Browse a selection of impactful findings and insights published this quarter that have captured the attention of leading biotech and pharmaceutical companies worldwide.

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The relentless pursuit of novel therapeutics drives the engine of the biotech and pharma industry. In this dynamic landscape, staying abreast of the latest research is paramount.

This article distills some of the most impactful findings published this quarter, capturing the attention of leading biotech and pharmaceutical companies worldwide. From real-world applications of AI and machine learning in drug discovery to revolutionary approaches in target identification, read on to explore trending topics generating buzz in the industry.

ACS Publications Article Highlights: Biotech & Pharma

Image from the article: How AI/ML techniques fit into the Design-Decide-Make-Test-Learn (D2MTL) cycle.
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Real-World Applications and Experiences of AI/ML Deployment for Drug Discovery

Will R. Pitt*, Jonathan Bentley, Christophe Boldron, Lionel Colliandre, Carmen Esposito, Elizabeth H. Frush, Jola Kopec, Stéphanie Labouille, Jerome Meneyrol, David A. Pardoe, Ferruccio Palazzesi, Alfonso Pozzan, Jacob M. Remington, René Rex, Michelle Southey, Sachin Vishwakarma, and Paul Walker
DOI: 10.1021/acs.jmedchem.4c03044
A portion of the abstract image from the article depicting KRASG12C
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Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers

James Cregg*, Kristof Pota, Aidan C. A. Tomlinson, Jason Yano, Abby Marquez, Yang Liu, Christopher J. Schulze, Kyle J. Seamon, Matthew Holderfield, Xing Wei, Yongxian Zhuang, Yu Chi Yang, Jingjing Jiang, Yue Huang, Ruiping Zhao, Yun Ling, Zhican Wang, Michael Flagella, Zhengping Wang, Mallika Singh, John E. Knox, Robert Nichols, David Wildes, Jacqueline A. M. Smith, Elena S. Koltun, and Adrian L. Gill*
DOI: 10.1021/acs.jmedchem.4c02313
An image from the article: Ground state molecular dynamics simulation of compound 10.
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Discovery of INCB159020, an Orally Bioavailable KRAS G12D Inhibitor

Qinda Ye, Artem Shvartsbart, Zhenwu Li, Pei Gan, Rocco L. Policarpo, Chao Qi, Jeremy J. Roach, Wenyu Zhu, Matthew S. McCammant, Bin Hu, Gencheng Li, Haolin Yin, Peter Carlsen, Gia Hoang, Le Zhao, Robert Susick, Fenglei Zhang, Cheng-Tsung Lai, Abdellah Allali Hassani, Leslie B. Epling, Alexandra Gallion, Kerri Kurzeja-Lipinski, Karen Gallagher, Valerie Roman, Matthew R. Farren, Weixi Kong, Marc C. Deller, Guofeng Zhang, Maryanne Covington, Sharon Diamond, Sunkyu Kim, Wenqing Yao, Alexander Sokolsky*, and Xiaozhao Wang
DOI: 10.1021/acs.jmedchem.4c02662
An image from the article: Compound 6 in a tri-complex with GMPPNP bound KRASG12V(ON). The urea moiety (compound 6) forms a large hydrophobic interface with SWI of RAS at the P34 and Y32 sidechains (PDB ID 9BG7).
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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers

James Cregg*, Anne V. Edwards, Stephanie Chang, Bianca J. Lee, John E. Knox, Aidan C. A. Tomlinson, Abby Marquez, Yang Liu, Rebecca Freilich, Naing Aay, Yingyun Wang, Lingyan Jiang, Jingjing Jiang, Zhican Wang, Michael Flagella, David Wildes, Jacqueline A.M. Smith, Mallika Singh, Zhengping Wang, Adrian L. Gill, and Elena S. Koltun*
DOI: 10.1021/acs.jmedchem.4c02314

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