Discover the Most-Read Biological Chemistry Articles of July 2017

What were chemists reading in July of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in July 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great July 2017 Chemistry Research:
Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices
ACS Biomater. Sci. Eng., 2017, 3 (7), pp 1172–1174
DOI: 10.1021/acsbiomaterials.7b00372

3D Fabrication of Polymeric Scaffolds for Regenerative Therapy
ACS Biomater. Sci. Eng., 2017, 3 (7), pp 1175–1194
DOI: 10.1021/acsbiomaterials.6b00370

Overview of the Development, Applications, and Future Perspectives of Decellularized Tissues and Organs
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (7), pp 1236–1244
DOI: 10.1021/acsbiomaterials.6b00506

Titanium Coatings and Surface Modifications: Toward Clinically Useful Bioactive Implants
ACS Biomater. Sci. Eng., 2017, 3 (7), pp 1245–1261
DOI: 10.1021/acsbiomaterials.6b00604

Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair
ACS Biomater. Sci. Eng., 2017, 3 (7), pp 1221–1235
DOI: 10.1021/acsbiomaterials.6b00500

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ACS Catalysis

Ceria Catalysts at Nanoscale: How Do Crystal Shapes Shape Catalysis?
ACS Catal., 2017, 7 (7), pp 4716–4735
DOI: 10.1021/acscatal.7b01246

Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (7), pp 4381–4385
DOI: 10.1021/acscatal.7b01444

Engaging Radicals in Transition Metal-Catalyzed Cross-Coupling with Alkyl
ACS Catal., 2017, 7 (7), pp 4697–4706
DOI: 10.1021/acscatal.7b01405

Global Scholarly Publishing and the Impact of Catalysis
ACS Catal., 2017, 7 (7), pp 4621–4622
DOI: 10.1021/acscatal.7b01764

Understanding Selectivity for the Electrochemical Reduction of Carbon Dioxide to Formic Acid and Carbon Monoxide on Metal Electrodes
ACS Catal., 2017, 7 (7), pp 4822–4827
DOI: 10.1021/acscatal.7b00687

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ACS Chemical Biology

Yellow and Orange Fluorescent Proteins with Tryptophan-based Chromophores
ACS Chem. Biol., 2017, 12 (7), pp 1867–1873
DOI: 10.1021/acschembio.7b00337

Activation of Natural Products Biosynthetic Pathways via a Protein Modification Level Regulation
ACS Chem. Biol., 2017, 12 (7), pp 1732–1736
DOI: 10.1021/acschembio.7b00225

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ
ACS Chem. Biol., 2017, 12 (7), pp 1947–1955
DOI: 10.1021/acschembio.7b00323

Stabilization of Glucocerebrosidase by Active Site Occupancy
Open Access through ACS AuthorChoice
ACS Chem. Biol., 2017, 12 (7), pp 1830–1841
DOI: 10.1021/acschembio.7b00276

P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides
ACS Chem. Biol., 2017, 12 (7), pp 1726–1731
DOI: 10.1021/acschembio.7b00358

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ACS Chemical Neuroscience

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease?
ACS Chem. Neurosci., 2017, 8 (7), pp 1435–1437
DOI: 10.1021/acschemneuro.7b00188

Is the Microbiome the Fifth Horseman of the Apocalypse in Drug Discovery? Implications for the Gut–Brain Axis
ACS Chem. Neurosci., 2017, 8 (7), pp 1430–1430
DOI: 10.1021/acschemneuro.7b00234

Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders
ACS Chem. Neurosci., 2017, 8 (7), pp 1438–1447
DOI: 10.1021/acschemneuro.7b00176

Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics
ACS Chem. Neurosci., 2017, 8 (7), pp 1570–1576
DOI: 10.1021/acschemneuro.7b00079

The Psychiatric Impact of HIV
ACS Chem. Neurosci., 2017, 8 (7), pp 1432–1434
DOI: 10.1021/acschemneuro.7b00169

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ACS Infectious Diseases

In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1
Open Access through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (7), pp 492–501
DOI: 10.1021/acsinfecdis.7b00017

Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights
ACS Infect. Dis., 2017, 3 (7), pp 479–491
DOI: 10.1021/acsinfecdis.6b00189

Structural Basis for Xenosiderophore Utilization by the Human Pathogen Staphylococcus aureus
ACS Infect. Dis., 2017, 3 (7), pp 542–553
DOI: 10.1021/acsinfecdis.7b00036

