Discover the Most-Read Biological Chemistry Articles of August 2017

What were chemists reading in August of 2017? To find out, we’ve compiled lists of the five most-read articles that appeared in each biological chemistry ACS Publications journal in August 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great August 2017 Chemistry Research:
Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

ACS Biomaterials Science & Engineering

Preparation of Biodegradable Cationic Polycarbonates and Hydrogels through the Direct Polymerization of Quaternized Cyclic Carbonates
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1567–1575
DOI: 10.1021/acsbiomaterials.7b00335

Advanced Biomanufacturing: A Radical Manufacturing Paradigm Shift from Conventional, Centralized, Off-the-Shelf Production to On-Demand, Decentralized, Plug-and-Play Production of Cell- and Tissue-Based Products
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1460–1461
DOI: 10.1021/acsbiomaterials.7b00535

Predehydration and Ice Seeding in the Presence of Trehalose Enable Cell Cryopreservation
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1758–1768
DOI: 10.1021/acsbiomaterials.7b00201

π-Conjugated Chromophore Incorporated Polystyrene Nanobeads as Single Optical Agent for Three-Channel Fluorescent Probe in Bioimaging Application
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1788–1798
DOI: 10.1021/acsbiomaterials.7b00259

Polydopamine Nanocapsule: A Theranostic Agent for Photoacoustic Imaging and Chemo-Photothermal Synergistic Therapy
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1799–1808
DOI: 10.1021/acsbiomaterials.7b00260

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ACS Catalysis

Photochemical Generation of Nitrogen-Centered Amidyl, Hydrazonyl, and Imidyl Radicals: Methodology Developments and Catalytic Applications
ACS Catal., 2017, 7 (8), pp 4999–5022
DOI: 10.1021/acscatal.7b01385

The Surface Chemistry of Metal-Based Hydrogenation Catalysis
ACS Catal., 2017, 7 (8), pp 4947–4967
DOI: 10.1021/acscatal.7b01368

Synergistic Copper/Palladium Catalysis for the Regio- and Stereoselective Synthesis of Borylated Skipped Dienes
ACS Catal., 2017, 7 (8), pp 5340–5344
DOI: 10.1021/acscatal.7b01833

Interface Engineering in Nanostructured Nickel Phosphide Catalyst for Efficient and Stable Water Oxidation
ACS Catal., 2017, 7 (8), pp 5450–5455
DOI: 10.1021/acscatal.7b01954

Electrochemical CO2 Conversion Using Skeleton (Sponge) Type of Cu Catalysts
ACS Catal., 2017, 7 (8), pp 5431–5437
DOI: 10.1021/acscatal.7b01548

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ACS Chemical Biology

Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target
Open access through ACS AuthorChoice
ACS Chem. Biol., 2017, 12 (8), pp 1986–1992
DOI: 10.1021/acschembio.7b00370

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue
ACS Chem. Biol., 2017, 12 (8), pp 2015–2020
DOI: 10.1021/acschembio.7b00403

Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H2S Donors
Open access through ACS AuthorChoice
ACS Chem. Biol., 2017, 12 (8), pp 2117–2123
DOI: 10.1021/acschembio.7b00279

Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites
ACS Chem. Biol., 2017, 12 (8), pp 2040–2050
DOI: 10.1021/acschembio.7b00346

Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents
ACS Chem. Biol., 2017, 12 (8), pp 2201–2208
DOI: 10.1021/acschembio.7b00444

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ACS Chemical Neuroscience

ACS Chemical Neuroscience: Most Cited Papers from 2015
ACS Chem. Neurosci., 2017, 8 (8), pp 1633–1634
DOI: 10.1021/acschemneuro.7b00246

Chronic Traumatic Encephalopathy (CTE): A Brief Historical Overview and Recent Focus on NFL Players
ACS Chem. Neurosci., 2017, 8 (8), pp 1629–1631
DOI: 10.1021/acschemneuro.7b00291

Sigma 2 Receptor/Tmem97 Agonists Produce Long Lasting Antineuropathic Pain Effects in Mice
ACS Chem. Neurosci., 2017, 8 (8), pp 1801–1811
DOI: 10.1021/acschemneuro.7b00200

Therapeutic Role and Drug Delivery Potential of Neuroinflammation as a Target in Neurodegenerative Disorders
ACS Chem. Neurosci., 2017, 8 (8), pp 1645–1655
DOI: 10.1021/acschemneuro.7b00144

Novel Opioid Analgesics and Side Effects
ACS Chem. Neurosci., 2017, 8 (8), pp 1638–1640
DOI: 10.1021/acschemneuro.7b00195

