Observed annually on December 1, World AIDS Day is a global initiative aimed at raising awareness about HIV/AIDS and supporting ongoing efforts to combat the disease.
With an estimated 40.8 million people living with HIV globally and 630,000 deaths reported annually, HIV remains a major global health challenge. Research continues to focus on advancing prevention, treatment, and ultimately, a cure.
To mark this year’s World AIDS Day, ACS Publications is partnering with the ACS Webinars team and the Science History Institute to host a FREE webinar on Monday, December 1, 2025, from 1:00 PM to 2:15 PM (ET). This event will feature leading researchers discussing the history of HIV, recent breakthroughs, and the challenges that remain.
Paul Volberding from University of California San Francisco will explore the evolution of HIV treatment guidelines. And Moupali Das from Gilead Sciences will present on Lenacapavir, an injectable drug approved by the FDA in 2022 for multi-drug-resistant HIV, which demonstrated high effectiveness in 2024 clinical trials. This webinar is moderated by Cheng Fang from Annovis Bio.
Register now for the free webinar to gain insights into the progress made since the 1980s, emerging prevention strategies, and the scientific, social, and global barriers that still stand in the way of a cure.
In conjunction with this timely webinar, ACS Publications has curated a collection of recent, high-impact research articles covering a wide range of topics, including:
- Novel antiretroviral therapies and drug delivery systems
- Mechanisms of HIV resistance and viral replication
- Advances in HIV vaccine development
- Host-pathogen interactions and immune response
- Strategies for long-acting prevention and treatment
- Environmental and biochemical factors influencing HIV transmission
We invite you to explore this collection and join the global effort to combat HIV through science, education, and collaboration.
Explore Recent HIV/AIDS Research from ACS Journals
Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis
Eda Canales*, Winston Tse, Scott D. Schroeder, Chien-Hung Chou, Qi Liu, Jennifer Zhang, Scott E. Lazerwith, Philip Morganelli, Roland D. Saito, Gediminas Brizgys et al.
DOI: 10.1021/acs.jmedchem.5c01625
Structural Analysis of HIV-1 RNase H Bound to a Galloyl Active Site Inhibitor and Computational Compound Modification
Shixuan Wei, Kohei Fujimoto, Kai Tang, Peng Zhan, Luis Menéndez-Arias, and Tyuji Hoshino*
DOI: 10.1021/acs.biochem.5c00266
Design, Synthesis, and Biological Activity of Amine-Type Cyclopentanepyridinone Derivatives as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
Nancy Vanessa Castro-Perea, Gibran Rodríguez-Vega, Julio Cesar Abarca-Magaña, Mirna Berenice Ruiz-Rivera, José L. Medina-Franco, Leonor Huerta, and Daniel Chávez*
DOI: 10.1021/acsomega.5c03953
Utilizing Machine Learning to Improve Neutralization Potency of an HIV-1 Antibody Targeting the gp41 N-Heptad Repeat
Maria V. Filsinger Interrante, Shaogeng Tang, Soohyun Kim, Varun R. Shanker, Brian L. Hie, Theodora U. J. Bruun, Wesley Wu, John E. Pak, Daniel Fernandez, and Peter S. Kim*
DOI: 10.1021/acschembio.5c00035
In Vitro Selection of Cyclized, Glycosylated Peptide Antigens That Tightly Bind HIV High Mannose Patch Antibodies
Jennifer K. Bailey, Satoru Horiya, Mahesh Neralkar, Viktor Horvath, Kosuke Nakamoto, J. Sebastian Temme, Raphael J. Turra, and Isaac J. Krauss*
DOI: 10.1021/acscentsci.5c00539
Zinc Complexes of Cationic Ammonium Phenyl and Methylpyridinium Porphyrins Display Synergistic Anti-HIV-1 and Broad-Spectrum Antibacterial Activity
Debdulal Sharma, Madhu Rai, Nandita Das, Ravi Kumar Kapavarapu, Piyush Pandey*, Ritu Gaur*, and Devashish Sengupta*
DOI: 10.1021/acsomega.4c09535
Temporal, Spatial, and Methodological Considerations in Wastewater-Based Epidemiology for Sexually Transmitted Infections
William Chen and Kyle Bibby*
DOI: 10.1021/acsestwater.5c00104
ReaxFF-Guided Optimization of VIRIP-Based HIV-1 Entry Inhibitors
Fabian Zech*, Christoph Jung, Armando Alexei Rodríguez Alfonso, Janet Köhler, Ludger Ständker, Gilbert Weidinger, Timo Jacob, and Frank Kirchhoff
DOI: 10.1021/acs.jpcb.5c00440
Synthesis of Thioloformate-Containing Lathyrane Diterpene Derivates via a [3,3] Sigmatropic Rearrangement and Their Anti-HIV Activity
Lanfei Ji, Sihao Deng, Jin-Bu Xu, Xiaohuan Li, Steven De Jonghe, Dominique Schols*, and Feng Gao*
DOI: 10.1021/acs.jnatprod.5c00087
Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents
Thane Jones, Renuka Raman, Ana C. Puhl, Thomas R. Lane, Olga Riabova, Elena Kazakova, Vadim Makarov, and Sean Ekins*
DOI: 10.1021/acschemneuro.4c00725
Design, Synthesis, and Biological Evaluation of Darunavir Analogs as HIV-1 Protease Inhibitors
Muhammad Asad Ur Rehman, Hathaichanok Chuntakaruk, Soraat Amphan, Aphinya Suroengrit, Kowit Hengphasatporn, Yasuteru Shigeta, Thanyada Rungrotmongkol, Kuakarun Krusong, Siwaporn Boonyasuppayakorn, Chanat Aonbangkhen, and Tanatorn Khotavivattana*
DOI: 10.1021/acsbiomedchemau.4c00040
Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase–RNA interactions
Elisa Patacchini, Valentina Noemi Madia*, Aurora Albano, Giuseppe Ruggieri, Antonella Messore, Davide Ialongo, Francesco Saccoliti, Luigi Scipione, Sandro Cosconati, Pratibha C. Koneru et al.
