Discover the Most-Read Organic/Inorganic Chemistry Articles of June 2017

What were chemists reading in June of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in June 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great June 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

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ACS Catalysis

Visible Light-Mediated Direct Decarboxylative C–H Functionalization of Heteroarenes
ACS Catal., 2017, 7 (6), pp 4057–4061
DOI: 10.1021/acscatal.7b01133

Nest-like NiCoP for Highly Efficient Overall Water Splitting
ACS Catal., 2017, 7 (6), pp 4131–4137
DOI: 10.1021/acscatal.7b00662

Ultrathin Nitrogen-Doped Carbon Coated with CoP for Efficient Hydrogen Evolution
ACS Catal., 2017, 7 (6), pp 3824–3831
DOI: 10.1021/acscatal.7b00587

Nickel-Catalyzed C(sp2)–H/C(sp3)–H Oxidative Coupling of Indoles with Toluene Derivatives
ACS Catal., 2017, 7 (6), pp 4202–4208
DOI: 10.1021/acscatal.7b01044

Yin and Yang Dual Characters of CuOx Clusters for C–C Bond Oxidation Driven by Visible Light
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (6), pp 3850–3859
DOI: 10.1021/acscatal.7b00629

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ACS Combinatorial Science

Diversity-Oriented Synthesis of Libraries Based on Benzofuran and 2,3-Dihydrobenzofuran Scaffolds
Open access through ACS AuthorChoice
ACS Comb. Sci., 2017, 19 (6), pp 370–376
DOI: 10.1021/acscombsci.7b00014

Interplay Of Stereochemistry, Conformational Rigidity, And Ease Of Synthesis For 13-Membered Cyclic Peptidomimetics Containing APC Residues
ACS Comb. Sci., 2017, 19 (6), pp 414–421
DOI: 10.1021/acscombsci.7b00041

Diastereoselective Synthesis of Symmetrical and Unsymmetrical Tetrahydropyridines Catalyzed by Bi(III) Immobilized on Triazine Dendrimer Stabilized Magnetic Nanoparticles
ACS Comb. Sci., 2017, 19 (6), pp 356–364
DOI: 10.1021/acscombsci.6b00180

Synthesis of 3,5-Disubstituted Isoxazoles Containing Privileged Substructures with a Diverse Display of Polar Surface Area
ACS Comb. Sci., 2017, 19 (6), pp 407–413
DOI: 10.1021/acscombsci.7b00032

Assembly of Macrocycle Dye Derivatives into Particles for Fluorescence and Photoacoustic Applications
ACS Comb. Sci., 2017, 19 (6), pp 397–406
DOI: 10.1021/acscombsci.7b00031

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ACS Medicinal Chemistry Letters

Practical High-Throughput Experimentation for Chemists
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (6), pp 601–607
DOI: 10.1021/acsmedchemlett.7b00165

Where Are Drugs Invented, and Why Does It Matter?
ACS Med. Chem. Lett., 2017, 8 (6), pp 589–591
DOI: 10.1021/acsmedchemlett.7b00185

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (6), pp 608–613
DOI: 10.1021/acsmedchemlett.7b00103

Janus-Associated Kinase 1 (JAK1) Inhibitors as Potential Treatment for Immune Disorders
ACS Med. Chem. Lett., 2017, 8 (6), pp 598–600
DOI: 10.1021/acsmedchemlett.7b00209

Inhibitors of DNA Gyrase-GyrB Subunit and/or Topoisomerase IV-ParE Subunit May Treat Infectious Diseases Caused by Antibiotic-Resistant Bacteria
ACS Med. Chem. Lett., 2017, 8 (6), pp 592–594
DOI: 10.1021/acsmedchemlett.7b00207

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Bioconjugate Chemistry

Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs
Bioconjugate Chem., 2017, 28 (6), pp 1791–1800
DOI: 10.1021/acs.bioconjchem.7b00252

Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis
Bioconjugate Chem., 2017, 28 (6), pp 1625–1629
DOI: 10.1021/acs.bioconjchem.7b00292

Bioorthogonal Protein Conjugation: Application to the Development of a Highly Sensitive Bioluminescent Immunoassay for the Detection of Interferon-γ
Bioconjugate Chem., 2017, 28 (6), pp 1749–1757
DOI: 10.1021/acs.bioconjchem.7b00220

Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (6), pp 1734–1740
DOI: 10.1021/acs.bioconjchem.7b00185

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor
Bioconjugate Chem., 2017, 28 (6), pp 1669–1676
DOI: 10.1021/acs.bioconjchem.7b00132

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Inorganic Chemistry

Ruthenium(II) Bipyridyl Complexes with Cyclometalated NHC Ligands
Inorg. Chem., 2017, 56 (12), pp 7217–7229
DOI: 10.1021/acs.inorgchem.7b00831

Next-Generation Magnetic Resonance Imaging Contrast Agents
Inorg. Chem., 2017, 56 (11), pp 6029–6034
DOI: 10.1021/acs.inorgchem.7b01277

An Amino-Coordinated Metal–Organic Framework for Selective Gas Adsorption
Inorg. Chem., 2017, 56 (12), pp 6938–6942
DOI: 10.1021/acs.inorgchem.7b00436

Tunable Luminescent Heterometallic Zn2Ln2 Edge-Defective Molecular Cubane with Stimuli-Responsive Properties
Inorg. Chem., 2017, 56 (12), pp 6768–6771
DOI: 10.1021/acs.inorgchem.7b00567

“Turn-on” Fluorescence Sensing and Discriminative Detection of Aliphatic Amines Using a 5-Fold-Interpenetrated Coordination Polymer
Inorg. Chem., 2017, 56 (12), pp 6772–6775
DOI: 10.1021/acs.inorgchem.7b00787

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Journal of Medicinal Chemistry

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases
Open access through ACS AuthorChoice
J. Med. Chem., 2017, 60 (12), pp 5120–5145
DOI: 10.1021/acs.jmedchem.7b00475

Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
J. Med. Chem., 2017, 60 (12), pp 4869–4881
DOI: 10.1021/acs.jmedchem.6b01862

Drug Annotation
J. Med. Chem., 2017, 60 (11), pp 4559–4572
DOI: 10.1021/acs.jmedchem.7b00408

Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability
J. Med. Chem., 2017, 60 (12), pp 4923–4931
DOI: 10.1021/acs.jmedchem.7b00208

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
Open access through ACS AuthorChoice
J. Med. Chem., 2017, 60 (12), pp 5209–5215
DOI: 10.1021/acs.jmedchem.6b01224

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Journal of Natural Products

Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity
J. Nat. Prod., 2017, 80 (6), pp 1767–1775
DOI: 10.1021/acs.jnatprod.6b01099

The First Enantioselective Total Synthesis of (−)-trans-Dihydronarciclasine
J. Nat. Prod., 2017, 80 (6), pp 1909–1917
DOI: 10.1021/acs.jnatprod.7b00208

Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa
J. Nat. Prod., 2017, 80 (6), pp 1798–1807
DOI: 10.1021/acs.jnatprod.7b00004

Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (6), pp 1883–1892
DOI: 10.1021/acs.jnatprod.7b00189

Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii
J. Nat. Prod., 2017, 80 (6), pp 1714–1724
DOI: 10.1021/acs.jnatprod.6b00730

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The Journal of Organic Chemistry

From Highly Fluorescent Donors to Strongly Absorbing Acceptors: The Tunable Properties of Fluorubines
J. Org. Chem., 2017, 82 (12), pp 6153–6162
DOI: 10.1021/acs.joc.7b00676

A Palladium-Catalyzed α-Arylation of Oxindoles with Aryl Tosylates
J. Org. Chem., 2017, 82 (12), pp 6468–6473
DOI: 10.1021/acs.joc.7b00855

Electrocatalytic C–H/N–H Coupling of 2′-Aminoacetophenones for the Synthesis of Isatins
J. Org. Chem., 2017, 82 (12), pp 6434–6440
DOI: 10.1021/acs.joc.7b00635

Organocatalytic Asymmetric Michael-Hemiacetalization Reaction Between 2-Hydroxyacetophenones and Enals: A Route to Chiral β,γ-Disubstituted γ-Butyrolactones
J. Org. Chem., 2017, 82 (12), pp 6409–6416
DOI: 10.1021/acs.joc.7b00363

Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles
J. Org. Chem., 2017, 82 (12), pp 6163–6171
DOI: 10.1021/acs.joc.7b00752

