Discover the Most-Read Biological Chemistry Articles of May 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in May 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of May’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

Biomimetic Tooth Repair: Amelogenin-Derived Peptide Enables in Vitro Remineralization of Human Enamel
ACS Biomater. Sci. Eng., 2018, 4 (5), pp 1788–1796
DOI: 10.1021/acsbiomaterials.7b00959

Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties
ACS Biomater. Sci. Eng., 2018, 4 (5), pp 1558–1567
DOI: 10.1021/acsbiomaterials.8b00135

Graphene Oxide-Based Biocompatible 3D Mesh with a Tunable Porosity and Tensility for Cell Culture
ACS Biomater. Sci. Eng., 2018, 4 (5), pp 1505–1517
DOI: 10.1021/acsbiomaterials.8b00190

Hyaluronic Acid-Modified Polymeric Gatekeepers on Biodegradable Mesoporous Silica Nanoparticles for Targeted Cancer Therapy
ACS Biomater. Sci. Eng., 2018, 4 (5), pp 1716–1722
DOI: 10.1021/acsbiomaterials.8b00218

Iron(III) Coordinated Polymeric Nanomaterial: A Next-Generation Theranostic Agent for High-Resolution T1-Weighted Magnetic Resonance Imaging and Anticancer Drug Delivery
ACS Biomater. Sci. Eng., 2018, 4 (5), pp 1738–1749
DOI: 10.1021/acsbiomaterials.8b00294

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ACS Catalysis

ACS Catalysis Appoints Second Early Career Advisory Board and New Associate Editor
ACS Catal., 2018, 8 (5), pp 4582–4582
DOI: 10.1021/acscatal.8b01493

Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel
ACS Catal., 2018, 8 (5), pp 4622–4627
DOI: 10.1021/acscatal.8b01224

Design Strategy toward Recyclable and Highly Efficient Heterogeneous Catalysts for the Hydrogenation of CO2 to Formate
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (5), pp 4346–4353
DOI: 10.1021/acscatal.8b00392

Engineering Cobalt Defects in Cobalt Oxide for Highly Efficient Electrocatalytic Oxygen Evolution
ACS Catal., 2018, 8 (5), pp 3803–3811
DOI: 10.1021/acscatal.8b01046

Ion Pair-Directed C–H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines
Open access through ACS AuthorChoice
ACS Catal., 2018, 8 (5), pp 3764–3769
DOI: 10.1021/acscatal.8b00423

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ACS Chemical Biology

A Common Mechanism Links Activities of Butyrate in the Colon
ACS Chem. Biol., 2018, 13 (5), pp 1291–1298
DOI: 10.1021/acschembio.8b00073

Biosynthesis of the 15-Membered Ring Depsipeptide Neoantimycin
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (5), pp 1398–1406
DOI: 10.1021/acschembio.8b00298

Capturing Post-Translational Modification-Triggered Protein–Protein Interactions Using Dual Noncanonical Amino Acid Mutagenesis
ACS Chem. Biol., 2018, 13 (5), pp 1137–1141
DOI: 10.1021/acschembio.8b00021

Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes
ACS Chem. Biol., 2018, 13 (5), pp 1307–1312
DOI: 10.1021/acschembio.8b00101

Live Cell Visualization of Multiple Protein–Protein Interactions with BiFC Rainbow
ACS Chem. Biol., 2018, 13 (5), pp 1180–1188
DOI: 10.1021/acschembio.7b00931

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ACS Chemical Neuroscience

Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors
ACS Chem. Neurosci., 2018, 9 (5), pp 894–900
DOI: 10.1021/acschemneuro.7b00435

Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer’s Disease
ACS Chem. Neurosci., 2018, 9 (5), pp 988–1000
DOI: 10.1021/acschemneuro.7b00410

From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein
ACS Chem. Neurosci., 2018, 9 (5), pp 1051–1065
DOI: 10.1021/acschemneuro.7b00446

Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer’s Disease
ACS Chem. Neurosci., 2018, 9 (5), pp 912–924
DOI: 10.1021/acschemneuro.7b00260