Overcoming an Extremely Drug Resistant (XDR) Pathogen: Avibactam Restores Susceptibility to Ceftazidime for Burkholderia cepacia Complex Isolates from Cystic Fibrosis Patients
ACS Infect. Dis., 2017, 3 (7), pp 502–511
DOI: 10.1021/acsinfecdis.7b00020

An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall
ACS Infect. Dis., 2017, 3 (7), pp 462–466
DOI: 10.1021/acsinfecdis.7b00019

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ACS Medicinal Chemistry Letters

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
ACS Med. Chem. Lett., 2017, 8 (7), pp 771–774
DOI: 10.1021/acsmedchemlett.7b00211

Taking Pharmaceutical Innovation to the Masses
ACS Med. Chem. Lett., 2017, 8 (7), pp 686–689
DOI: 10.1021/acsmedchemlett.7b00173

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor
ACS Med. Chem. Lett., 2017, 8 (7), pp 694–700
DOI: 10.1021/acsmedchemlett.7b00224

Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole
ACS Med. Chem. Lett., 2017, 8 (7), pp 762–765
DOI: 10.1021/acsmedchemlett.7b00189

Biosimilars: Imitation Games
ACS Med. Chem. Lett., 2017, 8 (7), pp 690–693
DOI: 10.1021/acsmedchemlett.7b00199

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ACS Synthetic Biology

A Straightforward Approach for 3D Bacterial Printing
Open Access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (7), pp 1124–1130
DOI: 10.1021/acssynbio.6b00395

A Visual Language for Protein Design
ACS Synth. Biol., 2017, 6 (7), pp 1120–1123
DOI: 10.1021/acssynbio.6b00286

ROC’n’Ribo: Characterizing a Riboswitching Expression System by Modeling Single-Cell Data
ACS Synth. Biol., 2017, 6 (7), pp 1211–1224
DOI: 10.1021/acssynbio.6b00322

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (7), pp 1235–1247
DOI: 10.1021/acssynbio.7b00232

Repurposing a Two-Component System-Based Biosensor for the Killing of Vibrio cholerae
ACS Synth. Biol., 2017, 6 (7), pp 1403–1415
DOI: 10.1021/acssynbio.7b00058

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Biochemistry

Hole Hopping through Tryptophan in Cytochrome P450
Open Access through ACS Editors’ Choice
Biochemistry, 2017, 56 (28), pp 3531–3538
DOI: 10.1021/acs.biochem.7b00432

Identification of Microprotein–Protein Interactions via APEX Tagging
Open Access through ACS Editors’ Choice
Biochemistry, 2017, 56 (26), pp 3299–3306
DOI: 10.1021/acs.biochem.7b00265

Beyond Immunoprecipitation: Exploring New Interaction Spaces with Proximity Biotinylation
Biochemistry, 2017, 56 (26), pp 3297–3298
DOI: 10.1021/acs.biochem.7b00466

Bacterial Cell Mechanics
Biochemistry, 2017, 56 (29), pp 3710–3724
DOI: 10.1021/acs.biochem.7b00346

Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis
Biochemistry, 2017, 56 (28), pp 3519–3522
DOI: 10.1021/acs.biochem.7b00472

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Bioconjugate Chemistry

Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (7), pp 1826–1833
DOI: 10.1021/acs.bioconjchem.7b00304

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling
Bioconjugate Chem., 2017, 28 (7), pp 1801–1806
DOI: 10.1021/acs.bioconjchem.7b00190

Targeting CpG Adjuvant to Lymph Node via Dextran Conjugate Enhances Antitumor Immunotherapy
Bioconjugate Chem., 2017, 28 (7), pp 1993–2000
DOI: 10.1021/acs.bioconjchem.7b00313

Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery
Bioconjugate Chem., 2017, 28 (7), pp 1944–1954
DOI: 10.1021/acs.bioconjchem.7b00274

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]–Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization
Bioconjugate Chem., 2017, 28 (7), pp 1916–1924
DOI: 10.1021/acs.bioconjchem.7b00242

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Biomacromolecules

Reduction- and pH-Sensitive Hyaluronan Nanoparticles for Delivery of Iridium(III) Anticancer Drugs
Biomacromolecules, 2017, 18 (7), pp 2102–2117
DOI: 10.1021/acs.biomac.7b00445

Construction of Injectable Double-Network Hydrogels for Cell Delivery
Biomacromolecules, 2017, 18 (7), pp 2128–2138
DOI: 10.1021/acs.biomac.7b00452

