This week: The medicinal chemistry of dengue virus, natural products as sources for new drugs, dramatic seasonal shifts in groundwater arsenic– and more! Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of […]
This week: The medicinal chemistry of dengue virus, natural products as sources for new drugs, dramatic seasonal shifts in groundwater arsenic– and more!
Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.
Check out this week’s picks!
Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging
Hinako Eto, Fuminori Hyodo, Kenji Nakano, and Hideo Utsumi
DOI: 10.1021/acs.analchem.5b04821
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Natural Products as Sources of New Drugs from 1981 to 2014
David J. Newman and Gordon M. Cragg
DOI: 10.1021/acs.jnatprod.5b01055
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Soluble Dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene Derivatives for Solution-Processed Organic Field-Effect Transistors
Masanori Sawamoto, Myeong Jin Kang, Eigo Miyazaki, Hiroyoshi Sugino, Itaru Osaka, and Kazuo Takimiya
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Aquifer Arsenic Cycling Induced by Seasonal Hydrologic Changes within the Yangtze River Basin
Michael V. Schaefer, Samantha C. Ying, Shawn G. Benner, Yanhua Duan, Yanxin Wang, and Scott Fendorf
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Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma
Keith Biggadike, Mahbub Ahmed, Doug I. Ball, Diane M. Coe, Deidre A. Dalmas Wilk, Chris D. Edwards, Bob H. Gibbon, Charlotte J. Hardy, Stephen A. Hermitage, Joanne O. Hessey, Aimee E. Hillegas, Stephen C. Hughes, Linos Lazarides, Xiao Q. Lewell, Amanda Lucas, David N. Mallett, Mark A. Price, Fiona M. Priest, Diana J. Quint, Poonam Shah, Anesh Sitaram, Stephen A. Smith, Richard Stocker, Naimisha A. Trivedi, Daphne C. Tsitoura, and Victoria Weller
DOI: 10.1021/acs.jmedchem.5b01647
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Highly Regio- and Enantioselective Hydroformylation of Vinyl Esters Using Bidentate Phosphine,P-Chiral Phosphorodiamidite Ligands
Christian Schmitz, Katharina Holthusen, Walter Leitner, and Giancarlo Franciò
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The Medicinal Chemistry of Dengue Virus
Mira A. M. Behnam, Christoph Nitsche, Veaceslav Boldescu, and Christian D. Klein
DOI: 10.1021/acs.jmedchem.5b01653
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