Discover the Most-Read Biological Chemistry Articles of September 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in September 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of September’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering

Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection
ACS Biomater. Sci. Eng., 2018, 4 (9), pp 3356–3363
DOI: 10.1021/acsbiomaterials.8b00653

Ultraflexible Self-Healing Guar Gum-Glycerol Hydrogel with Injectable, Antifreeze, and Strain-Sensitive Properties
ACS Biomater. Sci. Eng., 2018, 4 (9), pp 3397–3404
DOI: 10.1021/acsbiomaterials.8b00657

Bioprinting of Stem Cells: Interplay of Bioprinting Process, Bioinks, and Stem Cell Properties
ACS Biomater. Sci. Eng., 2018, 4 (9), pp 3108–3124
DOI: 10.1021/acsbiomaterials.8b00399

Modulating Bone Regeneration in Rabbit Condyle Defects with Three Surface-Structured Tricalcium Phosphate Ceramics
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2018, 4 (9), pp 3347–3355
DOI: 10.1021/acsbiomaterials.8b00630

Rational Surface Design of Upconversion Nanoparticles with Polyethylenimine Coating for Biomedical Applications: Better Safe than Brighter?
ACS Biomater. Sci. Eng., 2018, 4 (9), pp 3143–3153
DOI: 10.1021/acsbiomaterials.8b00633

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ACS Catalysis

Dehydration, Dienes, High Octane, and High Pressures: Contributions from Vladimir Nikolaevich Ipatieff, a Father of Catalysis
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (9), pp 8531–8539
DOI: 10.1021/acscatal.8b02310

A Matter of Life(time) and Death
ACS Catal., 2018, 8 (9), pp 8597–8599
DOI: 10.1021/acscatal.8b03199

Viewpoint on the Partial Oxidation of Methane to Methanol Using Cu- and Fe-Exchanged Zeolites
ACS Catal., 2018, 8 (9), pp 8306–8313
DOI: 10.1021/acscatal.8b01180

The Use of Controls for Consistent and Accurate Measurements of Electrocatalytic Ammonia Synthesis from Dinitrogen
ACS Catal., 2018, 8 (9), pp 7820–7827
DOI: 10.1021/acscatal.8b02120

Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)-ones
ACS Catal., 2018, 8 (9), pp 8925–8931
DOI: 10.1021/acscatal.8b02445

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Quantitative Live-Cell Kinetic Degradation and Mechanistic Profiling of PROTAC Mode of Action
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (9), pp 2758–2770
DOI: 10.1021/acschembio.8b00692

Development of a Multiplexed Activity-Based Protein Profiling Assay to Evaluate Activity of Endocannabinoid Hydrolase Inhibitors
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (9), pp 2406–2413
DOI: 10.1021/acschembio.8b00534

Homo-PROTACs for the Chemical Knockdown of Cereblon
ACS Chem. Biol., 2018, 13 (9), pp 2771–2782
DOI: 10.1021/acschembio.8b00693

Introducing Our Authors
ACS Chem. Biol., 2018, 13 (9), pp 2360–2363
DOI: 10.1021/acschembio.8b00831

SNAP-Tagged Nanobodies Enable Reversible Optical Control of a G Protein-Coupled Receptor via a Remotely Tethered Photoswitchable Ligand
ACS Chem. Biol., 2018, 13 (9), pp 2682–2688
DOI: 10.1021/acschembio.8b00628

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ACS Chemical Neuroscience

What Papers Are People Citing and What Are People Reading?
ACS Chem. Neurosci., 2018, 9 (9), pp 2097–2098
DOI: 10.1021/acschemneuro.8b00438

Role of Endogenous Metabolite Alterations in Neuropsychiatric Disease
This article is part of the Synaptic Plasticity special issue.
ACS Chem. Neurosci., 2018, 9 (9), pp 2101–2113
DOI: 10.1021/acschemneuro.8b00145

Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
This article is part of the Synaptic Plasticity special issue.
ACS Chem. Neurosci., 2018, 9 (9), pp 2114–2126
DOI: 10.1021/acschemneuro.7b00420

Intracellular GPCRs Play Key Roles in Synaptic Plasticity
This article is part of the Synaptic Plasticity special issue.
ACS Chem. Neurosci., 2018, 9 (9), pp 2162–2172
DOI: 10.1021/acschemneuro.7b00516

In This Issue, Volume 9, Issue 9
This article is part of the Synaptic Plasticity special issue.
ACS Chem. Neurosci., 2018, 9 (9), pp 2099–2100
DOI: 10.1021/acschemneuro.8b00467

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ACS Infectious Diseases

Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (9), pp 1355–1367
DOI: 10.1021/acsinfecdis.8b00093

Nature Builds Macrocycles and Heterocycles into Its Antimicrobial Frameworks: Deciphering Biosynthetic Strategy
ACS Infect. Dis., 2018, 4 (9), pp 1283–1299
DOI: 10.1021/acsinfecdis.8b00101

Evaluating LC–MS/MS To Measure Accumulation of Compounds within Bacteria
ACS Infect. Dis., 2018, 4 (9), pp 1336–1345
DOI: 10.1021/acsinfecdis.8b00083

Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein
ACS Infect. Dis., 2018, 4 (9), pp 1395–1406
DOI: 10.1021/acsinfecdis.8b00127

Synthesis and Preclinical Evaluation of TPA-Based Zinc Chelators as Metallo-β-lactamase Inhibitors
ACS Infect. Dis., 2018, 4 (9), pp 1407–1422
DOI: 10.1021/acsinfecdis.8b00137

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ACS Medicinal Chemistry Letters

Precedence and Promise of Covalent Inhibitors of EGFR and KRAS for Patients with Non-Small-Cell Lung Cancer
ACS Med. Chem. Lett., 2018, 9 (9), pp 861–863
DOI: 10.1021/acsmedchemlett.8b00311

VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
ACS Med. Chem. Lett., 2018, 9 (9), pp 917–922
DOI: 10.1021/acsmedchemlett.8b00261

5-HT2C Receptor Agonists for the Treatment of Obesity
ACS Med. Chem. Lett., 2018, 9 (9), pp 864–865
DOI: 10.1021/acsmedchemlett.8b00328

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
ACS Med. Chem. Lett., 2018, 9 (9), pp 941–946
DOI: 10.1021/acsmedchemlett.8b00296

A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth
ACS Med. Chem. Lett., 2018, 9 (9), pp 901–906
DOI: 10.1021/acsmedchemlett.8b00212

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ACS Synthetic Biology

Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins
ACS Synth. Biol., 2018, 7 (9), pp 2014–2022
DOI: 10.1021/acssynbio.8b00155

Establishing a High-Yielding Cell-Free Protein Synthesis Platform Derived from Vibrio natriegens
ACS Synth. Biol., 2018, 7 (9), pp 2245–2255
DOI: 10.1021/acssynbio.8b00252

Engineering Riboswitches in Vivo Using Dual Genetic Selection and Fluorescence-Activated Cell Sorting
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (9), pp 2000–2006
DOI: 10.1021/acssynbio.8b00099

Birth of a Photosynthetic Chassis: A MoClo Toolkit Enabling Synthetic Biology in the Microalga Chlamydomonas reinhardtii
ACS Synth. Biol., 2018, 7 (9), pp 2074–2086
DOI: 10.1021/acssynbio.8b00251

Quorum Sensing Can Be Repurposed To Promote Information Transfer between Bacteria in the Mammalian Gut
ACS Synth. Biol., 2018, 7 (9), pp 2270–2281
DOI: 10.1021/acssynbio.8b00271

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Biochemistry

Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation
Biochemistry, 2018, 57 (35), pp 5183–5187
DOI: 10.1021/acs.biochem.8b00314

