Call for Papers: Advances and Challenges in DMPK in Drug Discovery

The Journal of Medicinal Chemistry is accepting submissions for the Special Issue "Advances and Challenges in DMPK in Drug Discovery." This Special Issue will highlight cutting-edge research and emerging innovations that are shaping the future of drug metabolism and pharmacokinetics in drug discovery.

We welcome contributions that advance the fundamental science underlying DMPK, address persistent challenges in translating preclinical findings to clinical outcomes, and provide new approaches to improving the discovery, optimization, and development of therapeutics. Through these contributions, the Special Issue aims to showcase scientific advances that are expanding the impact of DMPK across modern drug discovery and development.

Topics include, but are not limited to:

• Metabolic enzymes, biomarkers, and metabolism prediction
• Drug transporters and mechanisms of drug disposition
• PBPK, quantitative pharmacology, and AI-enabled DMPK
• Advanced experimental and microphysiological model systems
• Drug-drug interactions, metabolite characterization, and translational DMPK
• DMPK challenges and optimization strategies for novel therapeutic modalities

For more information, please read the accompanying Editorial. Submit your manuscript by April 30, 2027.

Organizing Editors

Tashinga E. Bapiro, Guest Editor
DMPK Oncology R&D, AstraZeneca, United Kingdom

Submission Information

We welcome submissions for this Special Issue through April 30, 2027. For more information on submission requirements, please review the journal’s Author Guidelines.

Manuscript types considered for this Special Issue include research articles, perspectives, and drug annotations. All submissions will undergo the full, rigorous peer review process expected from ACS journals. Papers accepted for publication in this Special Issue will be available online ASAP (as soon as publishable). Once all accepted papers are published, they will be compiled on a dedicated landing page to form the Special Issue.

Open Access: There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

How to Submit

• Log in to the ACS Publishing Center.
• Select your manuscript type; upload your manuscript and related files.
• Review the title and abstract fields to confirm any pre-populated information has transferred correctly.
• Under “Special Issue Selection,” select Advances and Challenges in DMPK in Drug Discovery.
• Confirm all other information is correct.
• Submit your article.

If you have any general questions regarding submission to this Special Issue, please contact jmc@jmedchem.acs.org.