Call for Papers: Getting Technical With It—“Toolbox” Innovations at ACS Medicinal Chemistry Letters

Given the success of our Special Issue featuring recent developments in the design and implementation of new enabling medicinal chemistry technologies, the Editors of ACS Medicinal Chemistry Letters would like to encourage further submissions in this area in the form of Technical Notes. It is evident that progress in many areas of science is driven by new technologies. ACS Medicinal Chemistry Letters Technical Notes describe technical innovations that facilitate the practice of medicinal chemistry and are likely to become essential items in our “toolbox”.

Topics include, but are not limited to:

• Production of and screening of DNA encoded libraries including new synthetic methods and library design.
• High-throughput experimentation and rapid analytical systems.
• Parallel synthesis libraries design, production and accelerated rapid purification and library screening technologies.
• New analytical technologies for compound characterization.
• Fully integrated closed loop design-make-test (DMT) platforms and direct-to-biology.
• Development of new photoaffinity probes for target identification proteomic studies
• Design of cellular target engagement approaches, (e.g. CETSA assays, NanoBRET probe design and assay setup, MS-based profiling methods).
• Targeted protein degradation (TPD), molecular glue,s and proximity inducing agents
• Novel covalent warheads.
• Artificial intelligence (AI) based design methods and generative chemistry.
• Rapid hit-to-lead and lead optimization techniques.
• New computational QSAR approaches.
• Laboratory automation, fully automated chemical synthesis systems, and robotics.
• Peptide synthesis including macrocycles.
• Design of screening collections, microarrays, mRNA display, and phage display (using on phage chemistry).
• New software developments in robotics, faster molecular modeling algorithms, and applications of AI drive conceptual advances

Submission Information

We welcome submissions for this article type. For more information on submission requirements for Technical Notes, please visit the journal’s Author Guidelines page.

Technical Notes accepted for publication will be available ASAP (as soon as publishable) online. They will then be published in the next available issue of ACS Medicinal Chemistry Letters. Manuscripts submitted for consideration will undergo the full rigorous peer review process expected from ACS journals.

Open Access: There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

How to Submit

• Log in to the ACS Publishing Center.
• Select the "Journals" tab.
• Choose ACS Medicinal Chemistry Letters.
• Click "Submit."
• Select Technical Notes.

If you have any general questions regarding submission of this article type, please contact eic@medchemlett.acs.org.