Genistein: A Dual Inhibitor of Both Amyloid β and Human Islet Amylin Peptides
ACS Chem. Neurosci., 2018, 9 (5), pp 1215–1224
DOI: 10.1021/acschemneuro.8b00039

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ACS Infectious Diseases

Antibacterial Drug Discovery: Some Assembly Required
ACS Infect. Dis., 2018, 4 (5), pp 686–695
DOI: 10.1021/acsinfecdis.8b00027

Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection
ACS Infect. Dis., 2018, 4 (5), pp 806–814
DOI: 10.1021/acsinfecdis.7b00235

Development of a Multiplexed Microsphere PCR for Culture-Free Detection and Gram-Typing of Bacteria in Human Blood Samples
ACS Infect. Dis., 2018, 4 (5), pp 837–844
DOI: 10.1021/acsinfecdis.7b00277

Developments in Glycopeptide Antibiotics
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (5), pp 715–735
DOI: 10.1021/acsinfecdis.7b00258

Fucosylated Molecules Competitively Interfere with Cholera Toxin Binding to Host Cells
ACS Infect. Dis., 2018, 4 (5), pp 758–770
DOI: 10.1021/acsinfecdis.7b00085

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ACS Medicinal Chemistry Letters

2,7-Diazaspiro[4,4]nonanes for the Treatment or Prevention of Cancers and Diabetes
ACS Med. Chem. Lett., 2018, 9 (5), pp 401–402
DOI: 10.1021/acsmedchemlett.8b00159

Academic Drug Development: The DRIVE Model
ACS Med. Chem. Lett., 2018, 9 (5), pp 403–407
DOI: 10.1021/acsmedchemlett.8b00124

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue
ACS Med. Chem. Lett., 2018, 9 (5), pp 398–399
DOI: 10.1021/acsmedchemlett.8b00174

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)
ACS Med. Chem. Lett., 2018, 9 (5), pp 417–421
DOI: 10.1021/acsmedchemlett.7b00427

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
ACS Med. Chem. Lett., 2018, 9 (5), pp 472–477
DOI: 10.1021/acsmedchemlett.8b00080

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ACS Synthetic Biology

A Dynamic Model of Resource Allocation in Response to the Presence of a Synthetic Construct
ACS Synth. Biol., 2018, 7 (5), pp 1201–1210
DOI: 10.1021/acssynbio.8b00015

A Transcription Factor-Based Biosensor for Detection of Itaconic Acid
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (5), pp 1436–1446
DOI: 10.1021/acssynbio.8b00057

An Automated Design Framework for Multicellular Recombinase Logic
ACS Synth. Biol., 2018, 7 (5), pp 1406–1412
DOI: 10.1021/acssynbio.8b00016

Engineering the Ultrasensitive Transcription Factors by Fusing a Modular Oligomerization Domain
ACS Synth. Biol., 2018, 7 (5), pp 1188–1194
DOI: 10.1021/acssynbio.7b00414

Macromolecular Crowding Induces Spatial Correlations That Control Gene Expression Bursting Patterns
ACS Synth. Biol., 2018, 7 (5), pp 1251–1258
DOI: 10.1021/acssynbio.8b00139

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Biochemistry

Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins
This article is part of the Membrane-Less Organelles special issue.
Biochemistry, 2018, 57 (17), pp 2405–2414
DOI: 10.1021/acs.biochem.8b00056

Deciphering Human Gut Microbiota–Nutrient Interactions: A Role for Biochemistry
Biochemistry, 2018, 57 (18), pp 2567–2577
DOI: 10.1021/acs.biochem.7b01277

Function and Regulation of Phase-Separated Biological Condensates
This article is part of the Membrane-Less Organelles special issue.
Biochemistry, 2018, 57 (17), pp 2452–2461
DOI: 10.1021/acs.biochem.7b01228

Life and Work of Stress Granules and Processing Bodies: New Insights into Their Formation and Function
This article is part of the Membrane-Less Organelles special issue.
Biochemistry,2018, 57 (17), pp 2488–2498
DOI: 10.1021/acs.biochem.8b00025