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ACS Infectious Diseases

Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2017, 3 (8), pp 595–605
DOI: 10.1021/acsinfecdis.7b00064

Nano Tools Pave the Way to New Solutions in Infectious Disease
ACS Infect. Dis., 2017, 3 (8), pp 554–558
DOI: 10.1021/acsinfecdis.7b00104

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?
ACS Infect. Dis., 2017, 3 (8), pp 559–563
DOI: 10.1021/acsinfecdis.7b00071

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes
ACS Infect. Dis., 2017, 3 (8), pp 606–619
DOI: 10.1021/acsinfecdis.7b00065

The Tyrosine Kinase Inhibitor Gefitinib Restricts Mycobacterium tuberculosis Growth through Increased Lysosomal Biogenesis and Modulation of Cytokine Signaling
ACS Infect. Dis., 2017, 3 (8), pp 564–574
DOI: 10.1021/acsinfecdis.7b00046

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ACS Medicinal Chemistry Letters

1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (8), pp 886–891
DOI: 10.1021/acsmedchemlett.7b00230

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
ACS Med. Chem. Lett., 2017, 8 (8), pp 869–874
DOI: 10.1021/acsmedchemlett.7b00220

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group
ACS Med. Chem. Lett., 2017, 8 (8), pp 864–868
DOI: 10.1021/acsmedchemlett.7b00212

Synthesis and Activity of a New Series of Antileishmanial Agents
ACS Med. Chem. Lett., 2017, 8 (8), pp 797–801
DOI: 10.1021/acsmedchemlett.7b00039

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.7b00205

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ACS Synthetic Biology

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (8), pp 1435–1439
DOI: 10.1021/acssynbio.7b00275

Design of a Toolbox of RNA Thermometers
ACS Synth. Biol., 2017, 6 (8), pp 1461–1470
DOI: 10.1021/acssynbio.6b00301

Centromeric DNA Facilitates Nonconventional Yeast Genetic Engineering
ACS Synth. Biol., 2017, 6 (8), pp 1545–1553
DOI: 10.1021/acssynbio.7b00046

Amplifying Riboswitch Signal Output Using Cellular Wiring
ACS Synth. Biol., 2017, 6 (8), pp 1440–1444
DOI: 10.1021/acssynbio.6b00191

Synthetic Protein Scaffolds for Biosynthetic Pathway Colocalization on Lipid Droplet Membranes
ACS Synth. Biol., 2017, 6 (8), pp 1534–1544
DOI: 10.1021/acssynbio.7b00041

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Biochemistry

Residue-Specific Peptide Modification: A Chemist’s Guide
Biochemistry, 2017, 56 (30), pp 3863–3873
DOI: 10.1021/acs.biochem.7b00536

Genomic Enzymology: Web Tools for Leveraging Protein Family Sequence–Function Space and Genome Context to Discover Novel Functions
Open access through Editors’ Choice
Biochemistry, 2017, 56 (33), pp 4293–4308
DOI: 10.1021/acs.biochem.7b00614

Solution NMR Provides New Insight into Lipid–Protein Interaction
Biochemistry, 2017, 56 (33), pp 4291–4292
DOI: 10.1021/acs.biochem.7b00336

The New Biochemistry Editorial Team
Biochemistry, 2017, 56 (33), pp 4289–4290
DOI: 10.1021/acs.biochem.7b00720

Enormous Hydrogen Bond Strength Enhancement through π-Conjugation Gain: Implications for Enzyme Catalysis
Biochemistry, 2017, 56 (33), pp 4318–4322
DOI: 10.1021/acs.biochem.7b00395

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Bioconjugate Chemistry

Versatile Site-Selective Protein Reaction Guided by WW Domain–Peptide Motif Interaction
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (8), pp 2199–2205
DOI: 10.1021/acs.bioconjchem.7b00334

Extensive Survey of Antibody Invariant Positions for Efficient Chemical Conjugation Using Expanded Genetic Codes
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (8), pp 2099–2108
DOI: 10.1021/acs.bioconjchem.7b00265

Development of an Activatable Fluorescent Probe for Prostate Cancer Imaging
Bioconjugate Chem., 2017, 28 (8), pp 2069–2076
DOI: 10.1021/acs.bioconjchem.7b00233

GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization
Bioconjugate Chem., 2017, 28 (8), pp 2109–2113
DOI: 10.1021/acs.bioconjchem.7b00295

