There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in December 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of December’s most-read articles.

ACS Applied Bio Materials


Stimulus-Responsive Biopolymeric Surface: Molecular Switches for Oil/Water Separation
DOI: 10.1021/acsabm.9b00531

Aggregate Formation of BODIPY-Tethered Oligonucleotides That Led to Efficient Intracellular Penetration and Gene Regulation
DOI: 10.1021/acsabm.9b00631

Rapid and Reversible Reaction-Based Ratiometric Fluorescent Probe for Imaging of Different Glutathione Levels in Living Cells
DOI: 10.1021/acsabm.9b00642

Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification
DOI: 10.1021/acsabm.9b00622

Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors
DOI: 10.1021/acsabm.9b00501

ACS Biomaterials Science & Engineering


Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications
DOI: 10.1021/acsbiomaterials.9b00464

Exosomes as Carriers for Antitumor Therapy
DOI: 10.1021/acsbiomaterials.9b00417

How Functionalized Surfaces Can Inhibit Bacterial Adhesion and Viability
DOI: 10.1021/acsbiomaterials.9b00849

Differentiation of Bioengineered Skeletal Muscle within a 3D Printed Perfusion Bioreactor Reduces Atrophic and Inflammatory Gene Expression
DOI: 10.1021/acsbiomaterials.9b00975

Biodegradable Microneedle Patch Delivering Antigenic Peptide–Hyaluronate Conjugate for Cancer Immunotherapy
DOI: 10.1021/acsbiomaterials.9b00961

ACS Catalysis


Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis
DOI: 10.1021/acscatal.9b03084

Catalysis of Organic Reactions through Halogen Bonding
DOI: 10.1021/acscatal.9b02894

Nickel/Cobalt-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
DOI: 10.1021/acscatal.9b03352

Gold-Catalyzed C–H Functionalization with Aryl Germanes
Open Access through ACS AuthorChoice
DOI: 10.1021/acscatal.9b02841

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
Open Access through ACS AuthorChoice
DOI: 10.1021/acscatal.9b03190


ACS Chemical Biology


Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway
DOI: 10.1021/acschembio.9b00525

Extending the Detection Limit in Fragment Screening of Proteins Using Reverse Micelle Encapsulation
DOI: 10.1021/acschembio.9b00537

Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00560

ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00640

L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00427

ACS Chemical Neuroscience


NeuroChat with Professor Catherine Abbott
DOI: 10.1021/acschemneuro.9b00511

Hexahydropyrrolo[2,3-b]indole Compounds as Potential Therapeutics for Alzheimer’s Disease
DOI: 10.1021/acschemneuro.9b00297

Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate
DOI: 10.1021/acschemneuro.9b00287

Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease
DOI: 10.1021/acschemneuro.9b00430

Detecting Alcohol-Induced Brain Damage Noninvasively Using Diffusion Tensor Imaging
DOI: 10.1021/acschemneuro.9b00481


ACS Infectious Diseases


Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.9b00128

Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches
DOI: 10.1021/acsinfecdis.9b00249

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206
DOI: 10.1021/acsinfecdis.9b00217

Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits
DOI: 10.1021/acsinfecdis.9b00256

Sugar-Modified Analogs of Auranofin Are Potent Inhibitors of the Gastric Pathogen Helicobacter pylori
DOI: 10.1021/acsinfecdis.9b00251

ACS Medicinal Chemistry Letters


PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00397

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00301

AβTau”, Lobby or Religion?
DOI: 10.1021/acsmedchemlett.9b00439

PROTAC Degradation of IRAK4 for the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00423

Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00310

ACS Synthetic Biology


Exploiting Day- and Night-Time Metabolism of Synechocystis sp. PCC 6803 for Fitness-Coupled Fumarate Production around the Clock
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00289

An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics
DOI: 10.1021/acssynbio.9b00175

Mevalonate Pathway Promiscuity Enables Noncanonical Terpene Production
DOI: 10.1021/acssynbio.9b00230

HOLMESv2: A CRISPR-Cas12b-Assisted Platform for Nucleic Acid Detection and DNA Methylation Quantitation
DOI: 10.1021/acssynbio.9b00209

Modular Thermal Control of Protein Dimerization
DOI: 10.1021/acssynbio.9b00275



The EFI Web Resource for Genomic Enzymology Tools: Leveraging Protein, Genome, and Metagenome Databases to Discover Novel Enzymes and Metabolic Pathways
DOI: 10.1021/acs.biochem.9b00735

Nuclear Magnetic Resonance Solution Structure and Functional Behavior of the Human Proton Channel
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.biochem.9b00471

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biochem.9b00592

Interaction of the Full-Length Heme-Based CO Sensor Protein RcoM-2 with Ligands
DOI: 10.1021/acs.biochem.9b00623

NosP Modulates Cyclic-di-GMP Signaling in Legionella pneumophila
DOI: 10.1021/acs.biochem.9b00618

Bioconjugate Chemistry


Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
DOI: 10.1021/acs.bioconjchem.9b00306

