There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]

Celebrating Prof. Renato Zenobi at Ions and Photons in Analytical Science 2021

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that were published in each ACS Publications journal during September 2021, including papers, reviews, perspectives, and editorial pieces. These lists were not chosen by the journals’ editors and should not be taken as a “best of” list, but as another perspective on what newly published research attracted the most attention in a particular month.

Click on your favorite journal below to see their most-read articles that were published in September 2021.

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Browse Other Monthly Most-Read Article Lists From 2021


InVitro and In Vivo Investigation of S1PR1 Expression in the Central Nervous System Using [3H]CS1P1 and [11C]CS1P1
DOI: 10.1021/acschemneuro.1c00492

Validation of Dexamethasone-Enhanced Continuous-Online Microdialysis for Monitoring Glucose for 10 Days after Brain Injury
Open Access
DOI: 10.1021/acschemneuro.1c00231

Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3 Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders
Open Access
DOI: 10.1021/acschemneuro.1c00368

Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation
DOI: 10.1021/acschemneuro.1c00429

Citrullination of Amyloid-β Peptides in Alzheimer’s Disease
DOI: 10.1021/acschemneuro.1c00474


Computer Prediction of pKa Values in Small Molecules and Proteins
This article is part of the Medicinal Chemistry in Portugal and Spain: A Strong Iberian Alliance special issue.
DOI: 10.1021/acsmedchemlett.1c00435

Dual Inhibition of KRAS G12C and G12D Mutants as a Potential Treatment in Cancer Therapy
DOI: 10.1021/acsmedchemlett.1c00441

KRAS Mutant Combination Therapy for the Effective Treatment of Cancer
DOI: 10.1021/acsmedchemlett.1c00466

Imidazo[1,2-b]pyridazines as IL-17A Inhibitors for Treating Psoriasis, Rheumatoid Arthritis, and Multiple Sclerosis
DOI: 10.1021/acsmedchemlett.1c00470

2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
Open Access
DOI: 10.1021/acsmedchemlett.1c00399


Reactions of 9-Carbene-9-Borafluorene Monoanion and Selenium: Synthesis of Boryl-Substituted Selenides and Diselenides
Open Access
DOI: 10.1021/acs.inorgchem.1c02124

In Appreciation of Reviewers
DOI: 10.1021/acs.inorgchem.1c02810

Expanding the Concepts Trans Influence and Back-Donation: Hybrid and Side Donations in [Cp*MsupIII(L)XY] (M = Rh, Ir) Complexes with CO, CN–, and CNR Ligands. A Window to Cis Influence
DOI: 10.1021/acs.inorgchem.1c02189

Mr. Inorganic Chemistry: M. Frederick Hawthorne (August 24, 1928–July 8, 2021)
DOI: 10.1021/acs.inorgchem.1c02482

C–H Bond Cleavage by Bioinspired Nonheme Metal Complexes
DOI: 10.1021/acs.inorgchem.1c01754


Simultaneous Multiphase Flash and Stability Analysis Calculations Including Solid CO2 for CO2–CH4, CO2–CH4–N2, and CO2–CH4–N2–O2 Mixtures
Open Access
DOI: 10.1021/acs.jced.1c00330

Viscosity Measurement and Correlation of Unloaded and CO2-Loaded Aqueous Blend of Monoethanolamine and Piperazine
Open Access
DOI: 10.1021/acs.jced.1c00510

Application of Gas Hydrates in the Separation and Purification of Xenon from a Mixture of Xenon and Argon
DOI: 10.1021/acs.jced.1c00435

Density, Speeds of Sound, and Refractive Index of Pure and Binary Mixtures of Ionic Liquids Based on Imidazolium Cations and Tetrafluoroborate Anions with Cyclohexylamine
DOI: 10.1021/acs.jced.1c00419

Thermodynamic Properties from Adiabatic and Combustion Calorimetry of Two Polycyclic Aromatic Hydrocarbons, Benz[a]anthracene and Chrysene
DOI: 10.1021/acs.jced.1c00152


FEPrepare: A Web-Based Tool for Automating the Setup of Relative Binding Free Energy Calculations
Open Access
DOI: 10.1021/acs.jcim.1c00215

SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern
Open Access
DOI: 10.1021/acs.jcim.1c00857

Modeling Kinetics and Thermodynamics of Guest Encapsulation into the [M4L6]12– Supramolecular Organometallic Cage
Open Access
DOI: 10.1021/acs.jcim.1c00348

Maximum Common Substructure Searching in Combinatorial Make-on-Demand Compound Spaces
Open Access
DOI: 10.1021/acs.jcim.1c00640

Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics API
Open Access
DOI: 10.1021/acs.jcim.1c00743


Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer
DOI: 10.1021/acs.jmedchem.1c00900

Strategies for Structural Modification of Small Molecules to Improve Blood–Brain Barrier Penetration: A Recent Perspective
DOI: 10.1021/acs.jmedchem.1c00910

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy
DOI: 10.1021/acs.jmedchem.1c00613

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Open Access
DOI: 10.1021/acs.jmedchem.1c00575

Chemical Probes for Understudied Kinases: Challenges and Opportunities
DOI: 10.1021/acs.jmedchem.1c00980


Photoredox-Catalyzed Dehydrogenative Csp3–Csp2 Cross-Coupling of Alkylarenes to Aldehydes in Flow
Open Access
DOI: 10.1021/acs.joc.1c01621

Synthesis of Saddle-Shape Octaaminotetraphenylene Octahydrochloride
DOI: 10.1021/acs.joc.1c01127

Copper-Catalyzed Conjugate Addition of Carbonyls as Carbanion Equivalent via Hydrazones
DOI: 10.1021/acs.joc.1c01380

Total Syntheses of (+)-Peniciketals A-B and (−)-Diocollettines A Exploiting a Photoisomerization/Cyclization Union Protocol
DOI: 10.1021/acs.joc.1c01635

1,5-Hydrogen Atom Transfer/Surzur–Tanner Rearrangement: A Radical Cascade Approach for the Synthesis of 1,6-Dioxaspiro[4.5]decane and 6,8-Dioxabicyclo[3.2.1]octane Scaffolds in Carbohydrate Systems
Open Access
DOI: 10.1021/acs.joc.1c01376


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