This Virtual Special Issue aims to provide a platform for the scientific community to present their high- quality research in polymer-drug conjugates. Submit your manuscript by June 30, 2024.

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Polymer-drug conjugates constitute an essential aspect of polymer therapeutics, wherein the therapeutic agent forms a chemical bond with a polymer. This encompasses the linkage to not only small drug molecules but also biomacromolecules such as antibodies or therapeutic proteins/peptides. Chemistry therefore plays a central role in this context as the character and attributes of the linker connecting the polymer and therapeutic components are crucial, as the cleavage of this linker dictates the drug release kinetics and consequently influences the therapeutic outcome.

These conjugates can take the form of water-soluble macromolecules, polymer nanoparticles, polymersomes, polymer micelles, giant amphiphiles, protein nanoparticles, inorganic nanocarriers, and many others, representing a diverse range of nanoscale drug delivery systems.

This Virtual Special Issue from Chemistry of Materials aims to provide a platform for the scientific community to present their high- quality research in the field of polymer-drug conjugates. Relevant topics on polymer-drug conjugates will be discussed, including ideas for the design of new types of polymer-drug conjugates, as well as new strategies for improving their selectivity, efficacy and safety.

We invite Articles, Perspectives, Reviews, or Methods & Protocols on all topics related to polymer-drug conjugates, including (but not limited to):

  • Well-defined polymer-drug and polymer-protein/peptide conjugates
  • Stimuli-sensitive and/or targeted polymer-drug conjugates
  • New chemistry to synthesize polymer-drug conjugates
  • Innovative polymer-drug linkers
  • Formulation of polymer-drug conjugates
  • Advanced characterization of polymer-drug conjugates
  • Clinical translation of polymer-drug conjugates

Organizing Editor

Professor Julien Nicolas, Associate Editor, Chemistry of Materials
Université de Paris-Saclay, France

Submission Information

We welcome submissions for this Virtual Special Issue through June 30, 2024. Submissions must comply with our Author Guidelines and will be subject to the usual rigorous peer review to ensure they fit the scope and conform to the high-quality and significance standards of Chemistry of Materials before acceptance. Papers accepted for publication for this Virtual Special Issue will be first published as they are accepted in a regular issue of the journal with a note indicating that they are part of the Virtual Special Issue. After all submissions have been published, they will then be compiled online on a dedicated landing page to form the Virtual Special Issue.

How to Submit

  • Log in to the ACS Paragon Plus submission site.
  • Choose Chemistry of Materials.
  • Select your manuscript type, and, under "Special Issue Selection," choose "Polymer-Drug Conjugate Materials."
Open Access

There are diverse open-access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

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