Discover the Most-Read Biological Chemistry Articles of June 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in June 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of June’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering

Antitumor Photodynamic Therapy Based on Dipeptide Fibrous Hydrogels with Incorporation of Photosensitive Drugs
This article is part of the Biomaterials Science and Engineering in China special issue.
ACS Biomater. Sci. Eng., 2018, 4 (6), pp 2046-2052
DOI: 10.1021/acsbiomaterials.7b00624

Fabrication of Amyloid Curli Fibers-Alginate Nanocomposite Hydrogels with Enhanced Stiffness
ACS Biomater. Sci. Eng., 2018, 4 (6), pp 2100-2105
DOI: 10.1021/acsbiomaterials.8b00364

Fabrication of Low-Cost Flexible Superhydrophobic Antibacterial Surface with Dual-Scale Roughness
ACS Biomater. Sci. Eng., 2018, 4 (6), pp 2213-2223
DOI: 10.1021/acsbiomaterials.8b00209

Manganese-Doped Carbon Dots for Magnetic Resonance/Optical Dual-Modal Imaging of Tiny Brain Glioma
ACS Biomater. Sci. Eng., 2018, 4 (6), pp 2089-2094
DOI: 10.1021/acsbiomaterials.7b01008

Modification of α-Cyclodextrin Polyrotaxanes by ATRP for Conjugating Drug and Prolonging Blood Circulation
This article is part of the Biomaterials Science and Engineering in China special issue.
ACS Biomater. Sci. Eng., 2018, 4 (6), pp 1963-1968
DOI: 10.1021/acsbiomaterials.7b00464

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ACS Catalysis

ACS Catalysis Goes to China
ACS Catal., 2018, 8 (6), pp 5636-5636
DOI: 10.1021/acscatal.8b01908

An Electrocatalytic Approach to the Radical Difunctionalization of Alkenes
ACS Catal., 2018, 8 (6), pp 5175-5187
DOI: 10.1021/acscatal.8b01069

Calculations of Product Selectivity in Electrochemical CO2 Reduction
Open access through ACS AuthorChoice
ACS Catal., 2018, 8 (6), pp 5240-5249
DOI: 10.1021/acscatal.7b03308

Catalytic Asymmetric Oxidative Enamine Transformations
ACS Catal., 2018, 8 (6), pp 5466-5484
DOI: 10.1021/acscatal.8b01263

Cobalt-Catalyzed Electrochemical Oxidative C-H/N-H Carbonylation with Hydrogen Evolution
ACS Catal., 2018, 8 (6), pp 5448-5453
DOI: 10.1021/acscatal.8b00683

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ACS Chemical Biology

Biomarker-Based Metabolic Labeling for Redirected and Enhanced Immune Response
ACS Chem. Biol., 2018, 13 (6), pp 1686-1694
DOI: 10.1021/acschembio.8b00350

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (6), pp 1569-1576
DOI: 10.1021/acschembio.8b00155

Detection of Chemical Engagement of Solute Carrier Proteins by a Cellular Thermal Shift Assay
ACS Chem. Biol., 2018, 13 (6), pp 1480-1486
DOI: 10.1021/acschembio.8b00270

Self-Resistance of Natural Product Producers: Past, Present, and Future Focusing on Self-Resistant Protein Variants
ACS Chem. Biol., 2018, 13 (6), pp 1426-1437
DOI: 10.1021/acschembio.8b00173

Spatially Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome
ACS Chem. Biol., 2018, 13 (6), pp 1474-1479
DOI: 10.1021/acschembio.8b00262

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ACS Chemical Neuroscience

In Silico Identification and Experimental Validation of Novel Anti-Alzheimer’s Multitargeted Ligands from a Marine Source Featuring a “2-Aminoimidazole plus Aromatic Group” Scaffold
ACS Chem. Neurosci., 2018, 9 (6), pp 1290-1303
DOI: 10.1021/acschemneuro.7b00416

