Discover the Most-Read Organic/Inorganic Chemistry Articles of August 2017

What were chemists reading in August of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic/inorganic chemistry ACS Publications journal in August 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great August 2017 Chemistry Research:
Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

ACS Catalysis

Photochemical Generation of Nitrogen-Centered Amidyl, Hydrazonyl, and Imidyl Radicals: Methodology Developments and Catalytic Applications
ACS Catal., 2017, 7 (8), pp 4999–5022
DOI: 10.1021/acscatal.7b01385

The Surface Chemistry of Metal-Based Hydrogenation Catalysis
ACS Catal., 2017, 7 (8), pp 4947–4967
DOI: 10.1021/acscatal.7b01368

Synergistic Copper/Palladium Catalysis for the Regio- and Stereoselective Synthesis of Borylated Skipped Dienes
ACS Catal., 2017, 7 (8), pp 5340–5344
DOI: 10.1021/acscatal.7b01833

Interface Engineering in Nanostructured Nickel Phosphide Catalyst for Efficient and Stable Water Oxidation
ACS Catal., 2017, 7 (8), pp 5450–5455
DOI: 10.1021/acscatal.7b01954

Electrochemical CO2 Conversion Using Skeleton (Sponge) Type of Cu Catalysts
ACS Catal., 2017, 7 (8), pp 5431–5437
DOI: 10.1021/acscatal.7b01548

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ACS Combinatorial Science

Identification of Biologically Active Pyrimido[5,4-b]indoles That Prolong NF-κB Activation without Intrinsic Activity
ACS Comb. Sci., 2017, 19 (8), pp 533–543
DOI: 10.1021/acscombsci.7b00080

Poisson Statistics of Combinatorial Library Sampling Predict False Discovery Rates of Screening
Open access through ACS Editors’ Choice
ACS Comb. Sci., 2017, 19 (8), pp 524–532
DOI: 10.1021/acscombsci.7b00061

Microwave-Assisted Synthesis of Diversely Substituted Quinoline-Based Dihydropyridopyrimidine and Dihydropyrazolopyridine Hybrids
ACS Comb. Sci., 2017, 19 (8), pp 555–563
DOI: 10.1021/acscombsci.7b00091

Bias-Free Chemically Diverse Test Sets from Machine Learning
ACS Comb. Sci., 2017, 19 (8), pp 544–554
DOI: 10.1021/acscombsci.7b00087

Speeding up Early Drug Discovery in Antiviral Research: A Fragment-Based in Silico Approach for the Design of Virtual Anti-Hepatitis C Leads
ACS Comb. Sci., 2017, 19 (8), pp 501–512
DOI: 10.1021/acscombsci.7b00039

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ACS Medicinal Chemistry Letters

1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (8), pp 886–891
DOI: 10.1021/acsmedchemlett.7b00230

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
ACS Med. Chem. Lett., 2017, 8 (8), pp 869–874
DOI: 10.1021/acsmedchemlett.7b00220

Evaluation of Oxetan-3-ol, Thietan-3-ol, and Derivatives Thereof as Bioisosteres of the Carboxylic Acid Functional Group
ACS Med. Chem. Lett., 2017, 8 (8), pp 864–868
DOI: 10.1021/acsmedchemlett.7b00212

Synthesis and Activity of a New Series of Antileishmanial Agents
ACS Med. Chem. Lett., 2017, 8 (8), pp 797–801
DOI: 10.1021/acsmedchemlett.7b00039

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.7b00205

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Bioconjugate Chemistry

Versatile Site-Selective Protein Reaction Guided by WW Domain–Peptide Motif Interaction
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (8), pp 2199–2205
DOI: 10.1021/acs.bioconjchem.7b00334

Extensive Survey of Antibody Invariant Positions for Efficient Chemical Conjugation Using Expanded Genetic Codes
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (8), pp 2099–2108
DOI: 10.1021/acs.bioconjchem.7b00265

Development of an Activatable Fluorescent Probe for Prostate Cancer Imaging
Bioconjugate Chem., 2017, 28 (8), pp 2069–2076
DOI: 10.1021/acs.bioconjchem.7b00233

GlcNAc Conjugated Atorvastatin with Enhanced Water Solubility and Cellular Internalization
Bioconjugate Chem., 2017, 28 (8), pp 2109–2113
DOI: 10.1021/acs.bioconjchem.7b00295

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (8), pp 2086–2098
DOI: 10.1021/acs.bioconjchem.7b00258

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Inorganic Chemistry

Consequence of Ligand Bite Angle on Bismuth Lewis Acidity
Inorg. Chem., 2017, 56 (16), pp 9391–9395
DOI: 10.1021/acs.inorgchem.7b01243

