We’ve compiled lists of the most-read chemistry articles across ACS journals in 2016, including research, reviews, perspectives and editorial pieces.
There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.
Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.
Read more most-read articles: Analytical | Applied | Materials Science & Engineering | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering
Designing Biomaterials for 3D Printing
This article is part of the 3D Bioprinting special issue.
ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1679–1693
DOI: 10.1021/acsbiomaterials.6b00121
3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1781–1786
DOI: 10.1021/acsbiomaterials.6b00170
Liquid-like Solids Support Cells in 3D
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1787–1795
DOI: 10.1021/acsbiomaterials.6b00218
Critical Length of PEG Grafts on lPEI/DNA Nanoparticles for Efficient in Vivo Delivery
Open Access Through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2016, 2 (4), pp 567–578
DOI: 10.1021/acsbiomaterials.5b00551
Polymeric Biomaterials for Medical Implants and Devices
ACS Biomater. Sci. Eng., 2016, 2 (4), pp 454–472
DOI: 10.1021/acsbiomaterials.5b00429
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Cobalt-Catalyzed C–H Activation
ACS Catal., 2016, 6 (2), pp 498–525
DOI: 10.1021/acscatal.5b02344
Toward Benchmarking in Catalysis Science: Best Practices, Challenges, and Opportunities
Open Access Through ACS Editors’ Choice
ACS Catal., 2016, 6 (4), pp 2590–2602
DOI: 10.1021/acscatal.6b00183
Metal-Catalyzed Carboxylation of Organic (Pseudo)halides with CO2
ACS Catal., 2016, 6 (10), pp 6739–6749
DOI: 10.1021/acscatal.6b02124
Catalytic Methods for Aromatic C–H Amination: An Ideal Strategy for Nitrogen-Based Functional Molecules
ACS Catal., 2016, 6 (2), pp 610–633
DOI: 10.1021/acscatal.5b02417
Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis
ACS Catal., 2016, 6 (9), pp 5887–5903
DOI: 10.1021/acscatal.6b01222
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ACS Central Science
Catalytic Oxidation of Methane into Methanol over Copper-Exchanged Zeolites with Oxygen at Low Temperature
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (6), pp 424–429
DOI: 10.1021/acscentsci.6b00139
Achieving Gender Balance in the Chemistry Professoriate Is Not Rocket Science
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (4), pp 181–182
DOI: 10.1021/acscentsci.6b00102
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (10), pp 687–701
DOI: 10.1021/acscentsci.6b00086
Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (5), pp 302–308
DOI: 10.1021/acscentsci.6b00091
Neural Networks for the Prediction of Organic Chemistry Reactions
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (10), pp 725–732
DOI: 10.1021/acscentsci.6b00219
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Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries
ACS Chem. Biol., Article ASAP
DOI: 10.1021/acschembio.6b00646
Strategies and Approaches of Targeting STAT3 for Cancer Treatment
ACS Chem. Biol., 2016, 11 (2), pp 308–318
DOI: 10.1021/acschembio.5b00945
Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering
ACS Chem. Biol., 2016, 11 (3), pp 681–688
DOI: 10.1021/acschembio.5b01019
A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo
ACS Chem. Biol., 2016, 11 (4), pp 1058–1065
DOI: 10.1021/acschembio.5b01006
Why Nature Chose Selenium
ACS Chem. Biol., 2016, 11 (4), pp 821–841
DOI: 10.1021/acschembio.6b00031
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Lost in Translation: The Death of Basic Science
ACS Chem. Neurosci., 2016, 7 (8), pp 1024–1024
DOI: 10.1021/acschemneuro.6b00206
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
Open Access Through ACS Editors’ Choice
Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model
Open Access Through ACS Editors’ Choice
ACS Chem. Neurosci., 2016, 7 (5), pp 588–598
DOI: 10.1021/acschemneuro.5b00342
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids
The Critical Role of Organic Chemistry in Drug Discovery
ACS Chem. Neurosci., 2016, 7 (10), pp 1315–1316
DOI: 10.1021/acschemneuro.6b00280
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ACS Infectious Diseases
Zika Virus: Diagnosis, Therapeutics, and Vaccine
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (3), pp 170–172
DOI: 10.1021/acsinfecdis.6b00030
Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (10), pp 674–681
DOI: 10.1021/acsinfecdis.6b00109
Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody Recruitment
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (4), pp 302–309
DOI: 10.1021/acsinfecdis.6b00007
A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (7), pp 489–499
DOI: 10.1021/acsinfecdis.6b00044
De Novo Sequencing and Resurrection of a Human Astrovirus-Neutralizing Antibody
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (5), pp 313–321
DOI: 10.1021/acsinfecdis.6b00026
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ACS Medicinal Chemistry Letters
