Here, we discover the most-read organic/inorganic chemistry articles March 2018, including research, reviews, perspectives, and editorial pieces.
There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in March 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
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Read more of March’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical
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ACS Catalysis
Aluminum-Catalyzed Hydroboration of Alkenes
ACS Catal., 2018, 8 (3), pp 2001–2005
DOI: 10.1021/acscatal.7b04279
Consciously Constructing Heterojunction or Direct Z-Scheme Photocatalysts by Regulating Electron Flow Direction
ACS Catal., 2018, 8 (3), pp 2209–2217
DOI: 10.1021/acscatal.7b04323
Decarboxylative Olefination of Activated Aliphatic Acids Enabled by Dual Organophotoredox/Copper Catalysis
ACS Catal., 2018, 8 (3), pp 1715–1719
DOI: 10.1021/acscatal.7b04281
Liquid-Phase Modeling in Heterogeneous Catalysis
ACS Catal., 2018, 8 (3), pp 2188–2194
DOI: 10.1021/acscatal.7b04367
Mo- and Fe-Modified Ni(OH)2/NiOOH Nanosheets as Highly Active and Stable Electrocatalysts for Oxygen Evolution Reaction
ACS Catal., 2018, 8 (3), pp 2359–2363
DOI: 10.1021/acscatal.7b04226
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ACS Combinatorial Science
Crystallographic Structure Analysis of a Ti–Ta Thin Film Materials Library Fabricated by Combinatorial Magnetron Sputtering
ACS Comb. Sci., 2018, 20 (3), pp 137–150
DOI: 10.1021/acscombsci.7b00135
Detection of Circulating Tumor Cells Using Microfluidics
ACS Comb. Sci., 2018, 20 (3), pp 107–126
DOI: 10.1021/acscombsci.7b00146
Efficient Access to Imidazo[1,2-a]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent
ACS Comb. Sci., 2018, 20 (3), pp 164–171
DOI: 10.1021/acscombsci.7b00173
Enediyne-Comprising Amino Aldehydes in the Passerini Reaction
ACS Comb. Sci., 2018, 20 (3), pp 151–155
DOI: 10.1021/acscombsci.7b00167
Rapid Construction of Fe–Co–Ni Composition-Phase Map by Combinatorial Materials Chip Approach
ACS Comb. Sci., 2018, 20 (3), pp 127–131
DOI: 10.1021/acscombsci.7b00171
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ACS Medicinal Chemistry Letters
2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4
ACS Med. Chem. Lett., 2018, 9 (3), pp 215–220
DOI: 10.1021/acsmedchemlett.7b00485
Acyl Sulfonamides NaV1.7 Blockers Useful for the Treatment of Pain
ACS Med. Chem. Lett., 2018, 9 (3), pp 161–162
DOI: 10.1021/acsmedchemlett.8b00038
Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment
ACS Med. Chem. Lett., 2018, 9 (3), pp 163–164
DOI: 10.1021/acsmedchemlett.8b00039
Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer’s Disease
ACS Med. Chem. Lett., 2018, 9 (3), pp 165–166
DOI: 10.1021/acsmedchemlett.8b00043
Data Sets Representative of the Structures and Experimental Properties of FDA-Approved Drugs
ACS Med. Chem. Lett., 2018, 9 (3), pp 204–209
DOI: 10.1021/acsmedchemlett.7b00462
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Bioconjugate Chemistry
Bioconjugate Materials in Vaccines and Immunotherapies
Bioconjugate Chem., 2018, 29 (3), pp 571–571
DOI: 10.1021/acs.bioconjchem.8b001
Bioconjugation Approaches to Producing Subunit Vaccines Composed of Protein or Peptide Antigens and Covalently Attached Toll-Like Receptor Ligands
Bioconjugate Chem., 2018, 29 (3), pp 572–586
DOI: 10.1021/acs.bioconjchem.7b00478
Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy
Bioconjugate Chem., 2018, 29 (3), pp 624–634
DOI: 10.1021/acs.bioconjchem.7b00669
Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy
Bioconjugate Chem., 2018, 29 (3), pp 702–708
DOI: 10.1021/acs.bioconjchem.7b00619
Covalent Conjugation of Peptide Antigen to Mesoporous Silica Rods to Enhance Cellular Responses