The Stabilities of the Soluble Ectodomain and Fusion Peptide Hairpins of the Influenza Virus Hemagglutinin Subunit II Protein Are Positively Correlated with Membrane Fusion
Biochemistry, 2018, 57 (37), pp 5480–5493
DOI: 10.1021/acs.biochem.8b00764

Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin
Biochemistry, 2018, 57 (36), pp 5282–5288
DOI: 10.1021/acs.biochem.8b00576

Reverse Binding Mode of Phosphotyrosine Peptides with SH2 Protein
Biochemistry, 2018, 57 (35), pp 5257–5269
DOI: 10.1021/acs.biochem.8b00677

How Does Polymerization Regulate Human Acetyl-CoA Carboxylase 1?
Biochemistry, 2018, 57 (38), pp 5495–5496
DOI: 10.1021/acs.biochem.8b00881

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Bioconjugate Chemistry

Protein–Polymer Delivery: Chemistry from the Cold Chain to the Clinic
Bioconjugate Chem., 2018, 29 (9), pp 2867–2883
DOI: 10.1021/acs.bioconjchem.8b00483

Drug “Clicking” on Cell-Penetrating Fluorescent Nanoparticles for In Cellulo Chemical Proteomics
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (9), pp 3154–3160
DOI: 10.1021/acs.bioconjchem.8b00481

Highly Stable and Selective Tetrazines for the Coordination-Assisted Bioorthogonal Ligation with Vinylboronic Acids
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (9), pp 3054–3059
DOI: 10.1021/acs.bioconjchem.8b00439

Water-Soluble Isatoic Anhydrides: A Platform for RNA-SHAPE Analysis and Protein Bioconjugation
Bioconjugate Chem., 2018, 29 (9), pp 3196–3202
DOI: 10.1021/acs.bioconjchem.8b00518

Long-Acting Human Growth Hormone Analogue by Noncovalent Albumin Binding
Bioconjugate Chem., 2018, 29 (9), pp 3129–3143
DOI: 10.1021/acs.bioconjchem.8b00463

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Biomacromolecules

Recombinant Spidroins Fully Replicate Primary Mechanical Properties of Natural Spider Silk
Biomacromolecules, 2018, 19 (9), pp 3853–3860
DOI: 10.1021/acs.biomac.8b00980

Fabrication of Acidic pH-Cleavable Polymer for Anticancer Drug Delivery Using a Dual Functional Monomer
Biomacromolecules, 2018, 19 (9), pp 3874–3882
DOI: 10.1021/acs.biomac.8b01001

Angiogenic Self-Assembling Peptide Scaffolds for Functional Tissue Regeneration
Biomacromolecules, 2018, 19 (9), pp 3597–3611
DOI: 10.1021/acs.biomac.8b01137

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer
Biomacromolecules, 2018, 19 (9), pp 3840–3852
DOI: 10.1021/acs.biomac.8b00959

pH- and GSH-Sensitive Hyaluronic Acid-MP Conjugate Micelles for Intracellular Delivery of Doxorubicin to Colon Cancer Cells and Cancer Stem Cells
Biomacromolecules, 2018, 19 (9), pp 3725–3737
DOI: 10.1021/acs.biomac.8b00856
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Journal of Agricultural and Food Chemistry

Condensed Tannin Reacts with SO2 during Wine Aging, Yielding Flavan-3-ol Sulfonates
J. Agric. Food Chem., 2018, 66 (35), pp 9259–9268
DOI: 10.1021/acs.jafc.8b01996

Prevention of Atherosclerosis by Berries: The Case of Blueberries
J. Agric. Food Chem., 2018, 66 (35), pp 9172–9188
DOI: 10.1021/acs.jafc.8b03201

Perspectives on Liquid Chromatography–High-Resolution Mass Spectrometry for Pesticide Screening in Foods
J. Agric. Food Chem., 2018, 66 (37), pp 9573–9581
DOI: 10.1021/acs.jafc.8b03468

Two-Dimensional Tannin Fingerprints by Liquid Chromatography Tandem Mass Spectrometry Offer a New Dimension to Plant Tannin Analyses and Help To Visualize the Tannin Diversity in Plants
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (35), pp 9162–9171
DOI: 10.1021/acs.jafc.8b02115

