Most Read Articles of 2016: Organic/Inorganic Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering  | Physical
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ACS Catalysis

Cobalt-Catalyzed C–H Activation

ACS Catal., 2016, 6 (2), pp 498–525
DOI: 10.1021/acscatal.5b02344

Toward Benchmarking in Catalysis Science: Best Practices, Challenges, and Opportunities
Open Access Through ACS Editors’ Choice

ACS Catal., 2016, 6 (4), pp 2590–2602
DOI: 10.1021/acscatal.6b00183

Metal-Catalyzed Carboxylation of Organic (Pseudo)halides with CO2

ACS Catal., 2016, 6 (10), pp 6739–6749
DOI: 10.1021/acscatal.6b02124

Catalytic Methods for Aromatic C–H Amination: An Ideal Strategy for Nitrogen-Based Functional Molecules

ACS Catal., 2016, 6 (2), pp 610–633
DOI: 10.1021/acscatal.5b02417

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

ACS Catal., 2016, 6 (9), pp 5887–5903
DOI: 10.1021/acscatal.6b01222

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ACS Combinatorial Science

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Comb. Sci., 2016, 18 (1), pp 1–14
DOI: 10.1021/acscombsci.5b00087

Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 75–85
DOI: 10.1021/acscombsci.5b00164

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (6), pp 320–329
DOI: 10.1021/acscombsci.5b00194

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 51–64
DOI: 10.1021/acscombsci.5b00126

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure–Activity Relationships

ACS Comb. Sci., 2016, 18 (7), pp 415–424
DOI: 10.1021/acscombsci.6b00001

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ACS Medicinal Chemistry Letters

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
DOI: 10.1021/acsmedchemlett.6b00005

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

ACS Med. Chem. Lett., 2016, 7 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.5b00475

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (11), pp 977–982
DOI: 10.1021/acsmedchemlett.6b00195

High Drug Prices Hurt Everyone

ACS Med. Chem. Lett., 2016, 7 (6), pp 544–546
DOI: 10.1021/acsmedchemlett.6b00139

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (6), pp 552–557
DOI: 10.1021/acsmedchemlett.6b00092

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Bioconjugate Chemistry

Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (1), pp 217–225
DOI: 10.1021/acs.bioconjchem.5b00613

Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (12), pp 2931–2942
DOI: 10.1021/acs.bioconjchem.6b00603

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (2), pp 298–301
DOI: 10.1021/acs.bioconjchem.5b00504

New Chelators for Low Temperature Al18F-Labeling of Biomolecules
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (3), pp 790–798
DOI: 10.1021/acs.bioconjchem.6b00012

NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence

Bioconjugate Chem., 2016, 27 (5), pp 1175–1187
DOI: 10.1021/acs.bioconjchem.6b00112

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Inorganic Chemistry

Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt ATCUN Metallopeptide
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (4), pp 1355–1357
DOI: 10.1021/acs.inorgchem.5b02157

Lead-Free MA2CuClxBr4–x Hybrid Perovskites

Inorg. Chem., 2016, 55 (3), pp 1044–1052
DOI: 10.1021/acs.inorgchem.5b01896

Heterobimetallic N-Heterocyclic Carbene Complexes: A Synthetic, Spectroscopic, and Theoretical Study
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (14), pp 6882–6891
DOI: 10.1021/acs.inorgchem.6b00222

Homogeneous Photocatalytic Water Oxidation with a Dinuclear CoIII–Pyridylmethylamine Complex

Inorg. Chem., 2016, 55 (3), pp 1154–1164
DOI: 10.1021/acs.inorgchem.5b02336

UiO-67-type Metal–Organic Frameworks with Enhanced Water Stability and Methane Adsorption Capacity

Inorg. Chem., 2016, 55 (5), pp 1986–1991
DOI: 10.1021/acs.inorgchem.5b02257
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Journal of Medicinal Chemistry

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (13), pp 6027–6044
DOI: 10.1021/acs.jmedchem.5b01833

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Open Access Through ACS AuthorChoice


J. Med. Chem., 2016, 59 (10), pp 4443–4458
DOI: 10.1021/acs.jmedchem.5b01409

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective


Open Access Through ACS AuthorChoice
J. Med. Chem., 2016, 59 (8), pp 3593–3608
DOI: 10.1021/acs.jmedchem.5b01273

The Medicinal Chemistry of Dengue Virus
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (12), pp 5622–5649
DOI: 10.1021/acs.jmedchem.5b01653

A Real-World Perspective on Molecular Design
This article is part of the Computational Methods for Medicinal Chemistry special issue.


