What were chemists reading in February of 2017? To find out, we’ve compiled lists of the five most-read organic and inorganic chemistry articles that appeared in each related ACS Publications journal in February 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take […]
What were chemists reading in February of 2017? To find out, we’ve compiled lists of the five most-read organic and inorganic chemistry articles that appeared in each related ACS Publications journal in February 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.
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ACS Catalysis
A Versatile Disulfide-Driven Recycling System for NADP+ with High Cofactor Turnover Number
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1025–1029
DOI: 10.1021/acscatal.6b03061
Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1432–1437
DOI: 10.1021/acscatal.6b03388
Breaking Amides using Nickel Catalysis
ACS Catal., 2017, 7 (2), pp 1413–1423
DOI: 10.1021/acscatal.6b03277
Metal–Metal Bonds in Catalysis
ACS Catal., 2017, 7 (2), pp 936–958
DOI: 10.1021/acscatal.6b02692
Catalytic Zirconium/Hafnium-Based Metal–Organic Frameworks
ACS Catal., 2017, 7 (2), pp 997–1014
DOI: 10.1021/acscatal.6b02923
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ACS Combinatorial Science
Synthesis of Novel 5,6-Disubstituted Pyrrolo [2,3-d]Pyrimidine-2,4-Diones Via One-Pot Three-Component Reactions
ACS Comb. Sci., 2017, 19 (2), pp 108–112
DOI: 10.1021/acscombsci.6b00147
Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease
ACS Comb. Sci., 2017, 19 (2), pp 55–80
DOI: 10.1021/acscombsci.6b00116
Neural-Network-Biased Genetic Algorithms for Materials Design: Evolutionary Algorithms That Learn
ACS Comb. Sci., 2017, 19 (2), pp 96–107
DOI: 10.1021/acscombsci.6b00136
Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds
ACS Comb. Sci., 2017, 19 (2), pp 85–95
DOI: 10.1021/acscombsci.6b00119
Fluorophore Metal–Organic Complexes: High-Throughput Optical Screening for Aprotic Electrochemical Systems
ACS Comb. Sci., 2017, 19 (2), pp 81–84
DOI: 10.1021/acscombsci.6b00171
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ACS Medicinal Chemistry Letters
Communicating Our Science to Our Customers: Drug Discovery in Five Simple Experiments.
ACS Med. Chem. Lett., 2017, 8 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.7b00015
Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry
ACS Med. Chem. Lett., 2017, 8 (2), pp 139–142
DOI: 10.1021/acsmedchemlett.7b00002
Design and Synthesis of Novel, Selective GPR40 AgoPAMs
ACS Med. Chem. Lett., 2017, 8 (2), pp 221–226
DOI: 10.1021/acsmedchemlett.6b00443
Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2
ACS Med. Chem. Lett., 2017, 8 (2), pp 256–260
DOI: 10.1021/acsmedchemlett.6b00486
Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (2), pp 239–244
DOI: 10.1021/acsmedchemlett.6b00464
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Bioconjugate Chemistry
Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody–Drug Conjugate with Cleavable Linker
Bioconjugate Chem., 2017, 28 (2), pp 620–626
DOI: 10.1021/acs.bioconjchem.6b00695
Peptide-Based Stealth Nanoparticles for Targeted and pH-Triggered Delivery
Bioconjugate Chem., 2017, 28 (2), pp 627–635
DOI: 10.1021/acs.bioconjchem.6b00701
Investigation of Hydrophilic Auristatin Derivatives for Use in Antibody Drug Conjugates
Bioconjugate Chem., 2017, 28 (2), pp 371–381
DOI: 10.1021/acs.bioconjchem.6b00530
Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes
Bioconjugate Chem., 2017, 28 (2), pp 341–352
DOI: 10.1021/acs.bioconjchem.6b00433
Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers
Bioconjugate Chem., 2017, 28 (2), pp 583–589
DOI: 10.1021/acs.bioconjchem.6b00678
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Inorganic Chemistry
Activating Fe(I) Porphyrins for the Hydrogen Evolution Reaction Using Second-Sphere Proton Transfer Residues
Inorg. Chem., 2017, 56 (4), pp 1783–1793
DOI: 10.1021/acs.inorgchem.6b01707
Bifunctional Imidazolium-Based Ionic Liquid Decorated UiO-67 Type MOF for Selective CO2 Adsorption and Catalytic Property for CO2 Cycloaddition with Epoxides
Inorg. Chem., 2017, 56 (4), pp 2337–2344
DOI: 10.1021/acs.inorgchem.6b03169
Green Synthesis of Zr-CAU-28: Structure and Properties of the First Zr-MOF Based on 2,5-Furandicarboxylic Acid
Inorg. Chem., 2017, 56 (4), pp 2270–2277
DOI: 10.1021/acs.inorgchem.6b02969
Photoluminescent and Slow Magnetic Relaxation Studies on Lanthanide(III)-2,5-pyrazinedicarboxylate Frameworks
Inorg. Chem., 2017, 56 (4), pp 2108–2123
DOI: 10.1021/acs.inorgchem.6b02774
Water-Stable In(III)-Based Metal–Organic Frameworks with Rod-Shaped Secondary Building Units: Single-Crystal to Single-Crystal Transformation and Selective Sorption of C2H2 over CO2 and CH4
Inorg. Chem., 2017, 56 (4), pp 2188–2197
DOI: 10.1021/acs.inorgchem.6b02840
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Journal of Medicinal Chemistry
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
J. Med. Chem., 2017, 60 (4), pp 1247–1261
DOI: 10.1021/acs.jmedchem.6b01751
Recent Advances in Scaffold Hopping
J. Med. Chem., 2017, 60 (4), pp 1238–1246
DOI: 10.1021/acs.jmedchem.6b01437
Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions
J. Med. Chem., 2017, 60 (3), pp 839–885
DOI: 10.1021/acs.jmedchem.6b00788
Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
J. Med. Chem., 2017, 60 (3), pp 1000–1017
DOI: 10.1021/acs.jmedchem.6b01329
Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
J. Med. Chem., 2017, 60 (3), pp 1060–1075
DOI: 10.1021/acs.jmedchem.6b01460
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Journal of Natural Products
Diterpenoids and Lignans from Cephalotaxus fortunei
J. Nat. Prod., 2017, 80 (2), pp 356–362
DOI: 10.1021/acs.jnatprod.6b00802
Concise Syntheses of Hyrtioreticulins C and D via a C-4 Pictet–Spengler Reaction: Revised Signs of Specific Rotations
J. Nat. Prod., 2017, 80 (2), pp 241–245
DOI: 10.1021/acs.jnatprod.7b00008
Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227
J. Nat. Prod., 2017, 80 (2), pp 569–573
DOI: 10.1021/acs.jnatprod.6b01107
Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges
J. Nat. Prod., 2017, 80 (2), pp 235–240
DOI: 10.1021/acs.jnatprod.6b00838
Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum
J. Nat. Prod., 2017, 80 (2), pp 298–307
DOI: 10.1021/acs.jnatprod.6b00694
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The Journal of Organic Chemistry
Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides
Open access through ACS Editors’ Choice
J. Org. Chem., 2017, 82 (4), pp 1888–1894
DOI: 10.1021/acs.joc.6b03034
Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides
J. Org. Chem., 2017, 82 (4), pp 2059–2066
DOI: 10.1021/acs.joc.6b02891
Photoredox-Assisted Reductive Cross-Coupling: Mechanistic Insight into Catalytic Aryl–Alkyl Cross-Couplings
J. Org. Chem., 2017, 82 (4), pp 1996–2003
DOI: 10.1021/acs.joc.6b02830
Synthesis of Rings DEF of Solanoeclepin A
J. Org. Chem., 2017, 82 (4), pp 2045–2058
DOI: 10.1021/acs.joc.6b02886
Synthesis of 5H-Dibenzo[c,e]azepine-5,7(6H)-diones from Benzamides via Palladium-Catalyzed Double C–H Bond Activation
J. Org. Chem., 2017, 82 (4), pp 2288–2293
DOI: 10.1021/acs.joc.6b03087