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Open Access Through ACS Editors’ Choice
ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
DOI: 10.1021/acsmedchemlett.6b00005
Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer
ACS Med. Chem. Lett., 2016, 7 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.5b00475
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Open Access Through ACS Editors’ Choice
ACS Med. Chem. Lett., 2016, 7 (11), pp 977–982
DOI: 10.1021/acsmedchemlett.6b00195
High Drug Prices Hurt Everyone
ACS Med. Chem. Lett., 2016, 7 (6), pp 544–546
DOI: 10.1021/acsmedchemlett.6b00139
GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Open Access Through ACS Editors’ Choice
ACS Med. Chem. Lett., 2016, 7 (6), pp 552–557
DOI: 10.1021/acsmedchemlett.6b00092
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ACS Synthetic Biology
Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR–Cas9-Mediated Genome Editing in Yarrowia lipolytica
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2016, 5 (4), pp 356–359
DOI: 10.1021/acssynbio.5b00162
Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2016, 5 (5), pp 375–385
DOI: 10.1021/acssynbio.5b00216
Rapid and Efficient One-Step Metabolic Pathway Integration in E. coli
ACS Synth. Biol., 2016, 5 (7), pp 561–568
DOI: 10.1021/acssynbio.5b00187
Cell–Cell Communication in Yeast Using Auxin Biosynthesis and Auxin Responsive CRISPR Transcription Factors
ACS Synth. Biol., 2016, 5 (4), pp 279–286
DOI: 10.1021/acssynbio.5b00064
Multiple Gene Repression in Cyanobacteria Using CRISPRi
ACS Synth. Biol., 2016, 5 (3), pp 207–212
DOI: 10.1021/acssynbio.5b00264
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On the Temperature Dependence of Enzyme-Catalyzed Rates
Open Access Through ACS Editors’ Choice
Biochemistry, 2016, 55 (12), pp 1681–1688
DOI: 10.1021/acs.biochem.5b01094
A Soluble, Folded Protein without Charged Amino Acid Residues
Open Access Through ACS Editors’ Choice
Biochemistry, 2016, 55 (28), pp 3949–3956
DOI: 10.1021/acs.biochem.6b00269
PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease
This article is part of the Epigenetics special issue.
Biochemistry, 2016, 55 (11), pp 1600–1614
DOI: 10.1021/acs.biochem.5b01191
Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides
Biochemistry, 2016, 55 (18), pp 2601–2612
DOI: 10.1021/acs.biochem.6b00226
Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin
This article is part of the Epigenetics special issue.
Biochemistry, 2016, 55 (11), pp 1615–1630
DOI: 10.1021/acs.biochem.5b01141
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Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2016, 27 (1), pp 217–225
DOI: 10.1021/acs.bioconjchem.5b00613
Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Open Access Through ACS Editors’ Choice
Bioconjugate Chem., 2016, 27 (12), pp 2931–2942
DOI: 10.1021/acs.bioconjchem.6b00603
18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2016, 27 (2), pp 298–301
DOI: 10.1021/acs.bioconjchem.5b00504
New Chelators for Low Temperature Al18F-Labeling of Biomolecules
Open Access Through ACS Editors’ Choice
Bioconjugate Chem., 2016, 27 (3), pp 790–798
DOI: 10.1021/acs.bioconjchem.6b00012
NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence
Bioconjugate Chem., 2016, 27 (5), pp 1175–1187
DOI: 10.1021/acs.bioconjchem.6b00112
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Optically Transparent Wood from a Nanoporous Cellulosic Template: Combining Functional and Structural Performance
Open Access Through ACS AuthorChoice
Biomacromolecules, 2016, 17 (4), pp 1358–1364
DOI: 10.1021/acs.biomac.6b00145
Biomimetic Polymers for Cardiac Tissue Engineering
Open Access Through ACS Editors’ Choice
Biomacromolecules, 2016, 17 (5), pp 1593–1601
DOI: 10.1021/acs.biomac.5b01734
Click Chemistry in Biomaterials, Nanomedicine, and Drug Delivery
Biomacromolecules, 2016, 17 (1), pp 1–3
DOI: 10.1021/acs.biomac.5b01660
Thermoresponsive Delivery of Paclitaxel by β-Cyclodextrin-Based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation
Open Access Through ACS Editors’ Choice
Biomacromolecules, 2016, 17 (12), pp 3957–3963
DOI: 10.1021/acs.biomac.6b01344
Thermodynamic Presynthetic Considerations for Ring-Opening Polymerization
Biomacromolecules, 2016, 17 (3), pp 699–709
DOI: 10.1021/acs.biomac.5b01698
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Journal of Agricultural and Food Chemistry
Determination of Glyphosate Levels in Breast Milk Samples from Germany by LC-MS/MS and GC-MS/MS
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2016, 64 (6), pp 1414–1421
DOI: 10.1021/acs.jafc.5b05852
Antioxidant Mechanism of Betaine without Free Radical Scavenging Ability
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2016, 64 (42), pp 7921–7930
DOI: 10.1021/acs.jafc.6b03592
Nanoencapsulation, Nano-guard for Pesticides: A New Window for Safe Application
J. Agric. Food Chem., 2016, 64 (7), pp 1447–1483
DOI: 10.1021/acs.jafc.5b05214
