This Special Issue will highlight recent advancements in our understanding of intrinsically disordered proteins. Submit your manuscript by March 31, 2026.
Intrinsic disorder is pervasive across proteomes and plays a crucial role in biological functions. Our understanding of protein disorder, to a large extent, depends on our ability to describe the physical and chemical properties of these proteins and their polymer properties. We are now at a time where these concepts can be bridged to proteome and evolutionary scales by combining experiments, theory and simulations.
The Journal of Physical Chemistry B is accepting submissions for a topical Special Issue on “Conformations, Interactions, and Functions of Intrinsically Disordered Proteins.” IDPs and IDRs (intrinsically disordered proteins and regions, respectively) are involved in regulation, signaling, phase separation, and disease pathways. In understanding them on a fundamental level we can develop better models for biomedical and biotechnological applications.
Topics include, but are not limited to:
- Conformational ensembles and dynamics of IDPs
- Protein-protein interactions mediated by IDPs
- Polymer models
- Interplay between IDRs and folded domains
- Biomolecular condensates involving IDPs
Organizing Editors
Professor Christophe Chipot, Senior Editor, The Journal of Physical Chemistry
University of Illinois Urbana-Champaign, United States
Centre National de la Recherche Scientifique, France
Professor Martin Blackledge, Guest Editor
Institut de Biologie Structurale, France
Professor Kresten Lindorff-Larsen, Guest Editor
University of Copenhagen, Denmark
Professor Sarah Rauscher, Guest Editor
University of Toronto Mississauga, Canada
Submission Information
We welcome submissions for this Special Issue through March 31, 2026. For more information on submission requirements, please visit the journal’s Author Guidelines page.
Papers accepted for publication for this Special Issue will be available ASAP (as soon as publishable) online. After all submissions have been published, they will then be compiled online on a dedicated landing page to form the Special Issue. Manuscripts submitted for consideration will undergo the full rigorous peer review process expected from ACS journals.
Indicate that you wish to be included in the Special Issue in your cover letter, not in the manuscript itself.
As with all submissions to The Journal of Physical Chemistry, your manuscript should represent a rigorous scientific report of original research, as it will be peer-reviewed as a regular article. Manuscripts are expected to provide new physical insight and/or present new theoretical or experimental methods of broad interest.
Open access: There are diverse open access options for publications in American Chemical Society journals. Please visit our Open Science Resource Center for more information.
How to Submit
- Log in to the ACS Publishing Center.
- Select the "Journals" tab.
- Choose The Journal of Physical Chemistry B.
- Click "Submit."
- Reminder: Please indicate in your cover letter that you wish to be included in the "Conformations, Interactions and Functions of Intrinsically Disordered Proteins" Special Issue.
If you have any general questions regarding submission to this Special Issue, please contact Christophe Chipot (Chipot@illinois.edu), Martin Blackledge (martin.blackledge@ibs.fr), Kresten Lindorff-Larsen (lindorff@bio.ku.dk) or Sarah Rauscher (sarah.rauscher@utoronto.ca).
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