Clathrin-Independent Killing of Intracellular Mycobacteria and Biofilm Disruptions Using Synthetic Antimicrobial Polymers
Biomacromolecules, 2017, 18 (7), pp 2024–2033
DOI: 10.1021/acs.biomac.7b00106

A Thermogelling Supramolecular Hydrogel with Sponge-Like Morphology as a Cytocompatible Bioink
Biomacromolecules, 2017, 18 (7), pp 2161–2171
DOI: 10.1021/acs.biomac.7b00481

Photoluminescent Hybrids of Cellulose Nanocrystals and Carbon Quantum Dots as Cytocompatible Probes for in Vitro Bioimaging
Biomacromolecules, 2017, 18 (7), pp 2045–2055
DOI: 10.1021/acs.biomac.7b00306

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Journal of Agricultural and Food Chemistry

Safety Assessment of Food and Feed from GM Crops in Europe: Evaluating EFSA’s Alternative Framework for the Rat 90-day Feeding Study
Open Access Through ACS Editor’s Choice
J. Agric. Food Chem., 2017, 65 (27), pp 5545–5560
DOI: 10.1021/acs.jafc.7b01492

The Discovery of Citral-Like Thiophenes in Fried Chicken
J. Agric. Food Chem., 2017, 65 (28), pp 5690–5699
DOI: 10.1021/acs.jafc.7b01371

Isolation and Characterization of Sesquiterpenoids from Cassia Buds and Their Antimicrobial Activities
J. Agric. Food Chem., 2017, 65 (28), pp 5614–5619
DOI: 10.1021/acs.jafc.7b01294

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
J. Agric. Food Chem., 2017, 65 (28), pp 5639–5649
DOI: 10.1021/acs.jafc.7b01668

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (27), pp 5480–5493
DOI: 10.1021/acs.jafc.7b02049

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Journal of Chemical Information and Modeling

Machine Learning Consensus Scoring Improves Performance Across Targets in Structure-Based Virtual Screening
J. Chem. Inf. Model., 2017, 57 (7), pp 1579–1590
DOI: 10.1021/acs.jcim.7b00153

Discovery and Evaluation of Anti-Fibrinolytic Plasmin Inhibitors Derived from 5-(4-Piperidyl)isoxazol-3-ol (4-PIOL)
J. Chem. Inf. Model., 2017, 57 (7), pp 1703–1714
DOI: 10.1021/acs.jcim.7b00255

Modeling Binding with Large Conformational Changes: Key Points in Ensemble-Docking Approaches
J. Chem. Inf. Model., 2017, 57 (7), pp 1563–1578
DOI: 10.1021/acs.jcim.7b00125

Statistical Analysis, Investigation, and Prediction of the Water Positions in the Binding Sites of Proteins
J. Chem. Inf. Model., 2017, 57 (7), pp 1517–1528
DOI: 10.1021/acs.jcim.6b00620

Rigidity Strengthening: A Mechanism for Protein–Ligand Binding
J. Chem. Inf. Model., 2017, 57 (7), pp 1715–1721
DOI: 10.1021/acs.jcim.7b00226

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Journal of Medicinal Chemistry

The Fragment Network: A Chemistry Recommendation Engine Built Using a Graph Database
Open Access Through ACS Editor’s Choice
J. Med. Chem., 2017, 60 (14), pp 6440–6450
DOI: 10.1021/acs.jmedchem.7b00809

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1
J. Med. Chem., 2017, 60 (13), pp 5857–5867
DOI: 10.1021/acs.jmedchem.7b00293

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer
J. Med. Chem., 2017, 60 (14), pp 6018–6035
DOI: 10.1021/acs.jmedchem.7b00076

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
J. Med. Chem., 2017, 60 (13), pp 5717–5735
DOI: 10.1021/acs.jmedchem.7b00425

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B
J. Med. Chem., 2017, 60 (14), pp 6137–6151
DOI: 10.1021/acs.jmedchem.7b00365

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Journal of Natural Products

Gaditanone, a Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from Euphorbia gaditana
J. Nat. Prod., 2017, 80 (7), pp 2161–2165
DOI: 10.1021/acs.jnatprod.7b00332

Spirograterpene A, a Tetracyclic Spiro-Diterpene with a Fused 5/5/5/5 Ring System from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475
J. Nat. Prod., 2017, 80 (7), pp 2174–2177
DOI: 10.1021/acs.jnatprod.7b00475

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking
J. Nat. Prod., 2017, 80 (7), pp 2051–2059
DOI: 10.1021/acs.jnatprod.7b00233