DOI: 10.1021/acsmedchemlett.4c00268
Synthesis and Structure Optimization of Star Copolymers as Tunable Macromolecular Carriers for Minimal Immunogen Vaccine Delivery
Gabriela Mixová, Eva Tihlaříková, Yaling Zhu, Lucie Schindler, Ladislav Androvič, Lucie Kracíková, Eliška Hrdá, Bedřich Porsch, Michal Pechar, Christopher M. Garliss et al.
DOI: 10.1021/acs.bioconjchem.4c00273
Structure-Guided Antiviral Peptides Identification Targeting the HIV-1 Integrase
Md. Shahadat Hossain, Md. Siddik Alom, Mohammad Salauddin Kader, Mohammed Akhter Hossain, and Mohammad A. Halim*
DOI: 10.1021/acsphyschemau.4c00006
HIV-1 Infection Reduces NAD Capping of Host Cell snRNA and snoRNA
Barbora Benoni, Jiří František Potužník, Anton Škríba, Roberto Benoni, Jana Trylcova, Matouš Tulpa, Kristína Spustová, Katarzyna Grab, Maria-Bianca Mititelu, Jan Pačes et al.
DOI: 10.1021/acschembio.4c00151
Gag HIV-1 Virus-like Particles and Extracellular Vesicles Functionalization with Spike Epitopes of SARS-CoV-2 Using a Copper-Free Click Chemistry Approach
Marc García-Trujillo*, Jesús Lavado-García, Arnau Boix-Besora, Francesc Gòdia, and Laura Cervera*
DOI: 10.1021/acs.bioconjchem.4c00559
N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants
Pankaj S. Mahajan, Steven J. Smith, Min Li, Robert Craigie, Stephen H. Hughes, Xue Zhi Zhao, and Terrence R. Burke Jr.*
DOI: 10.1021/acsinfecdis.3c00525
Differences in Oligomerization of the SARS-CoV-2 Envelope Protein, Poliovirus VP4, and HIV Vpu
Julia A. Townsend, Oluwaseun Fapohunda, Zhihan Wang, Hieu Pham, Michael T. Taylor, Brian Kloss, Sang Ho Park, Stanley Opella, Craig A. Aspinwall, and Michael T. Marty*
DOI: 10.1021/acs.biochem.3c00437
Prodrug Strategy Extends the Use of Anti-HIV Sulfanylbenzamides for Application In Vivo
Marco Robello, Herman Nikolayevskiy, Michael T. Scerba, Rogers Alberto Nahui Palomino, Vincenzo Mercurio, and Daniel H. Appella*
DOI: 10.1021/acsptsci.3c00260
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent
Raju Subramanian*, Jennifer Tang, Jim Zheng, Bing Lu, Kelly Wang, Stephen R. Yant, George J. Stepan, Andrew Mulato, Helen Yu, Scott Schroeder et al.
DOI: 10.1021/acs.molpharmaceut.3c00626
Bcl-2 Antagonist Obatoclax Reactivates Latent HIV-1 via the NF-κB Pathway and Induces Latent Reservoir Cell Apoptosis in Latently Infected Cells
Chenliang Zhou, Ting Li, Muye Xia, Ziyao Wu, Xuelin Zhong, Axing Li, Huba Khamis Rashid, Chengnuo Ma, Ruijing Zhou, Heng Duan, Xuanxuan Zhang*, Jie Peng*, and Lin Li*
DOI: 10.1021/acsinfecdis.3c00218
Consideration of Nevirapine Analogs To Reduce Metabolically Linked Hepatotoxicity: A Cautionary Tale of the Deuteration Approach
Sylvie E. Kandel, Emily G. Gracey, and Jed N. Lampe*
DOI: 10.1021/acs.chemrestox.3c00192
Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
Winnie Zambrana and Alexandria B. Boehm*
DOI: 10.1021/acsenvironau.3c00025
Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles
Zhao Wang, Prem Prakash Sharma, Brijesh Rathi, Minghui Xie, Erik De Clercq, Christophe Pannecouque*, Dongwei Kang*, Peng Zhan*, and Xinyong Liu*
DOI: 10.1021/acs.jmedchem.3c00275
Layer-by-Layer Particles Deliver Epigenetic Silencing siRNA to HIV-1 Latent Reservoir Cell Types
Ewa Czuba-Wojnilowicz, Vera Klemm, Christina Cortez-Jugo*, Stuart Turville, Anupriya Aggarwal, Frank Caruso, Anthony D. Kelleher, and Chantelle L. Ahlenstiel*
DOI: 10.1021/acs.molpharmaceut.2c01030
