World Sepsis Day is a global initiative aimed at raising awareness of sepsis—a life-threatening condition caused by the body’s extreme response to infection. Read on for recent research, advances in the field, and details on a free webinar featuring leading experts.
World Sepsis Day, held on September 13th each year, is a call for action to raise awareness for the fight against sepsis. With more than 49 million cases and 11 million deaths reported each year, sepsis remains a significant global health challenge. Timely recognition and treatment are critical, and there is an urgent need for innovative approaches to prevention, diagnosis, and therapy.
To mark this year’s World Sepsis Day, ACS Publications is partnering with the ACS Webinars team to host a FREE webinar on Wednesday, September 10, 2025, from 11:00 AM to 12:15 PM (ET). This event will bring together leading researchers in the field to discuss recent advances in sepsis detection and treatment.
Elisa Jentho from the Gulbenkian Institute for Molecular Medicine will speak on the role of metabolic rewiring in infection response and its implications for sepsis prevention. Joe Butler from the Amsterdam Medical Center will provide valuable insights on leveraging whole-blood transcriptomics to understand patient-specific host responses within a two-dimensional severity–dysregulation framework. This webinar is moderated by Alan Hennessy from Global Antibiotic Research & Development Partnership (GARDP).
Register now for the free webinar to gain insights from these experts and explore the latest strategies in sepsis research and clinical management.
Explore Recent Sepsis Research from ACS Journals
In conjunction with this timely webinar, ACS Publications has curated a collection of recent, high-impact research articles covering a wide range of topics, including:
- Host-directed therapies
- Immunotherapy
- Diagnostics and biomarkers
- Biomaterials and nanotechnology
- Antimicrobial agents
We invite you to explore this collection and join the global effort to combat sepsis through science, education, and collaboration.
Electrochemical Biosensors for Sepsis Detection in Liver Cirrhosis: Advances and Insights
ACS Appl. Bio Mater. 2025, 8, 7, 5496–5511
DOI: 10.1021/acsabm.5c00545
Synthesis of the Tetrasaccharide Repeating Unit from Klebsiella pneumoniae Serotype K2 Capsular Polysaccharide
ACS Omega 2025, 10, 26, 28382–28394
DOI: 10.1021/acsomega.5c03675
Deciphering the Regulatory Role and Molecular Interactions That Drive the Competence Regulon Quorum Sensing Circuitry in Streptococcus constellatus
Biochemistry 2025, 64, 14, 3104–3113
DOI: 10.1021/acs.biochem.5c00195
The Extraordinary Benefit of Nature’s Chemistry to Health, Society, and the Economy
J. Nat. Prod. 2025, 88, 6, 1541–1548
DOI: 10.1021/acs.jnatprod.5c00554
Harnessing Telodendrimer Nanotraps in Nanogels for Systemic Immune Modulation in Sepsis Treatment
ACS Pharmacol. Transl. Sci. 2025, 8, 7, 2204–2219
DOI: 10.1021/acsptsci.5c00249
Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis
J. Med. Chem. 2025, 68, 11, 11606–11627
DOI: 10.1021/acs.jmedchem.5c00493
A Point-of-Care Aptasensor for the Real-Time Detection of Sepsis Biomarker
Langmuir 2025, 41, 26, 16822–16831
DOI: 10.1021/acs.langmuir.5c00784
Multifunctional Plasticized Hyaluronic-Acid-Based Nanogel Dressing for Accelerating Diabetic and Nondiabetic Wounds
Biomacromolecules 2025, 26, 6, 3495–3513
DOI: 10.1021/acs.biomac.5c00126
Advances in the Treatment of Spinal Cord Injury with Nanozymes
Bioconjugate Chem. 2025, 36, 4, 627–651
DOI: 10.1021/acs.bioconjchem.5c00100
Monitoring Populations of Single Extracellular Vesicles from Pseudomonas aeruginosa Using Large Parallel Arrays of Zero-Mode Waveguides
Precis. Chem. 2025, 3, 6, 348–356
DOI: 10.1021/prechem.5c00012
Multiplex Detection of Biomarkers Empowered by Nanomaterials
Precis. Chem. 2025, 3, 6, 297–318
DOI: 10.1021/prechem.4c00096
Fragment Screening Identifies Novel Allosteric Binders and Binding Sites in the VHR (DUSP3) Phosphatase