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (8), pp 2086–2098
DOI: 10.1021/acs.bioconjchem.7b00258

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Biomacromolecules

Next Generation Hemostatic Materials Based on NHS-Ester Functionalized Poly(2-oxazoline)s
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (8), pp 2529–2538
DOI: 10.1021/acs.biomac.7b00683

Biodegradable Strain-Promoted Click Hydrogels for Encapsulation of Drug-Loaded Nanoparticles and Sustained Release of Therapeutics
Biomacromolecules, 2017, 18 (8), pp 2277–2285
DOI: 10.1021/acs.biomac.7b00377

Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems
Biomacromolecules, 2017, 18 (8), pp 2231–2246
DOI: 10.1021/acs.biomac.7b00803

Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices
Biomacromolecules, 2017, 18 (8), pp 2539–2551
DOI: 10.1021/acs.biomac.7b00686

Self-Healing Dynamic Hydrogel as Injectable Shock-Absorbing Artificial Nucleus Pulposus
Biomacromolecules, 2017, 18 (8), pp 2360–2370
DOI: 10.1021/acs.biomac.7b00566

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Journal of Agricultural and Food Chemistry

Detection of Pesticide Residues in Food Using Surface-Enhanced Raman Spectroscopy: A Review
J. Agric. Food Chem., 2017, 65 (32), pp 6719–6726
DOI: 10.1021/acs.jafc.7b02504

Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from d-Fructose
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (30), pp 6093–6099
DOI: 10.1021/acs.jafc.7b01601

A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9–16 Carbon Atoms as Potential Ligands of the Receptor
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (31), pp 6647–6655
DOI: 10.1021/acs.jafc.7b01890

Edible Nanoencapsulation Vehicles for Oral Delivery of Phytochemicals: A Perspective Paper
J. Agric. Food Chem., 2017, 65 (32), pp 6727–6735
DOI: 10.1021/acs.jafc.7b0212

Diarylheptanoids from Rhizomes of Alpinia officinarum Inhibit Aggregation of α-Synuclein
J. Agric. Food Chem., 2017, 65 (31), pp 6608–6614
DOI: 10.1021/acs.jafc.7b020218

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Journal of Chemical Theory and Computation

An Ab Initio Exciton Model Including Charge-Transfer Excited States
Open access through ACS ACS Editors’ Choice
J. Chem. Theory Comput., 2017, 13 (8), pp 3493–3504
DOI: 10.1021/acs.jctc.7b00171

Kinetics from Replica Exchange Molecular Dynamics Simulations
J. Chem. Theory Comput., 2017, 13 (8), pp 3927–3935
DOI: 10.1021/acs.jctc.7b00372

Marcus Theory of Ion-Pairing
J. Chem. Theory Comput., 2017, 13 (8), pp 3470–3477
DOI: 10.1021/acs.jctc.7b00332

Redox Potentials from Ab Initio Molecular Dynamics and Explicit Entropy Calculations: Application to Transition Metals in Aqueous Solution
J. Chem. Theory Comput., 2017, 13 (8), pp 3432–3441
DOI: 10.1021/acs.jctc.7b00314

Accurate DFT-D3 Calculations in a Small Basis Set
J. Chem. Theory Comput., 2017, 13 (8), pp 3575–3585
DOI: 10.1021/acs.jctc.7b00365

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Journal of Medicinal Chemistry

Synthetic Approaches to the New Drugs Approved During 2015
Open access through ACS ACS Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6480–6515
DOI: 10.1021/acs.jmedchem.7b00010

Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
Open access through ACS ACS Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6704–6720
DOI: 10.1021/acs.jmedchem.7b00669

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors
J. Med. Chem., 2017, 60 (15), pp 6516–6527
DOI: 10.1021/acs.jmedchem.7b00360

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides
J. Med. Chem., 2017, 60 (16), pp 7123–7138
DOI: 10.1021/acs.jmedchem.7b00731

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
J. Med. Chem., 2017, 60 (16), pp 7029–7042
DOI: 10.1021/acs.jmedchem.7b00598

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Journal of Natural Products

Bioinspired Indole Prenylation Reactions in Water
Open access through ACS ACS Editors’ Choice
J. Nat. Prod., 2017, 80 (8), pp 2371–2378
DOI: 10.1021/acs.jnatprod.7b00464

Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species
J. Nat. Prod., 2017, 80 (8), pp 2311–2318
DOI: 10.1021/acs.jnatprod.7b00331

Anti-inflammatory Meroterpenoids from Baeckea frutescens
J. Nat. Prod., 2017, 80 (8), pp 2204–2214
DOI: 10.1021/acs.jnatprod.7b00042

Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri
J. Nat. Prod., 2017, 80 (8), pp 2263–2268
DOI: 10.1021/acs.jnatprod.7b00198

Antarctic Moss Biflavonoids Show High Antioxidant and Ultraviolet-Screening Activity
J. Nat. Prod., 2017, 80 (8), pp 2224–2231
DOI: 10.1021/acs.jnatprod.7b00085

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The Journal of Physical Chemistry B

Crowding in Cellular Environments at an Atomistic Level from Computer Simulations
Open access through ACS ACS Editors’ Choice
J. Phys. Chem. B, 2017, 121 (34), pp 8009–8025
DOI: 10.1021/acs.jpcb.7b03570

Kinetic Model for Two-Step Nucleation of Peptide Assembly
J. Phys. Chem. B, 2017, 121 (31), pp 7401–7411
DOI: 10.1021/acs.jpcb.7b03085

Limits on Natural Photosynthesis
J. Phys. Chem. B, 2017, 121 (30), pp 7229–7234
DOI: 10.1021/acs.jpcb.7b03024

Glucose and Mannose: A Link between Hydration and Sweetness
J. Phys. Chem. B, 2017, 121 (33), pp 7771–7776
DOI: 10.1021/acs.jpcb.7b03919

C–H···O Interaction in Methanol–Water Solution Revealed from Raman Spectroscopy and Theoretical Calculations
J. Phys. Chem. B, 2017, 121 (34), pp 8179–8187
DOI: 10.1021/acs.jpcb.7b06036

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The Journal of Physical Chemistry Letters

Building Blocks for High Performance in Electrocatalytic CO2 Reduction: Materials, Optimization Strategies, and Device Engineering
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2017, 8 (16), pp 3933–3944
DOI: 10.1021/acs.jpclett.7b01380

Simulating Chemical Kinetics Without Differential Equations: A Quantitative Theory Based on Chemical Pathways
J. Phys. Chem. Lett., 2017, 8 (16), pp 3826–3833
DOI: 10.1021/acs.jpclett.7b01760

In the Limelight
J. Phys. Chem. Lett., 2017, 8 (15), pp 3718–3719
DOI: 10.1021/acs.jpclett.7b01914

Biexciton Resonances Reveal Exciton Localization in Stacked Perovskite Quantum Wells
J. Phys. Chem. Lett., 2017, 8 (16), pp 3895–3901
DOI: 10.1021/acs.jpclett.7b01621

Dynamic Disorder and Potential Fluctuation in Two-Dimensional Perovskite
J. Phys. Chem. Lett., 2017, 8 (16), pp 3875–3880
DOI: 10.1021/acs.jpclett.7b01501

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Journal of Proteome Research

Quantitative Analysis of Human Red Blood Cell Proteome
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (8), pp 2752–2761
DOI: 10.1021/acs.jproteome.7b00025

Targeted Feature Detection for Data-Dependent Shotgun Proteomics
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (8), pp 2964–2974
DOI: 10.1021/acs.jproteome.7b00248

Quantitative Assessment of the Effects of Trypsin Digestion Methods on Affinity Purification–Mass Spectrometry-based Protein–Protein Interaction Analysis
J. Proteome Res., 2017, 16 (8), pp 3068–3082
DOI: 10.1021/acs.jproteome.7b00432

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (8), pp 2789–2801
DOI: 10.1021/acs.jproteome.7b00065

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics
J. Proteome Res., 2017, 16 (8), pp 3083–3091
DOI: 10.1021/acs.jproteome.7b00191

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Molecular Pharmaceutics

Polymers in Drug Delivery: Chemistry and Applications
Mol. Pharmaceutics, 2017, 14 (8), pp 2459–2459
DOI: 10.1021/acs.molpharmaceut.7b00567

Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host–Guest Interaction as Stimuli Responsive Linker
Mol. Pharmaceutics, 2017, 14 (8), pp 2475–2486
DOI: 10.1021/acs.molpharmaceut.7b00160

Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery
Mol. Pharmaceutics, 2017, 14 (8), pp 2460–2474
DOI: 10.1021/acs.molpharmaceut.7b00284

Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (8), pp 2629–2638
DOI: 10.1021/acs.molpharmaceut.7b00095

Multiresponsive Nanogels for Targeted Anticancer Drug Delivery
Mol. Pharmaceutics, 2017, 14 (8), pp 2624–2628
DOI: 10.1021/acs.molpharmaceut.7b00325

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.