Biological chemistry is an amalgamation of the chemical and life sciences. It is the study of the chemistry of living organisms at the cellular and molecular level, and is vital to the understanding of these living organisms. Applications are diverse and range from pharmaceuticals, diagnostics and cancer research, to agriculture. The Biological Chemistry technical symposia […]
Biological chemistry is an amalgamation of the chemical and life sciences. It is the study of the chemistry of living organisms at the cellular and molecular level, and is vital to the understanding of these living organisms. Applications are diverse and range from pharmaceuticals, diagnostics and cancer research, to agriculture. The Biological Chemistry technical symposia at Pacifichem 2015 features 28 sessions covering a myriad of topics, including peptide and protein chemistry, natural products, epigenetics/epigenomics, biocatalysis, and bioengineering.
Below is a collection of articles, from across the ACS Publications portfolio, designed to give you a sneak peek into the breadth of research that will be presented at Pacifichem 2015. We hope that this selection will stimulate your interest and inspire new ideas as you continue your research in this exciting field.
ACS Catalysis
Nonenzymatic Regeneration of Styrene Monooxygenase for Catalysis
Caroline E. Paul, Dirk Tischler, Anika Riedel, Thomas Heine, Nobuya Itoh, and Frank Hollmann
ACS Catalysis 2015 5 (5), 2961-2965
How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes
Alissa Rauwerdink and Romas J. Kazlauskas
ACS Catalysis 2015 5 (10), 6153-6176
ACS Central Science
Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
Christopher C. Farwell, Ruijie K. Zhang, John A. McIntosh, Todd K. Hyster, and Frances H. Arnold
ACS Central Science 2015 1 (2), 89-93
DOI: 10.1021/acscentsci.5b00056
ACS Chemical Biology
In Vitro Selection of Multiple Libraries Created by Genetic Code Reprogramming To Discover Macrocyclic Peptides That Antagonize VEGFR2 Activity in Living Cells
Takashi Kawakami, Takahiro Ishizawa, Tomoshige Fujino, Patrick C. Reid, Hiroaki Suga, and Hiroshi Murakami
ACS Chemical Biology 2013 8 (6), 1205-1214
Optical Control of the Ca2+ Concentration in a Live Specimen with a Genetically Encoded Ca2+-Releasing Molecular Tool
Noritaka Fukuda, Tomoki Matsuda, and Takeharu Nagai
ACS Chemical Biology 2014 9 (5), 1197-1203
ACS Chemical Neuroscience
Improved Orange and Red Ca2+ Indicators and Photo physical Considerations for Optogenetic Applications
Jiahui Wu, Lin Liu, Tomoki Matsuda, Yongxin Zhao, Aleksander Rebane, Mikhail Drobizhev, Yu-Fen Chang, Satoko Araki, Yoshiyuki Arai, Kelsey March, Thomas E. Hughes, Ken Sagou, Takaki Miyata, Takeharu Nagai, Wen-hog nLi, and Robert E. Campbell
ACS Chemical Neuroscience 2013 4 (6), 963-972
Single-Axonal Organelle Analysis Method Reveals New Protein-Motor Associations
Allyson E. Sgro, Sandra M. Bajjalieh, and Daniel T. Chiu
ACS Chemical Neuroscience 2013 4 (2), 277-284
ACS Combinatorial Science
Solid-Phase Synthesis of Diverse Spiroisoxazolinodiketopiperazines
Yi-Wen Pan, Chih-Wei Guo, Huang-Yao Tu, Chih-Wei Tsai, and Wei-Chieh Cheng
ACS Combinatorial Science 2013 15 (8), 425-434
ACS Medicinal Chemistry Letters
Chemically Accessible Hsp90 Inhibitor That Does Not Induce a Heat Shock Response
Yen Chin Koay, Jeanette R. McConnell, Yao Wang, Seong Jong Kim, Laura K. Buckton, Flora Mansour, and Shelli R. McAlpine
ACS Medicinal Chemistry Letters 2014 5 (7), 771-776
ACS Synthetic Biology
Targeted Capture and Heterologous Expression of the Pseudoalteromonas Alterochromide Gene Cluster in Escherichia coli Represents a Promising Natural Product Exploratory Platform
Avena C. Ross, Lauren E. S. Gulland, Pieter C. Dorrestein, and Bradley S. Moore
ACS Synthetic Biology 2015 4 (4), 414-420
Biochemistry
Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange
Irit Rappley, Cecília Monteiro, Marta Novais, Aleksandra Baranczak, Gregory Solis, R. Luke Wiseman, Stephen Helmke, Mathew S. Maurer, Teresa Coelho, Evan T. Powers, and Jeffery W. Kelly
Biochemistry 2014 53 (12), 1993-2006
Replication-Competent Influenza Virus and Respiratory Syncytial Virus Luciferase Reporter Strains Engineered for Co-Infections Identify Antiviral Compounds in Combination Screens
Dan Yan, Marco Weisshaar, Kristen Lamb, Hokyung K. Chung, Michael Z. Lin, and Richard K. Plemper
Biochemistry 2015 54 (36), 5589-5604