J. Med. Chem., 2016, 59 (9), pp 4087–4102
DOI: 10.1021/acs.jmedchem.5b01875

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Journal of Natural Products

Natural Products as Sources of New Drugs from 1981 to 2014
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 629–661
DOI: 10.1021/acs.jnatprod.5b01055

Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (8), pp 1962–1970
DOI: 10.1021/acs.jnatprod.6b00215

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 616–628
DOI: 10.1021/acs.jnatprod.5b00947

LC-MS- and 1H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (1), pp 30–37
DOI: 10.1021/acs.jnatprod.5b00556

Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (9), pp 2250–2256
DOI: 10.1021/acs.jnatprod.6b00345
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The Journal of Organic Chemistry

Photoredox Catalysis in Organic Chemistry
Open Access Through ACS Editors’ Choice

J. Org. Chem., 2016, 81 (16), pp 6898–6926
DOI: 10.1021/acs.joc.6b01449

Recent Advances in C–H Functionalization

J. Org. Chem., 2016, 81 (2), pp 343–350
DOI: 10.1021/acs.joc.5b02818

Total Synthesis of a Diacetonide Derivative of Thuggacin A

J. Org. Chem., 2016, 81 (5), pp 1786–1797
DOI: 10.1021/acs.joc.5b02426

Chan–Evans–Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem

J. Org. Chem., 2016, 81 (9), pp 3942–3950
DOI: 10.1021/acs.joc.6b00466

Palladium-Catalyzed Double-Suzuki–Miyaura Reactions Using Cyclic Dibenziodoniums: Synthesis of o-Tetraaryls
Open Access Through ACS Editors’ Choice

J. Org. Chem., 2016, 81 (4), pp 1317–1323
DOI: 10.1021/acs.joc.5b02255
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Molecular Pharmaceutics

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (7), pp 2524–2530
DOI: 10.1021/acs.molpharmaceut.6b00248

Applications of Deep Learning in Biomedicine

Mol. Pharmaceutics, 2016, 13 (5), pp 1445–1454
DOI: 10.1021/acs.molpharmaceut.5b00982

In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (2), pp 631–639
DOI: 10.1021/acs.molpharmaceut.5b00868

Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
Open Access Through ACS Editors’ Choice

Mol. Pharmaceutics, 2016, 13 (11), pp 3835–3841
DOI: 10.1021/acs.molpharmaceut.6b00633

Molecular Imaging of Pancreatic Cancer with Antibodies
Open Access Through ACS AuthorChoice

Mol. Pharmaceutics, 2016, 13 (1), pp 8–24
DOI: 10.1021/acs.molpharmaceut.5b00626
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Organic Letters

Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant
Open Access Through ACS Editors’ Choice

Org. Lett., 2016, 18 (11), pp 2596–2599
DOI: 10.1021/acs.orglett.6b00979

Time Economical Total Synthesis of (−)-Oseltamivir

Org. Lett., 2016, 18 (14), pp 3426–3429
DOI: 10.1021/acs.orglett.6b01595

Total Synthesis of (+)-Vicenin-2
Open Access Through ACS Editors’ Choice

Org. Lett., 2016, 18 (18), pp 4488–4490
DOI: 10.1021/acs.orglett.6b02203

Total Synthesis of Lycopalhine A

Org. Lett., 2016, 18 (6), pp 1494–1496
DOI: 10.1021/acs.orglett.6b00338

Total Synthesis of (±)-Gracilioether F

Org. Lett., 2016, 18 (5), pp 1032–1035
DOI: 10.1021/acs.orglett.6b00161
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Organic Process Research & Development

NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (3), pp 661–667
DOI: 10.1021/acs.oprd.5b00417

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Org. Process Res. Dev., 2016, 20 (2), pp 140–177
DOI: 10.1021/op500305s

Vacuum Desiccator as a Simple, Robust, and Inexpensive NMR Tube Cleaner

Org. Process Res. Dev., 2016, 20 (2), pp 319–319
DOI: 10.1021/acs.oprd.6b00001

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (1), pp 2–25
DOI: 10.1021/acs.oprd.5b00325

Toward a More Holistic Framework for Solvent Selection
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (4), pp 760–773
DOI: 10.1021/acs.oprd.6b00015
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Organometallics

An Editorial About Elemental Analysis
Organometallics, 2016, 35 (19), pp 3255–3256
DOI: 10.1021/acs.organomet.6b00720

A Frustrated Lewis Pair Based on a Cationic Aluminum Complex and Triphenylphosphine
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (2), pp 207–217
DOI: 10.1021/acs.organomet.5b00927

A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (7), pp 1008–1014
DOI: 10.1021/acs.organomet.6b00059

Pyramidanes: The Covalent Form of the Ionic Compounds
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (3), pp 346–356
DOI: 10.1021/acs.organomet.5b00924

Legacy of Richard Heck
Organometallics, 2016, 35 (9), pp 1177–1178
DOI: 10.1021/acs.organomet.6b00261
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Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Physical

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