Ligand Design toward Multifunctional Substrate Reductive Transformations
Inorg. Chem., 2017, 56 (16), pp 9505–9514
DOI: 10.1021/acs.inorgchem.7b00785

An Amine Functionalized Metal–Organic Framework as an Effective Catalyst for Conversion of CO2 and Biginelli Reactions
Inorg. Chem., 2017, 56 (16), pp 9765–9771
DOI: 10.1021/acs.inorgchem.7b01286

Coordination Polymer Gels with Modular Nanomorphologies, Tunable Emissions, and Stimuli-Responsive Behavior Based on an Amphiphilic Tripodal Gelator
Inorg. Chem., 2017, 56 (16), pp 9417–9425
DOI: 10.1021/acs.inorgchem.7b01002

Double Solvent Sensing Method for Improving Sensitivity and Accuracy of Hg(II) Detection Based on Different Signal Transduction of a Tetrazine-Functionalized Pillared Metal–Organic Framework
Inorg. Chem., 2017, 56 (16), pp 9646–9652
DOI: 10.1021/acs.inorgchem.7b01155

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Journal of Medicinal Chemistry

Synthetic Approaches to the New Drugs Approved During 2015
Open access through ACS ACS Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6480–6515
DOI: 10.1021/acs.jmedchem.7b00010

Discovery and Kinetic Profiling of 7-Aryl-1,2,4-triazolo[4,3-a]pyridines: Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2
Open access through ACS ACS Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6704–6720
DOI: 10.1021/acs.jmedchem.7b00669

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors
J. Med. Chem., 2017, 60 (15), pp 6516–6527
DOI: 10.1021/acs.jmedchem.7b00360

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides
J. Med. Chem., 2017, 60 (16), pp 7123–7138
DOI: 10.1021/acs.jmedchem.7b00731

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
J. Med. Chem., 2017, 60 (16), pp 7029–7042
DOI: 10.1021/acs.jmedchem.7b00598

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Journal of Natural Products

Bioinspired Indole Prenylation Reactions in Water
Open access through ACS ACS Editors’ Choice
J. Nat. Prod., 2017, 80 (8), pp 2371–2378
DOI: 10.1021/acs.jnatprod.7b00464

Dioxomorpholines and Derivatives from a Marine-Facultative Aspergillus Species
J. Nat. Prod., 2017, 80 (8), pp 2311–2318
DOI: 10.1021/acs.jnatprod.7b00331

Anti-inflammatory Meroterpenoids from Baeckea frutescens
J. Nat. Prod., 2017, 80 (8), pp 2204–2214
DOI: 10.1021/acs.jnatprod.7b00042

Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri
J. Nat. Prod., 2017, 80 (8), pp 2263–2268
DOI: 10.1021/acs.jnatprod.7b00198

Antarctic Moss Biflavonoids Show High Antioxidant and Ultraviolet-Screening Activity
J. Nat. Prod., 2017, 80 (8), pp 2224–2231
DOI: 10.1021/acs.jnatprod.7b00085

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The Journal of Organic Chemistry

Regioselective Ene-Type Allylic Chlorination of Electron-Rich Alkenes by Activated DMSO
J. Org. Chem., 2017, 82 (16), pp 8710–8715
DOI: 10.1021/acs.joc.7b01103

t-BuOK-Mediated Oxidative Dehydrogenative C(sp3)-H Arylation of 2-Alkylazaarenes with Nitroarenes
J. Org. Chem., 2017, 82 (16), pp 8703–8709
DOI: 10.1021/acs.joc.7b00732

Iron-Catalyzed Direct C3-Benzylation of Indoles with Benzyl Alcohols through Borrowing Hydrogen
J. Org. Chem., 2017, 82 (16), pp 8769–8775
DOI: 10.1021/acs.joc.7b01603

FeCl3-Catalyzed Allylation Reactions onto 3-Hydroxy-2-oxindoles: Formal Total Syntheses of Bis-cyclotryptamine Alkaloids, (±)-Chimonanthine, and (±)-Folicanthine
J. Org. Chem., 2017, 82 (16), pp 8548–8567
DOI: 10.1021/acs.joc.7b01232

Role of Orbital Interactions and Activation Strain (Distortion Energies) on Reactivities in the Normal and Inverse Electron-Demand Cycloadditions of Strained and Unstrained Cycloalkenes
J. Org. Chem., 2017, 82 (16), pp 8668–8675
DOI: 10.1021/acs.joc.7b01673

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Molecular Pharmaceutics

Polymers in Drug Delivery: Chemistry and Applications
Mol. Pharmaceutics, 2017, 14 (8), pp 2459–2459
DOI: 10.1021/acs.molpharmaceut.7b00567

