Stay up to date with a selection of recently published articles from ACS journals that were among the most read in September 2025.
The impact of a scientific article can be assessed in many ways, and one key indicator of reach and influence is its readership. Here, we present a curated list of 10 most-read chemistry articles during September 2025, showcasing influential and trending research across ACS journals.*
We hope you find these articles insightful and valuable. If you want to learn more about publishing in our journals, click below to discover how your own research can further our commitment to being the “Most Trusted. Most Cited. Most Read.”
Browse Highly Read ACS Journal Articles in September 2025
33 Unresolved Questions in Nanoscience and Nanotechnology
Chad A. Mirkin*, Sarah Hurst Petrosko, Natalie Artzi, Koray Aydin, Austin Biaggne, C. Jeffrey Brinker, Katherine E. Bujold, Y. Charles Cao, Rachel R. Chan, Chaojian Chen et al.
DOI: 10.1021/acsnano.5c12854
DOI: 10.1021/acsnano.5c12854
A 100,000-Fold Increase in C–H Bond Acidity Gives Palladium a Key Advantage in C(sp3)–H Activation Compared to Nickel
Lirong Lin, Tim K. Schramm, Pavel Kucheryavy, Roger A. Lalancette, Andreas Hansen*, and Demyan E. Prokopchuk*
DOI: 10.1021/jacs.5c07649
DOI: 10.1021/jacs.5c07649
A Perspective on the Role of Metformin in Treating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID
David Fineberg, Alain Moreau, Elena K. Schneider-Futschik*, and Christopher W. Armstrong*
DOI: 10.1021/acsptsci.5c00229
DOI: 10.1021/acsptsci.5c00229
Nickel-Catalyzed Cross-Dehydrogenative Coupling of Aldehydes and Alkenes toward Skipped Enones
Sidhant Wagulde, Pramod Rai, and Vladimir Gevorgyan*
DOI: 10.1021/jacs.5c10306
DOI: 10.1021/jacs.5c10306
BIOPTIC B1 Ultra-High-Throughput Virtual Screening System Discovers LRRK2 Ligands in Vast Chemical Space
Vlad Vinogradov*, Kong T. Nguyen*, Simon Steshin, Ivan Izmailov, and Andrey Doronichev
DOI: 10.1021/acs.jcim.5c00743
DOI: 10.1021/acs.jcim.5c00743
A General Copper-Catalyzed Radical Cross-Coupling of Unactivated Alkyl Halides
Fu-Li Wang*, Qian Xie, Xiao-Yu Chen, Xue-Man Ye, Ning-Yuan Yang, Jia-Le Deng, Shou-Hao Zhong, Yu-Xuan Zhang, Ji-Jun Chen*, and Xin-Yuan Liu*
DOI: 10.1021/jacs.5c10285
DOI: 10.1021/jacs.5c10285
Practically Significant Method Comparison Protocols for Machine Learning in Small Molecule Drug Discovery
Jeremy R. Ash, Cas Wognum*, Raquel Rodríguez-Pérez, Matteo Aldeghi, Alan C. Cheng, Djork-Arné Clevert, Ola Engkvist, Cheng Fang, Daniel J. Price, Jacqueline M. Hughes-Oliver, and W. Patrick Walters
DOI: 10.1021/acs.jcim.5c01609
DOI: 10.1021/acs.jcim.5c01609
Iodonitrene-Mediated Nitrogen Transfer to Alkenes for the Direct Synthesis of NH-Aziridines
Yuri Gelato, Laura Marraffa, Francesco Pasca, Philipp Natho, Giuseppe Romanazzi, Arianna Tota, Marco Colella, and Renzo Luisi*
DOI: 10.1021/jacs.5c10372
DOI: 10.1021/jacs.5c10372
Prospects of Nanoscience with Nanocrystals: 2025 Edition
Maria Ibáñez*, Simon C. Boehme, Raffaella Buonsanti, Jonathan De Roo, Delia J. Milliron, Sandrine Ithurria, Andrey L. Rogach, Andreu Cabot, Maksym Yarema, Brandi M. Cossairt et al.
DOI: 10.1021/acsnano.5c07838
DOI: 10.1021/acsnano.5c07838
Greenhouse Gas Reductions Driven by Vehicle Electrification across Powertrains, Classes, Locations, and Use Patterns
Elizabeth Smith, Maxwell Woody, Timothy J. Wallington, Christian Hitt, Hyung Chul Kim, Alan I. Taub, and Gregory A. Keoleian*
DOI: 10.1021/acs.est.5c05406
DOI: 10.1021/acs.est.5c05406
*These lists are not chosen by the journals’ editors and should not be taken as a “best of” collection, but as another perspective on what recently published research attracted the most attention in a particular month.