Flavor Retention and Release from Beverages: A Kinetic and Thermodynamic Perspective
J. Agric. Food Chem., 2018, 66 (38), pp 9869–9881
DOI: 10.1021/acs.jafc.8b04459
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Journal of Chemical Theory and Computation

Transferability in Machine Learning for Electronic Structure via the Molecular Orbital Basis
J. Chem. Theory Comput., 2018, 14 (9), pp 4772–4779
DOI: 10.1021/acs.jctc.8b00636

Method Calibration or Data Fitting?
J. Chem. Theory Comput., 2018, 14 (9), pp 4651–4661
DOI: 10.1021/acs.jctc.8b00477

ProPOSE: Direct Exhaustive Protein–Protein Docking with Side Chain Flexibility
J. Chem. Theory Comput., 2018, 14 (9), pp 4938–4947
DOI: 10.1021/acs.jctc.8b00225

Transferable Dynamic Molecular Charge Assignment Using Deep Neural Networks
J. Chem. Theory Comput., 2018, 14 (9), pp 4687–4698
DOI: 10.1021/acs.jctc.8b00524

Wavefunction-like Correlation Model for Use in Hybrid Density Functionals
J. Chem. Theory Comput., 2018, 14 (9), pp 4590–4599
DOI: 10.1021/acs.jctc.8b00337
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Journal of Medicinal Chemistry

What Makes a Great Medicinal Chemist? A Personal Perspective
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (17), pp 7419–7424
DOI: 10.1021/acs.jmedchem.7b01445

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
J. Med. Chem., 2018, 61 (18), pp 8120–8135
DOI: 10.1021/acs.jmedchem.8b01040

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
J. Med. Chem., 2018, 61 (17), pp 7785–7795
DOI: 10.1021/acs.jmedchem.8b00765

Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine
J. Med. Chem., 2018, 61 (18), pp 8202–8211
DOI: 10.1021/acs.jmedchem.8b00666

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-6-methyl-N8-neopentylpyrido[3,4-d]pyrimidine-2,8-diamine (BOS172722)
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (18), pp 8226–8240
DOI: 10.1021/acs.jmedchem.8b00690
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Journal of Natural Products

Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review
J. Nat. Prod., 2018, 81 (9), pp 2138–2154
DOI: 10.1021/acs.jnatprod.8b00159

Rare Thioglycosides from the Roots of Wasabia japonica
J. Nat. Prod., 2018, 81 (9), pp 2129–2133
DOI: 10.1021/acs.jnatprod.8b00570

Absolute Configurations and Bioactivities of Guaiane-Type Sesquiterpenoids Isolated from Pogostemon cablin
J. Nat. Prod., 2018, 81 (9), pp 1919–1927
DOI: 10.1021/acs.jnatprod.7b00690

Dinghupeptins A–D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces
J. Nat. Prod., 2018, 81 (9), pp 1928–1936
DOI: 10.1021/acs.jnatprod.7b01009

GEX1A, a Polyketide from Streptomyces chromofuscus, Corrects the Cellular Defects Associated with Niemann-Pick Type C1 in Human Fibroblasts
J. Nat. Prod., 2018, 81 (9), pp 2018–2025
DOI: 10.1021/acs.jnatprod.8b00314
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The Journal of Physical Chemistry B

Virtual Issue on Physical Chemistry in South Korea
J. Phys. Chem. B, 2018, 122 (35), pp 8315–8316
DOI: 10.1021/acs.jpcb.8b07245

Long-Range Modulations of Electric Fields in Proteins
J. Phys. Chem. B, 2018, 122 (35), pp 8330–8342
DOI: 10.1021/acs.jpcb.8b03870

Come Together: Molecular Details into the Synergistic Effects of Polymer–Surfactant Adsorption at the Oil/Water Interface
J. Phys. Chem. B, 2018, 122 (36), pp 8582–8590
DOI: 10.1021/acs.jpcb.8b05432

