biochemistry, 2017, 56 (1), pp 3–13
DOI: 10.1021/acs.biochem.6b01106

Structure and Function of AApeptides
Biochemistry, 2017, 56 (3), pp 445–457
DOI: 10.1021/acs.biochem.6b01132

β-Lactone Synthetase Found in the Olefin Biosynthesis Pathway
Biochemistry, 2017, 56 (2), pp 348–351
DOI: 10.1021/acs.biochem.6b01199

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Bioconjugate Chemistry

New Advances in Nanotechnology-Based Diagnosis and Therapeutics for Breast Cancer: An Assessment of Active-Targeting Inorganic Nanoplatforms
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 135–152
DOI: 10.1021/acs.bioconjchem.6b00591

Interfacing Inorganic Nanoparticles with Biology
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 1–2
DOI: 10.1021/acs.bioconjchem.6b00727

Characterizing Self-Assembled Monolayers on Gold Nanoparticles
Open Access Through ACS AuthorChoice
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 11–22
DOI: 10.1021/acs.bioconjchem.6b00587

Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 23–32
DOI: 10.1021/acs.bioconjchem.6b00569

Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
Open Access Through ACS Editors’ Choice

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Biomacromolecules

Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers
Open Access Through ACS Editors’ Choice
Biomacromolecules, 2017, 18 (1), pp 127–140
DOI: 10.1021/acs.biomac.6b01413

Injectable and 3D Bioprinted Polysaccharide Hydrogels: From Cartilage to Osteochondral Tissue Engineering
Biomacromolecules, 2017, 18 (1), pp 1–26
DOI: 10.1021/acs.biomac.6b01619

Poly(ethylene glycol) Crowding as Critical Factor To Determine pDNA Packaging Scheme into Polyplex Micelles for Enhanced Gene Expression
Open Access Through ACS Editors’ Choice
Biomacromolecules, 2017, 18 (1), pp 36–43
DOI: 10.1021/acs.biomac.6b01247

Injectable, Guest–Host Assembled Polyethylenimine Hydrogel for siRNA Delivery
Biomacromolecules, 2017, 18 (1), pp 77–86
DOI: 10.1021/acs.biomac.6b01378

Versatile Synthesis of Amino Acid Functional Polymers without Protection Group Chemistry
Biomacromolecules, 2017, 18 (1), pp 272–280
DOI: 10.1021/acs.biomac.6b01618

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Insights into the Key Compounds of Durian (Durio zibethinus L. ‘Monthong’) Pulp Odor by Odorant Quantitation and Aroma Simulation Experiments
J. Agric. Food Chem., 2017, 65 (3), pp 639–647
DOI: 10.1021/acs.jafc.6b05299

Harnessing Insect–Microbe Chemical Communications To Control Insect Pests of Agricultural Systems
Open Access Through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (1), pp 23–28
DOI: 10.1021/acs.jafc.6b04298

JAFC—Most Trusted Partner in a Global Transition of Agriculture–Food–Nutrition Research!
J. Agric. Food Chem., 2017, 65 (1), pp 1–3
DOI: 10.1021/acs.jafc.6b05545

Per- and Polyfluoroalkyl Substances (PFASs) in Food and Human Dietary Intake: A Review of the Recent Scientific Literature
J. Agric. Food Chem., 2017, 65 (3), pp 533–543
DOI: 10.1021/acs.jafc.6b04683

1,8-Cineole in French Red Wines: Evidence for a Contribution Related to Its Various Origins
J. Agric. Food Chem., 2017, 65 (2), pp 383–393
DOI: 10.1021/acs.jafc.6b03042

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Journal of Chemical Theory and Computation

Different Ways of Hydrogen Bonding in Water – Why Does Warm Water Freeze Faster than Cold Water?
J. Chem. Theory Comput., 2017, 13 (1), pp 55–76
DOI: 10.1021/acs.jctc.6b00735

A Reflection on Klaus Schulten
J. Chem. Theory Comput., 2017, 13 (1), pp 1–2
DOI: 10.1021/acs.jctc.6b01111

Gaussian Accelerated Molecular Dynamics in NAMD
J. Chem. Theory Comput., 2017, 13 (1), pp 9–19
DOI: 10.1021/acs.jctc.6b00931

Rapid, Accurate, Precise, and Reliable Relative Free Energy Prediction Using Ensemble Based Thermodynamic Integration
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (1), pp 210–222
DOI: 10.1021/acs.jctc.6b00979

Accurate Modeling of Scaffold Hopping Transformations in Drug Discovery
J. Chem. Theory Comput., 2017, 13 (1), pp 42–54
DOI: 10.1021/acs.jctc.6b00991

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Journal of Medicinal Chemistry

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (1), pp 157–169
DOI: 10.1021/acs.jmedchem.6b00923

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
J. Med. Chem., 2017, 60 (2), pp 797–804
DOI: 10.1021/acs.jmedchem.6b01691

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
J. Med. Chem., 2017, 60 (2), pp 767–786
DOI: 10.1021/acs.jmedchem.6b01634

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 2017, 60 (2), pp 608–626
DOI: 10.1021/acs.jmedchem.6b01007

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Journal of Natural Products

α-Glucosidase Inhibitors from Malbranchea flavorosea
J. Nat. Prod., 2017, 80 (1), pp 190–195
DOI: 10.1021/acs.jnatprod.6b00977

Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum
J. Nat. Prod., 2017, 80 (1), pp 134–140
DOI: 10.1021/acs.jnatprod.6b00758

Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa
J. Nat. Prod., 2017, 80 (1), pp 169–180
DOI: 10.1021/acs.jnatprod.6b00809

Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure–Activity Relationships
J. Nat. Prod., 2017, 80 (1), pp 96–107
DOI: 10.1021/acs.jnatprod.6b00744

Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts
J. Nat. Prod., 2017, 80 (1), pp 126–133
DOI: 10.1021/acs.jnatprod.6b00773

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The Journal of Physical Chemistry B

Mechanism of Unfolding of Human Prion Protein
J. Phys. Chem. B, 2017, 121 (3), pp 550–564
DOI: 10.1021/acs.jpcb.6b11416

The Grateful Infrared: Sequential Protein Structural Changes Resolved by Infrared Difference Spectroscopy
J. Phys. Chem. B, 2017, 121 (2), pp 335–350
DOI: 10.1021/acs.jpcb.6b09222

Modeling of Transient Absorption Spectra in Exciton–Charge-Transfer Systems
J. Phys. Chem. B, 2017, 121 (3), pp 463–470
DOI: 10.1021/acs.jpcb.6b09858

Interactions in Water–Ionic Liquid Mixtures: Comparing Protic and Aprotic Systems
J. Phys. Chem. B, 2017, 121 (3), pp 599–609
DOI: 10.1021/acs.jpcb.6b10562

Modeling Carbon Dioxide Vibrational Frequencies in Ionic Liquids: I. Ab Initio Calculations
J. Phys. Chem. B, 2017, 121 (1), pp 208–220
DOI: 10.1021/acs.jpcb.6b09489

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High Defect Tolerance in Lead Halide Perovskite CsPbBr3
J. Phys. Chem. Lett., 2017, 8 (2), pp 489–493
DOI: 10.1021/acs.jpclett.6b02800

HLE16: A Local Kohn–Sham Gradient Approximation with Good Performance for Semiconductor Band Gaps and Molecular Excitation Energies
J. Phys. Chem. Lett., 2017, 8 (2), pp 380–387
DOI: 10.1021/acs.jpclett.6b02757

Construction of Compact Methylammonium Bismuth Iodide Film Promoting Lead-Free Inverted Planar Heterojunction Organohalide Solar Cells with Open-Circuit Voltage over 0.8 V
J. Phys. Chem. Lett., 2017, 8 (2), pp 394–400
DOI: 10.1021/acs.jpclett.6b02578

Excitation Energy Transfer by Coherent and Incoherent Mechanisms in the Peridinin–Chlorophyll a Protein
J. Phys. Chem. Lett., 2017, 8 (2), pp 463–469
DOI: 10.1021/acs.jpclett.6b02881

Developments of Metal Phosphides as Efficient OER Precatalysts
J. Phys. Chem. Lett., 2017, 8 (1), pp 144–152
DOI: 10.1021/acs.jpclett.6b02249

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Journal of Proteome Research

The Immune System and the Proteome
This article is part of the The Immune System and the Proteome 2016 special issue.
J. Proteome Res., 2017, 16 (1), pp 1–1
DOI: 10.1021/acs.jproteome.6b00607

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling
This article is part of the The Immune System and the Proteome 2016 special issue.
J. Proteome Res., 2017, 16 (1), pp 14–33
DOI: 10.1021/acs.jproteome.6b00728

Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages
This article is part of the The Immune System and the Proteome 2016 special issue.
J. Proteome Res., 2017, 16 (1), pp 170–178
DOI: 10.1021/acs.jproteome.6b00599

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-
ATPase Catalytic Subunit A in Neuronal Cells

In Memoriam: Thomas Edward Fehniger
J. Proteome Res., 2017, 16 (1), pp 2–2
DOI: 10.1021/acs.jproteome.6b00964

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Molecular Pharmaceutics

Improving Therapeutic Potential of Farnesylthiosalicylic Acid: Tumor Specific Delivery via Conjugation with Heptamethine Cyanine Dye
Mol. Pharmaceutics, 2017, 14 (1), pp 1–13
DOI: 10.1021/acs.molpharmaceut.5b00906

Improved Micellar Formulation for Enhanced Delivery for Paclitaxel
Mol. Pharmaceutics, 2017, 14 (1), pp 31–41
DOI: 10.1021/acs.molpharmaceut.6b00581

Targeted Biomimetic Nanoparticles for Synergistic Combination Chemotherapy of Paclitaxel and Doxorubicin
Mol. Pharmaceutics, 2017, 14 (1), pp 107–123
DOI: 10.1021/acs.molpharmaceut.6b00732

NIR Light-Activated Drug Release for Synergetic Chemo–Photothermal Therapy
Mol. Pharmaceutics, 2017, 14 (1), pp 242–251
DOI: 10.1021/acs.molpharmaceut.6b00820

Long-Term Physical Stability of PVP- and PVPVA-Amorphous Solid Dispersions
Mol. Pharmaceutics, 2017, 14 (1), pp 157–171
DOI: 10.1021/acs.molpharmaceut.6b00763