Get inspired by fellow process chemists’ recent breakthroughs by joining ACS Publications Industry Webinars or exploring a selection of trending journal articles published by researchers working in biotech and pharmaceutical R&D.
Process chemists play a crucial role in bridging discovery and manufacturing—optimizing reactions, scaling up production, and ensuring reproducibility under real-world conditions. Whether it’s improving yield, reducing impurities, or developing greener processes, chances are many process chemists have encountered—and overcome—similar challenges. Learning from their approaches can often spark new ideas for your own work in the field.
Here, we present a selection of recent journal articles published by researchers in biotech and pharma R&D, as well as webinars led by R&D scientists from top companies such Amgen and Takeda Pharmaceuticals.
We hope you find the information presented in these articles and webinars valuable and inspiring. To explore more leading research in your area, subscribe to ACS Industry Insider. Each month, we’ll send you five hand-picked, high impact articles in the topics that matter most to you.
Trending process chemistry articles in October 2025:
Tetramethylchloroformamidinium Hexafluorophosphate–N-Methylimidazole Amidation in Water: Successes, Limitations, and a Regression Model for Prediction
Richard J. Fox*, Dung L. Golden*, Caitlin C. Chartrand, Lauren N. Grant, William P. Gallagher, and Matthew J. Goldfogel
DOI: 10.1021/acs.oprd.5c00299
DOI: 10.1021/acs.oprd.5c00299
Route Development toward a Pyrazine Building Block to Enable Early Scale-Up Campaigns
Peter J. Lindsay-Scott*, Scott Boyd, Daniela Dimitrova, Laura Evans, and Stuart Pearson
DOI: 10.1021/acs.oprd.5c00280
DOI: 10.1021/acs.oprd.5c00280
Environmentally Benign Synthesis of Anticancer Drug Lenalidomide
Raj S. Wandre, Kirti Sharma, Ahemad M. Pathan, Maryam Nabi, and Amol B. Gade*
DOI: 10.1021/acs.oprd.5c00339
DOI: 10.1021/acs.oprd.5c00339
Impurity Qualification Thresholds: An IQ Survey on Emerging Industry Experience with Health Authority Feedback
Jennifer Alleva*, Kate Arnot*, Elizabeth A. Martin, Alejandra Trejo-Martin, John Nicolette, Mayur S. Mitra, Teresa Wegesser, Kaushik Datta, Sathanandam S. Anand, and Joel Bercu
DOI: 10.1021/acs.oprd.5c00300
DOI: 10.1021/acs.oprd.5c00300
Identification of Tamsulosin-Dimeric Impurity, Leading to the Efficient Manufacturing Process of the Active Pharmaceutical Ingredient
Sadayuki Maeda, Tetsuya Kawashima, Daijiro Hayashi, Tatsunori Sato*, Hiroki Moriwaki, and Kanji Meguro
DOI: 10.1021/acs.oprd.5c00211
DOI: 10.1021/acs.oprd.5c00211
ACS industry webinars on process chemistry:
Development of an Improved Process for a Key Sotorasib Intermediate
In this webinar, guest speaker Amanda Stahl, an associate scientist at Amgen, unveils the fascinating journey behind the development of the second-generation process for producing rac-4, a key intermediate in the manufacture of Sotorasib. Through innovation, the improved process has achieved remarkable results—97% reduction in organic solvent usage and 71% reduction in wastewater generation. Whether you're deep in the lab or leading process development, this session presents actionable insights for process chemists aiming to enhance sustainability and boost efficiency—particularly in drug manufacturing. Sign up to watch on demand.
Behind the Failures of Suzuki–Miyaura Coupling Scale-Up: A Real-World Case Study
In this webinar, guest speaker Dr. Yamamoto from Takeda Pharmaceuticals will share a real-world case study of an unexpected failure during API manufacturing involving the Suzuki-Miyaura coupling. The discussion will focus on the unforeseen root causes that emerged during scale-up and how the team addressed and overcame these challenges. Register and reserve your spot today!