Alzheimer’s Disease, Dendritic Spines, and Calcineurin Inhibitors: A New Approach?rel=12408&
ACS Chem. Neurosci., 2018, 9 (6), pp 1233-1234
DOI: 10.1021/acschemneuro.8b00213

Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging
ACS Chem. Neurosci., 2018, 9 (6), pp 1226-1229
DOI: 10.1021/acschemneuro.8b00176

Dendritic Learning as a Paradigm Shift in Brain Learning
ACS Chem. Neurosci., 2018, 9 (6), pp 1230-1232
DOI: 10.1021/acschemneuro.8b00204

Efficacious Vaccine against Heroin Contaminated with Fentanyl
ACS Chem. Neurosci., 2018, 9 (6), pp 1269-1275
DOI: 10.1021/acschemneuro.8b00079

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2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization
Open access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (6), pp 954-969
DOI: 10.1021/acsinfecdis.7b00275

Carbapenems and Lipid Bilayers: Localization, Partitioning, and Energetics
ACS Infect. Dis., 2018, 4 (6), pp 926-935
DOI: 10.1021/acsinfecdis.7b00156

Cell Membrane Derived Platform To Study Virus Binding Kinetics and Diffusion with Single Particle Sensitivity
ACS Infect. Dis., 2018, 4 (6), pp 944-953
DOI: 10.1021/acsinfecdis.7b00270

Compartment-Specific Labeling of Bacterial Periplasmic Proteins by Peroxidase-Mediated Biotinylation
ACS Infect. Dis., 2018, 4 (6), pp 918-925
DOI: 10.1021/acsinfecdis.8b00044

Copper Influences the Antibacterial Outcomes of a β-Lactamase-Activated Prochelator against Drug-Resistant Bacteria
ACS Infect. Dis., 2018, 4 (6), pp 1019-1029
DOI: 10.1021/acsinfecdis.8b00037

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Chemical Proteomic Characterization of a Covalent KRASG12C Inhibitor
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 557-562
DOI: 10.1021/acsmedchemlett.8b00110

Current Innovations in Medicinal Chemistry and Chemical Biology
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 513-514
DOI: 10.1021/acsmedchemlett.8b00252

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 540-545
DOI: 10.1021/acsmedchemlett.8b00011

Expansion of cat-ELCCA for the Discovery of Small Molecule Inhibitors of the Pre-let-7-Lin28 RNA-Protein Interaction
Open access through ACS Editors’ Choice
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 517-521
DOI: 10.1021/acsmedchemlett.8b00126

Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift
Open access through ACS AuthorChoice
This article is part of the Med Chem Tech: Driving Drug Development special issue.
ACS Med. Chem. Lett., 2018, 9 (6), pp 546-551
DOI: 10.1021/acsmedchemlett.8b00081

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A Framework for Engineering Stress Resilient Plants Using Genetic Feedback Control and Regulatory Network Rewiring
ACS Synth. Biol., 2018, 7 (6), pp 1553-1564
DOI: 10.1021/acssynbio.8b00037

Drug-Inducible Control of Lethality Genes: A Low Background Destabilizing Domain Architecture Applied to the Gal4-UAS System in Drosophila
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (6), pp 1496-1506
DOI: 10.1021/acssynbio.7b00302

Engineering a Functional Small RNA Negative Autoregulation Network with Model-Guided Design
ACS Synth. Biol., 2018, 7 (6), pp 1507-1518
DOI: 10.1021/acssynbio.7b00440

Homogeneous Time Constants Promote Oscillations in Negative Feedback Loops
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (6), pp 1481-1487
DOI: 10.1021/acssynbio.7b00442

Multiplexed CRISPR-Cpf1-Mediated Genome Editing in Clostridium difficile toward the Understanding of Pathogenesis of C. difficile Infection
ACS Synth. Biol., 2018, 7 (6), pp 1588-1600
DOI: 10.1021/acssynbio.8b00087

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Biochemistry

A Random-Sequential Kinetic Mechanism for Polysaccharide Monooxygenases
This article is part of the Current Topics in Mechanistic Enzymology special issue.
Biochemistry, 2018, 57 (22), pp 3191-3199
DOI: 10.1021/acs.biochem.8b00129

Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides
This article is part of the Current Topics in Mechanistic Enzymology special issue.
Biochemistry, 2018, 57 (23), pp 3201-3209
DOI: 10.1021/acs.biochem.8b00114

Hydrogen Bonds: Simple after All?rel=12408&
This article is part of the Current Topics in Mechanistic Enzymology special issue.
Biochemistry, 2018, 57 (24), pp 3338-3352
DOI: 10.1021/acs.biochem.8b00217

Kinetic Solvent Viscosity Effects as Probes for Studying the Mechanisms of Enzyme Action
This article is part of the Current Topics in Mechanistic Enzymology special issue.
Biochemistry, 2018, 57 (25), pp 3445-3453
DOI: 10.1021/acs.biochem.8b00232

Mechanism and Structure of γ-Resorcylate Decarboxylase
This article is part of the Current Topics in Mechanistic Enzymology special issue.
Biochemistry, 2018, 57 (22), pp 3167-3175
DOI: 10.1021/acs.biochem.7b01213

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Bioconjugate Chemistry

Combinatorially Screened Peptide as Targeted Covalent Binder: Alteration of Bait-Conjugated Peptide to Reactive Modifier
Bioconjugate Chem., 2018, 29 (6), pp 1866-1871
DOI: 10.1021/acs.bioconjchem.8b00301

Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR
Bioconjugate Chem., 2018, 29 (6), pp 2050-2057
DOI: 10.1021/acs.bioconjchem.8b00250

Design and Development of Polysaccharide-Doxorubicin-Peptide Bioconjugates for Dual Synergistic Effects of Integrin-Targeted and Cell-Penetrating Peptides for Cancer Chemotherapy
Bioconjugate Chem., 2018, 29 (6), pp 1973-2000
DOI: 10.1021/acs.bioconjchem.8b00208

Enhanced DNA Binding and Photocleavage Abilities of β-Cyclodextrin Appended Ru(II) Complex through Supramolecular Strategy
Bioconjugate Chem., 2018, 29 (6), pp 1829-1833
DOI: 10.1021/acs.bioconjchem.8b00191

Fluorogenic Probing of Membrane Protein Trafficking
Bioconjugate Chem., 2018, 29 (6), pp 1823-1828
DOI: 10.1021/acs.bioconjchem.8b00180

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Biomacromolecules

Conducting Polymers for Tissue Engineering
This article is part of the Biomacromolecules Asian Special Issue special issue.
Biomacromolecules, 2018, 19 (6), pp 1764-1782
DOI: 10.1021/acs.biomac.8b00276

Dynamic Bonds between Boronic Acid and Alginate: Hydrogels with Stretchable, Self-Healing, Stimuli-Responsive, Remoldable, and Adhesive Properties
This article is part of the Biomacromolecules Asian Special Issue special issue.
Biomacromolecules, 2018, 19 (6), pp 2053-2061
DOI: 10.1021/acs.biomac.8b00144

Photoresponsive Drug/Gene Delivery Systems
This article is part of the Biomacromolecules Asian Special Issue special issue.
Biomacromolecules, 2018, 19 (6), pp 1840-1857
DOI: 10.1021/acs.biomac.8b00422

Polymers from Nature and for Nature
This article is part of the Biomacromolecules Asian Special Issue special issue.
Biomacromolecules, 2018, 19 (6), pp 1697-1700
DOI: 10.1021/acs.biomac.8b00830

Recent Advances in Biodegradable Conducting Polymers and Their Biomedical Applications
This article is part of the Biomacromolecules Asian Special Issue special issue.
Biomacromolecules, 2018, 19 (6), pp 1783-1803
DOI: 10.1021/acs.biomac.8b00275

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Journal of Agricultural and Food Chemistry

Advances on Fungal Phytotoxins and Their Role in Grapevine Trunk Diseases
J. Agric. Food Chem., 2018, 66 (24), pp 5948-5958
DOI: 10.1021/acs.jafc.8b00773

Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As Inhibition of COX-2 Activity
J. Agric. Food Chem., 2018, 66 (23), pp 5790-5801
DOI: 10.1021/acs.jafc.8b00437

Bioactivity-Guided Metabolite Profiling of Feijoa (Acca sellowiana) Cultivars Identifies 4-Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis
J. Agric. Food Chem., 2018, 66 (22), pp 5531-5539
DOI: 10.1021/acs.jafc.7b06154

Dietary Carotenoid Roles in Redox Homeostasis and Human Health
J. Agric. Food Chem., 2018, 66 (23), pp 5733-5740
DOI: 10.1021/acs.jafc.8b00866

Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli
J. Agric. Food Chem., 2018, 66 (22), pp 5621-5634
DOI: 10.1021/acs.jafc.8b02092

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Accurate Treatment of Charge-Transfer Excitations and Thermally Activated Delayed Fluorescence Using the Particle-Particle Random Phase Approximation
J. Chem. Theory Comput., 2018, 14 (6), pp 3196-3204
DOI: 10.1021/acs.jctc.8b00153

Adaptive, Geometric Networks for Efficient Coarse-Grained Ab Initio Molecular Dynamics with Post-Hartree-Fock Accuracy
J. Chem. Theory Comput., 2018, 14 (6), pp 2852-2866
DOI: 10.1021/acs.jctc.8b00186

Enhanced Monte Carlo Methods for Modeling Proteins Including Computation of Absolute Free Energies of Binding
J. Chem. Theory Comput., 2018, 14 (6), pp 3279-3288
DOI: 10.1021/acs.jctc.8b00031

Link between Membrane Composition and Permeability to Drugs
J. Chem. Theory Comput., 2018, 14 (6), pp 2895-2909
DOI: 10.1021/acs.jctc.8b00272

Many-Body Descriptors for Predicting Molecular Properties with Machine Learning: Analysis of Pairwise and Three-Body Interactions in Molecules
J. Chem. Theory Comput., 2018, 14 (6), pp 2991-3003
DOI: 10.1021/acs.jctc.8b00110

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Design of Small Molecule Autophagy Modulators: A Promising Druggable Strategy
J. Med. Chem., 2018, 61 (11), pp 4656-4687
DOI: 10.1021/acs.jmedchem.7b01019

Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors
Open access through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (12), pp 5435-5441
DOI: 10.1021/acs.jmedchem.8b00447

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)
Open access through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (11), pp 4704-4719
DOI: 10.1021/acs.jmedchem.8b00164

Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (11), pp 4883-4903
DOI: 10.1021/acs.jmedchem.8b00270

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
J. Med. Chem., 2018, 61 (11), pp 4978-4992
DOI: 10.1021/acs.jmedchem.8b00421

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Journal of Natural Products

Chloramphenicol Derivatives with Antibacterial Activity Identified by Functional Metagenomics
J. Nat. Prod., 2018, 81 (6), pp 1321-1332
DOI: 10.1021/acs.jnatprod.7b00903

Evodialones A and B: Polyprenylated Acylcyclopentanone Racemates with a 3-Ethyl-1,1-diisopentyl-4-methylcyclopentane Skeleton from Evodia lepta
J. Nat. Prod., 2018, 81 (6), pp 1483-1487
DOI: 10.1021/acs.jnatprod.7b00993

Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production
J. Nat. Prod., 2018, 81 (6), pp 1468-1473
DOI: 10.1021/acs.jnatprod.8b00229

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine
J. Nat. Prod., 2018, 81 (6), pp 1451-1459
DOI: 10.1021/acs.jnatprod.8b00218

Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea
Open access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (6), pp 1417-1425
DOI: 10.1021/acs.jnatprod.8b00117

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Crowding Stabilizes DMSO-Water Hydrogen-Bonding Interactions
J. Phys. Chem. B, 2018, 122 (22), pp 5984-5990
DOI: 10.1021/acs.jpcb.8b02739

