Contribute your expertise and recommendations to this ongoing Review Series in ACS Pharmacology & Translational Science—and browse examples of published work in this topic area.

A 3d image of a green, blue, and yellow molecule.

Tool compounds are used in biological and pharmacological studies to help researchers gain insight into certain biological processes and validate potential drug targets during early stages of drug discovery. While tool compounds have tremendous potential for advancing life science research, they are broadly defined, and it is often difficult for a researcher to determine the best tool compounds to employ during the research process. There remains a great need for more tool compound databases and authoritative sources of information from experts in the field.

To address this need, ACS Pharmacology & Translational Science seeks comprehensive review articles on recommended tool compounds. Medicinal chemists with some knowledge of pharmacology or interdisciplinary teams of authors will be perfectly suited to write articles on “Recommended Tool Compounds” for a certain target or a target family (see example). Ideally, these tool compounds should be commercially available or otherwise accessible. If this is not the case, your article may even initiate subsequent commercialization of particular best-in-class tool compounds.

Many scientists will be extremely grateful for a resource that will help them identify and select the best molecular tools for their studies. If you have any questions or wish to discuss whether a specific topic would be suitable for this Review Series, please contact Editor-in-Chief Prof. Christa E. Müller.

Explore Related Articles, Reviews, and Perspectives on Tool Compounds

Phosphinic Peptides as Tool Compounds for the Study of Pharmacologically Relevant Zn-Metalloproteases
Dimitris Georgiadis*, Nikolaos Skoulikas, Athanasios Papakyriakou, and Efstratios Stratikos
DOI: 10.1021/acsptsci.2c00183

Small-Molecule Probes as Pharmacological Tools for the Bone Morphogenetic Protein Signaling Pathway
Daniel Riege, Sven Herschel, Teresa Fenkl, and Dennis Schade*
DOI: 10.1021/acsptsci.3c00170

Analysis of the Selective Antagonist SAFit2 as a Chemical Probe for the FK506-Binding Protein 51
Vanessa Buffa, Fabian H. Knaup, Tim Heymann, Margherita Springer, Mathias V. Schmidt, and Felix Hausch*
DOI: 10.1021/acsptsci.2c00234

Recommended tool compounds and drugs for blocking P2X and P2Y receptors
Christa E. Müller* and Vigneshwaran Namasivayam
DOI: 10.1007/s11302-021-09813-7

Report and Application of a Tool Compound Data Set
Kyle V. Butler, Ian A. MacDonald, Nathaniel A. Hathaway, and Jian Jin*
DOI: 10.1021/acs.jcim.7b00343

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