P-Bodies: Composition, Properties, and Functions
This article is part of the Membrane-Less Organelles special issue.
Biochemistry,2018, 57 (17), pp 2424–2431
DOI: 10.1021/acs.biochem.7b01162

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Bioconjugate Chemistry

A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo
Bioconjugate Chem., 2018, 29 (5), pp 1729–1735
DOI: 10.1021/acs.bioconjchem.8b00177

Disintegrable NIR Light Triggered Gold Nanorods Supported Liposomal Nanohybrids for Cancer Theranostics
Bioconjugate Chem., 2018, 29 (5), pp 1510–1518
DOI: 10.1021/acs.bioconjchem.7b00801

Fluorescent BODIPY-Anionic Boron Cluster Conjugates as Potential Agents for Cell Tracking
Bioconjugate Chem., 2018, 29 (5), pp 1763–1773
DOI: 10.1021/acs.bioconjchem.8b00204

Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive 19F MRI Nanoprobes
Bioconjugate Chem., 2018, 29 (5), pp 1720–1728
DOI: 10.1021/acs.bioconjchem.8b00167

Investigation on Sugar–Protein Connectivity in Salmonella O-Antigen Glycoconjugate Vaccines
Bioconjugate Chem., 2018, 29 (5), pp 1736–1747
DOI: 10.1021/acs.bioconjchem.8b00178

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Biomacromolecules

Distributions: The Importance of the Chemist’s Molecular View for Biological Materials
Open access through ACS Editors’ Choice
Biomacromolecules, 2018, 19 (5), pp 1469–1484
DOI: 10.1021/acs.biomac.8b00375

Exploiting Ring-Opening Aminolysis–Condensation as a Polymerization Pathway to Structurally Diverse Biobased Polyamides
Open access through ACS Editors’ Choice
Biomacromolecules, 2018, 19 (5), pp 1573–1581
DOI: 10.1021/acs.biomac.8b00322

In Situ Forming, Cytocompatible, and Self-Recoverable Tough Hydrogels Based on Dual Ionic and Click Cross-Linked Alginate
Biomacromolecules, 2018, 19 (5), pp 1646–1662
DOI: 10.1021/acs.biomac.8b00140

Influence of Grafted Block Copolymer Structure on Thermoresponsiveness of Superparamagnetic Core–Shell Nanoparticles
Open access through ACS AuthorChoice
This article is part of the Stimuli-Sensitive and -Responsive Polymer Biomaterials special issue.
Biomacromolecules, 2018, 19 (5), pp 1435–1444
DOI: 10.1021/acs.biomac.7b01403

Molecular Weight and Charge Density Effects of Guanidinylated Biodegradable Polycarbonates on Antimicrobial Activity and Selectivity
This article is part of the Stimuli-Sensitive and -Responsive Polymer Biomaterials special issue.
Biomacromolecules, 2018, 19 (5), pp 1389–1401
DOI: 10.1021/acs.biomac.7b01245

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Antidiabetic Mechanism of Dietary Polysaccharides Based on Their Gastrointestinal Functions
J. Agric. Food Chem., 2018, 66 (19), pp 4781–4786
DOI: 10.1021/acs.jafc.7b05410

Can Glycation Reduce Food Allergenicity?
J. Agric. Food Chem., 2018, 66 (17), pp 4295–4299
DOI: 10.1021/acs.jafc.8b00660

Distribution Analysis of Anthocyanins, Sugars, and Organic Acids in Strawberry Fruits Using Matrix-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry
J. Agric. Food Chem., 2018, 66 (19), pp 4958–4965
DOI: 10.1021/acs.jafc.8b00853

Fabrication and Characterization of Quinoa Protein Nanoparticle-Stabilized Food-Grade Pickering Emulsions with Ultrasound Treatment: Interfacial Adsorption/Arrangement Properties
J. Agric. Food Chem., 2018, 66 (17), pp 4449–4457
DOI: 10.1021/acs.jafc.8b00225

Identification and Characterization of Phenolic Compounds in Black Walnut Kernels
J. Agric. Food Chem., 2018, 66 (17), pp 4503–4511
DOI: 10.1021/acs.jafc.8b01181