Electric-Field Effects on Ionic Hydration: A Molecular Dynamics Study
J. Phys. Chem. B, 2018, 122 (22), pp 5991-5998
DOI: 10.1021/acs.jpcb.8b02773

Exploring GPCR-Lipid Interactions by Molecular Dynamics Simulations: Excitements, Challenges, and the Way Forward
J. Phys. Chem. B, 2018, 122 (22), pp 5727-5737
DOI: 10.1021/acs.jpcb.8b01657

Hydronium Ions Accompanying Buried Acidic Residues Lead to High Apparent Dielectric Constants in the Interior of Proteins
J. Phys. Chem. B, 2018, 122 (23), pp 6215-6223
DOI: 10.1021/acs.jpcb.8b04584

Influence of Cholesterol on the Dynamics of Hydration in Phospholipid Bilayers
J. Phys. Chem. B, 2018, 122 (22), pp 5897-5907
DOI: 10.1021/acs.jpcb.8b00360

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Collective Variables from Local Fluctuations
J. Phys. Chem. Lett., 2018, 9 (11), pp 2776-2781
DOI: 10.1021/acs.jpclett.8b00733

Constructing Sensitive and Fast Lead-Free Single-Crystalline Perovskite Photodetectors
J. Phys. Chem. Lett., 2018, 9 (11), pp 3087-3092
DOI: 10.1021/acs.jpclett.8b01116

Dual Emission through Thermally Activated Delayed Fluorescence and Room-Temperature Phosphorescence, and Their Thermal Enhancement via Solid-State Structural Change in a Carbazole-Quinoline Conjugate
J. Phys. Chem. Lett., 2018, 9 (11), pp 2733-2738
DOI: 10.1021/acs.jpclett.8b00937

Infrared Spectroscopy as a Probe of Electronic Energy Transfer
J. Phys. Chem. Lett., 2018, 9 (12), pp 3217-3223
DOI: 10.1021/acs.jpclett.8b01216

Light Absorption Coefficient of CsPbBr3 Perovskite Nanocrystals
J. Phys. Chem. Lett., 2018, 9 (11), pp 3093-3097
DOI: 10.1021/acs.jpclett.8b01065

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An Adaptive Pipeline To Maximize Isobaric Tagging Data in Large-Scale MS-Based Proteomics
J. Proteome Res., 2018, 17 (6), pp 2165-2173
DOI: 10.1021/acs.jproteome.8b00110

Chemical-Mediated Digestion: An Alternative Realm for Middle-down Proteomics?rel=12408&
J. Proteome Res., 2018, 17 (6), pp 2005-2016
DOI: 10.1021/acs.jproteome.7b00834

High Field Asymmetric Waveform Ion Mobility Spectrometry in Nontargeted Bottom-up Proteomics of Dried Blood Spots
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (6), pp 1997-2004
DOI: 10.1021/acs.jproteome.7b00746

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20
J. Proteome Res., 2018, 17 (6), pp 2182-2191
DOI: 10.1021/acs.jproteome.8b00139

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome
J. Proteome Res., 2018, 17 (6), pp 2072-2091
DOI: 10.1021/acs.jproteome.8b00018

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Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function
Mol. Pharmaceutics, 2018, 15 (6), pp 2413-2422
DOI: 10.1021/acs.molpharmaceut.8b00250

Co-Stabilization of Amorphous Pharmaceuticals-The Case of Nifedipine and Nimodipine
Mol. Pharmaceutics, 2018, 15 (6), pp 2455-2465
DOI: 10.1021/acs.molpharmaceut.8b00308

Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery
Mol. Pharmaceutics, 2018, 15 (6), pp 2069-2083
DOI: 10.1021/acs.molpharmaceut.8b00319

Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid
Mol. Pharmaceutics, 2018, 15 (6), pp 2098-2106
DOI: 10.1021/acs.molpharmaceut.7b01009

Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (6), pp 2224-2233
DOI: 10.1021/acs.molpharmaceut.8b00064