This Special Issue will focus on new developments in protein and nucleic acid delivery: new tools and techniques, biochemical mechanisms that impact delivery, and strategies to manipulate biology and biological matter to facilitate delivery. Submit by September 30, 2024.

The development of new therapeutics often begins with the discovery of a high-affinity inhibitor, but is not complete until that drug can be safely and reliably delivered to the target site. This delivery is complicated by transport, physical barriers and other aspects of host biology, and has become a greater challenge as more biologics enter the drug development pipeline.

Protein and nucleic acid-derived drugs are the fastest growing segment of therapeutic development, treating diseases from late-stage cancer to emerging pathogens and societally impacting autoimmune conditions. The impact of protein and nucleic acid-derived molecules on human health could be even greater if these molecules could reliably and efficiently reach the cell interior.

A new Special Issue from Biochemistry will focus on new developments in protein and nucleic acid delivery: new tools and techniques to study delivery, biochemical mechanisms that impact delivery, and strategies to manipulate biology and biological matter to facilitate delivery.

Relevant topics include:

  • Virus-like particles
  • Virus-derived machines
  • Endosomal escape
  • Protein conjugation
  • The blood-brain barrier
  • New physicochemical frameworks
  • New tools/techniques to monitor drug delivery

How to Submit:

  • Log in to the ACS Paragon Plus submission site
  • Choose Biochemistry as your journal
  • Select your manuscript type
  • Under ‘Special Issue Selection’, choose ‘Drug Delivery.'

Please see Biochemistry’s Author Guidelines for more information on submission requirements. The deadline for submissions is September 30, 2024.

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