ACS Omega 2025, 10, 5, 4912–4926
DOI: 10.1021/acsomega.4c10321
Engineering Cellular Vesicles for Immunotherapy
Acc. Mater. Res. 2025, 6, 3, 327–339
DOI: 10.1021/accountsmr.4c00362
Dual-Functional Antibiotic Adjuvant Displays Potency against Complicated Gram-Negative Bacterial Infections and Exhibits Immunomodulatory Properties
ACS Cent. Sci. 2025, 11, 2, 279–293
DOI: 10.1021/acscentsci.4c02060
Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate
ACS Synth. Biol. 2025, 14, 1, 101–112
DOI: 10.1021/acssynbio.4c00399
Optimization of the Amoeba Plate Test for the Isolation of Legionella and Other Opportunistic Pathogens from Environmental Water Samples
ACS EST Water 2025, 5, 1, 387–397
DOI: 10.1021/acsestwater.4c00915
Microneedles Constructed by Swellable Hydrogels Loaded with Celastrol for Efficient Treatment of Skin Infections Induced by Drug-Resistant Bacterial Strains
Langmuir 2024, 40, 49, 26125–26136
DOI: 10.1021/acs.langmuir.4c03593
Sialyl Lewisx Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation
ACS Med. Chem. Lett. 2025, 16, 1, 64–71
DOI: 10.1021/acsmedchemlett.4c00452
Antibacterial, Antibiofilm, and Anti-inflammatory Effects of a Novel Thrombin-Derived Peptide in Sepsis Models: Insights into Underlying Mechanisms
J. Med. Chem. 2024, 67, 21, 19791–19812
DOI: 10.1021/acs.jmedchem.4c02157
Carrier-Free Small Molecule-Assembled Nanoparticles for Treatment of Sepsis
ACS Appl. Nano Mater. 2024, 7, 20, 24049–24060
DOI: 10.1021/acsanm.4c04630
Phenanthrenes from Juncus articulatus with Antibacterial and Biofilm Formation Inhibitory Activity
J. Nat. Prod. 2024, 87, 8, 2068–2080
DOI: 10.1021/acs.jnatprod.4c00577
Phenotypic Landscape of Immune Cells in Sepsis: Insights from High-Dimensional Mass Cytometry
ACS Infect. Dis. 2024, 10, 7, 2390–2402
DOI: 10.1021/acsinfecdis.4c00066
Development of Nontoxic Peptides for Lipopolysaccharide Neutralization and Sepsis Treatment
ACS Pharmacol. Transl. Sci. 2024, 7, 6, 1795–1806
DOI: 10.1021/acsptsci.4c00033
Multifunctional Selenium-Based Metal Polyphenol Nanoparticles Impede the Pathological Cross-talk Between Reactive Oxygen Species and Inflammation in Sepsis
ACS Materials Lett. 2024, 6, 6, 2434–2445
DOI: 10.1021/acsmaterialslett.4c00084
PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway
ACS Infect. Dis. 2024, 10, 4, 1370–1378
DOI: 10.1021/acsinfecdis.4c00052
Mechanisms of SARS-CoV-2 Inactivation Using UVC Laser Radiation
ACS Photonics 2024, 11, 1, 42–52
DOI: 10.1021/acsphotonics.3c00828
AlGaN/AlN Stranski–Krastanov Quantum Dots for Highly Efficient Electron Beam-Pumped Emitters: The Role of Miniaturization and Composition to Attain Far UV-C Emission
ACS Photonics 2023, 10, 12, 4225–4235
DOI: 10.1021/acsphotonics.3c00948
Repolarization of Inflammation-Associated Macrophages by Dual Drug-Loaded Liposomes for Acute Lung Sepsis Antibacterial and Anti-inflammatory Therapy
ACS Appl. Nano Mater. 2023, 6, 17, 15829–15840
DOI: 10.1021/acsanm.3c02758
Role of Imaging Modalities and N-Acetylcysteine Treatment in Sepsis-Associated Encephalopathy
ACS Chem. Neurosci. 2023, 14, 11, 2172–2182
DOI: 10.1021/acschemneuro.3c00180
6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
Chem. Res. Toxicol. 2023, 36, 3, 552–560
DOI: 10.1021/acs.chemrestox.3c00002
Achieving Ultrasensitive Chromogenic Probes for Rapid, Direct Detection of Carbapenemase-Producing Bacteria in Sputum
JACS Au 2023, 3, 1, 227–238
DOI: 10.1021/jacsau.2c00607
10-Residue MyD88-Peptide Adopts β-Sheet Structure, Self-Assembles, Binds to Lipopolysaccharides, and Rescues Mice from Endotoxin-Mediated Lung-Infection and Death
ACS Chem. Biol. 2022, 17, 12, 3420–3434
DOI: 10.1021/acschembio.2c00569
Triton X-114 and Amine-Based Wash Strategy Reduces Lipopolysaccharides to FDA Limit and Achieves Purer, More Potent Recombinant Immunotoxin
Bioconjugate Chem. 2021, 32, 4, 713–720
DOI: 10.1021/acs.bioconjchem.1c00013
Enzymatic Synthesis of Chondroitin Sulfate E to Attenuate Bacteria Lipopolysaccharide-Induced Organ Damage
ACS Cent. Sci. 2020, 6, 7, 1199–1207
DOI: 10.1021/acscentsci.0c00712