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation
DOI: 10.1021/acs.bioconjchem.9b00639

Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes
DOI: 10.1021/acs.bioconjchem.9b00582

Zwitterionic Modification of Nanomaterials for Improved Diagnosis of Cancer Cells
DOI: 10.1021/acs.bioconjchem.9b00543

Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention
DOI: 10.1021/acs.bioconjchem.9b00587



Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00701

Predicting Protein–Polymer Block Copolymer Self-Assembly from Protein Properties
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00768

Extracellular Antifreeze Protein Significantly Enhances the Cryopreservation of Cell Monolayers
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00951

Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers
DOI: 10.1021/acs.biomac.9b01024

Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00512

Journal of Agricultural and Food Chemistry


Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jafc.9b04435

Melanoidins from Coffee, Cocoa, and Bread Are Able to Scavenge α-Dicarbonyl Compounds under Simulated Physiological Conditions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03744

Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of myo-Inositol Phosphate Esters in Various Feed Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03919

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors
DOI: 10.1021/acs.jafc.9b04009

New Acylated Phenolic Glycosides with ROS-Scavenging Activity from Psidium guajava Leaves
DOI: 10.1021/acs.jafc.9b04318

Journal of Chemical Theory and Computation


Pitfalls of the Martini Model
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00473

Self-Consistent Density-Functional Embedding: A Novel Approach for Density-Functional Approximations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00063

Insights into Membrane Protein–Lipid Interactions from Free Energy Calculations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00548

A Linear-Scaling Method for Noncovalent Interactions: An Efficient Combination of Absolutely Localized Molecular Orbitals and a Local Random Phase Approximation Approach
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00615

Accuracy of Spin-Component-Scaled CC2 Excitation Energies and Potential Energy Surfaces
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00676

Journal of Medicinal Chemistry


Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
DOI: 10.1021/acs.jmedchem.9b01234

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases
DOI: 10.1021/acs.jmedchem.9b01612

Antibiotic Adjuvants: Make Antibiotics Great Again!
DOI: 10.1021/acs.jmedchem.8b01781

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
DOI: 10.1021/acs.jmedchem.9b00444

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
DOI: 10.1021/acs.jmedchem.9b00533

Journal of Natural Products


Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114
DOI: 10.1021/acs.jnatprod.8b01056

Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2
DOI: 10.1021/acs.jnatprod.9b00212

Anti-Lymphangiogenic Alkaloids from the Zoanthid Zoanthus vietnamensis Collected in Taiwan
DOI: 10.1021/acs.jnatprod.9b00451

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
DOI: 10.1021/acs.jnatprod.9b00522

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
DOI: 10.1021/acs.jnatprod.9b00522

The Journal of Physical Chemistry B


Proteins: “Boil ’Em, Mash ’Em, Stick ’Em in a Stew”
DOI: 10.1021/acs.jpcb.9b05467

Physical Chemistry of Epigenetics: Single-Molecule Investigations
DOI: 10.1021/acs.jpcb.9b06214

Insights into Proton-Transfer Pathways during Water Oxidation in Photosystem II
DOI: 10.1021/acs.jpcb.9b06244

Electrolytes Change the Interfacial Water Structure but Not the Vibrational Dynamics
DOI: 10.1021/acs.jpcb.9b08131

The Widom Line and the Lennard-Jones Potential
DOI: 10.1021/acs.jpcb.9b05426

The Journal of Physical Chemistry Letters


The Causes of Degradation of Perovskite Solar Cells
DOI: 10.1021/acs.jpclett.9b00613

Two Dimensions Are Better for Perovskites
DOI: 10.1021/acs.jpclett.9b01568

Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b02531

Journey of Making Cesium Lead Halide Perovskite Nanocrystals: What’s Next
DOI: 10.1021/acs.jpclett.9b02412

Outstanding Challenges of Zero-Dimensional Perovskite Materials
DOI: 10.1021/acs.jpclett.9b00175

Journal of Proteome Research


Common Repository of FBS Proteins (cRFP) To Be Added to a Search Database for Mass Spectrometric Analysis of Cell Secretome
DOI: 10.1021/acs.jproteome.9b00475

Current Understanding of Human Metaproteome Association and Modulation
DOI: 10.1021/acs.jproteome.9b00301

Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis
DOI: 10.1021/acs.jproteome.9b00254

One Thousand and One Software for Proteomics: Tales of the Toolmakers of Science
DOI: 10.1021/acs.jproteome.9b00219

Extremely Fast and Accurate Open Modification Spectral Library Searching of High-Resolution Mass Spectra Using Feature Hashing and Graphics Processing Units
DOI: 10.1021/acs.jproteome.9b00291

Molecular Pharmaceutics


Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00703

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00406

Recent Advances in Understanding the Micro- and Nanoscale Phenomena of Amorphous Solid Dispersions
DOI: 10.1021/acs.molpharmaceut.9b00601

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00730

From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design
DOI: 10.1021/acs.molpharmaceut.9b00634

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