There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of October’s most-read articles.

ACS Catalysis


Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis
DOI: 10.1021/acscatal.9b03084

Catalysis of Organic Reactions through Halogen Bonding
DOI: 10.1021/acscatal.9b02894

Nickel/Cobalt-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
DOI: 10.1021/acscatal.9b03352

Gold-Catalyzed C–H Functionalization with Aryl Germanes
DOI: 10.1021/acscatal.9b02841

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
DOI: 10.1021/acscatal.9b03190


ACS Combinatorial Science


A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis
DOI: 10.1021/acscombsci.9b00113

Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives
DOI: 10.1021/acscombsci.9b00124

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides
DOI: 10.1021/acscombsci.9b00144

Enzyme Degassing for Oxygen-Sensitive Reactions in Open Vessels of an Automated Parallel Synthesizer: RAFT Polymerizations
DOI: 10.1021/acscombsci.9b00082

Scanning Electrochemical Flow Cell with Online Mass Spectroscopy for Accelerated Screening of Carbon Dioxide Reduction Electrocatalysts
DOI: 10.1021/acscombsci.9b00130

ACS Medicinal Chemistry Letters


PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00397

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00301

“AβTau”, Lobby or Religion?
DOI: 10.1021/acsmedchemlett.9b00439

PROTAC Degradation of IRAK4 for the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00423

Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00310

Bioconjugate Chemistry


Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
DOI: 10.1021/acs.bioconjchem.9b00306

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation
DOI: 10.1021/acs.bioconjchem.9b00639

Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes
DOI: 10.1021/acs.bioconjchem.9b00582

Zwitterionic Modification of Nanomaterials for Improved Diagnosis of Cancer Cells
DOI: 10.1021/acs.bioconjchem.9b00543

Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention
DOI: 10.1021/acs.bioconjchem.9b00587

Inorganic Chemistry


The Chemistry Women Mentorship Network (ChemWMN): A Tool for Creating Critical Mass in Academic Chemistry
DOI: 10.1021/acs.inorgchem.9b02707

Metals in Biology: From Metallomics to Trafficking
DOI: 10.1021/acs.inorgchem.9b02965

Structure and Properties of a Five-Coordinate Nickel(II) Porphyrin
DOI: 10.1021/acs.inorgchem.9b00348

Inorganic Chemistry Approaches to Activity-Based Sensing: From Metal Sensors to Bioorthogonal Metal Chemistry
DOI: 10.1021/acs.inorgchem.9b01221

Spectroscopic X-ray and Mössbauer Characterization of M6 and M5 Iron(Molybdenum)-Carbonyl Carbide Clusters: High Carbide-Iron Covalency Enhances Local Iron Site Electron Density Despite Cluster Oxidation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.9b01870

Journal of Medicinal Chemistry


Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
DOI: 10.1021/acs.jmedchem.9b01234

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases
DOI: 10.1021/acs.jmedchem.9b01612

Antibiotic Adjuvants: Make Antibiotics Great Again!
DOI: 10.1021/acs.jmedchem.8b01781

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
DOI: 10.1021/acs.jmedchem.9b00444

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
DOI: 10.1021/acs.jmedchem.9b00533

Journal of Natural Products


Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114
DOI: 10.1021/acs.jnatprod.8b01056

Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2
DOI: 10.1021/acs.jnatprod.9b00212

Anti-Lymphangiogenic Alkaloids from the Zoanthid Zoanthus vietnamensis Collected in Taiwan
DOI: 10.1021/acs.jnatprod.9b00451

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
DOI: 10.1021/acs.jnatprod.9b00522

Tripterfordins A–O, Dihydro-β-agarofuran Sesquiterpenoids from the Leaves of Tripterygium wilfordii
DOI: 10.1021/acs.jnatprod.9b00089

The Journal of Organic Chemistry


The Breadth and Depth of C–H Functionalization
DOI: 10.1021/acs.joc.9b02663

Axial Chirality at the Boron–Carbon Bond: Synthesis, Stereodynamic Analysis, and Atropisomeric Resolution of 6-Aryl-5,6-dihydrodibenzo[c,e][1,2]azaborinines
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.9b01550

N-Amino-7-azaindole as the N,N′-Bidentate Directing Group: Ruthenium-Catalyzed Oxidative Annulation of N-(7-Azaindole)benzamides with Alkynes via C–H Bond Activation
DOI: 10.1021/acs.joc.9b01598

En Route to Intermolecular Cross-Dehydrogenative Coupling Reactions
DOI: 10.1021/acs.joc.9b01704

Development of an Imine Chaperone for Selective C–H Functionalization of Alcohols via Radical Relay
DOI: 10.1021/acs.joc.9b02052


Molecular Pharmaceutics


Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00703

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00406

Recent Advances in Understanding the Micro- and Nanoscale Phenomena of Amorphous Solid Dispersions
DOI: 10.1021/acs.molpharmaceut.9b00601

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00730

From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design
DOI: 10.1021/acs.molpharmaceut.9b00634

Organic Letters


Characterization of Leptazolines A–D, Polar Oxazolines from the Cyanobacterium Leptolyngbya sp., Reveals a Glitch with the “Willoughby–Hoye” Scripts for Calculating NMR Chemical Shifts
DOI: 10.1021/acs.orglett.9b03216

Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes
DOI: 10.1021/acs.orglett.9b02779

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent
DOI: 10.1021/acs.orglett.9b03024

Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.9b03018

Visible-Light-Induced Copper-Catalyzed Intermolecular Markovnikov Hydroamination of Alkenes
DOI: 10.1021/acs.orglett.9b02863

Organic Process Research & Development


Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00412

Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00276

The Role of Process Chemistry in Providing Healthy Food for a Healthy and Growing Planet
DOI: 10.1021/acs.oprd.9b00383

Applications of the 12 Principles of Green Chemistry in the Crop Protection Industry
DOI: 10.1021/acs.oprd.9b00305

Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1H-pyrazol-1-yl)pyridine
DOI: 10.1021/acs.oprd.9b00127




Isolation and Characterization of a Homoleptic Tetramethylcobalt(III) Distorted Square-Planar Complex
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.9b00387

Asymmetric Synthesis Enabled by Organometallic Complexes
DOI: 10.1021/acs.organomet.9b00627

Synthesis, Structure, and Reactivity of an NHC Silyl Gold(I) Complex
DOI: 10.1021/acs.organomet.9b00574

Synthesis of (MeCN)2Pd(CF3)OTs, a General Precursor to Palladium(II) Trifluoromethyl Complexes LPd(CF3)X
DOI: 10.1021/acs.organomet.9b00516

Dioxo-, Oxo-imido-, and Bis-imido-Molybdenum(VI) Complexes with a Bis-phenolate-NHC Ligand
DOI: 10.1021/acs.organomet.9b00472

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