Bioconjugate Chem., 2018, 29 (3), pp 733–741
DOI: 10.1021/acs.bioconjchem.7b00656
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Inorganic Chemistry
A Dual-Functional Luminescent MOF Sensor for Phenylmethanol Molecule and Tb3+ Cation
Inorg. Chem., 2018, 57 (5), pp 2654–2662
DOI: 10.1021/acs.inorgchem.7b03053
A Series of Banana-Shaped 3d-4f Heterometallic Cluster Substituted Polyoxometalates: Syntheses, Crystal Structures, and Magnetic Properties
Inorg. Chem., 2018, 57 (5), pp 2472–2479
DOI: 10.1021/acs.inorgchem.7b02728
Nanocrystals for Triplet Sensitization: Molecular Behavior from Quantum-Confined Materials
Inorg. Chem., 2018, 57 (5), pp 2351–2359
DOI: 10.1021/acs.inorgchem.7b03219
Pentagonal-Bipyramid Ln(III) Complexes Exhibiting Single-Ion-Magnet Behavior: A Rational Synthetic Approach for a Rigid Equatorial Plane
Inorg. Chem., 2018, 57 (5), pp 2398–2401
DOI: 10.1021/acs.inorgchem.8b00059
Relevance of Orbital Interactions and Pauli Repulsion in the Metal–Metal Bond of Coinage Metals
Open access through ACS AuthorChoice
Inorg. Chem., 2018, 57 (5), pp 2603–2608
DOI: 10.1021/acs.inorgchem.7b02994
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Journal of Medicinal Chemistry
Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts
J. Med. Chem., 2018, 61 (5), pp 1767–1773
DOI: 10.1021/acs.jmedchem.7b00762
Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo
J. Med. Chem., 2018, 61 (5), pp 2009–2017
DOI: 10.1021/acs.jmedchem.7b01634
Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (5), pp 1800–1820
DOI: 10.1021/acs.jmedchem.7b00925
Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors
J. Med. Chem., 2018, 61 (6), pp 2353–2371
DOI: 10.1021/acs.jmedchem.7b01612
Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile
J. Med. Chem., 2018, 61 (5), pp 1785–1799
DOI: 10.1021/acs.jmedchem.7b01690
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Journal of Natural Products
Anti-Influenza Triterpene Saponins from the Bark of Burkea africana
Open access through ACS AuthorChoice
J. Nat. Prod., 2018, 81 (3), pp 515–523
DOI: 10.1021/acs.jnatprod.7b00774
Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa
J. Nat. Prod., 2018, 81 (3), pp 475–483
DOI: 10.1021/acs.jnatprod.7b00579
Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners
J. Nat. Prod., 2018, 81 (3), pp 607–615
DOI: 10.1021/acs.jnatprod.8b00111
Marine Invertebrate Natural Products that Target Microtubules
J. Nat. Prod., 2018, 81 (3), pp 691–702
DOI: 10.1021/acs.jnatprod.7b00964
Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
J. Nat. Prod., 2018, 81 (3), pp 679–690
DOI: 10.1021/acs.jnatprod.7b00945
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The Journal of Organic Chemistry
Cyanthiwigin Natural Product Core as a Complex Molecular Scaffold for Comparative Late-Stage C–H Functionalization Studies
Open access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (6), pp 3023–3033
DOI: 10.1021/acs.joc.7b03291
Mechanism and Origins of Regio- and Enantioselectivities of Iridium-Catalyzed Hydroarylation of Alkenyl Ethers
J. Org. Chem., 2018, 83 (5), pp 2937–2947
DOI: 10.1021/acs.joc.8b00377
Mixing O-Containing and N-Containing Directing Groups for C–H Activation: A Strategy for the Synthesis of Highly Functionalized 2,2′-Biaryls
J. Org. Chem., 2018, 83 (5), pp 2582–2591
DOI: 10.1021/acs.joc.7b02863
Organocatalyzed, Visible-Light Photoredox-Mediated, One-Pot Minisci Reaction Using Carboxylic Acids via N-(Acyloxy)phthalimides
J. Org. Chem., 2018, 83 (5), pp 3000–3012
DOI: 10.1021/acs.joc.8b00205
Regio- and Stereoselective Synthesis of Isoindolin-1-ones through BuLi-Mediated Iodoaminocyclization of 2-(1-Alkynyl)benzamides
J. Org. Chem., 2018, 83 (6), pp 3339–3347
DOI: 10.1021/acs.joc.7b02903