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Journal of Chemical Theory and Computation

Ab Initio Potential Energy Surfaces and Quantum Dynamics for Polyatomic Bimolecular Reactions
J. Chem. Theory Comput., 2018, 14 (5), pp 2289–2303
DOI: 10.1021/acs.jctc.8b00006

Benchmarks and Reliable DFT Results for Spin Gaps of Small Ligand Fe(II) Complexes
J. Chem. Theory Comput., 2018, 14 (5), pp 2304–2311
DOI: 10.1021/acs.jctc.7b01196

Calculation of Ligand Dissociation Energies in Large Transition-Metal Complexes
J. Chem. Theory Comput., 2018, 14 (5), pp 2456–2468
DOI: 10.1021/acs.jctc.8b00061

Finite-Size Effects of Binary Mutual Diffusion Coefficients from Molecular Dynamics
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (5), pp 2667–2677
DOI: 10.1021/acs.jctc.8b00170

On the Computational Characterization of Charge-Transfer Effects in Noncovalently Bound Molecular Complexes
J. Chem. Theory Comput., 2018, 14 (5), pp 2401–2417
DOI: 10.1021/acs.jctc.7b01256

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Journal of Medicinal Chemistry

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic
J. Med. Chem., 2018, 61 (9), pp 3845–3854
DOI: 10.1021/acs.jmedchem.8b00218

A Trojan-Horse Strategy Including a Bacterial Suicide Action for the Efficient Use of a Specific Gram-Positive Antibiotic on Gram-Negative Bacteria
J. Med. Chem., 2018, 61 (9), pp 3842–3844
DOI: 10.1021/acs.jmedchem.8b00522

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
J. Med. Chem., 2018, 61 (10), pp 4335–4347
DOI: 10.1021/acs.jmedchem.7b01698

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
J. Med. Chem., 2018, 61 (9), pp 4189–4202
DOI: 10.1021/acs.jmedchem.8b00347

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (10), pp 4283–4289
DOI: 10.1021/acs.jmedchem.7b01120

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Journal of Natural Products

ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk (Zea mays)
J. Nat. Prod., 2018, 81 (5), pp 1225–1234
DOI: 10.1021/acs.jnatprod.7b01017

Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
J. Nat. Prod., 2018, 81 (5), pp 1266–1277
DOI: 10.1021/acs.jnatprod.8b00170

Antinociceptive Diterpenoids from the Leaves and Twigs of Rhododendron decorum
J. Nat. Prod., 2018, 81 (5), pp 1183–1192
DOI: 10.1021/acs.jnatprod.7b00941

Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila
J. Nat. Prod., 2018, 81 (5), pp 1260–1265
DOI: 10.1021/acs.jnatprod.8b00135

Bioactivity-Guided Isolation of Potential Antidiabetic and Antihyperlipidemic Compounds from Trigonella stellata
J. Nat. Prod., 2018, 81 (5), pp 1154–1161
DOI: 10.1021/acs.jnatprod.7b00707

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The Journal of Physical Chemistry B

Dynamics of Long-Distance Hydrogen-Bond Networks in Photosystem II
Open access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (17), pp 4625–4641
DOI: 10.1021/acs.jpcb.8b00649

Effect of Hydrogen-Bonding Interaction on the Arrangement and Dynamics of Water Confined in a Polyamide Membrane: A Molecular Dynamics Simulation
J. Phys. Chem. B, 2018, 122 (17), pp 4719–4728
DOI: 10.1021/acs.jpcb.7b12790

Elucidating Structural Evolution of Perylene Diimide Aggregates Using Vibrational Spectroscopy and Molecular Dynamics Simulations
J. Phys. Chem. B, 2018, 122 (18), pp 4891–4900
DOI: 10.1021/acs.jpcb.8b02355

Generic Schemes for Single-Molecule Kinetics. 3: Self-Consistent Pathway Solutions for Nonrenewal Processes
J. Phys. Chem. B, 2018, 122 (17), pp 4601–4610
DOI: 10.1021/acs.jpcb.7b10507