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Molecular Pharmaceutics
Polymer–Drug Nanoparticles Combine Doxorubicin Carrier and Heparin Bioactivity Functionalities for Primary and Metastatic Cancer Treatment
Mol. Pharmaceutics, 2017, 14 (2), pp 513–522
DOI: 10.1021/acs.molpharmaceut.6b00979
Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract
Mol. Pharmaceutics, 2017, 14 (2), pp 345–358
DOI: 10.1021/acs.molpharmaceut.6b00641
Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
Mol. Pharmaceutics, 2017, 14 (2), pp 459–467
DOI: 10.1021/acs.molpharmaceut.6b00896
Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties
Mol. Pharmaceutics, 2017, 14 (2), pp 523–532
DOI: 10.1021/acs.molpharmaceut.6b01010
Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins
Mol. Pharmaceutics, 2017, 14 (2), pp 368–376
DOI: 10.1021/acs.molpharmaceut.6b00678
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Organic Letters
Metal-Free C–H Functionalization of Alkanes by Aryldiazoacetates
Org. Lett., 2017, 19 (4), pp 770–773
DOI: 10.1021/acs.orglett.6b03681
Nickel-Catalyzed Stereoselective Alkenylation of C(sp3)–H Bonds with Terminal Alkynes
Org. Lett., 2017, 19 (4), pp 850–853
DOI: 10.1021/acs.orglett.6b03856
Selective C(sp2)–H Halogenation of “Click” 4-Aryl-1,2,3-triazoles
Org. Lett., 2017, 19 (4), pp 962–965
DOI: 10.1021/acs.orglett.7b00275
Enantioselective Synthesis of Cephalimysins B and C
Org. Lett., 2017, 19 (4), pp 750–753
DOI: 10.1021/acs.orglett.6b03373
Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium
Org. Lett., 2017, 19 (4), pp 890–893
DOI: 10.1021/acs.orglett.7b00047
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Organic Process Research & Development
Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (2), pp 142–152
DOI: 10.1021/acs.oprd.7b00027
In Praise of Short Papers for OPR&D
Org. Process Res. Dev., 2017, 21 (2), pp 141–141
DOI: 10.1021/acs.oprd.7b00012
Green Chemistry Articles of Interest to the Pharmaceutical Industry
Org. Process Res. Dev., 2017, 21 (2), pp 153–164
DOI: 10.1021/acs.oprd.7b00014
Process Development of a CRF1 Receptor Antagonist Based on the Selective Chlorination of a Benzimidazolone via Chlorine Migration
Org. Process Res. Dev., 2017, 21 (2), pp 222–230
DOI: 10.1021/acs.oprd.6b00389
Sustainable and Scalable Fe/ppm Pd Nanoparticle Nitro Group Reductions in Water at Room Temperature
Org. Process Res. Dev., 2017, 21 (2), pp 247–252
DOI: 10.1021/acs.oprd.6b00410
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Organometallics
Coordination Chemistry and Reactivity of Bis(aldimino)pyridine Nickel Complexes in Four Different Oxidation States
Organometallics, 2017, 36 (3), pp 582–593
DOI: 10.1021/acs.organomet.6b00793
Alkene Isomerization by “Sandwich” Diimine-Palladium Catalysts
Organometallics, 2017, 36 (4), pp 787–790
DOI: 10.1021/acs.organomet.6b00856
Flipping the Oxidation State Formalism: Charge Distribution in Organometallic Complexes As Reported by Carbon Monoxide
Organometallics, 2017, 36 (3), pp 622–631
DOI: 10.1021/acs.organomet.6b00820
Rhenium(I) Triscarbonyl Complexes with Redox-Active Amino- and Iminopyridine Ligands: Metal–Ligand Cooperation as Trigger for the Reversible Binding of CO2 via a Dearmomatization/Rearomatization Reaction Sequence
Organometallics, 2017, 36 (4), pp 839–848
DOI: 10.1021/acs.organomet.6b00897
Hidden Enantioselective Hydrogenation of N-Silyl Enamines and Silyl Enol Ethers in Net C═N and C═O Hydrosilylations Catalyzed by Ru–S Complexes with One Monodentate Chiral Phosphine Ligand
Organometallics, 2017, 36 (4), pp 935–943
DOI: 10.1021/acs.organomet.7b00030