This cross-journal Virtual Special Issue aims to showcase the latest research on natural products driven medicinal chemistry. Submit your manuscript by April 30, 2024.

A person holding a glass with a plant in it.

Natural products (NPs) have always served as important starting points in discovering drugs for various therapeutic interventions. More than 60% of FDA-approved drugs in the field of oncology, infectious diseases, and central nervous system (CNS) diseases contain a NP pharmacophore. In recent years, several NPs and NP-based leads have emerged as anti-infectives and anticancer drugs, and this trend continues with the recent discovery of several new NP-based preclinical leads. Looking at past indicators of NP contributions to drug discovery, there are undoubtedly many more unique and potent biologically active NPs waiting to be discovered.

With new advancements in synthetic chemistry tools, novel methodologies, deeper understanding of disease biology, and molecular target information; now is the time to refocus research on NP scaffolds to discover new potential leads. To showcase the latest research in this exciting field, we are launching a cross-journal thematic Virtual Special Issue in the Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, ACS Bio & Med Chem Au, Journal of Natural Products, ACS Chemical Neuroscience, and ACS Chemical Biology.

We welcome submissions on topics including the following, but not limited to:

  • Manuscripts comprising either a NP or a NP scaffold as a starting point/motivation for medicinal chemistry.
  • Virtual screening of NP libraries combined with a detailed investigation of the hits in biochemical/cellular, ADME and animal models.
  • Isolation of unique classes of NPs with promising biological activity, which are investigated in detail in biochemical/cellular, ADME and animal models.
  • Contemporary Perspectives and Reviews focused on NPs or NP scaffolds and discussing medicinal chemistry aspects.
The deadline for submissions is April 30, 2024.

Organizing Editors

Sandip B. Bharate, Editorial Advisory Board, Journal of Medicinal Chemistry
Indian Institute of Chemical Technology, India

Craig W. Lindsley
Editor-in-Chief, Journal of Medicinal Chemistry
Vanderbilt University Medical Center, United States

How to Submit

  • Log in to the ACS Paragon Plus submission site and choose any of the following journals: Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters, ACS Bio & Med Chem Au, Journal of Natural Products, ACS Chemical Neuroscience, or ACS Chemical Biology.
  • Select your manuscript type, and, under "Special Issue Selection," choose "Natural Products Driven Medicinal Chemistry."
Open Access

Please note that ACS Bio & Med Chem Au is a gold open access journal, which means your work will be immediately freely available for anyone to read in perpetuity. Article Publication Charges (APC) apply for publication in this fully open access journal.

Please visit our Open Science Resource Center for more information on Open Access Pricing, our ACS Country Discount & Waiver Policy, and ACS Read and Publish Agreements.

Safety Information in Journal Articles

Including a clear, articulate safety summary statement in your research is vital to ensuring that others who reproduce or expand upon your work can prepare for significant hazards and conduct their own methods as safely as possible. Read more about crafting safety statements in our ACS Axial post series.

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Diversity & Inclusion Cover Art Series - Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.
Journal of the American Chemical Society Cover

ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters publishes studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules.
Diversity & Inclusion Cover Art Series - ACS Bio & Med Chem Au

ACS Bio & Med Chem Au

ACS Bio & Med Chem Au is a broad scope, fully open access journal, publishing short letters, comprehensive articles, reviews, and perspectives in all aspects of biological and medicinal chemistry.
Journal of Natural Products journal cover

Journal of Natural Products

The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research, including the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
ACS Chemical Neuroscience journal cover

ACS Chemical Neuroscience

ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders.
Diversity & Inclusion Cover Art Series - ACS Chemical Biology

ACS Chemical Biology

ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology, serving as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities.

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