ACS Publications Proudly Supports ICBS 2020 Virtual Conference

To celebrate the rising stars, we are highlighting the contributions of past winners to the field of chemical biology through their ACS published research.

UPDATED: Learn about the 2021 ICBS Young Chemical Biologists

Congratulations ICBS Young Chemical Biologists!

2020

Gonçalo Bernardes, University of Cambridge

• Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells, ACS Chemical Biology
• Protein–Protein Conjugates: Tyrosine Delivers, Open Access, ACS Central Science
• Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles, Open Access, ACS Applied Materials & Interfaces

Jordan Meier, National Cancer Institute, NIH

• Defining the Orphan Functions of Lysine Acetyltransferases, Open Access, ACS Chemical Biology
• Chemical Control of a CRISPR-Cas9 Acetyltransferase, ACS Chemical Biology
• Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing, Open Access, Journal of the American Chemical Society

Amit Choudhary*, Harvard University and Broad Institute

• A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems, Biochemistry
• Precision Control of CRISPR-Cas9 Using Small Molecules and Light, Biochemistry
• Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond, Biochemistry

*Guest editor of the ACS Chemical Biology Special Issue on CRISPR

Ellen M. Sletten, University of California-Los Angeles

• From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions, Open Access, Accounts of Chemical Research
• A Strategy for the Selective Imaging of Glycans Using Caged Metabolic Precursors, Open Access, Journal of the American Chemical Society
• Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones, Open Access, Journal of the American Chemical Society

2019

Arun Kumar Shukla, Indian Institute of Technology Kanpur, India

• Structural Basis of Partial Agonism at the β2-Adrenergic Receptor, Biochemistry
• The Inside Story: Crystal Structure of the Chemokine Receptor CCR7 with an Intracellular Allosteric Antagonist, Biochemistry
• Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor, Open Access, ACS Medicinal Chemistry Letters

Shengying Li, Shandong University, China

• Enzymatic O-Glycosylation of Etoposide Aglycone by Exploration of the Substrate Promiscuity for Glycosyltransferases, ACS Synthetic Biology
• AbmV Catalyzes Tandem Ether Installation and Hydroxylation during Neoabyssomicin/Abyssomicin Biosynthesis, Organic Letters

Robert Spitale, University of California, Irvine, USA

• Expanding the Scope of RNA Metabolic Labeling with Vinyl Nucleosides and Inverse Electron-Demand Diels–Alder Chemistry, ACS Chemical Biology
• Spatially Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome, ACS Chemical Biology
• Biochemical Methods To Image and Analyze RNA Localization: From One to Many, Biochemistry

2018

Christina Woo, Harvard University, USA

• The O-GlcNAc Modification on Kinases, ACS Chemical Biology
• Mapping the Small Molecule Interactome by Mass Spectrometry, Biochemistry
• Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs, Journal of the American Chemical Society

Chu Wang, College of Chemistry and Molecular Engineering, Peking University, China

• Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans, Biochemistry
• Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker, ACS Chemical Biology
• Proteomic Identification of Protein Tyrosine Phosphatase and Substrate Interactions in Living Mammalian Cells by Genetic Encoding of Irreversible Enzyme Inhibitors, Journal of the American Chemical Society

Michael Cohen, Oregon Health and Science University, USA

• Combining Chemical Genetics with Proximity-Dependent Labeling Reveals Cellular Targets of Poly(ADP-ribose) Polymerase 14 (PARP14), ACS Chemical Biology
• Cell-specific Profiling of Nascent Proteomes Using Orthogonal Enzyme-mediated Puromycin Incorporation, ACS Chemical Biology
• A Clickable Aminooxy Probe for Monitoring Cellular ADP-Ribosylation, ACS Chemical Biology

2017

Toru Komatsu, University of Tokyo, Japan

• Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates, ACS Chemical Biology
• Boron Dipyrromethene As a Fluorescent Caging Group for Single-Photon Uncaging with Long-Wavelength Visible Light, ACS Chemical Biology
• Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC), ACS Chemical Biology

Qi Zhang, Fudan University, China

• Reductive Cleavage of Sulfoxide and Sulfone by Two Radical S-Adenosyl-l-methionine Enzymes, ACS Chemical Biology
• Biosynthetic Insights into Linaridin Natural Products from Genome Mining and Precursor Peptide Mutagenesis, ACS Chemical Biology
• Conserved SecA Signal Peptide-Binding Site Revealed by Engineered Protein Chimeras and Förster Resonance Energy Transfer, ACS Chemical Biology

Haitao Zhang, Zhejiang University, China

• Enhancing Lithium Adsorption and Diffusion toward Extraordinary Lithium Storage Capability of Freestanding Ti3C2Tx Mxene, The Journal of Physical Chemistry C
• Preadsorption of Serum Proteins Regulates Bacterial Infections and Subsequent Macrophage Phagocytosis on Biomaterial Surfaces, ACS Applied Bio Materials

2016

Yimon Aye, Cornell University, USA

• Empowering Global Chemical Biology at the Dawn of the New Decade, ACS Chemical Biology
• Precision Electrophile Tagging in Caenorhabditis elegans, Biochemistry
• On-Demand Targeting: Investigating Biology with Proximity-Directed Chemistry, Open Access, Journal of the American Chemical Society

Ratmir Derda, University of Alberta, Canada

• Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores, Journal of the American Chemical Society
• Freeze–Float Selection of Ice Nucleators, Langmuir
• Synergic “Click” Boronate/Thiosemicarbazone System for Fast and Irreversible Bioorthogonal Conjugation in Live Cells, Journal of the American Chemical Society

William Pomerantz, University of Minnesota, USA

• NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex, Biochemistry
• Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules, ACS Chemical Biology
• Protein-Observed Fluorine NMR Is a Complementary Ligand Discovery Method to 1H CPMG Ligand-Observed NMR, ACS Chemical Biology