Call For Papers: Site-Specific Chemistry

Site-specific chemical modification of biomolecules is a driving force for current and oncoming development of targeted therapeutics. More than ever, the growing implications of multispecific drug formats in the future of the biotechnological industry demand the emergence of novel chemistries for the modification of biomolecules in a fully controlled manner—not only for the combination of dissimilar modes of actions in a single scaffold, but for the precise, temporal control of its biological activity.

Bioconjugate Chemistry is pleased to announce an upcoming Special Issue aims to highlight the exciting research in this field. Please see below for submission information.

Topics include, but are not limited to:

• Novel site-specific chemical and enzymatic methods for the modification of native biomolecules
• Chemical approaches for the generation of protein–protein conjugates
• Proximity-driven strategies for the precise generation of covalent bonds
• Chemical strategies for the synthesis of homogeneous conjugates with multiple modes of action
• Site-specific chemistry in the modification of novel protein formats

Organizing Editors

Gonçalo Bernardes, Associate Editor, Bioconjugate Chemistry
University of Cambridge, United Kingdom

Aldrin Vasco, Guest Editor
University of Cambridge, United Kingdom

Submission Information

We welcome submissions for this Special Issue through August 31, 2025. For more information on submission requirements, please visit the journal’s Author Guidelines page.

Accepted manuscripts for consideration in this Special Issue will include research articles, communications and reviews. Proposals for Viewpoints will be considered by email prior to submission. Papers accepted for publication for this Special Issue will be available ASAP (as soon as publishable) online. After all submissions have been published, they will then be compiled online on a dedicated landing page to form the Special Issue. Manuscripts submitted for consideration will undergo the full rigorous peer review process expected from ACS journals.

Open Access: There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

How to Submit

• Log in to the ACS Publishing Center.
• Select the "Journals" tab.
• Choose Bioconjugate Chemistry.
• Click "Submit."
• Select your manuscript type, and, under "Special Issue Selection," choose “Site-Specific Chemistry."

If you have any general questions regarding submission to this Special Issue, please email bernardes-office@bioconj.acs.org or managing.editor@bioconj.acs.org.