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Molecular Pharmaceutics
Charge Reversible and Mitochondria/Nucleus Dual Target Lipid Hybrid Nanoparticles To Enhance Antitumor Activity of Doxorubicin
Mol. Pharmaceutics, 2018, 15 (3), pp 1296–1308
DOI: 10.1021/acs.molpharmaceut.7b01109
Delivery of Oxytocin to the Brain for the Treatment of Autism Spectrum Disorder by Nasal Application
Mol. Pharmaceutics, 2018, 15 (3), pp 1105–1111
DOI: 10.1021/acs.molpharmaceut.7b00991
Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality
Mol. Pharmaceutics, 2018, 15 (3), pp 1062–1072
DOI: 10.1021/acs.molpharmaceut.7b00933
Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System
Mol. Pharmaceutics, 2018, 15 (3), pp 1097–1104
DOI: 10.1021/acs.molpharmaceut.7b00988
Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides
Mol. Pharmaceutics, 2018, 15 (3), pp 1332–1340
DOI: 10.1021/acs.molpharmaceut.7b01130
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Organic Letters
2-Position-Selective C–H Perfluoroalkylation of Quinoline Derivatives
Org. Lett., 2018, 20 (6), pp 1593–1596
DOI: 10.1021/acs.orglett.8b00339
Collective Total Synthesis of (−)-Lundurines A–C
Org. Lett., 2018, 20 (6), pp 1509–1512
DOI: 10.1021/acs.orglett.8b00210
Divergent Synthesis of Oxindolylidene Acetates and Spirooxindolopyrrolidones from Arynes
Org. Lett., 2018, 20 (6), pp 1483–1486
DOI: 10.1021/acs.orglett.7b03661
Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow
Open access through ACS AuthorChoice
Org. Lett., 2018, 20 (5), pp 1338–1341
DOI: 10.1021/acs.orglett.8b00070
Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols
Org. Lett., 2018, 20 (6), pp 1580–1583
DOI: 10.1021/acs.orglett.8b00325
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Organic Process Research & Development
A New Synthetic Route to Avibactam: Lipase Catalytic Resolution and the Simultaneous Debenzylation/Sulfation
Org. Process Res. Dev., 2018, 22 (3), pp 267–272
DOI: 10.1021/acs.oprd.7b00290
An Alternative Indazole Synthesis for Merestinib
Org. Process Res. Dev., 2018, 22 (3), pp 409–419
DOI: 10.1021/acs.oprd.8b00016
An Efficient Through-Process for Chk1 Kinase Inhibitor GDC-0575
Org. Process Res. Dev., 2018, 22 (3), pp 344–350
DOI: 10.1021/acs.oprd.7b00388
Development and Scale-Up of a Crystallization Process To Improve an API’s Physiochemical and Bulk Powder Properties
Org. Process Res. Dev., 2018, 22 (3), pp 296–305
DOI: 10.1021/acs.oprd.7b00344
Development of an Organometallic Flow Chemistry Reaction at Pilot-Plant Scale for the Manufacture of Verubecestat
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2018, 22 (3), pp 403–408
DOI: 10.1021/acs.oprd.7b00385
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Organometallics
Acceptorless Alcohol Dehydrogenation: OH vs NH Effect in Bifunctional NHC–Ir(III) Complexes
Organometallics, 2018, 37 (5), pp 636–644
DOI: 10.1021/acs.organomet.7b00220
Accessing Alkyl- and Alkenylcyclopentanes from Cr-Catalyzed Ethylene Oligomerization Using 2-Phosphinophosphinine Ligands
Organometallics, 2018, 37 (6), pp 1062–1073
DOI: 10.1021/acs.organomet.8b00063
Applying a Trojan Horse Strategy to Ruthenium Complexes in the Pursuit of Novel Antibacterial Agents
Open access through ACS AuthorChoice
Organometallics, 2018, 37 (6), pp 915–923
DOI: 10.1021/acs.organomet.7b00885
Concurrently Improving the Thermal Stability and Activity of Ferrous Precatalysts for the Production of Saturated/Unsaturated Polyethylene
Organometallics, 2018, 37 (6), pp 957–970
DOI: 10.1021/acs.organomet.7b00909
Correction to Nitrogen–Nitrogen Bond Formation via a Substrate-Bound Anion at a Mononuclear Nickel Platform
Organometallics, 2018, 37 (6), pp 1086–1086
DOI: 10.1021/acs.organomet.8b00126