Reinforcement Learning Based Adaptive Sampling: REAPing Rewards by Exploring Protein Conformational Landscapes
J. Phys. Chem. B, 2018, 122 (35), pp 8386–8395
DOI: 10.1021/acs.jpcb.8b06521

Sugar-Mediated Stabilization of Protein against Chemical or Thermal Denaturation
J. Phys. Chem. B, 2018, 122 (37), pp 8685–8697
DOI: 10.1021/acs.jpcb.8b06572
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The Journal of Physical Chemistry Letters

Lonely Atoms with Special Gifts: Breaking Linear Scaling Relationships in Heterogeneous Catalysis with Single-Atom Alloys
J. Phys. Chem. Lett., 2018, 9 (18), pp 5636–5646
DOI: 10.1021/acs.jpclett.8b01888

Virtual Issue on Physical Chemistry in South Korea
J. Phys. Chem. Lett., 2018, 9 (17), pp 4893–4894
DOI: 10.1021/acs.jpclett.8b02345

Electrochemical Synthesis of Ammonia from N2 and H2O under Ambient Conditions Using Pore-Size-Controlled Hollow Gold Nanocatalysts with Tunable Plasmonic Properties
J. Phys. Chem. Lett., 2018, 9 (17), pp 5160–5166
DOI: 10.1021/acs.jpclett.8b02188

Point Defects and Green Emission in Zero-Dimensional Perovskites
J. Phys. Chem. Lett., 2018, 9 (18), pp 5490–5495
DOI: 10.1021/acs.jpclett.8b02477

Invalidity of Band-Gap Engineering Concept for Bi3+ Heterovalent Doping in CsPbBr3 Halide Perovskite
J. Phys. Chem. Lett., 2018, 9 (18), pp 5408–5411
DOI: 10.1021/acs.jpclett.8b02178
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Journal of Proteome Research

S-Trap, an Ultrafast Sample-Preparation Approach for Shotgun Proteomics
J. Proteome Res., 2018, 17 (9), pp 2917–2924
DOI: 10.1021/acs.jproteome.8b00505

Highly Efficient Phosphoproteome Capture and Analysis from Urinary Extracellular Vesicles
J. Proteome Res., 2018, 17 (9), pp 3308–3316
DOI: 10.1021/acs.jproteome.8b00459

Development of in Planta Chemical Cross-Linking-Based Quantitative Interactomics in Arabidopsis
J. Proteome Res., 2018, 17 (9), pp 3195–3213
DOI: 10.1021/acs.jproteome.8b00320

Proteomic Analysis of Urine from California Sea Lions (Zalophus californianus): A Resource for Urinary Biomarker Discovery
J. Proteome Res., 2018, 17 (9), pp 3281–3291
DOI: 10.1021/acs.jproteome.8b00416

HyPR-MS for Multiplexed Discovery of MALAT1, NEAT1, and NORAD lncRNA Protein Interactomes
J. Proteome Res., 2018, 17 (9), pp 3022–3038
DOI: 10.1021/acs.jproteome.8b00189
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Molecular Pharmaceutics

New Directions for Drug Delivery in Cancer Therapy
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3601–3602
DOI: 10.1021/acs.molpharmaceut.8b00860

Peptide-Based 68Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2018, 15 (9), pp 3946–3952
DOI: 10.1021/acs.molpharmaceut.8b00399

Drug Delivery in Cancer Therapy, Quo Vadis?
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3603–3616
DOI: 10.1021/acs.molpharmaceut.8b00037

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges
This article is part of the New Directions for Drug Delivery in Cancer Therapy special issue.
Mol. Pharmaceutics, 2018, 15 (9), pp 3625–3633
DOI: 10.1021/acs.molpharmaceut.8b00277

Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility
Mol. Pharmaceutics, 2018, 15 (9), pp 3846–3859
DOI: 10.1021/acs.molpharmaceut.8b00341