DOI: 10.1021/acs.biochem.5b00623
Bioconjugate Chemistry
A Clickable and Photocleavable Lipid Analogue for Cell Membrane Delivery and Release
Shahrina Alam, Daiane S. Alves, Stuart A. Whitehead, Andrew M. Bayer, Christopher D. McNitt, Vladimir V. Popik, Francisco N. Barrera, and Michael D. Best
Bioconjugate Chemistry 2015 26 (6), 1021-1031
DOI: 10.1021/acs.bioconjchem.5b00044
Targeted Delivery of Ubiquitin-Conjugated BH3 Peptide-Based Mcl-1 Inhibitors into Cancer Cells
Avinash Muppidi, Kenichiro Doi, Selvakumar Edwardraja, Surya V. S. R. K. Pulavarti, Thomas Szyperski, Hong-Gang Wang, and Qing Lin
Bioconjugate Chemistry 2014 25 (2), 424-432
Journal of Natural Products
Isolation of Pyrrolocins A-C: cis- and trans-Decalin Tetramic Acid Antibiotics from an Endophytic Fungal-Derived Pathway
Raquel C. Jadulco, Michael Koch, Thomas B. Kakule, Eric W. Schmidt, Anita Orendt, Haiyin He, Jeffrey E. Janso, Guy T. Carter, Erica C. Larson, Christopher Pond, Teatulohi K. Matainaho, and Louis R. Barrows
Journal of Natural Products 2014 77 (11), 2537-2544
Journal of Medicinal Chemistry
Heat Shock Protein 70 Inhibitors. 1. 2,5 ‘-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70
Yanlong Kang, Tony Taldone, Hardik J. Patel, Pallav D. Patel, Anna Rodina, Alexander Gozman, Ronnie Maharaj, Cristina C. Clement, Maulik R. Patel, Jeffrey L. Brodsky, Jason C. Young, and Gabriela Chiosis
Journal of Medicinal Chemistry 2014 57 (4), 1188-1207
De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one gamma-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo
Julien Dufour-Gallant, David Chatenet, and William D. Lubell
Journal of Medicinal Chemistry 2015 58 (11), 4624-4637
DOI: 10.1021/acs.jmedchem.5b00162
Journal of Organic Chemistry
Ratiometric Two-Photon Fluorescent Probes for Mitochondrial Hydrogen Sulfide in Living Cells
Xiu-Ling Liu, Xiao-Jiao Du, Chun-Guang Dai, and Qin-Hua Song
The Journal of Organic Chemistry 2014 79 (20), 9481-9489
Synthesis and Biophysical Properties of C5-Functionalized LNA (Locked Nucleic Acid)
Pawan Kumar, Michael E. Østergaard, Bharat Baral, Brooke A. Anderson, Dale C. Guenther, Mamta Kaura, Daniel J. Raible, Pawan K. Sharma, and Patrick J. Hrdlicka
The Journal of Organic Chemistry 2014 79 (11), 5047-5061
Journal of Proteome Research
Proteomic Characterization of a Natural Host–Pathogen Interaction: Repertoire of in Vivo Expressed Bacterial and Host Surface-Associated Proteins
Megan A. Rees, Oded Kleifeld, Paul K. Crellin, Bosco Ho, Timothy P. Stinear, A. Ian Smith, and Ross L. Coppel
Journal of Proteome Research 2015 14 (1), 120-132
Online Matrix Removal Platform for Coupling Gel-Based Separations to Whole Protein Electrospray Ionization Mass Spectrometry
Ki Hun Kim, Philip D. Compton, John C. Tran, and Neil L. Kelleher
Journal of Proteome Research 2015 14 (5), 2199-2206
Journal of the American Chemical Society
Glucagon-Secreting Alpha Cell Selective Two-Photon Fluorescent Probe TP-α: For Live Pancreatic Islet Imaging
Bikram Keshari Agrawalla, Yogeswari Chandran, Wut-Hmone Phue, Sung-Chan Lee, Yun-Mi Jeong, Si Yan Diana Wan, Nam-Young Kang, and Young-Tae Chang
Journal of the American Chemical Society 2015 137 (16), 5355-5362
Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel
Alexander G. Cioffi, Jennifer Hou, Anthony S. Grillo, Katrina A. Diaz, and Martin D. Burke
Journal of the American Chemical Society 2015 137 (32), 10096-10099
Molecular Pharmaceutics
A 3-D Artificial Colon Tissue Mimic for the Evaluation of Nanoparticle-Based Drug Delivery System
Zhen Huang, Zhenzhen Wang, Shanshan Long, Haoyang Jiang, Jiangning Chen, Junfeng Zhang, and Lei Dong
Molecular Pharmaceutics 2014 11 (7), 2051-2061
Nanoassembly of Surfactants with Interfacial Drug-Interactive Motifs as Tailor-Designed Drug Carriers
Xiang Gao, Yixian Huang, Alexander M. Makhov, Michael Epperly, Jianqin Lu, Sheila Grab, Peijun Zhang, Lisa Rohan, Xiang-Qun Xie, Peter Wipf, Joel Greenberger, and Song Li
Molecular Pharmaceutics 2013 10 (1), 187-198
Organometallics
Cytotoxicity Studies of Cyclometallated Ruthenium(II) Compounds: New Applications for Ruthenium Dyes
Bruno Peña, Amanda David, Christiane Pavani, Mauricio S. Baptista, Jean-Philippe Pellois, Claudia Turro, and Kim R. Dunbar
Organometallics 2014 33 (5), 1100-1103
Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C N-Chelated and Pyridine Ligands
Zhe Liu, Isolda Romero-Canelón, Abraha Habtemariam, Guy J. Clarkson, and Peter J. Sadler