Sulfoglucosides as Novel Modified Forms of the Mycotoxins Alternariol and Alternariol Monomethyl Ether
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2016, 64 (46), pp 8892–8901
DOI: 10.1021/acs.jafc.6b03120
Global Adoption of Genetically Modified (GM) Crops: Challenges for the Public Sector
J. Agric. Food Chem., 2016, 64 (2), pp 394–402
DOI: 10.1021/acs.jafc.5b05116
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Journal of Chemical Theory and Computation
CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
Open Access Through ACS AuthorChoice
Demonstrating an Order-of-Magnitude Sampling Enhancement in Molecular Dynamics Simulations of Complex Protein Systems
A Practical Guide to Density Matrix Embedding Theory in Quantum Chemistry
Open Access Through ACS Editors’ Choice
J. Chem. Theory Comput., 2016, 12 (6), pp 2706–2719
DOI: 10.1021/acs.jctc.6b00316
OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
Black-Box Description of Electron Correlation with the Spin-Extended Configuration Interaction Model: Implementation and Assessment
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Journal of Medicinal Chemistry
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Open Access Through ACS Editors’ Choice
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Open Access Through ACS AuthorChoice
AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective
The Medicinal Chemistry of Dengue Virus
Open Access Through ACS Editors’ Choice
A Real-World Perspective on Molecular Design
This article is part of the Computational Methods for Medicinal Chemistry special issue.
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Natural Products as Sources of New Drugs from 1981 to 2014
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2016, 79 (3), pp 629–661
DOI: 10.1021/acs.jnatprod.5b01055
Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2016, 79 (8), pp 1962–1970
DOI: 10.1021/acs.jnatprod.6b00215
Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2016, 79 (3), pp 616–628
DOI: 10.1021/acs.jnatprod.5b00947
LC-MS- and 1H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2016, 79 (1), pp 30–37
DOI: 10.1021/acs.jnatprod.5b00556
Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum
Open Access Through ACS Editors’ Choice
J. Nat. Prod., 2016, 79 (9), pp 2250–2256
DOI: 10.1021/acs.jnatprod.6b00345
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The Journal of Physical Chemistry B
Molecular Modeling of Water Interfaces: From Molecular Spectroscopy to Thermodynamics
Open Access Through ACS Editors’ Choice
Statistical Analyses of Hydrophobic Interactions: A Mini-Review
Open Access Through ACS Editors’ Choice
Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region
Open Access Through ACS Editors’ Choice
How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase
Open Access Through ACS Editors’ Choice
Advanced Potential Energy Surfaces for Molecular Simulation
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The Journal of Physical Chemistry Letters
Cesium Lead Halide Perovskites with Improved Stability for Tandem Solar Cells
Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis
Open Access Through ACS Editors’ Choice
Efficient Monolithic Perovskite/Silicon Tandem Solar Cell with Cell Area >1 cm2
Origin of J–V Hysteresis in Perovskite Solar Cells
Lead-Free Halide Double Perovskites via Heterovalent Substitution of Noble Metals
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Journal of Proteome Research
Proteomics Quality Control: Quality Control Software for MaxQuant Results
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice
J. Proteome Res., 2016, 15 (3), pp 777–787
DOI: 10.1021/acs.jproteome.5b00780
Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism
Open Access Through ACS AuthorChoice
J. Proteome Res., 2016, 15 (2), pp 608–618
DOI: 10.1021/acs.jproteome.5b01020
A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting
Open Access Through ACS AuthorChoice
J. Proteome Res., 2016, 15 (7), pp 2321–2326
DOI: 10.1021/acs.jproteome.6b00403
Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies
Open Access Through ACS AuthorChoice
J. Proteome Res., 2016, 15 (4), pp 1116–1125
DOI: 10.1021/acs.jproteome.5b00981
moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice
J. Proteome Res., 2016, 15 (3), pp 755–765
DOI: 10.1021/acs.jproteome.5b00824
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Molecular Pharmaceutics
Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
Open Access Through ACS Editors’ Choice
Applications of Deep Learning in Biomedicine
In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
Open Access Through ACS Editors’ Choice
Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
Open Access Through ACS Editors’ Choice
Molecular Imaging of Pancreatic Cancer with Antibodies
Open Access Through ACS AuthorChoice
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Read more most-read articles: Analytical | Applied | Materials Science & Engineering | Organic/Inorganic | Physical