Mushroom-Derived Indole Alkaloids
J. Nat. Prod., 2017, 80 (7), pp 2178–2187
DOI: 10.1021/acs.jnatprod.7b00390

Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (7), pp 2060–2066
DOI: 10.1021/acs.jnatprod.7b00255

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The Journal of Physical Chemistry B

Physical Chemistry in India
J. Phys. Chem. B, 2017, 121 (26), pp 6287–6293
DOI: 10.1021/acs.jpcb.7b05682

More than Virtual Reality: Important New Physical Insights in Simulations of Biomolecules and Synthetic Polymers
J. Phys. Chem. B, 2017, 121 (26), pp 6294–6294
DOI: 10.1021/acs.jpcb.7b05957

Origin of the Non-Arrhenius Behavior of the Rates of Enzymatic Reactions
J. Phys. Chem. B, 2017, 121 (27), pp 6520–6526
DOI: 10.1021/acs.jpcb.7b03698

“New Physical Chemistry Insight” in Experimental Bio-Physical Chemistry
J. Phys. Chem. B, 2017, 121 (27), pp 6455–6455
DOI: 10.1021/acs.jpcb.7b05757

Do Halogen–Hydrogen Bond Donor Interactions Dominate the Favorable Contribution of Halogens to Ligand–Protein Binding?
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (28), pp 6813–6821
DOI: 10.1021/acs.jpcb.7b04198

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The Journal of Physical Chemistry Letters

Physical Chemistry in India
J. Phys. Chem. Lett., 2017, 8 (13), pp 3122–3128
DOI: 10.1021/acs.jpclett.7b01499

How to Avoid Artifacts in Surface Photovoltage Measurements: A Case Study with Halide Perovskites
J. Phys. Chem. Lett., 2017, 8 (13), pp 2941–2943
DOI: 10.1021/acs.jpclett.7b01332

Correlation between Photoluminescence and Carrier Transport and a Simple In Situ Passivation Method for High-Bandgap Hybrid Perovskites
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (14), pp 3289–3298
DOI: 10.1021/acs.jpclett.7b01185

How Cubic Can Ice Be?
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2017, 8 (14), pp 3216–3222
DOI: 10.1021/acs.jpclett.7b01142

Suppressing Excimers in H-Aggregates of Perylene Bisimide Folda-Dimer: Role of Dimer Conformation and Competing Assembly Pathways
J. Phys. Chem. Lett., 2017, 8 (14), pp 3427–3432
DOI: 10.1021/acs.jpclett.7b01338

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Journal of Proteome Research

Noncoding after All: Biases in Proteomics Data Do Not Explain Observed Absence of lncRNA Translation Products
Open access through ACS Editors’ Choice
J. Proteome Res., 2017, 16 (7), pp 2508–2515
DOI: 10.1021/acs.jproteome.7b00085

In-Culture Cross-Linking of Bacterial Cells Reveals Large-Scale Dynamic Protein–Protein Interactions at the Peptide Level
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (7), pp 2457–2471
DOI: 10.1021/acs.jproteome.7b00068

Improvements in Mass Spectrometry Assay Library Generation for Targeted Proteomics
J. Proteome Res., 2017, 16 (7), pp 2384–2392
DOI: 10.1021/acs.jproteome.6b00928

Quantitative Performance Evaluator for Proteomics (QPEP): Web-based Application for Reproducible Evaluation of Proteomics Preprocessing Methods
J. Proteome Res., 2017, 16 (7), pp 2359–2369
DOI: 10.1021/acs.jproteome.6b00882

Quantitative Proteomics Analysis Confirmed Oxidative Metabolism Predominates in Streptomyces coelicolor versus Glycolytic Metabolism in Streptomyces lividans
J. Proteome Res., 2017, 16 (7), pp 2597–2613
DOI: 10.1021/acs.jproteome.7b00163

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Molecular Pharmaceutics

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (7), pp 2245–2253
DOI: 10.1021/acs.molpharmaceut.7b00076

Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (7), pp 2437–2449
DOI: 10.1021/acs.molpharmaceut.7b00338

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery
Mol. Pharmaceutics, 2017, 14 (7), pp 2422–2436
DOI: 10.1021/acs.molpharmaceut.7b00320

Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies
Mol. Pharmaceutics, 2017, 14 (7), pp 2177–2196
DOI: 10.1021/acs.molpharmaceut.7b00158

In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (7), pp 2307–2313
DOI: 10.1021/acs.molpharmaceut.7b00172