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Molecular Pharmaceutics

Functionalized Lipid–Polymer Hybrid Nanoparticles Mediated Codelivery of Methotrexate and Aceclofenac: A Synergistic Effect in Breast Cancer with Improved Pharmacokinetics Attributes
Mol. Pharmaceutics, 2017, 14 (6), pp 1883–1897
DOI: 10.1021/acs.molpharmaceut.6b01148

Development of a Biorelevant, Material-Sparing Membrane Flux Test for Rapid Screening of Bioavailability-Enhancing Drug Product Formulations
Mol. Pharmaceutics, 2017, 14 (6), pp 2032–2046
DOI: 10.1021/acs.molpharmaceut.7b00121

Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model
Mol. Pharmaceutics, 2017, 14 (6), pp 1929–1937
DOI: 10.1021/acs.molpharmaceut.7b00024

Superior Plasticity and Tabletability of Theophylline Monohydrate
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (6), pp 2047–2055
DOI: 10.1021/acs.molpharmaceut.7b00124

Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Mol. Pharmaceutics, 2017, 14 (6), pp 1852–1860
DOI: 10.1021/acs.molpharmaceut.6b01015

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Organic Letters

Decarbonylative Cyanation of Amides by Palladium Catalysis
Org. Lett., 2017, 19 (12), pp 3095–3098
DOI: 10.1021/acs.orglett.7b01199

Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (−)-Quebrachamine, (+)-Aspidospermidine, (−)-Aspidospermine, (−)-Pyrifolidine, and Related Natural Products
Org. Lett., 2017, 19 (12), pp 3167–3170
DOI: 10.1021/acs.orglett.7b01292

Spiroannulation of Oxindoles via Aryne and Alkyne Incorporation: Substituent-Diverted, Transition-Metal-Free, One-Pot Access to Spirooxindoles
Org. Lett., 2017, 19 (12), pp 3119–3122
DOI: 10.1021/acs.orglett.7b01233

Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides
Org. Lett., 2017, 19 (12), pp 3091–3094
DOI: 10.1021/acs.orglett.7b01194

Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C–H Nitration of Arenes with Removable Auxiliaries
Org. Lett., 2017, 19 (12), pp 3199–3202
DOI: 10.1021/acs.orglett.7b01297

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (6), pp 789–799
DOI: 10.1021/acs.oprd.7b00193

Development of a Continuous-Flow Sonogashira Cross-Coupling Protocol using Propyne Gas under Process Intensified Conditions
Org. Process Res. Dev., 2017, 21 (6), pp 878–884
DOI: 10.1021/acs.oprd.7b00160

Process Analytical Tools To Control Polymorphism and Particle Size in Batch Crystallization Processes
Org. Process Res. Dev., 2017, 21 (6), pp 855–865
DOI: 10.1021/acs.oprd.7b00087

Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant
Org. Process Res. Dev., 2017, 21 (6), pp 844–854
DOI: 10.1021/acs.oprd.7b00058

Selective One-Pot Three-Step Cascade Reaction: From Aromatic Aldehydes to 2,2-Diphenylethanol Derivatives
Org. Process Res. Dev., 2017, 21 (6), pp 835–843
DOI: 10.1021/acs.oprd.6b00382

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Organometallics

Side-Arm Control in Phosphine-Sulfonate Palladium- and Nickel-Catalyzed Ethylene Polymerization and Copolymerization
Organometallics, 2017, 36 (12), pp 2338–2344
DOI: 10.1021/acs.organomet.7b00294

Cp*Ir-Catalyzed Acceptorless Dehydrogenation of Carbon–Carbon Single Bonds
Organometallics, 2017, 36 (12), pp 2317–2322
DOI: 10.1021/acs.organomet.7b00245

Impact of Weak Agostic Interactions in Nickel Electrocatalysts for Hydrogen Oxidation
Organometallics, 2017, 36 (12), pp 2275–2284
DOI: 10.1021/acs.organomet.7b00103

Mechanism of the Suzuki–Miyaura Cross-Coupling Reaction Mediated by [Pd(NHC)(allyl)Cl] Precatalysts
Organometallics, 2017, 36 (11), pp 2088–2095
DOI: 10.1021/acs.organomet.7b00114

Rhodium/Lewis Acid Catalyzed Regioselective Addition of 1,3-Dicarbonyl Compounds to Internal Alkynes
Organometallics, 2017, 36 (12), pp 2323–2330
DOI: 10.1021/acs.organomet.7b00284