This Special Issue will highlight important details on negative results and unexpected troubles encountered in day-to-day research and development activities. Submit your manuscript by April 1, 2025.

Laboratory setup with flasks and scientific equipment illuminated in purple light, highlighting advanced research technology.

This Special Issue aims to share process researchers’ expertise in overcoming challenges associated with negative outcomes and unexpected results, addressing troubles caused by a lack of understanding of reactions and physical properties, emerging new impurities due to changes in manufacturing methods, examples of catalytic reaction deactivation during scale-up studies, difficulties in establishing global supply chains, and more.

Organic Process Research & Development is a journal that serves as an authoritative source of scalable procedures for synthetic chemists. As such, it is a communication tool between industrial chemists and chemists working in universities and research institutes. It reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign, and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society.

Topics include, but are not limited to:

  • Pharmaceuticals
  • Agrochemicals
  • Flavors and Food Additives
  • Fragrances, Cosmetics, and Personal Care Products
  • Polymers
  • Petrochemicals

Submit your manuscript by April 1, 2025.

Organizing Editors

Dr. Kai Rossen, Editor-in-Chief, Organic Process Research & Development
Jiuzhou Pharmaceutical, China

Dr. Yasumasa Hayashi, Editorial Advisory Board, Organic Process Research & Development
Sawai Pharmaceutical Co., Japan

Dr. Hirotsugu Usutani, Guest Editor
Sumitomo Pharma Co., Japan

Dr. Makoto Michida, Guest Editor
Daiichi Sankyo Co., Japan

Submission Information

We welcome submissions for this Special Issue through April 1, 2025. For more information on submission requirements, please visit the journal’s Author Guidelines page.

Accepted manuscripts for consideration in this Special Issue can be formatted as Articles, Reviews, or Perspectives. For Reviews and Perspectives, we ask that you discuss the proposed topic with us by sending an inquiry to Papers accepted for publication for this Special Issue will be available ASAP (as soon as publishable) online as soon as they are accepted. After all submissions have been published, they will then be compiled online on a dedicated landing page to form the Special Issue. Manuscripts submitted for consideration will undergo the full rigorous peer review process expected from ACS journals.

How to Submit

  • Log in to the ACS Paragon Plus submission site.
  • Choose Organic Process Research & Development.
  • Select your manuscript type, and, under "Special Issue Selection," choose “Lessons Learned in Organic Process Chemistry."

If you have any general questions regarding submission to this Special Issue, please contact the Editorial Office at

Open Access

There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.

Safety Information in Journal Articles

Including a clear, articulate safety summary statement in your research is vital to ensuring that others who reproduce or expand upon your work can prepare for significant hazards and conduct their own methods as safely as possible. Read more about crafting safety statements in our ACS Axial post series.

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