Hydrogen-Bond Networks near Supported Lipid Bilayers from Vibrational Sum Frequency Generation Experiments and Atomistic Simulations
J. Phys. Chem. B, 2018, 122 (18), pp 4870–4879
DOI: 10.1021/acs.jpcb.8b02138

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The Journal of Physical Chemistry Letters

Fourier Transform Infrared Analysis of the S-State Cycle of Water Oxidation in the Microcrystals of Photosystem II
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2018, 9 (9), pp 2121–2126
DOI: 10.1021/acs.jpclett.8b00638

HOMO Level Pinning in Molecular Junctions: Joint Theoretical and Experimental Evidence
J. Phys. Chem. Lett., 2018, 9 (9), pp 2394–2403
DOI: 10.1021/acs.jpclett.8b00575

Noncovalent Molecular Electronics
J. Phys. Chem. Lett., 2018, 9 (9), pp 2298–2304
DOI: 10.1021/acs.jpclett.8b00980

One-Dimensional Organic–Inorganic Hybrid Perovskite Incorporating Near-Infrared-Absorbing Cyanine Cations
J. Phys. Chem. Lett., 2018, 9 (9), pp 2438–2442
DOI: 10.1021/acs.jpclett.8b00458

Organic–Inorganic Hybrid Ruddlesden–Popper Perovskites: An Emerging Paradigm for High-Performance Light-Emitting Diodes
J. Phys. Chem. Lett., 2018, 9 (9), pp 2251–2258
DOI: 10.1021/acs.jpclett.8b00755

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Journal of Proteome Research

A Cost-Effective High-Throughput Plasma and Serum Proteomics Workflow Enables Mapping of the Molecular Impact of Total Pancreatectomy with Islet Autotransplantation
J. Proteome Res., 2018, 17 (5), pp 1983–1992
DOI: 10.1021/acs.jproteome.8b00111

Enhanced Global Post-translational Modification Discovery with MetaMorpheus
J. Proteome Res., 2018, 17 (5), pp 1844–1851
DOI: 10.1021/acs.jproteome.7b00873

In Silico Enhancing M. tuberculosis Protein Interaction Networks in STRING To Predict Drug-Resistance Pathways and Pharmacological Risks
J. Proteome Res., 2018, 17 (5), pp 1749–1760
DOI: 10.1021/acs.jproteome.7b00702

Labeling Carboxyl Groups of Surface-Exposed Proteins Provides an Orthogonal Approach for Cell Surface Isolation
J. Proteome Res., 2018, 17 (5), pp 1784–1793
DOI: 10.1021/acs.jproteome.7b00825

Native State Organization of Outer Membrane Porins Unraveled by HDx-MS
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (5), pp 1794–1800
DOI: 10.1021/acs.jproteome.7b00830

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Molecular Pharmaceutics

A Novel AS1411 Aptamer-Based Three-Way Junction Pocket DNA Nanostructure Loaded with Doxorubicin for Targeting Cancer Cells in Vitro and in Vivo
Mol. Pharmaceutics, 2018, 15 (5), pp 1972–1978
DOI: 10.1021/acs.molpharmaceut.8b00124

Grapefruit Flavonoid Naringenin Regulates the Expression of LXRα in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase
Mol. Pharmaceutics, 2018, 15 (5), pp 1735–1745
DOI: 10.1021/acs.molpharmaceut.7b00797

In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration
Mol. Pharmaceutics, 2018, 15 (5), pp 2060–2067
DOI: 10.1021/acs.molpharmaceut.7b01084

Iron Oxide Nanoparticles-Based Vaccine Delivery for Cancer Treatment
Mol. Pharmaceutics, 2018, 15 (5), pp 1791–1799
DOI: 10.1021/acs.molpharmaceut.7b01103

Multiple Linear Regression Modeling To Predict the Stability of Polymer–Drug Solid Dispersions: Comparison of the Effects of Polymers and Manufacturing Methods on Solid Dispersion Stability
Mol. Pharmaceutics, 2018, 15 (5), pp 1826–1841
DOI: 10.1021/acs.molpharmaceut.8b00021