Polymeric Nanocarriers Based on Cyclodextrins for Drug Delivery: Host–Guest Interaction as Stimuli Responsive Linker
Mol. Pharmaceutics, 2017, 14 (8), pp 2475–2486
DOI: 10.1021/acs.molpharmaceut.7b00160

Stimulus-Responsive Degradable Polylactide-Based Block Copolymer Nanoassemblies for Controlled/Enhanced Drug Delivery
Mol. Pharmaceutics, 2017, 14 (8), pp 2460–2474
DOI: 10.1021/acs.molpharmaceut.7b00284

Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (8), pp 2629–2638
DOI: 10.1021/acs.molpharmaceut.7b00095

Multiresponsive Nanogels for Targeted Anticancer Drug Delivery
Mol. Pharmaceutics, 2017, 14 (8), pp 2624–2628
DOI: 10.1021/acs.molpharmaceut.7b00325

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Organic Letters

Palladium-Catalyzed Formylation of Aryl Iodides with HCOOH as CO Source
Org. Lett., 2017, 19 (16), pp 4235–4238
DOI: 10.1021/acs.orglett.7b01882

Synergistic I2/Amine Promoted Povarov-Type Reaction for the Synthesis of 2-Acyl-3-aryl(alkyl)quinolines Using Aryl(alkyl)acetaldehydes as Alkene Surrogates
Org. Lett., 2017, 19 (16), pp 4179–4182
DOI: 10.1021/acs.orglett.7b01686

Organic Dye-Catalyzed Atom Transfer Radical Addition–Elimination (ATRE) Reaction for the Synthesis of Perfluoroalkylated Alkenes
Org. Lett., 2017, 19 (16), pp 4295–4298
DOI: 10.1021/acs.orglett.7b01952

Prolinate Salts as Catalysts for α-Aminoxylation of Aldehyde and Associated Mechanistic Insights
Org. Lett., 2017, 19 (16), pp 4155–4158
DOI: 10.1021/acs.orglett.7b01433

Total Synthesis and Stereochemical Revision of 4,8-Dihydroxy-3,4-dihydrovernoniyne
Org. Lett., 2017, 19 (16), pp 4167–4170
DOI: 10.1021/acs.orglett.7b01620

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Organic Process Research & Development

BMS-663068: Another Quiet Victory for Chemistry
Open access through Editors’ Choice
Org. Process Res. Dev., 2017, 21 (8), pp 1091–1094
DOI: 10.1021/acs.oprd.7b00208

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 1. Evolution of Enabling Strategies
Org. Process Res. Dev., 2017, 21 (8), pp 1095–1109
DOI: 10.1021/acs.oprd.7b00134

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 2. Strategic Selections in the Transition from an Enabling Route to a Commercial Synthesis
Org. Process Res. Dev., 2017, 21 (8), pp 1110–1121
DOI: 10.1021/acs.oprd.7b00121

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 3. Mechanistic Studies Enable a Scale-Independent Friedel–Crafts Acylation
Org. Process Res. Dev., 2017, 21 (8), pp 1122–1130
DOI: 10.1021/acs.oprd.7b00115

Preparation of the HIV Attachment Inhibitor BMS-663068. Part 9. Active Pharmaceutical Ingredient Process Development and Powder Properties
Org. Process Res. Dev., 2017, 21 (8), pp 1174–1185
DOI: 10.1021/acs.oprd.7b00138

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Organometallics

Tris(trimethylsilyl)silylboronate Esters: Novel Bulky, Air- and Moisture-Stable Silylboronate Ester Reagents for Boryl Substitution and Silaboration Reactions
Organometallics, 2017, 36 (16), pp 3019–3022
DOI: 10.1021/acs.organomet.7b00476

Literature-Based Teaching Strategies for Organometallic Courses
Organometallics, 2017, 36 (15), pp 2703–2705
DOI: 10.1021/acs.organomet.7b00450

Homolytic Cleavage Reactions of a Neutral Doubly Base Stabilized Diborane(4)
Organometallics, 2017, 36 (16), pp 3163–3170
DOI: 10.1021/acs.organomet.7b00522

Synthesis and Characterization of Bidentate NHC-CAryl Nickel(II) Complexes: Isocyanide Insertion To Form NHC-η2-iminoacyl Complexes
Organometallics, 2017, 36 (15), pp 2987–2995
DOI: 10.1021/acs.organomet.7b00463

Catalytic Reduction of Nitroarenes by Dipalladium Complexes: Synergistic Effect
Organometallics, 2017, 36 (16), pp 3110–3116
DOI: 10.1021/acs.organomet.7b00460

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.